Pol polyprotein

Details

Name
Pol polyprotein
Synonyms
  • 2.7.7.49
  • RT
Gene Name
pol
Organism
FIV
Amino acid sequence
>lcl|BSEQ0010982|Pol polyprotein
KEFGKLEGGASCSPSESNAASSNAICTSNGGETIGFVNYNKVGTTTTLEKRPEILIFVNG
YPIKFLLDTGADITILNRRDFQVKNSIENGRQNMIGVGGGKRGTNYINVHLEIRDENYKT
QCIFGNVCVLEDNSLIQPLLGRDNMIKFNIRLVMAQISDKIPVVKVKMKDPNKGPQIKQW
PLTNEKIEALTEIVERLEKEGKVKRADSNNPWNTPVFAIKKKSGKWRMLIDFRELNKLTE
KGAEVQLGLPHPAGLQIKKQVTVLDIGDAYFTIPLDPDYAPYTAFTLPRKNNAGPGRRFV
WCSLPQGWILSPLIYQSTLDNIIQPFIRQNPQLDIYQYMDDIYIGSNLSKKEHKEKVEEL
RKLLLWWGFETPEDKLQEEPPYTWMGYELHPLTWTIQQKQLDIPEQPTLNELQKLAGKIN
WASQAIPDLSIKALTNMMRGNQNLNSTRQWTKEARLEVQKAKKAIEEQVQLGYYDPSKEL
YAKLSLVGPHQISYQVYQKDPEKILWYGKMSRQKKKAENTCDIALRACYKIREESIIRIG
KEPRYEIPTSREAWESNLINSPYLKAPPPEVEYIHAALNIKRALSMIKDAPIPGAETWYI
DGGRKLGKAAKAAYWTDTGKWRVMDLEGSNQKAEIQALLLALKAGSEEMNIITDSQYVIN
IILQQPDMMEGIWQEVLEELEKKTAIFIDWVPGHKGIPGNEEVDKLCQTMMIIEGDGILD
KRSEDAGYDLLAAKEIHLLPGEVKVIPTGVKLMLPKGYWGLIIGKSSIGSKGLDVLGGVI
DEGYRGEIGVIMINVSRKSITLMERQKIAQLIILPCKHEVLEQGKVVMDSERGDNGYGST
GVFSSWVDRIEEAEINHEKFHSDPQYLRTEFNLPKMVAEEIRRKCPVCRIIGEQVGGQLK
IGPGIWQMDCTHFDGKIILVGIHVESGYIWAQIISQETADCTVKAVLQLLSAHNVTELQT
DNGPNFKNQKMEGVLNYMGVKHKFGIPGNPQSQALVENVNHTLKVWIQKFLPETTSLDNA
LSLAVHSLNFKRRGRIGGMAPYELLAQQESLRIQDYFSAIPQKLQAQWIYYKDQKDKKWK
GPMRVEYWGQGSVLLKDEEKGYFLIPRRHIRRVPEPCALPEGDE
Number of residues
1124
Molecular Weight
127493.025
Theoretical pI
8.06
GO Classification
Functions
aspartic-type endopeptidase activity / DNA binding / dUTP diphosphatase activity / exoribonuclease H activity / RNA-directed DNA polymerase activity / RNA-DNA hybrid ribonuclease activity / zinc ion binding
Processes
DNA integration / DNA recombination / dUTP metabolic process / establishment of integrated proviral latency / viral entry into host cell
General Function
Zinc ion binding
Specific Function
During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0002778|2993 bp
GTGTCTTAGAAGATAACTCATTAATACAACCATTATTAGGGAGAGATAATATGATTAAAT
TCAATATTAGGTTAGTAATGGCTCAAATTTCTGATAAGATTCCAGTAGTAAAAGTAAAAA
TGAAGGATCCTAATAAAGGACCTCAAATAAAACAATGGCCATTAACAAATGAAAAAATTG
AAGCCTTAACAGAAATAGTAGAAAGACTAGAAAGAGAAGGGAAAGTAAAAAGAGCAGATC
CAAATAATCCATGGAATACACCAGTATTTGCTATAAAAAAGAAAAGTGGAAAATGGAGAA
TGCTCATAGATTTTAGAGAATTAAACAAACTAACTGAGAAAGGAGCAGAGGTCCAGTTGG
GACTACCTCATCCTGCTGGTTTACAAATAAAAAAACAAGTAACAGTATTAGATATAGGGG
