Low molecular weight phosphotyrosine protein phosphatase

Details

Name
Low molecular weight phosphotyrosine protein phosphatase
Synonyms
  • 3.1.3.48
  • Adipocyte acid phosphatase
  • LMW-PTP
  • Low molecular weight cytosolic acid phosphatase
  • Red cell acid phosphatase 1
Gene Name
ACP1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0007263|Low molecular weight phosphotyrosine protein phosphatase
MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYEIGNPPDYRG
QSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGSY
DPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLEKAH
Number of residues
158
Molecular Weight
18042.315
Theoretical pI
6.73
GO Classification
Functions
acid phosphatase activity / non-membrane spanning protein tyrosine phosphatase activity
Components
cytoplasm / cytoplasmic side of plasma membrane / extracellular exosome
General Function
Non-membrane spanning protein tyrosine phosphatase activity
Specific Function
Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0012643|Low molecular weight phosphotyrosine protein phosphatase (ACP1)
ATGGCGGAACAGGCTACCAAGTCCGTGCTGTTTGTGTGTCTGGGTAACATTTGTCGATCA
CCCATTGCAGAAGCAGTTTTCAGGAAACTTGTAACCGATCAAAACATCTCAGAGAATTGG
AGGGTAGACAGCGCGGCAACTTCCGGGTATGAGATAGGGAACCCCCCTGACTACCGAGGG
CAGAGCTGCATGAAGAGGCACGGCATTCCCATGAGCCACGTTGCCCGGCAGGTACCGTCC
TTGGACTTGAAGTTGTGTGTTTTGTGTTTCAGTGGGTCATTGACAGCGGTGCTGTTTCTG
ACTGGAACGTGGGCCGGTCCCCAGACCCAAGAGCTGTGA
Chromosome Location
2
Locus
2p25
External Identifiers
ResourceLink
UniProtKB IDP24666
UniProtKB Entry NamePPAC_HUMAN
GenBank Protein ID179636
GenBank Gene IDM83653
HGNC IDHGNC:122
General References
  1. Dissing J, Johnsen AH, Sensabaugh GF: Human red cell acid phosphatase (ACP1). The amino acid sequence of the two isozymes Bf and Bs encoded by the ACP1*B allele. J Biol Chem. 1991 Nov 5;266(31):20619-25. [Article]
  2. Dissing J, Johnsen AH: Human red cell acid phosphatase (ACP1): the primary structure of the two pairs of isozymes encoded by the ACP1*A and ACP1*C alleles. Biochim Biophys Acta. 1992 Jun 24;1121(3):261-8. [Article]
  3. Wo YY, McCormack AL, Shabanowitz J, Hunt DF, Davis JP, Mitchell GL, Van Etten RL: Sequencing, cloning, and expression of human red cell-type acid phosphatase, a cytoplasmic phosphotyrosyl protein phosphatase. J Biol Chem. 1992 May 25;267(15):10856-65. [Article]
  4. Bryson GL, Massa H, Trask BJ, Van Etten RL: Gene structure, sequence, and chromosomal localization of the human red cell-type low-molecular-weight acid phosphotyrosyl phosphatase gene, ACP1. Genomics. 1995 Nov 20;30(2):133-40. [Article]
  5. Shekels LL, Smith AJ, Van Etten RL, Bernlohr DA: Identification of the adipocyte acid phosphatase as a PAO-sensitive tyrosyl phosphatase. Protein Sci. 1992 Jun;1(6):710-21. [Article]
  6. Tailor P, Gilman J, Williams S, Couture C, Mustelin T: Regulation of the low molecular weight phosphotyrosine phosphatase by phosphorylation at tyrosines 131 and 132. J Biol Chem. 1997 Feb 28;272(9):5371-4. [Article]
  7. Tailor P, Gilman J, Williams S, Mustelin T: A novel isoform of the low molecular weight phosphotyrosine phosphatase, LMPTP-C, arising from alternative mRNA splicing. Eur J Biochem. 1999 Jun;262(2):277-82. [Article]
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  12. Sensabaugh GF, Lazaruk KA: A TaqI site identifies the *A allele at the ACP1 locus. Hum Mol Genet. 1993 Jul;2(7):1079. [Article]
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  17. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
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  19. Zhang M, Stauffacher CV, Lin D, Van Etten RL: Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity. J Biol Chem. 1998 Aug 21;273(34):21714-20. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00173Adenineapproved, nutraceuticalunknownDetails
DB042144-Nitrophenyl PhosphateexperimentalunknownDetails