Solute carrier family 2, facilitated glucose transporter member 5

Details

Name
Solute carrier family 2, facilitated glucose transporter member 5
Synonyms
  • Fructose transporter
  • Glucose transporter type 5, small intestine
  • GLUT-5
  • GLUT5
Gene Name
SLC2A5
Organism
Humans
Amino acid sequence
>lcl|BSEQ0008980|Solute carrier family 2, facilitated glucose transporter member 5
MEQQDQSMKEGRLTLVLALATLIAAFGSSFQYGYNVAAVNSPALLMQQFYNETYYGRTGE
FMEDFPLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSR
VATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIF
GLRNLLANVDGWPILLGLTGVPAALQLLLLPFFPESPRYLLIQKKDEAAAKKALQTLRGW
DSVDREVAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQLSGVNAIYYYA
DQIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLT
AALALQDTVSWMPYISIVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHW
LSNFTVGLIFPFIQEGLGPYSFIVFAVICLLTTIYIFLIVPETKAKTFIEINQIFTKMNK
VSEVYPEKEELKELPPVTSEQ
Number of residues
501
Molecular Weight
54973.42
Theoretical pI
Not Available
GO Classification
Functions
fructose transmembrane transporter activity / glucose transmembrane transporter activity
Processes
carbohydrate metabolic process / cellular response to fructose stimulus / fructose transport / glucose transmembrane transport / glucose transport / hexose transport / small molecule metabolic process / transmembrane transport
Components
apical plasma membrane / extracellular exosome / integral component of membrane / plasma membrane
General Function
Glucose transmembrane transporter activity
Specific Function
Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter.
Pfam Domain Function
Transmembrane Regions
13-33 69-89 99-119 121-141 162-182 193-213 278-298 319-339 343-363 369-389 413-433 440-460
Cellular Location
Apical cell membrane
Gene sequence
>lcl|BSEQ0017662|Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5)
ATGGAGCAACAGGATCAGAGCATGAAGGAAGGGAGGCTGACGCTTGTGCTTGCCCTGGCA
ACCCTGATAGCTGCCTTTGGGTCATCCTTCCAGTATGGGTACAACGTGGCTGCTGTCAAC
TCCCCAGCACTGCTCATGCAACAATTTTACAATGAGACTTACTATGGTAGGACCGGTGAA
TTCATGGAAGACTTCCCCTTGACGTTGCTGTGGTCTGTAACCGTGTCCATGTTTCCATTT
GGAGGGTTTATCGGATCCCTCCTGGTCGGCCCCTTGGTGAATAAATTTGGCAGAAAAGGG
GCCTTGCTGTTCAACAACATATTTTCTATCGTGCCTGCGATCTTAATGGGATGCAGCAGA
GTCGCCACATCATTTGAGCTTATCATTATTTCCAGACTTTTGGTGGGAATATGTGCAGGT
GTATCTTCCAACGTGGTCCCCATGTACTTAGGGGAGCTGGCCCCTAAAAACCTGCGGGGG
GCTCTCGGGGTGGTGCCCCAGCTCTTCATCACTGTTGGCATCCTTGTGGCCCAGATCTTT
GGTCTTCGGAATCTCCTTGCAAACGTAGATGGTGAGTTCAGGACATCTCGGGAGCACCCC
CACCCCTTCACCACTACCCTTGGCCCCCTCCTTGTGTTCCAAAGCCACCACCACAGGACA
GGACTTTCTGCAGACTGGTCTCTTCTAACAGGCTGGATGTCCTTGGGGGGCCCATCCTGT
CCCGAGCCAACATAG
Chromosome Location
1
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP22732
UniProtKB Entry NameGTR5_HUMAN
HGNC IDHGNC:11010
General References
  1. Kayano T, Burant CF, Fukumoto H, Gould GW, Fan YS, Eddy RL, Byers MG, Shows TB, Seino S, Bell GI: Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6). J Biol Chem. 1990 Aug 5;265(22):13276-82. [Article]
  2. Mahraoui L, Takeda J, Mesonero J, Chantret I, Dussaulx E, Bell GI, Brot-Laroche E: Regulation of expression of the human fructose transporter (GLUT5) by cyclic AMP. Biochem J. 1994 Jul 1;301 ( Pt 1):169-75. [Article]
  3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB09502Fludeoxyglucose (18F)approved, investigationalnosubstrateDetails
DB09344Invert sugarexperimentalunknownsubstrateDetails
DB01914D-glucoseapproved, investigational, vet_approvednosubstrateDetails