1-phosphatidylinositol phosphodiesterase

Details

Name
1-phosphatidylinositol phosphodiesterase
Synonyms
  • 4.6.1.13
  • Phosphatidylinositol diacylglycerol-lyase
  • Phosphatidylinositol-specific phospholipase C
  • PI-PLC
Gene Name
Not Available
Organism
Bacillus cereus
Amino acid sequence
>lcl|BSEQ0011408|1-phosphatidylinositol phosphodiesterase
MSNKKLILKLFICSTIFITFVFALHDKRVVAASSVNELENWSKWMQPIPDSIPLARISIP
GTHDSGTFKLQNPIKQVWGMTQEYDFRYQMDHGARIFDIRGRLTDDNTIVLHHGPLYLYV
TLHEFINEAKQFLKDNPSETIIMSLKKEYEDMKGAEDSFSSTFEKKYFVDPIFLKTEGNI
KLGDARGKIVLLKRYSGSNEPGGYNNFYWPDNETFTTTVNQNANVTVQDKYKVSYDEKVK
SIKDTMDETMNNSEDLNHLYINFTSLSSGGTAWNSPYYYASYINPEIANYIKQKNPARVG
WVIQDYINEKWSPLLYQEVIRANKSLIKE
Number of residues
329
Molecular Weight
38108.93
Theoretical pI
6.9
GO Classification
Functions
phosphatidylinositol diacylglycerol-lyase activity / phosphoric diester hydrolase activity
Processes
lipid catabolic process
Components
extracellular region
General Function
Phosphoric diester hydrolase activity
Specific Function
Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0003872|990 bp
ATGAGCAATAAGAAGTTAATTTTGAAATTATTCATATGTAGTACAATATTTATCACATTT
GTATTTGCTTTACATGATAAGAGAGTAGTTGCAGCTAGCTCTGTTAATGAGCTTGAAAAT
TGGTCAAAATGGATGCAACCTATACCTGATAGTATCCCGTTAGCACGAATTTCAATTCCA
GGAACACACGATAGTGGGACGTTCAAGTTGCAAAATCCGATTAAGCAAGTATGGGGAATG
ACGCAAGAATATGATTTTCGCTATCAAATGGACCATGGAGCTCGCATTTTTGATATAAGA
GGACGTTTAACAGATGATAATACGATAGTTCTTCATCATGGGCCATTATATCTTTACGTA
ACACTGCATGAATTCATAAATGAAGCGAAACAATTTTTAAAAGATAACCCGAGTGAAACA
ATTATTATGTCTTTAAAAAAAGAGTATGAGGATATGAAAGGGGCAGAAGATTCATTTAGT
AGCACGTTTGAAAAAAAATATTTTGTTGATCCTATTTTTTTAAAAACAGAAGGAAATATA
AAGCTTGGAGATGCTCGTGGGAAAATTGTACTACTAAAAAGATATAGTGGTAGTAATGAA
CCTGGAGGATATAATAATTTTTATTGGCCAGATAATGAGACGTTTACCACAACTGTAAAC
CAAAATGCAAATGTAACAGTACAAGATAAATATAAAGTGAGCTATGATGAGAAAGTAAAA
TCTATTAAAGATACGATGGATGAAACGATGAACAATAGCGAGGATTTAAATCATCTATAT
ATTAATTTTACAAGCTTGTCTTCTGGTGGTACAGCATGGAATAGTCCATATTACTATGCC
TCTTATATAAATCCTGAAATTGCAAACTATATAAAACAAAAGAATCCTGCGAGAGTAGGC
TGGGTAATTCAAGACTACATAAATGAAAAGTGGTCACCATTATTGTATCAAGAAGTTATA
AGAGCGAATAAGTCATTAATAAAAGAATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP14262
UniProtKB Entry NamePLC_BACCE
GenBank Protein ID143340
GenBank Gene IDM30809
General References
  1. Kuppe A, Evans LM, McMillen DA, Griffith OH: Phosphatidylinositol-specific phospholipase C of Bacillus cereus: cloning, sequencing, and relationship to other phospholipases. J Bacteriol. 1989 Nov;171(11):6077-83. [Article]
  2. Heinz DW, Ryan M, Bullock TL, Griffith OH: Crystal structure of the phosphatidylinositol-specific phospholipase C from Bacillus cereus in complex with myo-inositol. EMBO J. 1995 Aug 15;14(16):3855-63. [Article]
  3. Heinz DW, Ryan M, Smith MP, Weaver LH, Keana JF, Griffith OH: Crystal structure of phosphatidylinositol-specific phospholipase C from Bacillus cereus in complex with glucosaminyl(alpha 1-->6)-D-myo-inositol, an essential fragment of GPI anchors. Biochemistry. 1996 Jul 23;35(29):9496-504. [Article]
  4. Gassler CS, Ryan M, Liu T, Griffith OH, Heinz DW: Probing the roles of active site residues in phosphatidylinositol-specific phospholipase C from Bacillus cereus by site-directed mutagenesis. Biochemistry. 1997 Oct 21;36(42):12802-13. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03106scyllo-inositolinvestigationalunknownDetails
DB03779Glucosaminyl-(Alpha-6)-D-Myo-InositolexperimentalunknownDetails