Potassium voltage-gated channel subfamily A member 4
Details
- Name
- Potassium voltage-gated channel subfamily A member 4
- Synonyms
- HPCN2
- KCNA4L
- Voltage-gated K(+) channel HuKII
- Voltage-gated potassium channel HBK4
- Voltage-gated potassium channel HK1
- Voltage-gated potassium channel subunit Kv1.4
- Gene Name
- KCNA4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0013149|Potassium voltage-gated channel subfamily A member 4 MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGSGGSGGG SHHHHQSRGACTSHDPQSSRGSRRRRRQRSEKKKAHYRQSSFPHCSDLMPSGSEEKILRE LSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVI NVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGR LKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYP ESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLE NSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLG TDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGL LIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIV GSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSS TSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV
- Number of residues
- 653
- Molecular Weight
- 73256.64
- Theoretical pI
- Not Available
- GO Classification
- Functionspotassium ion binding / voltage-gated potassium channel activityProcessespotassium ion transmembrane transport / potassium ion transport / protein homooligomerization / synaptic transmissionComponentsaxon / integral component of membrane / integral component of plasma membrane / plasma membrane / voltage-gated potassium channel complex
- General Function
- Voltage-gated potassium channel activity
- Specific Function
- Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:19912772, PubMed:8495559). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368).
- Pfam Domain Function
- Transmembrane Regions
- 305-326 371-392 404-424 440-460 476-497 539-567
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0013150|Potassium voltage-gated channel subfamily A member 4 (KCNA4) ATGGAGGTTGCAATGGTGAGTGCGGAGAGCTCAGGGTGCAACAGTCACATGCCTTATGGT TATGCTGCCCAGGCCCGGGCCCGGGAGCGGGAGAGGCTTGCTCACTCCAGGGCAGCTGCA GCAGCTGCTGTTGCAGCGGCCACAGCTGCTGTCGAAGGTAGCGGGGGTTCTGGTGGGGGC TCCCACCACCACCACCAGTCACGCGGGGCCTGTACCTCCCATGACCCTCAGAGCAGCCGG GGTAGTCGGAGGAGGAGGCGACAGCGGTCTGAGAAGAAGAAAGCCCACTACCGGCAGAGC AGCTTCCCTCATTGCTCTGACCTGATGCCCAGTGGCTCTGAGGAGAAGATCCTGAGGGAG CTGAGTGAGGAGGAGGAAGATGAGGAGGAGGAGGAAGAGGAGGAAGAGGAGGGAAGGTTT TACTATAGTGAAGATGACCATGGTGATGAGTGTTCCTACACGGATCTGCTGCCTCAGGAT GAGGGCGGTGGCGGCTACAGTTCAGTCCGCTACAGTGACTGTTGTGAACGTGTGGTGATA AATGTGTCAGGCCTACGCTTTGAGACCCAAATGAAAACTCTGGCCCAGTTTCCAGAGACT TTGTTGGGAGACCCTGAAAAGAGGACTCAGTACTTTGACCCTTTGCGCAATGAGTATTTT TTTGACAGGAACCGCCCCAGCTTTGATGCCATCTTGTATTATTATCAATCAGGAGGCCGC CTGAAGAGGCCAGTCAATGTCCCCTTTGATATCTTCACTGAGGAGGTGAAGTTCTATCAG TTGGGGGAGGAGGCCCTGTTGAAGTTTCGGGAGGACGAGGGCTTTGTGAGAGAAGAGGAA GACAGGGCCCTCCCCGAGAATGAATTTAAAAAGCAGATTTGGCTCCTCTTTGAATATCCA GAGAGCTCCAGTCCTGCAAGGGGCATAGCCATTGTGTCCGTCCTGGTCATCTTAATCTCC ATTGTCATCTTTTGCCTGGAAACCTTGCCTGAGTTTAGGGACGACAGGGATCTCGTCATG