Fibroblast growth factor receptor 2

Details

Name
Fibroblast growth factor receptor 2
Synonyms
  • 2.7.10.1
  • BEK
  • FGFR-2
  • K-sam
  • Keratinocyte growth factor receptor
  • KGFR
  • KSAM
Gene Name
FGFR2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0001492|Fibroblast growth factor receptor 2
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEV
RCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYF
MVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCP
AGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSI
NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSK
YGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL
PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTK
RIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDK
LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM
IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTF
KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT
TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH
RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYS
PSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
Number of residues
821
Molecular Weight
92024.29
Theoretical pI
5.68
GO Classification
Functions
ATP binding / fibroblast growth factor binding / fibroblast growth factor-activated receptor activity / heparin binding / protein homodimerization activity / protein tyrosine kinase activity
Processes
activation of MAPKK activity / angiogenesis / apoptotic process / axon guidance / axonogenesis / bone development / bone mineralization / bone morphogenesis / branch elongation involved in salivary gland morphogenesis / branching involved in labyrinthine layer morphogenesis / branching involved in prostate gland morphogenesis / branching involved in salivary gland morphogenesis / branching morphogenesis of a nerve / bud elongation involved in lung branching / cell fate commitment / cell-cell signaling / coronal suture morphogenesis / digestive tract development / embryonic cranial skeleton morphogenesis / embryonic digestive tract morphogenesis / embryonic organ development / embryonic organ morphogenesis / embryonic pattern specification / endodermal digestive tract morphogenesis / epidermal growth factor receptor signaling pathway / epidermis morphogenesis / epithelial cell differentiation / epithelial cell proliferation involved in salivary gland morphogenesis / epithelial to mesenchymal transition / Fc-epsilon receptor signaling pathway / fibroblast growth factor receptor signaling pathway / fibroblast growth factor receptor signaling pathway involved in hemopoiesis / fibroblast growth factor receptor signaling pathway involved in mammary gland specification / fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow / fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development / fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow / gland morphogenesis / hair follicle morphogenesis / in utero embryonic development / innate immune response / inner ear morphogenesis / insulin receptor signaling pathway / lacrimal gland development / lateral sprouting from an epithelium / lens fiber cell development / limb bud formation / lung alveolus development / lung development / lung lobe morphogenesis / lung-associated mesenchyme development / mammary gland bud formation / MAPK cascade / membranous septum morphogenesis / mesenchymal cell differentiation / mesenchymal cell differentiation involved in lung development / mesenchymal cell proliferation involved in lung development / mesodermal cell differentiation / midbrain development / morphogenesis of embryonic epithelium / multicellular organism growth / negative regulation of epithelial cell proliferation / negative regulation of mitotic nuclear division / negative regulation of transcription from RNA polymerase II promoter / neuromuscular junction development / neurotrophin TRK receptor signaling pathway / odontogenesis / orbitofrontal cortex development / organ growth / organ morphogenesis / otic vesicle formation / outflow tract septum morphogenesis / peptidyl-tyrosine phosphorylation / phosphatidylinositol-mediated signaling / positive regulation of canonical Wnt signaling pathway / positive regulation of cardiac muscle cell proliferation / positive regulation of cell cycle / positive regulation of cell division / positive regulation of cell proliferation / positive regulation of epithelial cell proliferation / positive regulation of epithelial cell proliferation involved in lung morphogenesis / positive regulation of ERK1 and ERK2 cascade / positive regulation of MAPK cascade / positive regulation of mesenchymal cell proliferation / positive regulation of phospholipase activity / positive regulation of smooth muscle cell proliferation / positive regulation of transcription from RNA polymerase II promoter / positive regulation of Wnt signaling pathway / post-embryonic development / prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis / prostate epithelial cord elongation / prostate gland morphogenesis / protein autophosphorylation / pyramidal neuron development / Ras protein signal transduction / regulation of branching involved in prostate gland morphogenesis / regulation of cell fate commitment / regulation of ERK1 and ERK2 cascade / regulation of fibroblast growth factor receptor signaling pathway / regulation of morphogenesis of a branching structure / regulation of multicellular organism growth / regulation of osteoblast differentiation / regulation of osteoblast proliferation / regulation of smooth muscle cell differentiation / regulation of smoothened signaling pathway / reproductive structure development / skeletal system morphogenesis / small GTPase mediated signal transduction / squamous basal epithelial stem cell differentiation involved in prostate gland acinus development / synaptic vesicle transport / ureteric bud development / vascular endothelial growth factor receptor signaling pathway / ventricular cardiac muscle tissue morphogenesis / ventricular zone neuroblast division
Components
cell cortex / cell surface / cytoplasm / cytoplasmic membrane-bounded vesicle / excitatory synapse / extracellular region / Golgi apparatus / integral component of membrane / integral component of plasma membrane / intracellular membrane-bounded organelle / membrane / nucleoplasm / nucleus / plasma membrane
General Function
Protein tyrosine kinase activity
Specific Function
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.
