UDP-glucuronosyltransferase 1-1

Details

Name
UDP-glucuronosyltransferase 1-1
Synonyms
  • 2.4.1.17
  • Bilirubin-specific UDPGT isozyme 1
  • GNT1
  • hUG-BR1
  • UDP-glucuronosyltransferase 1-A
  • UDP-glucuronosyltransferase 1A1
  • UDPGT 1-1
  • UGT-1A
  • UGT1
  • UGT1A
Gene Name
UGT1A1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0006823|UDP-glucuronosyltransferase 1-1
MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVL
APDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDS
AMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLE
FEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQR
EVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEH
GIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDL
LGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS
EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHD
LTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
Number of residues
533
Molecular Weight
59590.91
Theoretical pI
8.09
GO Classification
Functions
enzyme binding / enzyme inhibitor activity / glucuronosyltransferase activity / protein heterodimerization activity / protein homodimerization activity / retinoic acid binding / steroid binding
Processes
acute-phase response / bilirubin conjugation / biphenyl catabolic process / cellular glucuronidation / cellular response to ethanol / cellular response to glucocorticoid stimulus / cellular response to hormone stimulus / digestion / drug metabolic process / estrogen metabolic process / flavone metabolic process / flavonoid biosynthetic process / flavonoid glucuronidation / heme catabolic process / heterocycle metabolic process / liver development / negative regulation of catalytic activity / negative regulation of cellular glucuronidation / negative regulation of fatty acid metabolic process / negative regulation of glucuronosyltransferase activity / negative regulation of steroid metabolic process / organ regeneration / porphyrin-containing compound metabolic process / response to drug / response to lipopolysaccharide / response to nutrient / response to starvation / retinoic acid metabolic process / small molecule metabolic process / steroid metabolic process / xenobiotic glucuronidation / xenobiotic metabolic process
Components
cytochrome complex / endoplasmic reticulum / endoplasmic reticulum chaperone complex / endoplasmic reticulum membrane / integral component of plasma membrane
General Function
Steroid binding
Specific Function
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
Pfam Domain Function
Transmembrane Regions
491-507
Cellular Location
Microsome
Gene sequence
>lcl|BSEQ0021360|UDP-glucuronosyltransferase 1-1 (UGT1A1)
ATGGCTGTGGAGTCCCAGGGCGGACGCCCACTTGTCCTGGGCCTGCTGCTGTGTGTGCTG
GGCCCAGTGGTGTCCCATGCTGGGAAGATACTGTTGATCCCAGTGGATGGCAGCCACTGG
CTGAGCATGCTTGGGGCCATCCAGCAGCTGCAGCAGAGGGGACATGAAATAGTTGTCCTA
GCACCTGACGCCTCGTTGTACATCAGAGACGGAGCATTTTACACCTTGAAGACGTACCCT
GTGCCATTCCAAAGGGAGGATGTGAAAGAGTCTTTTGTTAGTCTCGGGCATAATGTTTTT
GAGAATGATTCTTTCCTGCAGCGTGTGATCAAAACATACAAGAAAATAAAAAAGGACTCT
GCTATGCTTTTGTCTGGCTGTTCCCACTTACTGCACAACAAGGAGCTCATGGCCTCCCTG
GCAGAAAGCAGCTTTGATGTCATGCTGACGGACCCTTTCCTTCCTTGCAGCCCCATCGTG
GCCCAGTACCTGTCTCTGCCCACTGTATTCTTCTTGCATGCACTGCCATGCAGCCTGGAA
TTTGAGGCTACCCAGTGCCCCAACCCATTCTCCTACGTGCCCAGGCCTCTCTCCTCTCAT
