Integrin beta-7
Details
- Name
- Integrin beta-7
- Synonyms
- Gut homing receptor beta subunit
- Gene Name
- ITGB7
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006662|Integrin beta-7 MVALPMVLVLLLVLSRGESELDAKIPSTGDATEWRNPHLSMLGSCQPAPSCQKCILSHPS CAWCKQLNFTASGEAEARRCARREELLARGCPLEELEEPRGQQEVLQDQPLSQGARGEGA TQLAPQRVRVTLRPGEPQQLQVRFLRAEGYPVDLYYLMDLSYSMKDDLERVRQLGHALLV RLQEVTHSVRIGFGSFVDKTVLPFVSTVPSKLRHPCPTRLERCQSPFSFHHVLSLTGDAQ AFEREVGRQSVSGNLDSPEGGFDAILQAALCQEQIGWRNVSRLLVFTSDDTFHTAGDGKL GGIFMPSDGHCHLDSNGLYSRSTEFDYPSVGQVAQALSAANIQPIFAVTSAALPVYQELS KLIPKSAVGELSEDSSNVVQLIMDAYNSLSSTVTLEHSSLPPGVHISYESQCEGPEKREG KAEDRGQCNHVRINQTVTFWVSLQATHCLPEPHLLRLRALGFSEELIVELHTLCDCNCSD TQPQAPHCSDGQGHLQCGVCSCAPGRLGRLCECSVAELSSPDLESGCRAPNGTGPLCSGK GHCQCGRCSCSGQSSGHLCECDDASCERHEGILCGGFGRCQCGVCHCHANRTGRACECSG DMDSCISPEGGLCSGHGRCKCNRCQCLDGYYGALCDQCPGCKTPCERHRDCAECGAFRTG PLATNCSTACAHTNVTLALAPILDDGWCKERTLDNQLFFFLVEDDARGTVVLRVRPQEKG ADHTQAIVLGCVGGIVAVGLGLVLAYRLSVEIYDRREYSRFEKEQQQLNWKQDSNPLYKS AITTTINPRFQEADSPTL
- Number of residues
- 798
- Molecular Weight
- 86902.415
- Theoretical pI
- 5.95
- GO Classification
- Functionscell adhesion molecule binding / metal ion binding / virus receptor activityProcessescell adhesion / cell-matrix adhesion / cell-matrix adhesion involved in ameboidal cell migration / extracellular matrix organization / heterotypic cell-cell adhesion / integrin-mediated signaling pathway / leukocyte tethering or rolling / receptor clustering / regulation of immune response / substrate adhesion-dependent cell spreading / T cell migrationComponentscell surface / extracellular exosome / integrin alpha4-beta7 complex / integrin complex / membrane / plasma membrane / receptor complex
- General Function
- Virus receptor activity
- Specific Function
- Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.
- Pfam Domain Function
- Transmembrane Regions
- 724-746
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0019419|Integrin beta-7 (ITGB7) ATGGTGGCTTTGCCAATGGTCCTTGTTTTGCTGCTGGTCCTGAGCAGAGGTGAGAGTGAA TTGGACGCCAAGATCCCATCCACAGGGGATGCCACAGAATGGCGGAATCCTCACCTGTCC ATGCTGGGGTCCTGCCAGCCAGCCCCCTCCTGCCAGAAGTGCATCCTCTCACACCCCAGC TGTGCATGGTGCAAGCAACTGAACTTCACCGCGTCGGGAGAGGCGGAGGCGCGGCGCTGC GCCCGACGAGAGGAGCTGCTGGCTCGAGGCTGCCCGCTGGAGGAGCTGGAGGAGCCCCGC GGCCAGCAGGAGGTGCTGCAGGACCAGCCGCTCAGCCAGGGCGCCCGCGGAGAGGGTGCC