Vascular endothelial growth factor A

Details

Name
Vascular endothelial growth factor A
Synonyms
  • Vascular permeability factor
  • VEGF
  • VEGF-A
  • VPF
Gene Name
VEGFA
Organism
Humans
Amino acid sequence
>lcl|BSEQ0000325|Vascular endothelial growth factor A
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVD
IFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEM
SFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPG
PHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
Number of residues
232
Molecular Weight
27042.205
Theoretical pI
9.08
GO Classification
Functions
chemoattractant activity / cytokine activity / extracellular matrix binding / fibronectin binding / growth factor activity / heparin binding / identical protein binding / neuropilin binding / platelet-derived growth factor receptor binding / protein heterodimerization activity / protein homodimerization activity / receptor agonist activity / vascular endothelial growth factor receptor 1 binding / vascular endothelial growth factor receptor 2 binding / vascular endothelial growth factor receptor binding
Processes
activation of protein kinase activity / angiogenesis / artery morphogenesis / basophil chemotaxis / blood coagulation / branching morphogenesis of an epithelial tube / camera-type eye morphogenesis / cardiac muscle fiber development / cardiac vascular smooth muscle cell development / cell maturation / cell migration involved in sprouting angiogenesis / cellular response to hypoxia / cellular response to vascular endothelial growth factor stimulus / commissural neuron axon guidance / coronary artery morphogenesis / coronary vein morphogenesis / dopaminergic neuron differentiation / endothelial cell chemotaxis / epithelial cell differentiation / eye photoreceptor cell development / growth / heart morphogenesis / in utero embryonic development / induction of positive chemotaxis / kidney development / lactation / lung development / lymph vessel morphogenesis / macrophage differentiation / mammary gland alveolus development / mesoderm development / monocyte differentiation / negative regulation of apoptotic process / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / negative regulation of transcription from RNA polymerase II promoter / nervous system development / outflow tract morphogenesis / ovarian follicle development / patterning of blood vessels / platelet activation / platelet degranulation / positive chemotaxis / positive regulation of angiogenesis / positive regulation of axon extension involved in axon guidance / positive regulation of blood vessel endothelial cell migration / positive regulation of branching involved in ureteric bud morphogenesis / positive regulation of cell adhesion / positive regulation of cell division / positive regulation of cell migration / positive regulation of cell migration involved in sprouting angiogenesis / positive regulation of cell proliferation / positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway / positive regulation of cellular component movement / positive regulation of CREB transcription factor activity / positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway / positive regulation of endothelial cell migration / positive regulation of endothelial cell proliferation / positive regulation of epithelial cell proliferation / positive regulation of ERK1 and ERK2 cascade / positive regulation of focal adhesion assembly / positive regulation of gene expression / positive regulation of histone deacetylase activity / positive regulation of leukocyte migration / positive regulation of MAP kinase activity / positive regulation of mast cell chemotaxis / positive regulation of mesenchymal cell proliferation / positive regulation of neuroblast proliferation / positive regulation of p38MAPK cascade / positive regulation of peptidyl-serine phosphorylation / positive regulation of peptidyl-tyrosine autophosphorylation / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of positive chemotaxis / positive regulation of protein