TCAGATCACATGACCTTCCTGCAGCGGGTGAAGAACATGCTCATTGCCTTTTCACAGAAC
TTTCTGTGCGACGTGGTTTATTCCCCGTATGCAACCCTTGCCTCAGAATTCCTTCAGAGA
GAGGTGACTGTCCAGGACCTATTGAGCTCTGCATCTGTCTGGCTGTTTAGAAGTGACTTT
GTGAAGGATTACCCTAGGCCCATCATGCCCAATATGGTTTTTGTTGGTGGAATCAACTGC
CTTCACCAAAATCCACTATCCCAGGAATTTGAAGCCTACATTAATGCTTCTGGAGAACAT
GGAATTGTGGTTTTCTCTTTGGGATCAATGGTCTCAGAAATTCCAGAGAAGAAAGCTATG
GCAATTGCTGATGCTTTGGGCAAAATCCCTCAGACAGTCCTGTGGCGGTACACTGGAACC
CGACCATCGAATCTTGCGAACAACACGATACTTGTTAAGTGGCTACCCCAAAACGATCTG
CTTGGTCACCCGATGACCCGTGCCTTTATCACCCATGCTGGTTCCCATGGTGTTTATGAA
AGCATATGCAATGGCGTTCCCATGGTGATGATGCCCTTGTTTGGTGATCAGATGGACAAT
GCAAAGCGCATGGAGACTAAGGGAGCTGGAGTGACCCTGAATGTTCTGGAAATGACTTCT
GAAGATTTAGAAAATGCTCTAAAAGCAGTCATCAATGACAAAAGTTACAAGGAGAACATC
ATGCGCCTCTCCAGCCTTCACAAGGACCGCCCGGTGGAGCCGCTGGACCTGGCCGTGTTC
TGGGTGGAGTTTGTGATGAGGCACAAGGGCGCGCCACACCTGCGCCCCGCAGCCCACGAC
CTCACCTGGTACCAGTACCATTCCTTGGACGTGATTGGTTTCCTCTTGGCCGTCGTGCTG
ACAGTGGCCTTCATCACCTTTAAATGTTGTGCTTATGGCTACCGGAAATGCTTGGGGAAA
AAAGGGCGAGTTAAGAAAGCCCACAAATCCAAGACCCATTGA
Chromosome Location
2
Locus
2q37
External Identifiers
ResourceLink
UniProtKB IDP22309
UniProtKB Entry NameUD11_HUMAN
GenBank Protein ID184473
GenBank Gene IDM57899
HGNC IDHGNC:12530
General References
  1. Ritter JK, Crawford JM, Owens IS: Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells. J Biol Chem. 1991 Jan 15;266(2):1043-7. [PubMed:1898728]
  2. Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS: A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. J Biol Chem. 1992 Feb 15;267(5):3257-61. [PubMed:1339448]
  3. Gong QH, Cho JW, Huang T, Potter C, Gholami N, Basu NK, Kubota S, Carvalho S, Pennington MW, Owens IS, Popescu NC: Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus. Pharmacogenetics. 2001 Jun;11(4):357-68. [PubMed:11434514]
  4. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [PubMed:15815621]
  5. Meunier L, Usherwood YK, Chung KT, Hendershot LM: A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins. Mol Biol Cell. 2002 Dec;13(12):4456-69. [PubMed:12475965]
  6. Levesque E, Girard H, Journault K, Lepine J, Guillemette C: Regulation of the UGT1A1 bilirubin-conjugating pathway: role of a new splicing event at the UGT1A locus. Hepatology. 2007 Jan;45(1):128-38. [PubMed:17187418]
  7. Udomuksorn W, Elliot DJ, Lewis BC, Mackenzie PI, Yoovathaworn K, Miners JO: Influence of mutations associated with Gilbert and Crigler-Najjar type II syndromes on the glucuronidation kinetics of bilirubin and other UDP-glucuronosyltransferase 1A substrates. Pharmacogenet Genomics. 2007 Dec;17(12):1017-29. [PubMed:18004206]
  8. Girard H, Levesque E, Bellemare J, Journault K, Caillier B, Guillemette C: Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity. Pharmacogenet Genomics. 2007 Dec;17(12):1077-89. [PubMed:18004212]
  9. Tang L, Singh R, Liu Z, Hu M: Structure and concentration changes affect characterization of UGT isoform-specific metabolism of isoflavones. Mol Pharm. 2009 Sep-Oct;6(5):1466-82. doi: 10.1021/mp8002557. [PubMed:19545173]
  10. Sneitz N, Bakker CT, de Knegt RJ, Halley DJ, Finel M, Bosma PJ: Crigler-Najjar syndrome in The Netherlands: identification of four novel UGT1A1 alleles, genotype-phenotype correlation, and functional analysis of 10 missense mutants. Hum Mutat. 2010 Jan;31(1):52-9. doi: 10.1002/humu.21133. [PubMed:19830808]
