Sodium-dependent noradrenaline transporter

Details

Name
Sodium-dependent noradrenaline transporter
Synonyms
  • NAT1
  • NET
  • NET1
  • Norepinephrine transporter
  • SLC6A5
  • Solute carrier family 6 member 2
Gene Name
SLC6A2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0000970|Sodium-dependent noradrenaline transporter
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
Number of residues
617
Molecular Weight
69331.42
Theoretical pI
7.53
GO Classification
Functions
monoamine transmembrane transporter activity / norepinephrine
Processes
monoamine transport / norepinephrine transport / response to pain / synaptic transmission / transmembrane transport / transport
Components
integral component of plasma membrane / membrane / neuron projection / plasma membrane
General Function
Norepinephrine:sodium symporter activity
Specific Function
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
Pfam Domain Function
Transmembrane Regions
65-85 93-112 136-156 235-253 262-279 315-332 344-365 398-417 444-462 478-498 519-538 557-575
Cellular Location
Membrane
Gene sequence
>lcl|BSEQ0010343|Sodium-dependent noradrenaline transporter (SLC6A2)
ATGCTTCTGGCGCGGATGAACCCGCAGGTGCAGCCCGAGAACAACGGGGCGGACACGGGT
CCAGAGCAGCCCCTTCGGGCGCGCAAAACTGCGGAGCTGCTGGTGGTGAAGGAGCGCAAC
GGCGTCCAGTGCCTGCTGGCGCCCCGCGACGGCGACGCGCAGCCCCGGGAGACCTGGGGC
AAGAAGATCGACTTCCTGCTGTCCGTAGTCGGCTTCGCAGTGGACCTGGCCAACGTGTGG
CGCTTCCCCTACCTCTGCTACAAGAACGGCGGCGGTGCCTTCTTGATCCCGTACACACTG
TTCCTTATCATCGCGGGGATGCCCCTGTTCTACATGGAGCTGGCTCTGGGACAGTACAAC
CGGGAGGGGGCTGCCACCGTTTGGAAAATCTGCCCATTCTTCAAAGGCGTTGGCTATGCT
GTCATCCTGATCGCCCTGTACGTTGGCTTCTACTACAACGTCATCATCGCCTGGTCACTC
TACTACCTCTTCTCCTCCTTCACCCTCAACCTGCCCTGGACCGACTGTGGCCACACCTGG
AACAGCCCCAACTGTACCGACCCCAAGCTCCTCAATGGCTCCGTGCTTGGCAACCACACC
AAGTACTCCAAGTACAAGTTCACGCCGGCAGCCGAGTTTTATGAGCGTGGTGTCCTGCAC
CTTCACGAGAGCAGCGGGATTCATGACATCGGCCTGCCCCAGTGGCAGCTCTTGCTCTGT
CTGATGGTCGTCGTCATCGTCTTGTATTTTAGCCTCTGGAAAGGGGTGAAGACATCAGGA
AAGGTGGTGTGGATCACAGCCACGCTGCCTTACTTCGTGCTGTTCGTGCTCCTGGTCCAT
GGCGTCACGCTGCCCGGAGCCTCCAATGGCATCAATGCCTACCTGCACATCGACTTCTAC
CGCTTGAAAGAGGCCACGGTATGGATTGATGCCGCAACTCAGATATTTTTTTCCTTGGGG
GCTGGATTTGGAGTATTGATTGCATTTGCCAGTTACAACAAATTTGACAACAACTGTTAC
AGGGATGCCCTGCTGACCAGCAGCATCAACTGTATCACCAGCTTCGTCTCTGGGTTCGCC
ATCTTCTCCATCCTTGGTTACATGGCCCATGAACACAAGGTCAACATTGAGGATGTGGCC
ACAGAAGGAGCTGGCCTAGTGTTCATCCTGTATCCAGAGGCCATTTCTACCCTGTCTGGA
TCTACATTCTGGGCTGTTGTGTTTTTCGTCATGCTCCTGGCGCTGGGCCTTGACAGCTCA
ATGGGAGGCATGGAGGCTGTCATCACGGGCCTGGCAGATGACTTCCAGGTCCTGAAGCGA
CACCGGAAACTCTTCACATTTGGCGTCACCTTCAGCACTTTCCTTCTCGCCCTGTTCTGC
ATAACCAAGGGTGGAATTTACGTCTTGACCCTCCTGGACACCTTTGCTGCGGGCACCTCC
ATCCTTTTTGCTGTCCTCATGGAAGCCATCGGAGTTTCCTGGTTTTATGGAGTGGACAGG
TTCAGCAACGACATCCAGCAGATGATGGGGTTCAGGCCGGGTCTATACTGGAGACTGTGC
TGGAAGTTCGTCAGTCCTGCCTTCCTCCTGTTCGTGGTTGTGGTCAGCATCATCAACTTC
AAGCCACTCACCTACGACGACTACATCTTCCCGCCCTGGGCCAACTGGGTGGGGTGGGGC
ATCGCCCTGTCCTCCATGGTCCTGGTGCCCATCTACGTCATCTATAAGTTCCTCAGCACG
CAGGGCTCTCTTTGGGAGAGACTGGCCTATGGCATCACGCCAGAGAACGAGCACCACCTG
GTGGCTCAGAGGGACATCAGACAGTTCCAGTTGCAACACTGGCTGGCCATCTGA
Chromosome Location
16
Locus
16q12.2
External Identifiers
ResourceLink
UniProtKB IDP23975
UniProtKB Entry NameSC6A2_HUMAN
GenBank Protein ID189258
GenBank Gene IDM65105
GenAtlas IDSLC6A2
HGNC IDHGNC:11048
General References
  1. Pacholczyk T, Blakely RD, Amara SG: Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature. 1991 Mar 28;350(6316):350-4. [PubMed:2008212]