ACCCAGCTGGCGCCGCAGCGGGTCCGGGTCACGCTGCGGCCTGGGGAGCCCCAGCAGCTC CAGGTCCGCTTCCTTCGTGCTGAGGGATACCCGGTGGACCTGTACTACCTTATGGACCTG AGCTACTCCATGAAGGACGACCTGGAACGCGTGCGCCAGCTCGGGCACGCTCTGCTGGTC CGGCTGCAGGAAGTCACCCATTCTGTGCGCATTGGTTTTGGTTCCTTTGTGGACAAAACG GTGCTGCCCTTTGTGAGCACAGTACCCTCCAAACTGCGCCACCCCTGCCCCACCCGGCTG GAGCGCTGCCAGTCACCATTCAGCTTTCACCATGTGCTGTCCCTGACGGGGGACGCACAA GCCTTCGAGCGGGAGGTGGGGCGCCAGAGTGTGTCCGGCAATCTGGACTCGCCTGAAGGT GGCTTCGATGCCATTCTGCAGGCTGCACTCTGCCAGGAGCAGATTGGCTGGAGAAATGTG TCCCGGCTGCTGGTGTTCACTTCAGACGACACATTCCATACAGCTGGGGACGGGAAGTTG GGCGGCATTTTCATGCCCAGTGATGGGCACTGCCACTTGGACAGCAATGGCCTCTACAGT CGCAGCACAGAGTTTGACTACCCTTCTGTGGGTCAGGTAGCCCAGGCCCTCTCTGCAGCA AATATCCAGCCCATCTTTGCTGTCACCAGTGCCGCACTGCCTGTCTACCAGGAGCTGAGT AAACTGATTCCTAAGTCTGCAGTTGGGGAGCTGAGTGAGGACTCCAGCAACGTGGTACAG CTCATCATGGATGCTTATAATAGCCTGTCTTCCACCGTGACCCTTGAACACTCTTCACTC CCTCCTGGGGTCCACATTTCTTACGAATCCCAGTGTGAGGGTCCTGAGAAGAGGGAGGGT AAGGCTGAGGATCGAGGACAGTGCAACCACGTCCGAATCAACCAGACGGTGACTTTCTGG GTTTCTCTCCAAGCCACCCACTGCCTCCCAGAGCCCCATCTCCTGAGGCTCCGGGCCCTT GGCTTCTCAGAGGAGCTGATTGTGGAGTTGCACACGCTGTGTGACTGTAATTGCAGTGAC ACCCAGCCCCAGGCTCCCCACTGCAGTGATGGCCAGGGACACCTACAATGTGGTGTATGC AGCTGTGCCCCTGGCCGCCTAGGTCGGCTCTGTGAGTGCTCTGTGGCAGAGCTGTCCTCC CCAGACCTGGAATCTGGGTGCCGGGCTCCCAATGGCACAGGGCCCCTGTGCAGTGGAAAG GGTCACTGTCAATGTGGACGCTGCAGCTGCAGTGGACAGAGCTCTGGGCATCTGTGCGAG TGTGACGATGCCAGCTGTGAGCGACATGAGGGCATCCTCTGCGGAGGCTTTGGTCGCTGC CAATGTGGAGTATGTCACTGTCATGCCAACCGCACGGGCAGAGCATGCGAATGCAGTGGG GACATGGACAGTTGCATCAGTCCCGAGGGAGGGCTCTGCAGTGGGCATGGACGCTGCAAA TGCAACCGCTGCCAGTGCTTGGACGGCTACTATGGTGCTCTATGCGACCAATGCCCAGGC TGCAAGACACCATGCGAGAGACACCGGGACTGTGCAGAGTGTGGGGCCTTCAGGACTGGC CCACTGGCCACCAACTGCAGTACAGCTTGTGCCCATACCAATGTGACCCTGGCCTTGGCC CCTATCTTGGATGATGGCTGGTGCAAAGAGCGGACCCTGGACAACCAGCTGTTCTTCTTC TTGGTGGAGGATGACGCCAGAGGCACGGTCGTGCTCAGAGTGAGACCCCAAGAAAAGGGA GCAGACCACACGCAGGCCATTGTGCTGGGCTGCGTAGGGGGCATCGTGGCAGTGGGGCTG GGGCTGGTCCTGGCTTACCGGCTCTCGGTGGAAATCTATGACCGCCGGGAATACAGTCGC TTTGAGAAGGAGCAGCAACAACTCAACTGGAAGCAGGACAGTAATCCTCTCTACAAAAGT GCCATCACGACCACCATCAATCCTCGCTTTCAAGAGGCAGACAGTCCCACTCTCTGA
- Chromosome Location
- 12
- Locus
- 12q13.13
- External Identifiers
Resource Link UniProtKB ID P26010 UniProtKB Entry Name ITB7_HUMAN GenBank Gene ID S80335 GenAtlas ID ITGB7 HGNC ID HGNC:6162 - General References
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