B-lymphocyte antigen CD20
Details
- Name
- B-lymphocyte antigen CD20
- Synonyms
- B-lymphocyte surface antigen B1
- Bp35
- CD20
- Leukocyte surface antigen Leu-16
- Membrane-spanning 4-domains subfamily A member 1
- Gene Name
- MS4A1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0000132|B-lymphocyte antigen CD20 MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNG LFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMN SLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPST QYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTI EIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP
- Number of residues
- 297
- Molecular Weight
- 33076.99
- Theoretical pI
- 4.73
- GO Classification
- FunctionsMHC class II protein complex bindingProcessesB cell proliferation / humoral immune responseComponentsexternal side of plasma membrane / extracellular exosome / extracellular space / integral component of plasma membrane
- General Function
- Mhc class ii protein complex binding
- Specific Function
- This protein may be involved in the regulation of B-cell activation and proliferation.
- Pfam Domain Function
- CD20 (PF04103)
- Transmembrane Regions
- 57-78 85-105 121-141 189-209
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0009913|B-lymphocyte antigen CD20 (MS4A1) ATGACAACACCCAGAAATTCAGTAAATGGGACTTTCCCGGCAGAGCCAATGAAAGGCCCT ATTGCTATGCAATCTGGTCCAAAACCACTCTTCAGGAGGATGTCTTCACTGGTGGGCCCC ACGCAAAGCTTCTTCATGAGGGAATCTAAGACTTTGGGGGCTGTCCAGATTATGAATGGG CTCTTCCACATTGCCCTGGGGGGTCTTCTGATGATCCCAGCAGGGATCTATGCACCCATC TGTGTGACTGTGTGGTACCCTCTCTGGGGAGGCATTATGTATATTATTTCCGGATCACTC CTGGCAGCAACGGAGAAAAACTCCAGGAAGTGTTTGGTCAAAGGAAAAATGATAATGAAT TCATTGAGCCTCTTTGCTGCCATTTCTGGAATGATTCTTTCAATCATGGACATACTTAAT ATTAAAATTTCCCATTTTTTAAAAATGGAGAGTCTGAATTTTATTAGAGCTCACACACCA TATATTAACATATACAACTGTGAACCAGCTAATCCCTCTGAGAAAAACTCCCCATCTACC CAATACTGTTACAGCATACAATCTCTGTTCTTGGGCATTTTGTCAGTGATGCTGATCTTT GCCTTCTTCCAGGAACTTGTAATAGCTGGCATCGTTGAGAATGAATGGAAAAGAACGTGC TCCAGACCCAAATCTAACATAGTTCTCCTGTCAGCAGAAGAAAAAAAAGAACAGACTATT GAAATAAAAGAAGAAGTGGTTGGGCTAACTGAAACATCTTCCCAACCAAAGAATGAAGAA GACATTGAAATTATTCCAATCCAAGAAGAGGAAGAAGAAGAAACAGAGACGAACTTTCCA GAACCTCCCCAAGATCAGGAATCCTCACCAATAGAAAATGACAGCTCTCCTTAA
- Chromosome Location
- 11
- Locus
- 11q12
- External Identifiers
Resource Link UniProtKB ID P11836 UniProtKB Entry Name CD20_HUMAN GenBank Protein ID 29774 GenBank Gene ID X12530 GenAtlas ID MS4A1 HGNC ID HGNC:7315 - General References
- Stamenkovic I, Seed B: Analysis of two cDNA clones encoding the B lymphocyte antigen CD20 (B1, Bp35), a type III integral membrane protein. J Exp Med. 1988 Jun 1;167(6):1975-80. [Article]
- Tedder TF, Streuli M, Schlossman SF, Saito H: Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes. Proc Natl Acad Sci U S A. 1988 Jan;85(1):208-12. [Article]
- Einfeld DA, Brown JP, Valentine MA, Clark EA, Ledbetter JA: Molecular cloning of the human B cell CD20 receptor predicts a hydrophobic protein with multiple transmembrane domains. EMBO J. 1988 Mar;7(3):711-7. [Article]
- Tedder TF, Klejman G, Schlossman SF, Saito H: Structure of the gene encoding the human B lymphocyte differentiation antigen CD20 (B1). J Immunol. 1989 Apr 1;142(7):2560-8. [Article]
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- Teeling JL, Mackus WJ, Wiegman LJ, van den Brakel JH, Beers SA, French RR, van Meerten T, Ebeling S, Vink T, Slootstra JW, Parren PW, Glennie MJ, van de Winkel JG: The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20. J Immunol. 2006 Jul 1;177(1):362-71. [Article]
- Carrascal M, Ovelleiro D, Casas V, Gay M, Abian J: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment. J Proteome Res. 2008 Dec;7(12):5167-76. [Article]
- Kuijpers TW, Bende RJ, Baars PA, Grummels A, Derks IA, Dolman KM, Beaumont T, Tedder TF, van Noesel CJ, Eldering E, van Lier RA: CD20 deficiency in humans results in impaired T cell-independent antibody responses. J Clin Invest. 2010 Jan;120(1):214-22. doi: 10.1172/JCI40231. Epub 2009 Dec 21. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00078 Ibritumomab tiuxetan approved, investigational yes antibodyregulator Details DB00081 Tositumomab approved, investigational yes antibody Details DB00073 Rituximab approved yes antibodyregulator Details DB06650 Ofatumumab approved yes antibodyregulator Details DB08935 Obinutuzumab approved, investigational yes antibodyregulator Details DB11988 Ocrelizumab approved, investigational yes antagonistantibody Details DB09336 Technetium Tc-99m nofetumomab merpentan approved, withdrawn yes binder Details DB11850 Ublituximab approved, investigational yes binderantibody Details DB15434 Mosunetuzumab approved, investigational yes binder Details DB16684 Odronextamab investigational yes binder Details DB16371 Glofitamab approved, investigational yes binderantibody Details DB16672 Epcoritamab approved, investigational yes binderantibody Details