  2. Porzgen P, Bonisch H, Bruss M: Molecular cloning and organization of the coding region of the human norepinephrine transporter gene. Biochem Biophys Res Commun. 1995 Oct 24;215(3):1145-50. [PubMed:7488042]
  3. Porzgen P, Bonisch H, Hammermann R, Bruss M: The human noradrenaline transporter gene contains multiple polyadenylation sites and two alternatively spliced C-terminal exons. Biochim Biophys Acta. 1998 Jul 9;1398(3):365-70. [PubMed:9655936]
  4. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039]
  5. Martin J, Han C, Gordon LA, Terry A, Prabhakar S, She X, Xie G, Hellsten U, Chan YM, Altherr M, Couronne O, Aerts A, Bajorek E, Black S, Blumer H, Branscomb E, Brown NC, Bruno WJ, Buckingham JM, Callen DF, Campbell CS, Campbell ML, Campbell EW, Caoile C, Challacombe JF, Chasteen LA, Chertkov O, Chi HC, Christensen M, Clark LM, Cohn JD, Denys M, Detter JC, Dickson M, Dimitrijevic-Bussod M, Escobar J, Fawcett JJ, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Goodwin LA, Grady DL, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Hildebrand CE, Huang W, Israni S, Jett J, Jewett PB, Kadner K, Kimball H, Kobayashi A, Krawczyk MC, Leyba T, Longmire JL, Lopez F, Lou Y, Lowry S, Ludeman T, Manohar CF, Mark GA, McMurray KL, Meincke LJ, Morgan J, Moyzis RK, Mundt MO, Munk AC, Nandkeshwar RD, Pitluck S, Pollard M, Predki P, Parson-Quintana B, Ramirez L, Rash S, Retterer J, Ricke DO, Robinson DL, Rodriguez A, Salamov A, Saunders EH, Scott D, Shough T, Stallings RL, Stalvey M, Sutherland RD, Tapia R, Tesmer JG, Thayer N, Thompson LS, Tice H, Torney DC, Tran-Gyamfi M, Tsai M, Ulanovsky LE, Ustaszewska A, Vo N, White PS, Williams AL, Wills PL, Wu JR, Wu K, Yang J, Dejong P, Bruce D, Doggett NA, Deaven L, Schmutz J, Grimwood J, Richardson P, Rokhsar DS, Eichler EE, Gilna P, Lucas SM, Myers RM, Rubin EM, Pennacchio LA: The sequence and analysis of duplication-rich human chromosome 16. Nature. 2004 Dec 23;432(7020):988-94. [PubMed:15616553]
  6. Torres GE, Yao WD, Mohn AR, Quan H, Kim KM, Levey AI, Staudinger J, Caron MG: Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. Neuron. 2001 Apr;30(1):121-34. [PubMed:11343649]
  7. Shannon JR, Flattem NL, Jordan J, Jacob G, Black BK, Biaggioni I, Blakely RD, Robertson D: Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency. N Engl J Med. 2000 Feb 24;342(8):541-9. [PubMed:10684912]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00191Phentermineapproved, illicityesinhibitorDetails
DB00234Reboxetineapproved, experimentalyesinhibitorDetails
DB00289AtomoxetineapprovedyesinhibitorDetails
DB00344ProtriptylineapprovedyesinhibitorDetails
DB00458ImipramineapprovedyesinhibitorDetails
DB00579Mazindolapproved, investigationalyesinhibitorDetails
DB00830Phenmetrazineapproved, illicityesinhibitorDetails
DB00937Diethylpropionapproved, illicityesinhibitorDetails
DB00193Tramadolapproved, investigationalyesinhibitorDetails
DB00226Guanadrelapprovedyespartial agonistDetails
DB00285VenlafaxineapprovedyesinhibitorDetails
DB00321AmitriptylineapprovedyesinhibitorDetails
DB00422Methylphenidateapproved, investigationalunknowninhibitorDetails
DB00476DuloxetineapprovedyesinhibitorDetails
DB00540NortriptylineapprovedyesinhibitorDetails
DB00543AmoxapineapprovedunknowninhibitorDetails
DB00726TrimipramineapprovedyesinhibitorDetails
DB00907Cocaineapproved, illicityesinhibitorDetails
DB00934Maprotilineapproved, investigationalyesinhibitorDetails