  11. Johnson AD, Kavousi M, Smith AV, Chen MH, Dehghan A, Aspelund T, Lin JP, van Duijn CM, Harris TB, Cupples LA, Uitterlinden AG, Launer L, Hofman A, Rivadeneira F, Stricker B, Yang Q, O'Donnell CJ, Gudnason V, Witteman JC: Genome-wide association meta-analysis for total serum bilirubin levels. Hum Mol Genet. 2009 Jul 15;18(14):2700-10. doi: 10.1093/hmg/ddp202. Epub 2009 May 4. [PubMed:19414484]
  12. Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. [PubMed:19159218]
  13. Bellemare J, Rouleau M, Girard H, Harvey M, Guillemette C: Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro. Drug Metab Dispos. 2010 Oct;38(10):1785-9. doi: 10.1124/dmd.110.034835. Epub 2010 Jul 7. [PubMed:20610558]
  14. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [PubMed:24275569]
  15. Bosma PJ, Chowdhury JR, Huang TJ, Lahiri P, Elferink RP, Van Es HH, Lederstein M, Whitington PF, Jansen PL, Chowdhury NR: Mechanisms of inherited deficiencies of multiple UDP-glucuronosyltransferase isoforms in two patients with Crigler-Najjar syndrome, type I. FASEB J. 1992 Jul;6(10):2859-63. [PubMed:1634050]
  16. Aono S, Yamada Y, Keino H, Hanada N, Nakagawa T, Sasaoka Y, Yazawa T, Sato H, Koiwai O: Identification of defect in the genes for bilirubin UDP-glucuronosyl-transferase in a patient with Crigler-Najjar syndrome type II. Biochem Biophys Res Commun. 1993 Dec 30;197(3):1239-44. [PubMed:8280139]
  17. Moghrabi N, Clarke DJ, Boxer M, Burchell B: Identification of an A-to-G missense mutation in exon 2 of the UGT1 gene complex that causes Crigler-Najjar syndrome type 2. Genomics. 1993 Oct;18(1):171-3. [PubMed:8276413]
  18. Ritter JK, Yeatman MT, Kaiser C, Gridelli B, Owens IS: A phenylalanine codon deletion at the UGT1 gene complex locus of a Crigler-Najjar type I patient generates a pH-sensitive bilirubin UDP-glucuronosyltransferase. J Biol Chem. 1993 Nov 5;268(31):23573-9. [PubMed:8226884]
  19. Labrune P, Myara A, Hadchouel M, Ronchi F, Bernard O, Trivin F, Chowdhury NR, Chowdhury JR, Munnich A, Odievre M: Genetic heterogeneity of Crigler-Najjar syndrome type I: a study of 14 cases. Hum Genet. 1994 Dec;94(6):693-7. [PubMed:7989045]
  20. Erps LT, Ritter JK, Hersh JH, Blossom D, Martin NC, Owens IS: Identification of two single base substitutions in the UGT1 gene locus which abolish bilirubin uridine diphosphate glucuronosyltransferase activity in vitro. J Clin Invest. 1994 Feb;93(2):564-70. [PubMed:7906695]
  21. Seppen J, Bosma PJ, Goldhoorn BG, Bakker CT, Chowdhury JR, Chowdhury NR, Jansen PL, Oude Elferink RP: Discrimination between Crigler-Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase. J Clin Invest. 1994 Dec;94(6):2385-91. [PubMed:7989595]
  22. Aono S, Adachi Y, Uyama E, Yamada Y, Keino H, Nanno T, Koiwai O, Sato H: Analysis of genes for bilirubin UDP-glucuronosyltransferase in Gilbert's syndrome. Lancet. 1995 Apr 15;345(8955):958-9. [PubMed:7715297]
  23. Seppen J, Steenken E, Lindhout D, Bosma PJ, Elferink RP: A mutation which disrupts the hydrophobic core of the signal peptide of bilirubin UDP-glucuronosyltransferase, an endoplasmic reticulum membrane protein, causes Crigler-Najjar type II. FEBS Lett. 1996 Jul 29;390(3):294-8. [PubMed:8706880]