GCACTGAGTGCTGGCGGGCATGGTGGGTTGTTGAATGATACTTCAGCACCCCATCTGGAG AACTCAGGGCACACAATATTCAATGACCCCTTCTTCATCGTGGAAACAGTCTGTATTGTA TGGTTTTCCTTTGAGTTTGTGGTTCGCTGCTTTGCTTGTCCCAGCCAAGCACTCTTCTTC AAAAACATCATGAACATCATTGACATTGTCTCCATTTTGCCTTACTTCATCACACTGGGC ACTGACCTGGCCCAGCAACAGGGGGGTGGCAATGGTCAGCAGCAGCAGGCCATGTCCTTT GCCATCCTCAGAATCATTCGTCTGGTCCGAGTATTCCGGATCTTCAAACTCTCCAGGCAC TCCAAAGGCCTGCAGATCCTGGGCCACACCCTCAGAGCCAGCATGCGGGAACTGGGCCTT CTGATCTTCTTCCTCTTCATTGGGGTCATCCTCTTTTCTAGTGCTGTGTATTTTGCAGAG GCGGATGAACCTACTACCCATTTCCAAAGCATCCCAGATGCATTTTGGTGGGCTGTGGTG ACCATGACAACTGTGGGCTATGGGGACATGAAGCCCATCACTGTAGGGGGCAAGATTGTC GGGTCCCTGTGTGCCATTGCGGGTGTCTTAACCATTGCTTTGCCAGTGCCAGTGATTGTC TCTAACTTTAACTATTTCTACCACAGAGAGACTGAAAATGAGGAACAGACACAGCTAACG CAGAATGCAGTCAGTTGTCCATACCTCCCCTCTAATTTGCTCAAGAAATTTCGGAGCTCT ACTTCTTCTTCCCTGGGGGACAAGTCAGAGTATCTAGAGATGGAAGAAGGAGTTAAGGAA TCTCTGTGTGCAAAGGAGGAGAAGTGTCAGGGAAAGGGGGATGACAGTGAGACAGATAAA AACAACTGTTCTAATGCAAAGGCTGTGGAGACTGATGTGTGA
- Chromosome Location
- 11
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P22459 UniProtKB Entry Name KCNA4_HUMAN HGNC ID HGNC:6222 - General References
- Philipson LH, Schaefer K, LaMendola J, Bell GI, Steiner DF: Sequence of a human fetal skeletal muscle potassium channel cDNA related to RCK4. Nucleic Acids Res. 1990 Dec 11;18(23):7160. [Article]
- Tamkun MM, Knoth KM, Walbridge JA, Kroemer H, Roden DM, Glover DM: Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle. FASEB J. 1991 Mar 1;5(3):331-7. [Article]
- Ramaswami M, Gautam M, Kamb A, Rudy B, Tanouye MA, Mathew MK: Human potassium channel genes: Molecular cloning and functional expression. Mol Cell Neurosci. 1990 Dec;1(3):214-23. [Article]
- Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [Article]
- Po S, Roberds S, Snyders DJ, Tamkun MM, Bennett PB: Heteromultimeric assembly of human potassium channels. Molecular basis of a transient outward current? Circ Res. 1993 Jun;72(6):1326-36. [Article]
- Imbrici P, D'Adamo MC, Kullmann DM, Pessia M: Episodic ataxia type 1 mutations in the KCNA1 gene impair the fast inactivation properties of the human potassium channels Kv1.4-1.1/Kvbeta1.1 and Kv1.4-1.1/Kvbeta1.2. Eur J Neurosci. 2006 Dec;24(11):3073-83. [Article]
- Usman H, Mathew MK: Potassium channel regulator KCNRG regulates surface expression of Shaker-type potassium channels. Biochem Biophys Res Commun. 2010 Jan 15;391(3):1301-5. doi: 10.1016/j.bbrc.2009.11.143. Epub 2009 Dec 5. [Article]
- Antz C, Geyer M, Fakler B, Schott MK, Guy HR, Frank R, Ruppersberg JP, Kalbitzer HR: NMR structure of inactivation gates from mammalian voltage-dependent potassium channels. Nature. 1997 Jan 16;385(6613):272-5. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB02299 Arginineamide experimental unknown Details DB06637 Dalfampridine approved yes antagonist Details DB00228 Enflurane approved, investigational, vet_approved unknown inhibitoractivator Details DB01069 Promethazine approved, investigational unknown inducer Details DB01110 Miconazole approved, investigational, vet_approved unknown inhibitor Details