Insulin-like growth factor-binding protein 3

Details

Name
Insulin-like growth factor-binding protein 3
Synonyms
  • IBP-3
  • IBP3
Gene Name
IGFBP3
Organism
Humans
Amino acid sequence
>lcl|BSEQ0001931|Insulin-like growth factor-binding protein 3
MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCAPPPAVCAE
LVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASAV
SRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKFHPLHSKIIIIKKGHA
KDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNC
DKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYTTKGKEDVHCYSMQSK
Number of residues
291
Molecular Weight
31673.87
Theoretical pI
8.78
GO Classification
Functions
fibronectin binding / insulin-like growth factor binding / insulin-like growth factor I binding / insulin-like growth factor II binding / metal ion binding / protein tyrosine phosphatase activator activity
Processes
apoptotic process / cellular protein metabolic process / negative regulation of cell proliferation / negative regulation of protein phosphorylation / negative regulation of signal transduction / negative regulation of smooth muscle cell migration / negative regulation of smooth muscle cell proliferation / osteoblast differentiation / positive regulation of apoptotic process / positive regulation of catalytic activity / positive regulation of insulin-like growth factor receptor signaling pathway / positive regulation of MAPK cascade / positive regulation of myoblast differentiation / protein phosphorylation / regulation of cell growth / regulation of glucose metabolic process / regulation of insulin-like growth factor receptor signaling pathway / type B pancreatic cell proliferation
Components
extracellular exosome / extracellular region / extracellular space / insulin-like growth factor binding protein complex / insulin-like growth factor ternary complex / nucleus
General Function
Protein tyrosine phosphatase activator activity
Specific Function
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0010680|Insulin-like growth factor-binding protein 3 (IGFBP3)
ATGCAGCGGGCGCGACCCACGCTCTGGGCCGCTGCGCTGACTCTGCTGGTGCTGCTCCGC
GGGCCGCCGGTGGCGCGGGCTGGCGCGAGCTCGGCGGGCTTGGGTCCCGTGGTGCGCTGC
GAGCCGTGCGACGCGCGTGCACTGGCCCAGTGCGCGCCTCCGCCCGCCGTGTGCGCGGAG
CTGGTGCGCGAGCCGGGCTGCGGCTGCTGCCTGACGTGCGCACTGAGCGAGGGCCAGCCG
TGCGGCATCTACACCGAGCGCTGTGGCTCCGGCCTTCGCTGCCAGCCGTCGCCCGACGAG
GCGCGACCGCTGCAGGCGCTGCTGGACGGCCGCGGGCTCTGCGTCAACGCTAGTGCCGTC
AGCCGCCTGCGCGCCTACCTGCTGCCAGCGCCGCCAGCTCCAGGAAATGCTAGTGAGTCG
GAGGAAGACCGCAGCGCCGGCAGTGTGGAGAGCCCGTCCGTCTCCAGCACGCACCGGGTG
TCTGATCCCAAGTTCCACCCCCTCCATTCAAAGATAATCATCATCAAGAAAGGGCATGCT
AAAGACAGCCAGCGCTACAAAGTTGACTACGAGTCTCAGAGCACAGATACCCAGAACTTC
TCCTCCGAGTCCAAGCGGGAGACAGAATATGGTCCCTGCCGTAGAGAAATGGAAGACACA
CTGAATCACCTGAAGTTCCTCAATGTGCTGAGTCCCAGGGGTGTACACATTCCCAACTGT
GACAAGAAGGGATTTTATAAGAAAAAGCAGTGTCGCCCTTCCAAAGGCAGGAAGCGGGGC
TTCTGCTGGTGTGTGGATAAGTATGGGCAGCCTCTCCCAGGCTACACCACCAAGGGGAAG
GAGGACGTGCACTGCTACAGCATGCAGAGCAAGTAG
Chromosome Location
7
Locus
7p13-p12
External Identifiers
ResourceLink
UniProtKB IDP17936
UniProtKB Entry NameIBP3_HUMAN
GenBank Protein ID183116
GenBank Gene IDM31159
GenAtlas IDIGFBP3
HGNC IDHGNC:5472
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01277Mecaserminapproved, investigationalunknownDetails
DB06448LonafarnibinvestigationalunknownDetails
DB00523Alitretinoinapproved, investigationalunknownDetails
DB01277Mecaserminapproved, investigationalunknowncarrierDetails