Listeriolysin regulatory protein
Details
- Name
- Listeriolysin regulatory protein
- Synonyms
- Not Available
- Gene Name
- prfA
- Organism
- Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
- Amino acid sequence
>lcl|BSEQ0010859|Listeriolysin regulatory protein MNAQAEEFKKYLETNGIKPKQFHKKELIFNQWDPQEYCIFLYDGITKLTSISENGTIMNL QYYKGAFVIMSGFIDTETSVGYYNLEVISEQATAYVIKINELKELLSKNLTHFFYVFQTL QKQVSYSLAKFNDFSINGKLGSICGQLLILTYVYGKETPDGIKITLDNLTMQELGYSSGI AHSSAVSRIISKLKQEKVIVYKNSCFYVQNLDYLKRYAPKLDEWFYLACPATWGKLN
- Number of residues
- 237
- Molecular Weight
- 27301.24
- Theoretical pI
- 8.25
- GO Classification
- FunctionsDNA binding / transcription factor activity, sequence-specific DNA bindingProcessespathogenesis / transcription, DNA-templatedComponentsintracellular
- General Function
- Transcription factor activity, sequence-specific dna binding
- Specific Function
- Positively regulates expression of listeriolysin, of 1-phosphadidylinositol phosphodiesterase (PI-PLC) and other virulence factors.
- Pfam Domain Function
- HTH_Crp_2 (PF13545)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0010860|Listeriolysin regulatory protein (prfA) ATGAACGCTCAAGCAGAAGAATTCAAAAAATATTTAGAAACTAACGGGATAAAACCAAAA CAATTTCATAAAAAAGAACTTATTTTTAACCAATGGGATCCACAAGAATATTGTATTTTT CTATATGATGGTATCACAAAGCTCACGAGTATTAGCGAGAACGGGACCATCATGAATTTA CAATACTACAAAGGGGCTTTCGTTATAATGTCTGGCTTTATTGATACAGAAACATCGGTT GGCTATTATAATTTAGAAGTCATTAGCGAGCAGGCTACCGCATACGTTATCAAAATAAAC GAACTAAAAGAACTACTGAGCAAAAATCTTACGCACTTTTTCTATGTTTTCCAAACCCTA CAAAAACAAGTTTCATACAGTCTAGCTAAATTTAATGATTTTTCGATTAACGGGAAGCTT GGCTCTATTTGCGGTCAACTTTTAATCCTGACCTATGTGTATGGTAAAGAAACTCCTGAT GGCATCAAGATTACACTGGATAATTTAACAATGCAGGAGTTAGGATATTCAAGTGGCATC GCACATAGCTCAGCTGTTAGCAGAATTATTTCCAAATTAAAGCAAGAGAAAGTTATCGTG TATAAAAATTCATGCTTTTATGTACAAAATCTTGATTATCTCAAAAGATATGCCCCTAAA TTAGATGAATGGTTTTATTTAGCATGTCCTGCTACTTGGGGAAAATTAAATTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P22262 UniProtKB Entry Name PRFA_LISMO GenBank Protein ID 48960 GenBank Gene ID X61210 - General References
- Mengaud J, Dramsi S, Gouin E, Vazquez-Boland JA, Milon G, Cossart P: Pleiotropic control of Listeria monocytogenes virulence factors by a gene that is autoregulated. Mol Microbiol. 1991 Sep;5(9):2273-83. [Article]
- Leimeister-Wachter M, Haffner C, Domann E, Goebel W, Chakraborty T: Identification of a gene that positively regulates expression of listeriolysin, the major virulence factor of listeria monocytogenes. Proc Natl Acad Sci U S A. 1990 Nov;87(21):8336-40. [Article]
- Ripio MT, Dominguez-Bernal G, Lara M, Suarez M, Vazquez-Boland JA: A Gly145Ser substitution in the transcriptional activator PrfA causes constitutive overexpression of virulence factors in Listeria monocytogenes. J Bacteriol. 1997 Mar;179(5):1533-40. [Article]
- Glaser P, Frangeul L, Buchrieser C, Rusniok C, Amend A, Baquero F, Berche P, Bloecker H, Brandt P, Chakraborty T, Charbit A, Chetouani F, Couve E, de Daruvar A, Dehoux P, Domann E, Dominguez-Bernal G, Duchaud E, Durant L, Dussurget O, Entian KD, Fsihi H, Garcia-del Portillo F, Garrido P, Gautier L, Goebel W, Gomez-Lopez N, Hain T, Hauf J, Jackson D, Jones LM, Kaerst U, Kreft J, Kuhn M, Kunst F, Kurapkat G, Madueno E, Maitournam A, Vicente JM, Ng E, Nedjari H, Nordsiek G, Novella S, de Pablos B, Perez-Diaz JC, Purcell R, Remmel B, Rose M, Schlueter T, Simoes N, Tierrez A, Vazquez-Boland JA, Voss H, Wehland J, Cossart P: Comparative genomics of Listeria species. Science. 2001 Oct 26;294(5543):849-52. [Article]