Sodium-dependent noradrenaline transporter
Details
- Name
- Sodium-dependent noradrenaline transporter
- Synonyms
- NAT1
- NET
- NET1
- Norepinephrine transporter
- SLC6A5
- Solute carrier family 6 member 2
- Gene Name
- SLC6A2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0000970|Sodium-dependent noradrenaline transporter MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL VAQRDIRQFQLQHWLAI
- Number of residues
- 617
- Molecular Weight
- 69331.42
- Theoretical pI
- 7.53
- GO Classification
- Functionsmonoamine transmembrane transporter activity / norepinephrineProcessesmonoamine transport / norepinephrine transport / response to pain / synaptic transmission / transmembrane transport / transportComponentsintegral component of plasma membrane / membrane / neuron projection / plasma membrane
- General Function
- Norepinephrine:sodium symporter activity
- Specific Function
- Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
- Pfam Domain Function
- SNF (PF00209)
- Transmembrane Regions
- 65-85 93-112 136-156 235-253 262-279 315-332 344-365 398-417 444-462 478-498 519-538 557-575
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0010343|Sodium-dependent noradrenaline transporter (SLC6A2) ATGCTTCTGGCGCGGATGAACCCGCAGGTGCAGCCCGAGAACAACGGGGCGGACACGGGT CCAGAGCAGCCCCTTCGGGCGCGCAAAACTGCGGAGCTGCTGGTGGTGAAGGAGCGCAAC GGCGTCCAGTGCCTGCTGGCGCCCCGCGACGGCGACGCGCAGCCCCGGGAGACCTGGGGC AAGAAGATCGACTTCCTGCTGTCCGTAGTCGGCTTCGCAGTGGACCTGGCCAACGTGTGG CGCTTCCCCTACCTCTGCTACAAGAACGGCGGCGGTGCCTTCTTGATCCCGTACACACTG TTCCTTATCATCGCGGGGATGCCCCTGTTCTACATGGAGCTGGCTCTGGGACAGTACAAC CGGGAGGGGGCTGCCACCGTTTGGAAAATCTGCCCATTCTTCAAAGGCGTTGGCTATGCT GTCATCCTGATCGCCCTGTACGTTGGCTTCTACTACAACGTCATCATCGCCTGGTCACTC TACTACCTCTTCTCCTCCTTCACCCTCAACCTGCCCTGGACCGACTGTGGCCACACCTGG AACAGCCCCAACTGTACCGACCCCAAGCTCCTCAATGGCTCCGTGCTTGGCAACCACACC AAGTACTCCAAGTACAAGTTCACGCCGGCAGCCGAGTTTTATGAGCGTGGTGTCCTGCAC CTTCACGAGAGCAGCGGGATTCATGACATCGGCCTGCCCCAGTGGCAGCTCTTGCTCTGT CTGATGGTCGTCGTCATCGTCTTGTATTTTAGCCTCTGGAAAGGGGTGAAGACATCAGGA AAGGTGGTGTGGATCACAGCCACGCTGCCTTACTTCGTGCTGTTCGTGCTCCTGGTCCAT GGCGTCACGCTGCCCGGAGCCTCCAATGGCATCAATGCCTACCTGCACATCGACTTCTAC CGCTTGAAAGAGGCCACGGTATGGATTGATGCCGCAACTCAGATATTTTTTTCCTTGGGG GCTGGATTTGGAGTATTGATTGCATTTGCCAGTTACAACAAATTTGACAACAACTGTTAC AGGGATGCCCTGCTGACCAGCAGCATCAACTGTATCACCAGCTTCGTCTCTGGGTTCGCC ATCTTCTCCATCCTTGGTTACATGGCCCATGAACACAAGGTCAACATTGAGGATGTGGCC ACAGAAGGAGCTGGCCTAGTGTTCATCCTGTATCCAGAGGCCATTTCTACCCTGTCTGGA TCTACATTCTGGGCTGTTGTGTTTTTCGTCATGCTCCTGGCGCTGGGCCTTGACAGCTCA ATGGGAGGCATGGAGGCTGTCATCACGGGCCTGGCAGATGACTTCCAGGTCCTGAAGCGA CACCGGAAACTCTTCACATTTGGCGTCACCTTCAGCACTTTCCTTCTCGCCCTGTTCTGC ATAACCAAGGGTGGAATTTACGTCTTGACCCTCCTGGACACCTTTGCTGCGGGCACCTCC ATCCTTTTTGCTGTCCTCATGGAAGCCATCGGAGTTTCCTGGTTTTATGGAGTGGACAGG TTCAGCAACGACATCCAGCAGATGATGGGGTTCAGGCCGGGTCTATACTGGAGACTGTGC TGGAAGTTCGTCAGTCCTGCCTTCCTCCTGTTCGTGGTTGTGGTCAGCATCATCAACTTC AAGCCACTCACCTACGACGACTACATCTTCCCGCCCTGGGCCAACTGGGTGGGGTGGGGC ATCGCCCTGTCCTCCATGGTCCTGGTGCCCATCTACGTCATCTATAAGTTCCTCAGCACG CAGGGCTCTCTTTGGGAGAGACTGGCCTATGGCATCACGCCAGAGAACGAGCACCACCTG GTGGCTCAGAGGGACATCAGACAGTTCCAGTTGCAACACTGGCTGGCCATCTGA
- Chromosome Location
- 16
- Locus
- 16q12.2
- External Identifiers
Resource Link UniProtKB ID P23975 UniProtKB Entry Name SC6A2_HUMAN GenBank Protein ID 189258 GenBank Gene ID M65105 GenAtlas ID SLC6A2 HGNC ID HGNC:11048 - General References
- Pacholczyk T, Blakely RD, Amara SG: Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature. 1991 Mar 28;350(6316):350-4. [Article]
- Porzgen P, Bonisch H, Bruss M: Molecular cloning and organization of the coding region of the human norepinephrine transporter gene. Biochem Biophys Res Commun. 1995 Oct 24;215(3):1145-50. [Article]
