Liver carboxylesterase 1
Details
- Name
- Liver carboxylesterase 1
- Synonyms
- ACAT
- Acyl-coenzyme A:cholesterol acyltransferase
- Brain carboxylesterase hBr1
- Carboxylesterase 1
- CE-1
- CES2
- Cocaine carboxylesterase
- Egasyn
- hCE-1
- HMSE
- Methylumbelliferyl-acetate deacetylase 1
- Monocyte/macrophage serine esterase
- REH
- Retinyl ester hydrolase
- Serine esterase 1
- SES1
- TGH
- Triacylglycerol hydrolase
- Gene Name
- CES1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0005305|Liver carboxylesterase 1 MWLRAFILATLSASAAWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPL GPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLN IYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLF HRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLK MKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIP MQLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDL IADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPF LKEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLK DKEVAFWTNLFAKKAVEKPPQTEHIEL
- Number of residues
- 567
- Molecular Weight
- 62520.62
- Theoretical pI
- 6.58
- GO Classification
- Functionscarboxylic ester hydrolase activity / methylumbelliferyl-acetate deacetylase activity / sterol esterase activity / triglyceride lipase activityProcessesepithelial cell differentiation / lipid catabolic process / metabolic process / response to toxic substance / small molecule metabolic process / xenobiotic metabolic processComponentsendoplasmic reticulum lumen / extracellular space
- General Function
- Triglyceride lipase activity
- Specific Function
- Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.
- Pfam Domain Function
- COesterase (PF00135)
- Transmembrane Regions
- Not Available
- Cellular Location
- Endoplasmic reticulum lumen
- Gene sequence
>lcl|BSEQ0021334|Liver carboxylesterase 1 (CES1) ATGTGGCTCCGTGCCTTTATCCTGGCCACTCTCTCTGCTTCCGCGGCTTGGGGGCATCCG TCCTCGCCACCTGTGGTGGACACCGTGCATGGCAAAGTGCTGGGGAAGTTCGTCAGCTTA GAAGGATTTGCACAGCCTGTGGCCATTTTCCTGGGAATCCCTTTTGCCAAGCCGCCTCTT GGACCCCTGAGGTTTACTCCACCGCAGCCTGCAGAACCATGGAGCTTTGTGAAGAATGCC ACCTCGTACCCTCCTATGTGCACCCAAGATCCCAAGGCGGGGCAGTTACTCTCAGAGCTA TTTACAAACCGAAAGGAGAACATTCCTCTCAAGCTTTCTGAAGACTGTCTTTACCTCAAT ATTTACACTCCTGCTGACTTGACCAAGAAAAACAGGCTGCCGGTGATGGTGTGGATCCAC GGAGGGGGGCTGATGGTGGGTGCGGCATCAACCTATGATGGGCTGGCCCTTGCTGCCCAT GAAAACGTGGTGGTGGTGACCATTCAATATCGCCTGGGCATCTGGGGATTCTTCAGCACA GGGGATGAACACAGCCGGGGGAACTGGGGTCACCTGGACCAGGTGGCTGCCCTGCGCTGG GTCCAGGACAACATTGCCAGCTTTGGAGGGAACCCAGGCTCTGTGACCATCTTTGGAGAG TCAGCGGGAGGAGAAAGTGTCTCTGTTCTTGTTTTGTCTCCATTGGCCAAGAACCTCTTC CACCGGGCCATTTCTGAGAGTGGCGTGGCCCTCACTTCTGTTCTGGTGAAGAAAGGTGAT GTCAAGCCCTTGGCTGAGCAAATTGCTATCACTGCTGGGTGCAAAACCACCACCTCTGCT GTCATGGTTCACTGCCTGCGACAGAAGACGGAAGAGGAGCTCTTGGAGACGACATTGAAA ATGAAATTCTTATCTCTGGACTTACAGGGAGACCCCAGAGAGAGTCAACCCCTTCTGGGC ACTGTGATTGATGGGATGCTGCTGCTGAAAACACCTGAAGAGCTTCAAGCTGAAAGGAAT TTCCACACTGTCCCCTACATGGTCGGAATTAACAAGCAGGAGTTTGGCTGGTTGATTCCA ATGCAGTTGATGAGCTATCCACTCTCCGAAGGGCAACTGGACCAGAAGACAGCCATGTCA CTCCTGTGGAAGTCCTATCCCCTTGTTTGCATTGCTAAGGAACTGATTCCAGAAGCCACT GAGAAATACTTAGGAGGAACAGACGACACTGTCAAAAAGAAAGACCTGTTCCTGGACTTG ATAGCAGATGTGATGTTTGGTGTCCCATCTGTGATTGTGGCCCGGAACCACAGAGATGCT GGAGCACCCACCTACATGTATGAGTTTCAGTACCGTCCAAGCTTCTCATCAGACATGAAA CCCAAGACGGTGATAGGAGACCACGGGGATGAGCTCTTCTCCGTCTTTGGGGCCCCATTT TTAAAAGAGGGTGCCTCAGAAGAGGAGATCAGACTTAGCAAGATGGTGATGAAATTCTGG GCCAACTTTGCTCGCAATGGAAACCCCAATGGGGAAGGGCTGCCCCACTGGCCAGAGTAC AACCAGAAGGAAGGGTATCTGCAGATTGGTGCCAACACCCAGGCGGCCCAGAAGCTGAAG GACAAAGAAGTAGCTTTCTGGACCAACCTCTTTGCCAAGAAGGCAGTGGAGAAGCCACCC CAGACAGAACACATAGAGCTGTGA