Pfam Domain Function
Transmembrane Regions
378-398
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0010527|Fibroblast growth factor receptor 2 (FGFR2)
ATGGTCAGCTGGGGTCGTTTCATCTGCCTGGTCGTGGTCACCATGGCAACCTTGTCCCTG
GCCCGGCCCTCCTTCAGTTTAGTTGAGGATACCACATTAGAGCCAGAAGAGCCACCAACC
AAATACCAAATCTCTCAACCAGAAGTGTACGTGGCTGCGCCAGGGGAGTCGCTAGAGGTG
CGCTGCCTGTTGAAAGATGCCGCCGTGATCAGTTGGACTAAGGATGGGGTGCACTTGGGG
CCCAACAATAGGACAGTGCTTATTGGGGAGTACTTGCAGATAAAGGGCGCCACGCCTAGA
GACTCCGGCCTCTATGCTTGTACTGCCAGTAGGACTGTAGACAGTGAAACTTGGTACTTC
ATGGTGAATGTCACAGATGCCATCTCATCCGGAGATGATGAGGATGACACCGATGGTGCG
GAAGATTTTGTCAGTGAGAACAGTAACAACAAGAGAGCACCATACTGGACCAACACAGAA
AAGATGGAAAAGCGGCTCCATGCTGTGCCTGCGGCCAACACTGTCAAGTTTCGCTGCCCA
GCCGGGGGGAACCCAATGCCAACCATGCGGTGGCTGAAAAACGGGAAGGAGTTTAAGCAG
GAGCATCGCATTGGAGGCTACAAGGTACGAAACCAGCACTGGAGCCTCATTATGGAAAGT
GTGGTCCCATCTGACAAGGGAAATTATACCTGTGTAGTGGAGAATGAATACGGGTCCATC
AATCACACGTACCACCTGGATGTTGTGGAGCGATCGCCTCACCGGCCCATCCTCCAAGCC
GGACTGCCGGCAAATGCCTCCACAGTGGTCGGAGGAGACGTAGAGTTTGTCTGCAAGGTT
TACAGTGATGCCCAGCCCCACATCCAGTGGATCAAGCACGTGGAAAAGAACGGCAGTAAA
TACGGGCCCGACGGGCTGCCCTACCTCAAGGTTCTCAAGGCCGCCGGTGTTAACACCACG
GACAAAGAGATTGAGGTTCTCTATATTCGGAATGTAACTTTTGAGGACGCTGGGGAATAT
ACGTGCTTGGCGGGTAATTCTATTGGGATATCCTTTCACTCTGCATGGTTGACAGTTCTG
CCAGCGCCTGGAAGAGAAAAGGAGATTACAGCTTCCCCAGACTACCTGGAGATAGCCATT
TACTGCATAGGGGTCTTCTTAATCGCCTGTATGGTGGTAACAGTCATCCTGTGCCGAATG
AAGAACACGACCAAGAAGCCAGACTTCAGCAGCCAGCCGGCTGTGCACAAGCTGACCAAA
CGTATCCCCCTGCGGAGACAGGTAACAGTTTCGGCTGAGTCCAGCTCCTCCATGAACTCC
AACACCCCGCTGGTGAGGATAACAACACGCCTCTCTTCAACGGCAGACACCCCCATGCTG
GCAGGGGTCTCCGAGTATGAACTTCCAGAGGACCCAAAATGGGAGTTTCCAAGAGATAAG
CTGACACTGGGCAAGCCCCTGGGAGAAGGTTGCTTTGGGCAAGTGGTCATGGCGGAAGCA
GTGGGAATTGACAAAGACAAGCCCAAGGAGGCGGTCACCGTGGCCGTGAAGATGTTGAAA
GATGATGCCACAGAGAAAGACCTTTCTGATCTGGTGTCAGAGATGGAGATGATGAAGATG
ATTGGGAAACACAAGAATATCATAAATCTTCTTGGAGCCTGCACACAGGATGGGCCTCTC