ATGCATATTTCACCATTCCTCTTGATCCAGATTATGCTCCTTATACAGCATTTACTTTAC
CTAGAAAAAATAATGCGGGACCAGGAAGGAGATTTGTGTGGTGTAGTCTACCACAAGGCT
GGATTTTAAGTCCATTGATATATCAAAGTACATTAGATAATATAATACAACCTTTTATTA
GACAAAATCCTCAATTAGATATTTACCAATATATGGATGACATTTATATAGGATCAAATT
TAAGTAAAAAGGAGCATAAAGAAAAGGTAGAAGAATTAAGAAAATTACTATTATGGTGGG
GATTTGAAACTCCAGAAGATAAATTACAGGAAGAACCCCCATATACATGGATGGGTTATG
AATTACATCCATTAACATGGACAATACAACAGAAACAGTTAGACATTCCAGAACAGCCCA
CTCTAAATGAGTTGCAAAAATTAGCAGGAAAAATTAATTGGGCTAGCCAAGCTATTCCAG
ACTTGAGTATAAAAGCATTAACTAACATGATGAGAGGAAATCAAAACCTAAATTCAACAA
GACAATGGACTAAAGAAGCTCGACTGGAAGTACAAAAGGCAAAAAAGGCTATAGAAGAAC
AAGTACAACTAGGATACTATGACCCCAGTAAGGAGTTATATGCTAAATTAAGTTTGGTGG
GACCACATCAAATAAGTTATCAAGTATATCAGAAGGATCCAGAAAAGATACTATGGTATG
GAAAAATGAGTAGACAAAAGAAAAAGGCAGAAAATACATGTGATATAGCCTTAAGAGCAT
GCTATAAGATAAGAGAAGAGTCTATTATAAGAATAGGAAAAGAACCAAGATATGAAATAC
CTACTTCTAGAGAAGCCTGGGAATCAAATTTAATTAATTCACCATATCTTAAGGCCCCAC
CTCCTGAGGTAGAATATATCCATGCTGCTTTGAATATAAAGAGAGCGTTAAGTATGATAA
AAGATGCTCCAATACCAGGAGCAGAAACATGGTATATAGATGGAGGTAGAAAGCTAGGAA
AAGCAGCAAAAGCAGCCTATTGGACAGATACAGGAAAGTGGCAAGTGATGGAATTAGAAG
GCAGTAATCAGAAGGCAGAAATACAAGCATTATTATTGGCATTAAAAGCAGGATCAGAGG
AGATGAATATTATAACAGATTCACAATATGTTATAAATATTATTCTTCAACAACCAGATA
TGATGGAGGGAATCTGGCAAGAAGTTTTAGAAGAATTGGAGAAGAAAACAGCAATATTTA
TAGATTGGGTCCCAGGACATAAAGGTATTCCAGGAAATGAGGAAGTAGATAAGCTTTGTC
AAACAATGATGATAATAGAAGGGGATGGGATATTAGATAAAAGGTCAGAAGATGCAGGAT
ATGATTTATTAGCTGCAAAAGAAATACATTTATTGCCAGGAGAGGTAAAAGTAATACCAA
CAGGGGTAAAGCTAATGTTGCCTAAAGGATATTGGGGATTAATAATAGGAAAAAGCTCGA
TAGGGAGTAAAGGATTGGATGTATTAGGAGGGGTAATAGACGAAGGATATCGAGGTGAAA
TTGGAGTAATAATGATTAATGTATCAAGAAAATCAATCACCTTAATGGAACGACAAAAGA
TAGCACAATTAATAATATTGCCTTGTAAACATGAAGTATTAGAACAAGGAAAAGTAGTAA
TGGATTCAGAGAGAGGAGACAATGGTTATGGGTCAACAGGAGTATTCTCCTCTTGGGTTG
ACAGAATTGAGGAAGCAGAAATAAATCATGAAAAATTTCACTCAGATCCACAGTACTTAA
GGACTGAATTTAATTTACCTAAAATGGTAGCAGAAGAGATAAGACGAAAATGCCCAGTAT
GCAGAATCAGAGGAGAACAAGTGGGAGGACAATTGAAAATAGGGCCTGGTATCTGGCAAA
TGGATTGCACACACTTTGATGGCAAAATAATTCTTGTGGGTATACATGTGGAATCAGGAT
ATATATGGGCACAAATAATTTCTCAAGAAACTGCTGACTGTACAGTTAAAGCTGTCTTAC
AATTGTTGAGTGCTCATAATGTTACTGAATTACAAACAGATAATGGACCAAATTTTAAAA
ATCAAAAGATGGAAGGAGTACTCAATTACATGGGTGTGAAACATAAGTTTGGTATCCCAG
GGAACCCACAGTCACAAGCATTAGTTGAAAATGTAAATCATACATTAAAAGTTTGGATTC