- Porzgen P, Bonisch H, Hammermann R, Bruss M: The human noradrenaline transporter gene contains multiple polyadenylation sites and two alternatively spliced C-terminal exons. Biochim Biophys Acta. 1998 Jul 9;1398(3):365-70. [Article]
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
- Martin J, Han C, Gordon LA, Terry A, Prabhakar S, She X, Xie G, Hellsten U, Chan YM, Altherr M, Couronne O, Aerts A, Bajorek E, Black S, Blumer H, Branscomb E, Brown NC, Bruno WJ, Buckingham JM, Callen DF, Campbell CS, Campbell ML, Campbell EW, Caoile C, Challacombe JF, Chasteen LA, Chertkov O, Chi HC, Christensen M, Clark LM, Cohn JD, Denys M, Detter JC, Dickson M, Dimitrijevic-Bussod M, Escobar J, Fawcett JJ, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Goodwin LA, Grady DL, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Hildebrand CE, Huang W, Israni S, Jett J, Jewett PB, Kadner K, Kimball H, Kobayashi A, Krawczyk MC, Leyba T, Longmire JL, Lopez F, Lou Y, Lowry S, Ludeman T, Manohar CF, Mark GA, McMurray KL, Meincke LJ, Morgan J, Moyzis RK, Mundt MO, Munk AC, Nandkeshwar RD, Pitluck S, Pollard M, Predki P, Parson-Quintana B, Ramirez L, Rash S, Retterer J, Ricke DO, Robinson DL, Rodriguez A, Salamov A, Saunders EH, Scott D, Shough T, Stallings RL, Stalvey M, Sutherland RD, Tapia R, Tesmer JG, Thayer N, Thompson LS, Tice H, Torney DC, Tran-Gyamfi M, Tsai M, Ulanovsky LE, Ustaszewska A, Vo N, White PS, Williams AL, Wills PL, Wu JR, Wu K, Yang J, Dejong P, Bruce D, Doggett NA, Deaven L, Schmutz J, Grimwood J, Richardson P, Rokhsar DS, Eichler EE, Gilna P, Lucas SM, Myers RM, Rubin EM, Pennacchio LA: The sequence and analysis of duplication-rich human chromosome 16. Nature. 2004 Dec 23;432(7020):988-94. [Article]
- Torres GE, Yao WD, Mohn AR, Quan H, Kim KM, Levey AI, Staudinger J, Caron MG: Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. Neuron. 2001 Apr;30(1):121-34. [Article]
- Shannon JR, Flattem NL, Jordan J, Jacob G, Black BK, Biaggioni I, Blakely RD, Robertson D: Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency. N Engl J Med. 2000 Feb 24;342(8):541-9. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00191 Phentermine approved, illicit yes inhibitor Details DB00234 Reboxetine approved, experimental yes inhibitor Details DB00289 Atomoxetine approved yes inhibitor Details DB00344 Protriptyline approved yes inhibitor Details DB00458 Imipramine approved yes inhibitor Details DB00579 Mazindol approved, investigational yes inhibitor Details DB00830 Phenmetrazine approved, illicit yes inhibitor Details DB00937 Diethylpropion approved, illicit yes inhibitor Details DB00193 Tramadol approved, investigational yes inhibitor Details DB00226 Guanadrel approved yes partial agonist Details DB00285 Venlafaxine approved yes inhibitor Details DB00321 Amitriptyline approved yes inhibitor Details DB00422 Methylphenidate approved, investigational unknown inhibitor Details DB00476 Duloxetine approved yes inhibitor Details DB00540 Nortriptyline approved yes inhibitor Details DB00543 Amoxapine approved unknown inhibitor Details DB00726 Trimipramine approved yes inhibitor Details DB00907 Cocaine approved, illicit yes inhibitor Details DB00934 Maprotiline approved, investigational yes inhibitor Details DB01105 Sibutramine approved, illicit, investigational, withdrawn yes inhibitor Details DB01142 Doxepin approved, investigational yes inhibitor Details DB01149 Nefazodone approved, withdrawn yes inhibitor Details DB01151 Desipramine approved, investigational yes inhibitor Details DB01156 Bupropion approved yes inhibitor Details DB01170 Guanethidine approved yes inducer