Substance-P receptor
Details
- Name
- Substance-P receptor
- Synonyms
- NK-1 receptor
- NK-1R
- NK1R
- SPR
- TAC1R
- Tachykinin receptor 1
- Gene Name
- TACR1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0000765|Substance-P receptor MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
- Number of residues
- 407
- Molecular Weight
- 46250.5
- Theoretical pI
- 7.22
- GO Classification
- Functionssubstance P receptor activity / tachykinin receptor activityProcessescell surface receptor signaling pathway / detection of abiotic stimulus / inflammatory response / neuropeptide signaling pathway / phospholipase C-activating G-protein coupled receptor signaling pathway / positive regulation of smooth muscle contraction / regulation of uterine smooth muscle contraction / response to pain / synaptic transmission / tachykinin receptor signaling pathwayComponentsintegral component of plasma membrane / plasma membrane
- General Function
- Tachykinin receptor activity
- Specific Function
- This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 32-54 65-86 107-128 149-169 195-219 249-270 284-308
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010126|Substance-P receptor (TACR1) ATGGATAACGTCCTCCCGGTGGACTCAGACCTCTCCCCAAACATCTCCACTAACACCTCG GAACCCAATCAGTTCGTGCAACCAGCCTGGCAAATTGTCCTTTGGGCAGCTGCCTACACG GTCATTGTGGTGACCTCTGTGGTGGGCAACGTGGTAGTGATGTGGATCATCTTAGCCCAC AAAAGAATGAGGACAGTGACGAACTATTTTCTGGTGAACCTGGCCTTCGCGGAGGCCTCC ATGGCTGCATTCAATACAGTGGTGAACTTCACCTATGCTGTCCACAACGAATGGTACTAC GGCCTGTTCTACTGCAAGTTCCACAACTTCTTTCCCATCGCCGCTGTCTTCGCCAGTATC TACTCCATGACGGCTGTGGCCTTTGATAGGTACATGGCCATCATACATCCCCTCCAGCCC CGGCTGTCAGCCACAGCCACCAAAGTGGTCATCTGTGTCATCTGGGTCCTGGCTCTCCTG CTGGCCTTCCCCCAGGGCTACTACTCAACCACAGAGACCATGCCCAGCAGAGTCGTGTGC ATGATCGAATGGCCAGAGCATCCGAACAAGATTTATGAGAAAGTGTACCACATCTGTGTG ACTGTGCTGATCTACTTCCTCCCCCTGCTGGTGATTGGCTATGCATACACCGTAGTGGGA ATCACACTATGGGCCAGTGAGATCCCCGGGGACTCCTCTGACCGCTACCACGAGCAAGTC TCTGCCAAGCGCAAGGTGGTCAAAATGATGATTGTCGTGGTGTGCACCTTCGCCATCTGC TGGCTGCCCTTCCACATCTTCTTCCTCCTGCCCTACATCAACCCAGATCTCTACCTGAAG AAGTTTATCCAGCAGGTCTACCTGGCCATCATGTGGCTGGCCATGAGCTCCACCATGTAC AACCCCATCATCTACTGCTGCCTCAATGACAGGTTCCGTCTGGGCTTCAAGCATGCCTTC CGGTGCTGCCCCTTCATCAGCGCCGGCGACTATGAGGGGCTGGAAATGAAATCCACCCGG TATCTCCAGACCCAGGGCAGTGTGTACAAAGTCAGCCGCCTGGAGACCACCATCTCCACA GTGGTGGGGGCCCACGAGGAGGAGCCAGAGGACGGCCCCAAGGCCACACCCTCGTCCCTG GACCTGACCTCCAACTGCTCTTCACGAAGTGACTCCAAGACCATGACAGAGAGCTTCAGC TTCTCCTCCAATGTGCTCTCCTAG
- Chromosome Location
- 2
- Locus
- 2p13.1
- External Identifiers
Resource Link UniProtKB ID P25103 UniProtKB Entry Name NK1R_HUMAN GenBank Protein ID 8176544 GenBank Gene ID S62045 GenAtlas ID TACR1 HGNC ID HGNC:11526 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00673 Aprepitant approved, investigational yes antagonist Details DB01221 Ketamine approved, vet_approved unknown antagonist Details DB04894 Vapreotide experimental, investigational unknown antagonist Details DB05072 AV608 investigational unknown Details DB05418 GW 597599 investigational unknown Details DB05421 CP-122721 investigational unknown Details DB05466 R673 investigational unknown Details DB05790 SR 140333 investigational unknown Details DB09048 Netupitant approved, investigational yes antagonist Details DB09291 Rolapitant approved, investigational yes antagonist Details DB06634 Casopitant investigational unknown Details DB11949 Vestipitant investigational unknown Details DB12436 Vofopitant investigational unknown Details DB14019 Fosnetupitant approved yes antagonist Details DB00193 Tramadol approved, investigational no inhibitor Details