  24. Ciotti M, Chen F, Rubaltelli FF, Owens IS: Coding defect and a TATA box mutation at the bilirubin UDP-glucuronosyltransferase gene cause Crigler-Najjar type I disease. Biochim Biophys Acta. 1998 Jul 1;1407(1):40-50. [PubMed:9639672]
  25. Yamamoto K, Soeda Y, Kamisako T, Hosaka H, Fukano M, Sato H, Fujiyama Y, Adachi Y, Satoh Y, Bamba T: Analysis of bilirubin uridine 5'-diphosphate (UDP)-glucuronosyltransferase gene mutations in seven patients with Crigler-Najjar syndrome type II. J Hum Genet. 1998;43(2):111-4. [PubMed:9621515]
  26. Maruo Y, Sato H, Yamano T, Doida Y, Shimada M: Gilbert syndrome caused by a homozygous missense mutation (Tyr486Asp) of bilirubin UDP-glucuronosyltransferase gene. J Pediatr. 1998 Jun;132(6):1045-7. [PubMed:9627603]
  27. Kadakol A, Ghosh SS, Sappal BS, Sharma G, Chowdhury JR, Chowdhury NR: Genetic lesions of bilirubin uridine-diphosphoglucuronate glucuronosyltransferase (UGT1A1) causing Crigler-Najjar and Gilbert syndromes: correlation of genotype to phenotype. Hum Mutat. 2000 Oct;16(4):297-306. [PubMed:11013440]
  28. Maruo Y, Nishizawa K, Sato H, Sawa H, Shimada M: Prolonged unconjugated hyperbilirubinemia associated with breast milk and mutations of the bilirubin uridine diphosphate- glucuronosyltransferase gene. Pediatrics. 2000 Nov;106(5):E59. [PubMed:11061796]
  29. Kadakol A, Sappal BS, Ghosh SS, Lowenheim M, Chowdhury A, Chowdhury S, Santra A, Arias IM, Chowdhury JR, Chowdhury NR: Interaction of coding region mutations and the Gilbert-type promoter abnormality of the UGT1A1 gene causes moderate degrees of unconjugated hyperbilirubinaemia and may lead to neonatal kernicterus. J Med Genet. 2001 Apr;38(4):244-9. [PubMed:11370628]
  30. Labrune P, Myara A, Chalas J, Le Bihan B, Capel L, Francoual J: Association of a homozygous (TA)8 promoter polymorphism and a N400D mutation of UGT1A1 in a child with Crigler-Najjar type II syndrome. Hum Mutat. 2002 Nov;20(5):399-401. [PubMed:12402338]
  31. Sutomo R, Laosombat V, Sadewa AH, Yokoyama N, Nakamura H, Matsuo M, Nishio H: Novel missense mutation of the UGT1A1 gene in Thai siblings with Gilbert's syndrome. Pediatr Int. 2002 Aug;44(4):427-32. [PubMed:12139570]
  32. Ohnishi A, Emi Y: Rapid proteasomal degradation of translocation-deficient UDP-glucuronosyltransferase 1A1 proteins in patients with Crigler-Najjar type II. Biochem Biophys Res Commun. 2003 Oct 24;310(3):735-41. [PubMed:14550264]
  33. Servedio V, d'Apolito M, Maiorano N, Minuti B, Torricelli F, Ronchi F, Zancan L, Perrotta S, Vajro P, Boschetto L, Iolascon A: Spectrum of UGT1A1 mutations in Crigler-Najjar (CN) syndrome patients: identification of twelve novel alleles and genotype-phenotype correlation. Hum Mutat. 2005 Mar;25(3):325. [PubMed:15712364]
  34. D'Apolito M, Marrone A, Servedio V, Vajro P, De Falco L, Iolascon A: Seven novel mutations of the UGT1A1 gene in patients with unconjugated hyperbilirubinemia. Haematologica. 2007 Jan;92(1):133-4. [PubMed:17229650]
  35. Khan S, Irfan M, Sher G, Zubaida B, Alvi MA, Yasinzai M, Naeem M: UGT1A1 gene mutations in Pakistani children suffering from inherited nonhemolytic unconjugated hyperbilirubinemias. Ann Hum Genet. 2013 Nov;77(6):482-7. doi: 10.1111/ahg.12039. Epub 2013 Aug 29. [PubMed:23992562]