Details DB01242 Clomipramine approved, investigational, vet_approved unknown inhibitor Details DB00715 Paroxetine approved, investigational unknown inhibitor Details DB04836 Amineptine illicit, withdrawn unknown Details DB04840 Debrisoquine approved, investigational yes inducer Details DB04889 Bicifadine investigational unknown Details DB04896 Milnacipran approved, investigational yes inhibitor Details DB05012 XEN-2174 investigational unknown Details DB05688 CRx-119 investigational unknown Details DB12305 Dasotraline investigational unknown Details DB06156 Tesofensine investigational unknown Details DB05964 Amitifadine investigational unknown Details DB05642 DDP-225 investigational unknown Details DB06204 Tapentadol approved unknown inhibitor Details DB06333 Trodusquemine investigational unknown Details DB04821 Nomifensine approved, withdrawn unknown Details DB01175 Escitalopram approved unknown inhibitor Details DB01114 Chlorpheniramine approved unknown inhibitor Details DB01381 Ginkgo biloba approved, investigational, nutraceutical unknown inhibitor Details DB01173 Orphenadrine approved yes inhibitor Details DB06700 Desvenlafaxine approved, investigational yes inhibitor Details DB06148 Mianserin approved, investigational unknown inhibitor Details DB06701 Dexmethylphenidate approved, investigational yes inhibitor Details DB00852 Pseudoephedrine approved yes inhibitor Details DB01576 Dextroamphetamine approved, illicit yes negative modulator Details DB01579 Phendimetrazine approved, illicit yes negative modulator Details DB01363 Ephedra sinica root nutraceutical yes negative modulator Details DB01442 MMDA experimental, illicit yes negative modulator Details DB01577 Metamfetamine approved, illicit, withdrawn yes negative modulator Details DB01454 Midomafetamine experimental, illicit, investigational yes negative modulator Details DB01364 Ephedrine approved unknown inverse agonist Details DB00368 Norepinephrine approved unknown substrate Details DB06262 Droxidopa approved, investigational unknown substrate Details DB01454 Midomafetamine experimental, illicit, investigational unknown Details DB06704 Iobenguane approved, investigational no substrate Details DB08918 Levomilnacipran approved, investigational yes inhibitor Details DB00408 Loxapine approved unknown binder Details DB00182 Amphetamine approved, illicit, investigational unknown agonistsubstrate Details DB00514 Dextromethorphan approved unknown inhibitor Details DB00988 Dopamine approved unknown inhibitor Details DB00454 Meperidine approved unknown inhibitor Details DB01221 Ketamine approved, vet_approved unknown inhibitor Details DB09068 Vortioxetine approved, investigational unknown blocker Details DB09546 Iobenguane sulfate I-123 approved, investigational no substrate Details DB09167 Dosulepin approved yes inhibitor Details DB09185 Viloxazine approved, investigational, withdrawn yes inhibitor Details DB09194 Etoperidone withdrawn no inhibitor Details DB13931 Netarsudil approved yes inhibitor Details DB09225 Zotepine approved, investigational, withdrawn yes antagonist Details DB09363 Rauwolfia serpentina root investigational unknown inhibitor Details DB00245 Benzatropine approved no inhibitor Details DB14754 Solriamfetol approved unknown Details DB00924 Cyclobenzaprine approved unknown inhibitor Details DB01104 Sertraline approved unknown inhibitordownregulator Details DB00852 Pseudoephedrine approved unknown inhibitor Details DB00540 Nortriptyline approved unknown substrateinhibitor Details DB00721 Procaine approved, investigational, vet_approved unknown inhibitor Details DB16629 Serdexmethylphenidate approved yes inhibitor Details