DB01105Sibutramineapproved, illicit, investigational, withdrawnyesinhibitorDetails
DB01142Doxepinapproved, investigationalyesinhibitorDetails
DB01149Nefazodoneapproved, withdrawnyesinhibitorDetails
DB01151Desipramineapproved, investigationalyesinhibitorDetails
DB01156BupropionapprovedyesinhibitorDetails
DB01170GuanethidineapprovedyesinducerDetails
DB01242Clomipramineapproved, investigational, vet_approvedunknowninhibitorDetails
DB00715Paroxetineapproved, investigationalunknowninhibitorDetails
DB04836Amineptineillicit, withdrawnunknownDetails
DB04840Debrisoquineapproved, investigationalyesinducerDetails
DB00696ErgotamineapprovedunknowninhibitorDetails
DB04889BicifadineinvestigationalunknownDetails
DB04896Milnacipranapproved, investigationalyesinhibitorDetails
DB05012XEN2174investigationalunknownDetails
DB05688CRx-119investigationalunknownDetails
DB12305DasotralineinvestigationalunknownDetails
DB06156TesofensineinvestigationalunknownDetails
DB05964AmitifadineinvestigationalunknownDetails
DB05642DDP-225investigationalunknownDetails
DB06204TapentadolapprovedyesinhibitorDetails
DB06333TrodusquemineinvestigationalunknownDetails
DB04821Nomifensineapproved, withdrawnunknownDetails
DB01175EscitalopramapprovedunknowninhibitorDetails
DB01114ChlorpheniramineapprovedunknowninhibitorDetails
DB01381Ginkgo bilobaapproved, investigational, nutraceuticalunknowninhibitorDetails
DB01173OrphenadrineapprovedyesinhibitorDetails
DB06700Desvenlafaxineapproved, investigationalyesinhibitorDetails
DB06148Mianserinapproved, investigationalunknowninhibitorDetails
DB06701Dexmethylphenidateapproved, investigationalyesinhibitorDetails
DB00852PseudoephedrineapprovedyesinhibitorDetails
DB01576Dextroamphetamineapproved, illicityesnegative modulatorDetails
DB01579Phendimetrazineapproved, illicityesnegative modulatorDetails
DB01363Ephedra sinica rootnutraceuticalyesnegative modulatorDetails
DB01442MMDAexperimental, illicityesnegative modulatorDetails
DB01577Metamfetamineapproved, illicityesnegative modulatorDetails
DB01454Midomafetamineexperimental, illicit, investigationalyesnegative modulatorDetails
DB01364Ephedrineapprovedunknowninverse agonistDetails
DB00368NorepinephrineapprovedunknownsubstrateDetails
DB06262Droxidopaapproved, investigationalunknownsubstrateDetails
DB01454Midomafetamineexperimental, illicit, investigationalunknownDetails
DB06704Iobenguaneapproved, investigationalyessubstrateDetails
DB08918Levomilnacipranapproved, investigationalyesinhibitorDetails
DB00408LoxapineapprovedunknownbinderDetails
DB00182Amphetamineapproved, illicit, investigationalunknownstimulatorDetails
DB00514DextromethorphanapprovedunknowninhibitorDetails
DB00988DopamineapprovedunknowninhibitorDetails
DB00454MeperidineapprovedunknowninhibitorDetails
DB01221Ketamineapproved, vet_approvedunknowninhibitorDetails
DB09068Vortioxetineapproved, investigationalunknownblockerDetails
DB09546Iobenguane sulfate I-123approved, investigationalnosubstrateDetails
DB09167DosulepinapprovedyesinhibitorDetails
DB09185Viloxazineapproved, investigational, withdrawnyesinhibitorDetails
DB09194EtoperidonewithdrawnunknowninhibitorDetails
DB13931NetarsudilapprovedyesinhibitorDetails
DB09225Zotepineapproved, investigational, withdrawnyesantagonistDetails
DB09363Rauwolfia serpentina rootinvestigationalunknowninhibitorDetails
DB00245BenzatropineapprovednoinhibitorDetails
DB14754SolriamfetolapprovedunknownDetails
DB00924CyclobenzaprineapprovedunknowninhibitorDetails