Hypoxanthine-guanine-xanthine phosphoribosyltransferase

Details

Name
Hypoxanthine-guanine-xanthine phosphoribosyltransferase
Synonyms
  • 2.4.2.22
  • HGPRT
Gene Name
LACZ
Organism
Plasmodium falciparum (isolate FCR-3 / Gambia)
Amino acid sequence
>lcl|BSEQ0019128|Hypoxanthine-guanine-xanthine phosphoribosyltransferase
MPIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYD
IKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQ
STGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPL
WNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKATSL
Number of residues
231
Molecular Weight
26348.18
Theoretical pI
7.49
GO Classification
Functions
guanine phosphoribosyltransferase activity / hypoxanthine phosphoribosyltransferase activity / metal ion binding / nucleotide binding / xanthine phosphoribosyltransferase activity
Processes
GMP salvage / IMP salvage / XMP salvage
Components
cytoplasm
General Function
Xanthine phosphoribosyltransferase activity
Specific Function
Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Works with guanine, hypoxanthine and xanthine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0003009|696 bp
ATGCCAATACCAAATAATCCAGGAGCTGGTGAAAATGCCTTTGATCCCGTTTTCGTAAAC
GATGACGATGGTTATGACCTTGATTCTTTTATGATCCCTGCACATTATAAAAAATATCTT
ACCAAGGTCTTAGTTCCAAATGGTGTCATAAAAAACCGTATTGAGAAATTGGCTTATGAT
ATTAAAAAGGTGTACAACAATGAAGAGTTTCATATTCTTTGTTTGTTGAAAGGTTCTCGT
GGTTTTTTCACTGCTCTCTTAAAGCATTTAAGTAGAATACATAATTATAGTGCCGTTGAG
ACGTCCAAACCATTATTTGGAGAACACTACGTACGTGTGAAATCCTATTGTAATGACCAA
TCAACAGGTACATTAGAAATTGTAAGTGAAGATTTATCTTGTTTAAAAGGAAAACATGTA
TTAATTGTTGAAGATATTATTGATACTGGTAAAACATTAGTAAAGTTTTGTGAATACTTA
AAGAAATTTGAAATAAAAACCGTTGCCATCGCTTGTCTTTTTATTAAAAGAACACCTTTG
TGGAATGGTTTTAAAGCTGATTTCGTTGGATTCTCAATTCCTGATCACTTTGTTGTTGGT
TATAGTTTAGACTATAATGAAATTTTCAGAGATCTTGACCATTGTTGTTTGGTTAATGAT
GAGGGAAAAAAGAAATATAAAGCAACTTCATTATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP20035
UniProtKB Entry NameHGXR_PLAFG
GenBank Protein ID9914
GenBank Gene IDX16279
General References
  1. Vasanthakumar G, Davis RL Jr, Sullivan MA, Donahue JP: Nucleotide sequence of cDNA clone for hypoxanthine-guanine phosphoribosyltransferase from Plasmodium falciparum. Nucleic Acids Res. 1989 Oct 25;17(20):8382. [Article]
  2. Vasanthakumar G, Davis RL Jr, Sullivan MA, Donahue JP: Cloning and expression in Escherichia coli of a hypoxanthine-guanine phosphoribosyltransferase-encoding cDNA from Plasmodium falciparum. Gene. 1990 Jul 2;91(1):63-9. [Article]
  3. Shi W, Li CM, Tyler PC, Furneaux RH, Cahill SM, Girvin ME, Grubmeyer C, Schramm VL, Almo SC: The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor. Biochemistry. 1999 Aug 3;38(31):9872-80. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02075[(2R,3R,4S,5S)-3,4-Dihydroxy-5-(4-oxo-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)-2-pyrrolidinyl]methyl dihydrogen phosphateexperimentalunknownDetails
DB11638Artenimolapproved, experimental, investigationalunknownligandDetails