  36. Minucci A, Canu G, Gentile L, Cimino V, Giardina B, Zuppi C, Capoluongo E: Identification of a novel mutation in UDP-glucuronosyltransferase (UGT1A1) gene in a child with neonatal unconjugated hyperbilirubinemia. Clin Biochem. 2013 Jan;46(1-2):170-2. doi: 10.1016/j.clinbiochem.2012.10.007. Epub 2012 Oct 22. [PubMed:23099197]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00688Mycophenolate mofetilapproved, investigationalunknownsubstrateDetails
DB01024Mycophenolic acidapprovedunknownsubstrateDetails
DB01048Abacavirapproved, investigationalunknownsubstrateDetails
DB00173Adenineapproved, nutraceuticalunknowninhibitorDetails
DB00197Troglitazoneinvestigational, withdrawnunknownsubstrateDetails
DB00586Diclofenacapproved, vet_approvedunknownsubstrateDetails
DB00762Irinotecanapproved, investigationalunknownsubstrateDetails
DB00783Estradiolapproved, investigational, vet_approvedunknownsubstrateDetails
DB00818Propofolapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB00973EzetimibeapprovedunknownsubstrateDetails
DB01045RifampicinapprovedunknowninducerDetails
DB00678LosartanapprovedunknownsubstrateDetails
DB00712Flurbiprofenapproved, investigationalunknownsubstrateinhibitorDetails
DB00328Indometacinapproved, investigationalunknownsubstrateinhibitorDetails
DB00788Naproxenapproved, vet_approvedunknownsubstrateDetails
DB00870Suprofenapproved, withdrawnunknownsubstrateDetails
DB06741GavestinelinvestigationalunknownsubstrateDetails
DB04868Nilotinibapproved, investigationalunknowninhibitorDetails
DB06210EltrombopagapprovedunknownsubstrateinhibitorDetails
DB00295Morphineapproved, investigationalnosubstrateDetails
DB05039IndacaterolapprovedunknownsubstrateDetails
DB06510MuraglitazarinvestigationalunknownsubstrateDetails
DB00704Naltrexoneapproved, investigational, vet_approvedunknownsubstrateDetails
DB06817RaltegravirapprovedunknownsubstrateDetails
DB04953Ezogabineapproved, investigationalunknownsubstrateDetails
DB01420Testosterone propionateapproved, investigational, vet_approved, withdrawnunknowninducerDetails
DB06589PazopanibapprovedunknowninhibitorDetails
DB06626Axitinibapproved, investigationalnosubstrateDetails
DB08896RegorafenibapprovedunknowninhibitorDetails
DB00316AcetaminophenapprovedunknownsubstrateDetails
DB01076AtorvastatinapprovednosubstrateDetails
DB00227Lovastatinapproved, investigationalnosubstrateDetails
DB00641SimvastatinapprovedunknownsubstrateDetails
DB01544Flunitrazepamapproved, illicitunknowninhibitorDetails
DB00530Erlotinibapproved, investigationalunknowninhibitorDetails
DB00773EtoposideapprovedunknownsubstrateDetails
DB01095FluvastatinapprovedunknownsubstrateDetails
DB00398Sorafenibapproved, investigationalunknowninhibitorDetails
DB08930DolutegravirapprovedunknownsubstrateDetails
DB11943Delafloxacinapproved, investigationalnosubstrateDetails
DB13874Enasidenibapproved, investigationalunknownsubstrateinhibitorDetails
DB13878Pibrentasvirapproved, investigationalunknowninhibitorDetails
DB13879Glecaprevirapproved, investigationalunknowninhibitorDetails
DB12070Letermovirapproved, investigationalnosubstrateDetails
DB12332Rucaparibapproved, investigationalunknowninhibitorDetails
DB11827Ertugliflozinapproved, investigationalnoinhibitorDetails
DB13952Estradiol acetateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13953Estradiol benzoateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13954Estradiol cypionateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13955Estradiol dienanthateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13956Estradiol valerateapproved, investigational, vet_approvedunknownsubstrateDetails