- Chromosome Location
- 16
- Locus
- 16q13-q22.1
- External Identifiers
Resource Link UniProtKB ID P23141 UniProtKB Entry Name EST1_HUMAN GenBank Gene ID M73499 GenAtlas ID CES1 HGNC ID HGNC:1863 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB04795 Thenoyltrifluoroacetone experimental unknown Details DB02161 Hydroxy-Phenyl-Acetic Acid 8-Methyl-8-Aza-Bicyclo[3.2.1]Oct-3-Yl Ester experimental unknown Details DB03721 N-acetyl-alpha-neuraminic acid experimental unknown Details DB06442 Avasimibe investigational unknown Details DB01101 Capecitabine approved, investigational no substrate Details DB00675 Tamoxifen approved unknown inhibitor Details DB00328 Indomethacin approved, investigational unknown substrate Details DB06693 Mevastatin experimental unknown inhibitor Details DB03056 4-Piperidino-Piperidine experimental unknown Details DB02659 Cholic Acid approved unknown Details DB07821 (1R)-1,2,2-trimethylpropyl (R)-methylphosphinate experimental unknown Details DB08224 (1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HY DROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENOL experimental unknown Details DB01410 Ciclesonide approved, investigational unknown substrate Details DB00583 Levocarnitine approved, investigational unknown Details DB04838 Cyclandelate approved unknown Details DB01599 Probucol approved, investigational unknown Details DB01086 Benzocaine approved, investigational unknown inhibitor Details DB00519 Trandolapril approved unknown substrate Details DB06201 Rufinamide approved unknown substrate Details DB06695 Dabigatran etexilate approved unknown substrate Details DB00758 Clopidogrel approved no substrate Details DB00688 Mycophenolate mofetil approved, investigational unknown substrate Details DB11362 Selexipag approved no substrate Details DB09269 Phenylacetic acid approved unknown substrate Details DB00454 Meperidine approved unknown Details DB00647 Dextropropoxyphene approved, illicit, investigational, withdrawn unknown Details DB01183 Naloxone approved, vet_approved unknown binder Details DB00382 Tacrine approved, investigational, withdrawn unknown Details DB00907 Cocaine approved, illicit unknown binder Details DB01452 Diamorphine approved, illicit, investigational unknown Details DB09342 Propoxycaine approved unknown substrate Details DB11181 Homatropine approved unknown substrate Details DB09299 Tenofovir alafenamide approved no substrate Details DB00198 Oseltamivir approved yes substrate Details DB00881 Quinapril approved, investigational unknown substrate Details DB01039 Fenofibrate approved unknown substrate Details DB00907 Cocaine approved, illicit unknown substrate Details DB12404 Remimazolam approved, investigational unknown substrate Details DB14845 Filgotinib approved, investigational unknown metabolizer Details DB14761 Remdesivir approved, investigational yes substrate Details DB00875 Flupentixol approved, investigational, withdrawn no inhibitor Details DB16349 Vicagrel investigational unknown substrate Details DB09061 Cannabidiol approved, investigational no inhibitor Details DB00470 Dronabinol approved, illicit no inhibitor Details DB14737 Cannabinol experimental, investigational unknown inhibitor Details DB14009 Medical Cannabis experimental, investigational unknown inhibitor Details DB00641 Simvastatin approved unknown inhibitor Details DB12095 Telotristat ethyl approved, investigational no substrate Details DB00762 Irinotecan approved, investigational unknown substrate Details