Potassium voltage-gated channel subfamily A member 6
Details
- Name
- Potassium voltage-gated channel subfamily A member 6
- Synonyms
- Voltage-gated potassium channel HBK2
- Voltage-gated potassium channel subunit Kv1.6
- Gene Name
- KCNA6
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0013278|Potassium voltage-gated channel subfamily A member 6 MRSEKSLTLAAPGEVRGPEGEQQDAGDFPEAGGGGGCCSSERLVINISGLRFETQLRTLS LFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFLEE IRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVS VLVILISIVIFCLETLPQFRVDGRGGNNGGVSRVSPVSRGSQEEEEDEDDSYTFHHGITP GEMGTGGSSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKPAFFRNIMNIID LVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSK GLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSLFPSIPDAFWWAVVTM TTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHV TCGQPAPDLRATDNGLGKPDFPEANRERRPSYLPTPHRAYAEKRMLTEV
- Number of residues
- 529
- Molecular Weight
- 58728.21
- Theoretical pI
- Not Available
- GO Classification
- Functionsdelayed rectifier potassium channel activity / voltage-gated potassium channel activityProcessespotassium ion transmembrane transport / potassium ion transport / protein homooligomerization / synaptic transmissionComponentsaxon terminus / integral component of plasma membrane / plasma membrane / potassium channel complex / voltage-gated potassium channel complex
- General Function
- Voltage-gated potassium channel activity
- Specific Function
- Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:2347305, PubMed:14575698). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2347305, PubMed:14575698). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). Homotetrameric channels display rapid activation and slow inactivation (PubMed:2347305).
- Pfam Domain Function
- Transmembrane Regions
- 172-193 263-284 296-316 338-358 374-395 437-465
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0013279|Potassium voltage-gated channel subfamily A member 6 (KCNA6) ATGAGATCGGAGAAATCCCTTACGCTGGCGGCGCCGGGGGAGGTCCGTGGGCCGGAGGGA GAGCAACAGGATGCGGGAGACTTCCCGGAGGCCGGCGGGGGCGGGGGCTGCTGTAGTAGC GAGCGGCTGGTGATCAATATCTCCGGGCTGCGCTTTGAGACACAATTGCGCACCCTGTCG CTGTTTCCGGACACGCTGCTCGGAGACCCTGGCCGGCGAGTCCGCTTCTTCGACCCCCTG AGGAACGAGTACTTCTTCGACCGCAACCGGCCCAGCTTCGACGCCATCCTCTACTACTAC CAGTCTGGGGGCCGCCTGCGGAGGCCGGTCAACGTGCCCCTGGACATTTTCCTGGAGGAG ATCCGCTTCTACCAGCTGGGGGACGAGGCCCTGGCGGCCTTCCGGGAGGACGAGGGCTGC CTGCCCGAAGGTGGCGAGGACGAGAAGCCGCTGCCCTCCCAGCCCTTCCAGCGCCAGGTG TGGCTGCTCTTTGAGTACCCAGAGAGCTCTGGGCCGGCCAGGGGCATCGCCATCGTCTCC GTGTTGGTCATTCTCATCTCCATAGTCATCTTTTGCCTGGAGACCTTACCCCAGTTCCGT GTAGATGGTCGAGGTGGAAACAATGGTGGTGTGAGTCGAGTCTCCCCAGTTTCCAGGGGG AGTCAGGAGGAAGAGGAGGATGAAGACGATTCCTACACATTTCATCATGGCATCACCCCT GGGGAAATGGGGACCGGGGGCTCCTCCTCACTCAGTACTCTTGGGGGCTCCTTCTTTACA GACCCCTTCTTTCTGGTGGAGACGCTGTGCATTGTCTGGTTCACTTTTGAGCTCCTGGTG CGCTTCTCCGCCTGCCCTAGCAAGCCGGCCTTCTTCCGGAACATCATGAACATCATTGAC TTGGTGGCTATCTTCCCCTACTTCATCACCCTGGGCACTGAGCTGGTGCAGCAGCAGGAG CAGCAACCAGCCAGTGGAGGAGGCGGCCAGAATGGGCAGCAGGCCATGTCCCTGGCCATC CTCCGAGTCATCCGCCTGGTCCGGGTGTTCCGCATCTTCAAGCTCTCCCGCCACTCCAAG GGGCTGCAGATCCTGGGCAAGACCTTGCAGGCCTCCATGAGGGAGCTGGGGCTGCTCATC TTCTTCCTCTTCATCGGGGTCATCCTCTTCTCCAGTGCCGTCTACTTCGCAGAGGCTGAC GATGACGATTCGCTTTTTCCCAGCATCCCGGATGCCTTCTGGTGGGCAGTGGTTACAATG ACCACGGTAGGTTACGGGGACATGTACCCCATGACTGTGGGGGGAAAGATCGTGGGCTCG CTGTGTGCCATCGCTGGGGTCCTCACCATTGCCCTGCCTGTGCCCGTCATCGTCTCCAAC TTCAACTACTTCTACCACCGGGAGACGGAGCAGGAGGAGCAAGGCCAGTATACCCACGTC ACTTGTGGGCAGCCTGCGCCGGACCTGAGGGCAACTGACAACGGACTTGGCAAGCCTGAC TTCCCCGAGGCTAACCGGGAACGGAGACCCAGCTACCTTCCTACACCACATCGGGCCTAT GCAGAGAAAAGAATGCTCACGGAGGTCTGA
- Chromosome Location
- 12
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P17658 UniProtKB Entry Name KCNA6_HUMAN HGNC ID HGNC:6225 - General References
- Grupe A, Schroter KH, Ruppersberg JP, Stocker M, Drewes T, Beckh S, Pongs O: Cloning and expression of a human voltage-gated potassium channel. A novel member of the RCK potassium channel family. EMBO J. 1990 Jun;9(6):1749-56. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Guihard G, Bellocq C, Grelet E, Escande D: Human Kv1.6 current displays a C-type-like inactivation when re-expressed in cos-7 cells. Biochem Biophys Res Commun. 2003 Nov 7;311(1):83-9. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB06637 Dalfampridine approved yes antagonist Details DB00228 Enflurane approved, investigational, vet_approved unknown inhibitoractivator Details DB01069 Promethazine approved, investigational unknown inducer Details DB01110 Miconazole approved, investigational, vet_approved unknown inhibitor Details