Heterogeneous nuclear ribonucleoprotein L

Details

Name
Heterogeneous nuclear ribonucleoprotein L
Synonyms
  • hnRNP L
  • HNRPL
Gene Name
HNRNPL
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049644|Heterogeneous nuclear ribonucleoprotein L
MSRRLLPRAEKRRRRLEQRQQPDEQRRRSGAMVKMAAAGGGGGGGRYYGGGSEGGRAPKR
LKTDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVE
ALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKIS
RPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDS
VQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPGSNP
NKRQRQPPLLGDHPAEYGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYG
PQYGHPPPPPPPPEYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPG
AAMVEMADGYAVDRAITHLNNNFMFGQKLNVCVSKQPAIMPGQSYGLEDGSCSYKDFSES
RNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPSSVKVFSGKSE
RSSSGLLEWESKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS
Number of residues
589
Molecular Weight
64132.45
Theoretical pI
Not Available
GO Classification
Functions
mRNA 3'-UTR binding / mRNA CDS binding / pre-mRNA intronic binding / RNA binding / transcription regulatory region DNA binding
Processes
cellular response to amino acid starvation / circadian rhythm / gene expression / mRNA splicing, via spliceosome / negative regulation of mRNA splicing, via spliceosome / positive regulation of mRNA binding / positive regulation of translation / regulation of alternative mRNA splicing, via spliceosome / response to peptide / RNA processing
Components
cytosol / extracellular exosome / intracellular ribonucleoprotein complex / membrane / nucleoplasm / nucleus / perinuclear region of cytoplasm / pronucleus / ribonucleoprotein granule
General Function
Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897).
Specific Function
Mrna 3'-utr binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0049645|Heterogeneous nuclear ribonucleoprotein L (HNRNPL)
ATGTCGCGGAGGCTGCTGCCCCGGGCGGAGAAGCGGCGTCGGCGGCTGGAGCAGAGGCAG
CAGCCGGACGAGCAGCGGAGGCGGTCGGGAGCGATGGTGAAGATGGCGGCGGCGGGCGGC
GGAGGCGGCGGTGGCCGCTACTACGGCGGCGGCAGTGAGGGCGGCCGGGCCCCTAAGCGG
CTCAAGACTGACAACGCCGGCGACCAGCACGGAGGCGGCGGCGGTGGCGGTGGAGGAGCC
GGGGCGGCGGGCGGCGGCGGCGGTGGGGAGAACTACGATGACCCGCACAAAACCCCTGCC
TCCCCAGTTGTCCACATCAGGGGCCTGATTGACGGTGTGGTGGAAGCAGACCTTGTGGAG
GCCTTGCAGGAGTTTGGACCCATCAGCTATGTGGTGGTAATGCCTAAAAAGAGACAAGCA
CTGGTGGAGTTTGAAGATGTGTTGGGGGCTTGCAACGCAGTGAACTACGCAGCCGACAAC
CAAATATACATTGCTGGTCACCCAGCTTTTGTCAACTACTCTACCAGCCAGAAGATCTCC
CGCCCTGGGGACTCGGATGACTCCCGGAGCGTGAACAGTGTGCTTCTCTTTACCATCCTG
AACCCCATTTATTCGATCACCACGGATGTTCTTTACACTATCTGTAATCCTTGTGGCCCT
GTCCAGAGAATTGTCATTTTCAGGAAGAATGGAGTTCAGGCGATGGTGGAATTTGACTCA
GTTCAAAGTGCCCAGCGGGCCAAGGCCTCTCTCAATGGGGCTGATATCTATTCTGGCTGT
TGCACTCTGAAGATCGAATACGCAAAGCCTACACGCTTGAATGTGTTCAAGAATGATCAG
GATACTTGGGACTACACAAACCCCAATCTCAGTGGACAAGGTGACCCTGGCAGCAACCCC
AACAAACGCCAGAGGCAGCCCCCTCTCCTGGGAGATCACCCCGCAGAATATGGAGGGCCC
CACGGTGGGTACCACAGCCATTACCATGATGAGGGCTACGGGCCCCCCCCACCTCACTAC
GAAGGGAGAAGGATGGGTCCACCAGTGGGGGGTCACCGTCGGGGCCCAAGTCGCTACGGC
CCCCAGTATGGGCACCCCCCACCCCCTCCCCCACCACCCGAGTATGGCCCTCACGCCGAC
AGCCCTGTGCTCATGGTCTATGGCTTGGATCAATCTAAGATGAACTGTGACCGAGTCTTC
AATGTCTTCTGCTTATATGGCAATGTGGAGAAGGTGAAATTCATGAAAAGCAAGCCGGGG
GCCGCCATGGTGGAGATGGCTGATGGCTACGCTGTAGACCGGGCCATTACCCACCTCAAC
AACAACTTCATGTTTGGGCAGAAGCTGAATGTCTGTGTCTCCAAGCAGCCAGCCATCATG
CCTGGTCAGTCATACGGGTTGGAAGACGGGTCTTGCAGTTACAAAGACTTCAGTGAATCC
CGGAACAATCGGTTCTCCACCCCAGAGCAGGCAGCCAAGAACCGCATCCAGCACCCCAGC
AACGTGCTGCACTTCTTCAACGCCCCGCTGGAGGTGACCGAGGAGAACTTCTTTGAGATC
TGCGATGAGCTGGGAGTGAAGCGGCCATCTTCTGTGAAAGTATTCTCAGGCAAAAGTGAG
CGCAGCTCCTCTGGACTGCTGGAGTGGGAATCCAAGAGCGATGCCCTGGAGACTCTGGGC
TTCCTGAACCATTACCAGATGAAAAACCCAAATGGTCCATACCCTTACACTCTGAAGTTG
TGTTTCTCCACTGCTCAGCACGCCTCCTAA
Chromosome Location
19
Locus
19q13.2
External Identifiers
ResourceLink
UniProtKB IDP14866
UniProtKB Entry NameHNRPL_HUMAN
HGNC IDHGNC:5045
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB09130Copperapproved, investigationalunknownDetails