DB11799Bictegravirapproved, investigationalunknownsubstrateDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails
DB01026Ketoconazoleapproved, investigationalunknowninhibitorDetails
DB00224IndinavirapprovedunknowninhibitorDetails
DB00564Carbamazepineapproved, investigationalnoinducerDetails
DB00776OxcarbazepineapprovednosubstrateinducerDetails
DB00252Phenytoinapproved, vet_approvednoinducerDetails
DB01174Phenobarbitalapproved, investigationalnoinducerDetails
DB00932Tipranavirapproved, investigationalnoinducerDetails
DB00220NelfinavirapprovednoinducerDetails
DB00503Ritonavirapproved, investigationalnoinducerDetails
DB00625Efavirenzapproved, investigationalnoinducerDetails
DB00555Lamotrigineapproved, investigationalnosubstrateinducerDetails
DB00794Primidoneapproved, vet_approvednoinducerDetails
DB00906Tiagabineapproved, investigationalnosubstrateDetails
DB00313Valproic Acidapproved, investigationalnosubstrateinhibitorDetails
DB00909Zonisamideapproved, investigationalnosubstrateDetails
DB00321AmitriptylineapprovednosubstrateinhibitorDetails
DB01136Carvedilolapproved, investigationalnosubstrateDetails
DB00924CyclobenzaprineapprovednosubstrateDetails
DB01039FenofibrateapprovednosubstrateDetails
DB03496Alvocidibexperimental, investigationalnosubstrateDetails
DB00695Furosemideapproved, vet_approvednosubstrateDetails
DB01241GemfibrozilapprovednosubstrateinhibitorDetails
DB01067Glipizideapproved, investigationalnosubstrateDetails
DB00451LevothyroxineapprovednosubstrateDetails
DB00916MetronidazoleapprovednosubstrateDetails
DB01183Naloxoneapproved, vet_approvednosubstrateDetails
DB00481Raloxifeneapproved, investigationalnosubstrateDetails
DB00193Tramadolapproved, investigationalnosubstrateDetails
DB00495ZidovudineapprovednosubstrateinducerDetails
DB09298Silibininexperimental, investigationalnoinhibitorDetails
DB09276Sodium aurothiomalateapproved, investigationalnoinhibitorDetails
DB00977EthinylestradiolapprovednosubstrateinducerDetails
DB00439Cerivastatinapproved, withdrawnnosubstrateDetails
DB00921Buprenorphineapproved, illicit, investigational, vet_approvednosubstrateDetails
DB00947Fulvestrantapproved, investigationalnosubstrateDetails
DB01009Ketoprofenapproved, vet_approvednosubstrateDetails
DB11967Binimetinibapproved, investigationalunknownsubstrateDetails
DB01072Atazanavirapproved, investigationalnoinhibitorDetails
DB12020Tecovirimatapproved, investigationalunknownDetails
DB05018Migalastatapproved, investigationalyessubstrateDetails
DB02703Fusidic Acidapproved, investigationalunknownsubstrateDetails
DB09288PropacetamolexperimentalnosubstrateDetails
DB01609Deferasiroxapproved, investigationalunknownsubstrateinhibitorDetails
DB14575EslicarbazepineapprovedunknownsubstrateDetails
DB09213Dexibuprofenapproved, investigationalunknownDetails
DB09119Eslicarbazepine acetateapprovedunknownsubstrateDetails
DB11963Dacomitinibapproved, investigationalnoinhibitorDetails
DB01032Probenecidapproved, investigationalnoinhibitorDetails
DB00350Minoxidilapproved, investigationalnosubstrateDetails
DB00279Liothyronineapproved, vet_approvednosubstrateDetails
DB00304DesogestrelapprovednoinducerDetails