3-dehydroquinate dehydratase

Details

Name
3-dehydroquinate dehydratase
Synonyms
  • 3-dehydroquinase
  • 4.2.1.10
  • Type II DHQase
Gene Name
aroQ
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Amino acid sequence
>lcl|BSEQ0011264|3-dehydroquinate dehydratase
MPRSLANAPIMILNGPNLNLLGQRQPEIYGSDTLADVEALCVKAAAAHGGTVDFRQSNHE
GELVDWIHEARLNHCGIVINPAAYSHTSVAILDALNTCDGLPVVEVHISNIHQREPFRHH
SYVSQRADGVVAGCGVQGYVFGVERIAALAGAGSARA
Number of residues
157
Molecular Weight
16681.69
Theoretical pI
6.41
GO Classification
Functions
3-dehydroquinate dehydratase activity
Processes
aromatic amino acid family biosynthetic process / chorismate biosynthetic process
General Function
3-dehydroquinate dehydratase activity
Specific Function
Catalyzes a trans-dehydration via an enolate intermediate.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0011265|3-dehydroquinate dehydratase (aroQ)
GTGCCCCGCAGCCTGGCCAACGCCCCGATCATGATCCTCAACGGCCCCAACCTGAACCTG
CTCGGCCAGCGCCAGCCGGAGATCTACGGCTCCGACACCCTCGCCGACGTCGAGGCGCTG
TGCGTGAAGGCGGCGGCCGCGCACGGCGGCACGGTGGACTTCCGGCAGTCCAACCACGAG
GGCGAACTGGTCGACTGGATCCACGAGGCCCGGCTGAACCACTGCGGGATCGTGATCAAC
CCCGCCGCCTACTCGCACACGTCCGTCGCCATCCTGGATGCGCTCAACACCTGCGACGGG
CTGCCGGTGGTGGAGGTCCACATCTCCAACATCCACCAGCGTGAGCCGTTCCGGCACCAC
TCCTACGTCTCGCAGCGCGCCGACGGCGTCGTCGCGGGGTGCGGTGTGCAGGGGTACGTC
TTCGGTGTGGAGCGGATCGCCGCCCTGGCCGGGGCGGGCTCGGCCAGGGCCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP15474
UniProtKB Entry NameAROQ_STRCO
GenBank Protein ID2558614
GenBank Gene IDAJ001493
General References
  1. Bentley SD, Chater KF, Cerdeno-Tarraga AM, Challis GL, Thomson NR, James KD, Harris DE, Quail MA, Kieser H, Harper D, Bateman A, Brown S, Chandra G, Chen CW, Collins M, Cronin A, Fraser A, Goble A, Hidalgo J, Hornsby T, Howarth S, Huang CH, Kieser T, Larke L, Murphy L, Oliver K, O'Neil S, Rabbinowitsch E, Rajandream MA, Rutherford K, Rutter S, Seeger K, Saunders D, Sharp S, Squares R, Squares S, Taylor K, Warren T, Wietzorrek A, Woodward J, Barrell BG, Parkhill J, Hopwood DA: Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature. 2002 May 9;417(6885):141-7. [Article]
  2. White PJ, Young J, Hunter IS, Nimmo HG, Coggins JR: The purification and characterization of 3-dehydroquinase from Streptomyces coelicolor. Biochem J. 1990 Feb 1;265(3):735-8. [Article]
  3. Krell T, Horsburgh MJ, Cooper A, Kelly SM, Coggins JR: Localization of the active site of type II dehydroquinases. Identification of a common arginine-containing motif in the two classes of dehydroquinases. J Biol Chem. 1996 Oct 4;271(40):24492-7. [Article]
  4. Roszak AW, Robinson DA, Krell T, Hunter IS, Fredrickson M, Abell C, Coggins JR, Lapthorn AJ: The structure and mechanism of the type II dehydroquinase from Streptomyces coelicolor. Structure. 2002 Apr;10(4):493-503. [Article]
  5. Frederickson M, Roszak AW, Coggins JR, Lapthorn AJ, Abell C: (1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases. Org Biomol Chem. 2004 Jun 7;2(11):1592-6. Epub 2004 May 6. [Article]
  6. Toscano MD, Stewart KA, Coggins JR, Lapthorn AJ, Abell C: Rational design of new bifunctional inhibitors of type II dehydroquinase. Org Biomol Chem. 2005 Sep 7;3(17):3102-4. Epub 2005 Aug 1. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB027862-Anhydro-3-Fluoro-Quinic AcidexperimentalunknownDetails
DB028012,3-Anhydro-quinic acidexperimentalunknownDetails
DB043473-DehydroshikimateexperimentalunknownDetails
DB046561,3,4-TRIHYDROXY-5-(3-PHENOXYPROPYL)-CYCLOHEXANE-1-CARBOXYLIC A CIDexperimentalunknownDetails
DB08485(1S,4S,5S)-1,4,5-TRIHYDROXY-3-[3-(PHENYLTHIO)PHENYL]CYCLOHEX-2-ENE-1-CARBOXYLIC ACIDexperimentalunknownDetails