Neuropeptide Y receptor type 1
Details
- Name
- Neuropeptide Y receptor type 1
- Synonyms
- NPY1-R
- NPYR
- NPYY1
- Gene Name
- NPY1R
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0011754|Neuropeptide Y receptor type 1 MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLA LIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQ CVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMT DEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKR RNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNL LFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVS KTSLKQASPVAFKKINNNDDNEKI
- Number of residues
- 384
- Molecular Weight
- 44391.535
- Theoretical pI
- 7.86
- GO Classification
- Functionsneuropeptide Y receptor activity / pancreatic polypeptide receptor activity / peptide YY receptor activityProcessesadenylate cyclase-inhibiting G-protein coupled receptor signaling pathway / blood circulation / cell surface receptor signaling pathway / feeding behavior / G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / glucose metabolic process / locomotory behavior / negative regulation of cytosolic calcium ion concentration / negative regulation of hormone secretion / neuropeptide signaling pathway / outflow tract morphogenesis / peristalsis / positive regulation of vasoconstriction / regulation of blood pressure / regulation of multicellular organism growth / response to estradiol / sensory perception of painComponentsaxon / cytosol / integral component of plasma membrane / plasma membrane / synaptic vesicle
- General Function
- Peptide yy receptor activity
- Specific Function
- Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 45-65 77-97 117-137 155-175 212-232 261-281 300-320
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0011755|Neuropeptide Y receptor type 1 (NPY1R) ATGAATTCAACATTATTTTCCCAGGTTGAAAATCATTCAGTCCACTCTAATTTCTCAGAG AAGAATGCCCAGCTTCTGGCTTTTGAAAATGATGATTGTCATCTGCCCTTGGCCATGATA TTTACCTTAGCTCTTGCTTATGGAGCTGTGATCATTCTTGGTGTCTCTGGAAACCTGGCC TTGATCATAATCATCTTGAAACAAAAGGAGATGAGAAATGTTACCAACATCCTGATTGTG AACCTTTCCTTCTCAGACTTGCTTGTTGCCATCATGTGTCTCCCCTTTACATTTGTCTAC ACATTAATGGACCACTGGGTCTTTGGTGAGGCGATGTGTAAGTTGAATCCTTTTGTGCAA TGTGTTTCAATCACTGTGTCCATTTTCTCTCTGGTTCTCATTGCTGTGGAACGACATCAG CTGATAATCAACCCTCGAGGGTGGAGACCAAATAATAGACATGCTTATGTAGGTATTGCT GTGATTTGGGTCCTTGCTGTGGCTTCTTCTTTGCCTTTCCTGATCTACCAAGTAATGACT GATGAGCCGTTCCAAAATGTAACACTTGATGCGTACAAAGACAAATACGTGTGCTTTGAT CAATTTCCATCGGACTCTCATAGGTTGTCTTATACCACTCTCCTCTTGGTGCTGCAGTAT TTTGGTCCACTTTGTTTTATATTTATTTGCTACTTCAAGATATATATACGCCTAAAAAGG AGAAACAACATGATGGACAAGATGAGAGACAATAAGTACAGGTCCAGTGAAACCAAAAGA ATCAATATCATGCTGCTCTCCATTGTGGTAGCATTTGCAGTCTGCTGGCTCCCTCTTACC ATCTTTAACACTGTGTTTGATTGGAATCATCAGATCATTGCTACCTGCAACCACAATCTG TTATTCCTGCTCTGCCACCTCACAGCAATGATATCCACTTGTGTCAACCCCATATTTTAT GGGTTCCTGAACAAAAACTTCCAGAGAGACTTGCAGTTCTTCTTCAACTTTTGTGATTTC CGGTCTCGGGATGATGATTATGAAACAATAGCCATGTCCACGATGCACACAGATGTTTCC AAAACTTCTTTGAAGCAAGCAAGCCCAGTCGCATTTAAAAAAATCAACAACAATGATGAT AATGAAAAAATCTGA
- Chromosome Location
- 4
- Locus
- 4q31.3-q32
- External Identifiers
Resource Link UniProtKB ID P25929 UniProtKB Entry Name NPY1R_HUMAN GenBank Gene ID M88461 GenAtlas ID NPY1R HGNC ID HGNC:7956 - General References
- Larhammar D, Blomqvist AG, Yee F, Jazin E, Yoo H, Wahlested C: Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type. J Biol Chem. 1992 Jun 5;267(16):10935-8. [Article]
- Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA: Cloned human neuropeptide Y receptor couples to two different second messenger systems. Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5794-8. [Article]
- Herzog H, Baumgartner M, Vivero C, Selbie LA, Auer B, Shine J: Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor. J Biol Chem. 1993 Mar 25;268(9):6703-7. [Article]
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