TATGTCATAGTTGAGTATGCCTCTAAAGGCAACCTCCGAGAATACCTCCGAGCCCGGAGG
CCACCCGGGATGGAGTACTCCTATGACATTAACCGTGTTCCTGAGGAGCAGATGACCTTC
AAGGACTTGGTGTCATGCACCTACCAGCTGGCCAGAGGCATGGAGTACTTGGCTTCCCAA
AAATGTATTCATCGAGATTTAGCAGCCAGAAATGTTTTGGTAACAGAAAACAATGTGATG
AAAATAGCAGACTTTGGACTCGCCAGAGATATCAACAATATAGACTATTACAAAAAGACC
ACCAATGGGCGGCTTCCAGTCAAGTGGATGGCTCCAGAAGCCCTGTTTGATAGAGTATAC
ACTCATCAGAGTGATGTCTGGTCCTTCGGGGTGTTAATGTGGGAGATCTTCACTTTAGGG
GGCTCGCCCTACCCAGGGATTCCCGTGGAGGAACTTTTTAAGCTGCTGAAGGAAGGACAC
AGAATGGATAAGCCAGCCAACTGCACCAACGAACTGTACATGATGATGAGGGACTGTTGG
CATGCAGTGCCCTCCCAGAGACCAACGTTCAAGCAGTTGGTAGAAGACTTGGATCGAATT
CTCACTCTCACAACCAATGAGGAATACTTGGACCTCAGCCAACCTCTCGAACAGTATTCA
CCTAGTTACCCTGACACAAGAAGTTCTTGTTCTTCAGGAGATGATTCTGTTTTTTCTCCA
GACCCCATGCCTTACGAACCATGCCTTCCTCAGTATCCACACATAAACGGCAGTGTTAAA
ACATGA
Chromosome Location
10
Locus
10q26
External Identifiers
ResourceLink
UniProtKB IDP21802
UniProtKB Entry NameFGFR2_HUMAN
GenBank Protein ID31374
GenBank Gene IDX52832
GenAtlas IDFGFR2
HGNC IDHGNC:3689
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00039PaliferminapprovedyesbinderDetails
DB024914-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-AmineexperimentalunknownDetails
DB02058SU4984experimentalunknownDetails
DB01041Thalidomideapproved, investigational, withdrawnyesantagonistDetails
DB08896RegorafenibapprovedyesinhibitorDetails
DB08901Ponatinibapproved, investigationalunknowninhibitorDetails
DB09078Lenvatinibapproved, investigationalyesinhibitorDetails
DB09079NintedanibapprovedyesinhibitorDetails
DB01901SucrosofateexperimentalunknownligandDetails
DB01109Heparinapproved, investigationalunknownDetails
DB10770Foreskin fibroblast (neonatal)approvedunknownagonistDetails
DB10772Foreskin keratinocyte (neonatal)approvedunknownagonistDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails
DB12147Erdafitinibapproved, investigationalyesinhibitorDetails