Proliferating cell nuclear antigen

Details

Name
Proliferating cell nuclear antigen
Synonyms
  • Cyclin
  • PCNA
Gene Name
PCNA
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049803|Proliferating cell nuclear antigen
MFEARLVQGSILKKVLEALKDLINEACWDISSSGVNLQSMDSSHVSLVQLTLRSEGFDTY
RCDRNLAMGVNLTSMSKILKCAGNEDIITLRAEDNADTLALVFEAPNQEKVSDYEMKLMD
LDVEQLGIPEQEYSCVVKMPSGEFARICRDLSHIGDAVVISCAKDGVKFSASGELGNGNI
KLSQTSNVDKEEEAVTIEMNEPVQLTFALRYLNFFTKATPLSSTVTLSMSADVPLVVEYK
IADMGHLKYYLAPKIEDEEGS
Number of residues
261
Molecular Weight
28768.48
Theoretical pI
Not Available
GO Classification
Functions
chromatin binding / damaged DNA binding / dinucleotide insertion or deletion binding / DNA polymerase binding / DNA polymerase processivity factor activity / enzyme binding / estrogen receptor binding / histone acetyltransferase binding / identical protein binding / MutLalpha complex binding / purine-specific mismatch base pair DNA N-glycosylase activity / receptor tyrosine kinase binding
Processes
cell proliferation / cellular response to hydrogen peroxide / cellular response to UV / DNA damage response, detection of DNA damage / DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest / DNA ligation / epithelial cell differentiation / error-free translesion synthesis / error-prone translesion synthesis / estrous cycle / G1/S transition of mitotic cell cycle / heart development / liver regeneration / mismatch repair / mitotic telomere maintenance via semi-conservative replication / nucleotide-excision repair, DNA gap filling / nucleotide-excision repair, DNA incision / nucleotide-excision repair, DNA incision, 5'-to lesion / positive regulation of deoxyribonuclease activity / positive regulation of DNA repair / positive regulation of DNA replication / protein sumoylation / regulation of transcription involved in G1/S transition of mitotic cell cycle / replication fork processing / response to cadmium ion / response to dexamethasone / response to estradiol / response to L-glutamate / telomere maintenance / telomere maintenance via recombination / transcription-coupled nucleotide-excision repair / translesion synthesis
Components
centrosome / DNA replication factor C complex / extracellular exosome / nuclear body / nuclear chromosome, telomeric region / nuclear replication fork / nucleoplasm / nucleus / PCNA complex / PCNA-p21 complex / replication fork / replisome
General Function
Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
Specific Function
Chromatin binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0049804|Proliferating cell nuclear antigen (PCNA)
ATGTTCGAGGCGCGCCTGGTCCAGGGCTCCATCCTCAAGAAGGTGTTGGAGGCACTCAAG
GACCTCATCAACGAGGCCTGCTGGGATATTAGCTCCAGCGGTGTAAACCTGCAGAGCATG
GACTCGTCCCACGTCTCTTTGGTGCAGCTCACCCTGCGGTCTGAGGGCTTCGACACCTAC
CGCTGCGACCGCAACCTGGCCATGGGCGTGAACCTCACCAGTATGTCCAAAATACTAAAA
TGCGCCGGCAATGAAGATATCATTACACTAAGGGCCGAAGATAACGCGGATACCTTGGCG
CTAGTATTTGAAGCACCAAACCAGGAGAAAGTTTCAGACTATGAAATGAAGTTGATGGAT
TTAGATGTTGAACAACTTGGAATTCCAGAACAGGAGTACAGCTGTGTAGTAAAGATGCCT
TCTGGTGAATTTGCACGTATATGCCGAGATCTCAGCCATATTGGAGATGCTGTTGTAATT
TCCTGTGCAAAAGACGGAGTGAAATTTTCTGCAAGTGGAGAACTTGGAAATGGAAACATT
AAATTGTCACAGACAAGTAATGTCGATAAAGAGGAGGAAGCTGTTACCATAGAGATGAAT
GAACCAGTTCAACTAACTTTTGCACTGAGGTACCTGAACTTCTTTACAAAAGCCACTCCA
CTCTCTTCAACGGTGACACTCAGTATGTCTGCAGATGTACCCCTTGTTGTAGAGTATAAA
ATTGCGGATATGGGACACTTAAAATACTACTTGGCTCCCAAGATCGAGGATGAAGAAGGA
TCTTAG
Chromosome Location
20
Locus
20p12.3
External Identifiers
ResourceLink
UniProtKB IDP12004
UniProtKB Entry NamePCNA_HUMAN
HGNC IDHGNC:8729
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00279Liothyronineapproved, vet_approvedunknownantagonistDetails
DB00945Acetylsalicylic acidapproved, vet_approvedunknowndownregulatorDetails