GGAAATTTTTGCCTGAAACAACCTCCTTGGATAATGCCTTATCTCTCGCTGTACATAGTC
TCAATTTTAAAAGAAGAGGTAGGATAGGAGGGATGGCCCCTTATGAATTATTAGCACAAC
AAGAATCCTTAAGAATACAAGATTATTTTTCTGCAATACCACAAAAATTGCAAGCACAGT
GGATTTATTATAAAGATCAAAAAGATAAGAAATGGAAAGGACCAATGAGAGTAGAATACT
GGGGACAGGGATCAGTATTATTAAAGGATGAAGAGAAGGGATATTTTCTTATACCTAGGA
GACACATAAGGAGAGTTCCAGAACCCTGCGCTCTTCCTGAAGGGGATGAGTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP16088
UniProtKB Entry NamePOL_FIVPE
GenBank Protein ID323935
GenBank Gene IDM25381
General References
  1. Talbott RL, Sparger EE, Lovelace KM, Fitch WM, Pedersen NC, Luciw PA, Elder JH: Nucleotide sequence and genomic organization of feline immunodeficiency virus. Proc Natl Acad Sci U S A. 1989 Aug;86(15):5743-7. [Article]
  2. Olmsted RA, Hirsch VM, Purcell RH, Johnson PR: Nucleotide sequence analysis of feline immunodeficiency virus: genome organization and relationship to other lentiviruses. Proc Natl Acad Sci U S A. 1989 Oct;86(20):8088-92. [Article]
  3. Elder JH, Schnolzer M, Hasselkus-Light CS, Henson M, Lerner DA, Phillips TR, Wagaman PC, Kent SB: Identification of proteolytic processing sites within the Gag and Pol polyproteins of feline immunodeficiency virus. J Virol. 1993 Apr;67(4):1869-76. [Article]
  4. Wlodawer A, Gustchina A, Reshetnikova L, Lubkowski J, Zdanov A, Hui KY, Angleton EL, Farmerie WG, Goodenow MM, Bhatt D, et al.: Structure of an inhibitor complex of the proteinase from feline immunodeficiency virus. Nat Struct Biol. 1995 Jun;2(6):480-8. [Article]
  5. Laco GS, Schalk-Hihi C, Lubkowski J, Morris G, Zdanov A, Olson A, Elder JH, Wlodawer A, Gustchina A: Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor. Biochemistry. 1997 Sep 2;36(35):10696-708. [Article]
  6. Prasad GS, Stura EA, McRee DE, Laco GS, Hasselkus-Light C, Elder JH, Stout CD: Crystal structure of dUTP pyrophosphatase from feline immunodeficiency virus. Protein Sci. 1996 Dec;5(12):2429-37. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01891Tl-3-093experimentalunknownDetails
DB02333Deoxyuridine-5'-TriphosphateexperimentalunknownDetails
DB03435Uridine-5'-DiphosphateexperimentalunknownDetails
DB03800Deoxyuridine monophosphateexperimentalunknownDetails
DB073651-Naphthyl-L-alanineexperimentalunknownDetails
DB08253NAM NAPTHYLAMINOALANINEexperimentalunknownDetails