autophosphorylation / positive regulation of protein complex assembly / positive regulation of protein kinase C signaling / positive regulation of protein kinase D signaling / positive regulation of protein localization to early endosome / positive regulation of protein phosphorylation / positive regulation of receptor internalization / positive regulation of retinal ganglion cell axon guidance / positive regulation of transcription from RNA polymerase II promoter / positive regulation of transcription from RNA polymerase II promoter in response to hypoxia / positive regulation of vascular endothelial growth factor receptor signaling pathway / positive regulation of vascular permeability / post-embryonic camera-type eye development / primitive erythrocyte differentiation / regulation of cell shape / regulation of cGMP metabolic process / regulation of retinal ganglion cell axon guidance / regulation of transcription from RNA polymerase II promoter / regulation of transcription from RNA polymerase II promoter in response to hypoxia / response to hypoxia / surfactant homeostasis / tube formation / vascular endothelial growth factor receptor signaling pathway / vascular endothelial growth factor signaling pathway / vasculogenesis / VEGF-activated neuropilin signaling pathway
Components
cell surface / cytoplasm / extracellular region / extracellular space / membrane / platelet alpha granule lumen / proteinaceous extracellular matrix / secretory granule
General Function
Vascular endothelial growth factor receptor binding
Specific Function
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0021644|Vascular endothelial growth factor A (VEGFA)
CTGACGGACAGACAGACAGACACCGCCCCCAGCCCCAGCTACCACCTCCTCCCCGGCCGG
CGGCGGACAGTGGACGCGGCGGCGAGCCGCGGGCAGGGGCCGGAGCCCGCGCCCGGAGGC
GGGGTGGAGGGGGTCGGGGCTCGCGGCGTCGCACTGAAACTTTTCGTCCAACTTCTGGGC
TGTTCTCGCTTCGGAGGAGCCGTGGTCCGCGCGGGGGAAGCCGAGCCGAGCGGAGCCGCG
AGAAGTGCTAGCTCGGGCCGGGAGGAGCCGCAGCCGGAGGAGGGGGAGGAGGAAGAAGAG
AAGGAAGAGGAGAGGGGGCCGCAGTGGCGACTCGGCGCTCGGAAGCCGGGCTCATGGACG
GGTGAGGCGGCGGTGTGCGCAGACAGTGCTCCAGCCGCGCGCGCTCCCCAGGCCCTGGCC
CGGGCCTCGGGCCGGGGAGGAAGAGTAGCTCGCCGAGGCGCCGAGGAGAGCGGGCCGCCC
CACAGCCCGAGCCGGAGAGGGAGCGCGAGCCGCGCCGGCCCCGGTCGGGCCTCCGAAACC
ATGAACTTTCTGCTGTCTTGGGTGCATTGGAGCCTTGCCTTGCTGCTCTACCTCCACCAT
GCCAAGTGGTCCCAGGCTGCACCCATGGCAGAAGGAGGAGGGCAGAATCATCACGAAGTG
GTGAAGTTCATGGATGTCTATCAGCGCAGCTACTGCCATCCAATCGAGACCCTGGTGGAC
ATCTTCCAGGAGTACCCTGATGAGATCGAGTACATCTTCAAGCCATCCTGTGTGCCCCTG
ATGCGATGCGGGGGCTGCTGCAATGACGAGGGCCTGGAGTGTGTGCCCACTGAGGAGTCC
AACATCACCATGCAGATTATGCGGATCAAACCTCACCAAGGCCAGCACATAGGAGAGATG
AGCTTCCTACAGCACAACAAATGTGAATGCAGACCAAAGAAAGATAGAGCAAGACAAGAA
AAAAAATCAGTTCGAGGAAAGGGAAAGGGGCAAAAACGAAAGCGCAAGAAATCCCGGTAT
AAGTCCTGGAGCGTGTACGTTGGTGCCCGCTGCTGTCTAATGCCCTGGAGCCTCCCTGGC
CCCCATCCCTGTGGGCCTTGCTCAGAGCGGAGAAAGCATTTGTTTGTACAAGATCCGCAG
ACGTGTAAATGTTCCTGCAAAAACACAGACTCGCGTTGCAAGGCGAGGCAGCTTGAGTTA
AACGAACGTACTTGCAGATGTGACAAGCCGAGGCGGTGA
Chromosome Location
6
Locus
6p12
External Identifiers
ResourceLink
UniProtKB IDP15692
UniProtKB Entry NameVEGFA_HUMAN
GenBank Protein ID181971
GenBank Gene IDM32977
GenAtlas IDVEGF
HGNC IDHGNC:12680
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01270RanibizumabapprovedyesDetails
DB01017Minocyclineapproved, investigationalunknowninhibitorDetails
DB01120Gliclazideapprovedunknownother/unknownDetails
DB01136Carvedilolapproved, investigationalunknownotherDetails
DB03088Pidolic acidapproved, investigationalunknownDetails
DB03754TromethamineapprovedunknownDetails
DB00112Bevacizumabapproved, investigationalyesDetails
DB05294VandetanibapprovedunknowninhibitorDetails
DB05434ABT-510investigationalunknownDetails
DB05890VeglininvestigationalunknownDetails
DB05932DenibulininvestigationalunknownDetails
DB05969SNS-032investigationalunknownDetails
DB06642BevasiranibinvestigationalunknownDetails
DB06779DalteparinapprovedyesinhibitorDetails
DB08885AfliberceptapprovedyesbinderDetails
DB09301Chondroitin sulfateapproved, investigational, nutraceuticalunknownDetails
DB10772Foreskin keratinocyte (neonatal)approvedyesagonistDetails