dTDP-4-dehydrorhamnose reductase

Details

Name
dTDP-4-dehydrorhamnose reductase
Synonyms
  • 1.1.1.133
  • dTDP-4-keto-L-rhamnose reductase
  • dTDP-6-deoxy-L-lyxo-4-hexulose reductase
  • dTDP-6-deoxy-L-mannose dehydrogenase
  • dTDP-L-rhamnose synthase
  • rmlD
Gene Name
rfbD
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Amino acid sequence
>lcl|BSEQ0011421|dTDP-4-dehydrorhamnose reductase
MNILLFGKTGQVGWELQRSLAPVGNLIALDVHSKEFCGDFSNPKGVAETVRKLRPDVIVN
AAAHTAVDKAESEPELAQLLNATSVEAIAKAANETGAWVVHYSTDYVFPGTGDIPWQETD
ATSPLNVYGKTKLAGEKALQDNCPKHLIFRTSWVYAGKGNNFAKTMLRLAKERQTLSVIN
DQYGAPTGAELLADCTAHAIRVALNKPEVAGLYHLVAGGTTTWHDYAALVFDEARKAGIT
LALTELNAVPTSAYPTPASRPGNSRLNTEKFQRNFDLILPQWELGVKRMLTEMFTTTTI
Number of residues
299
Molecular Weight
32553.76
Theoretical pI
6.88
GO Classification
Functions
dTDP-4-dehydrorhamnose reductase activity / metal ion binding
Processes
dTDP-rhamnose biosynthetic process / extracellular polysaccharide biosynthetic process / lipopolysaccharide biosynthetic process / O antigen biosynthetic process
General Function
Metal ion binding
Specific Function
Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0011422|dTDP-4-dehydrorhamnose reductase (rfbD)
ATGAATATCTTACTTTTTGGTAAGACAGGGCAAGTAGGCTGGGAGTTGCAACGTTCTCTG
GCACCGGTAGGGAATCTGATTGCCCTGGATGTCCATTCAAAAGAGTTTTGCGGTGATTTT
AGTAATCCGAAAGGCGTTGCCGAAACCGTTCGTAAGCTTCGTCCCGATGTGATTGTTAAC
GCAGCAGCCCATACTGCAGTAGATAAAGCAGAGTCTGAACCAGAACTGGCGCAGTTACTT
AACGCCACCAGTGTGGAAGCCATCGCTAAAGCAGCCAACGAAACTGGCGCATGGGTAGTG
CATTATTCAACCGATTATGTATTTCCTGGTACCGGCGATATCCCATGGCAGGAAACGGAC
GCTACGTCGCCGCTGAATGTCTATGGCAAAACCAAACTGGCGGGAGAAAAGGCCCTGCAG
GATAACTGCCCTAAACACCTTATCTTCCGCACCAGTTGGGTTTATGCAGGTAAGGGCAAT
AATTTCGCAAAGACAATGCTTCGTCTGGCGAAAGAGCGTCAGACACTTTCAGTCATTAAC
GATCAGTACGGTGCGCCAACCGGTGCGGAATTACTGGCTGACTGTACGGCGCATGCGATC
CGTGTGGCGTTAAATAAACCAGAAGTCGCAGGTCTTTACCATCTGGTTGCCGGGGGAACC
ACAACCTGGCATGACTACGCGGCCTTAGTCTTTGACGAGGCGCGCAAAGCAGGGATAACG
CTTGCGCTGACTGAGCTTAATGCTGTGCCGACCAGCGCCTACCCGACGCCGGCGAGCAGA
CCAGGCAATTCGCGTCTCAATACTGAAAAGTTTCAGCGTAATTTTGACCTTATTCTGCCT
CAATGGGAATTAGGAGTTAAGCGTATGCTGACTGAAATGTTTACGACGACAACCATCTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP26392
UniProtKB Entry NameRMLD_SALTY
GenBank Gene IDX56793
General References
  1. Jiang XM, Neal B, Santiago F, Lee SJ, Romana LK, Reeves PR: Structure and sequence of the rfb (O antigen) gene cluster of Salmonella serovar typhimurium (strain LT2). Mol Microbiol. 1991 Mar;5(3):695-713. [Article]
  2. McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, Hou S, Layman D, Leonard S, Nguyen C, Scott K, Holmes A, Grewal N, Mulvaney E, Ryan E, Sun H, Florea L, Miller W, Stoneking T, Nhan M, Waterston R, Wilson RK: Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature. 2001 Oct 25;413(6858):852-6. [Article]
  3. Blankenfeldt W, Kerr ID, Giraud MF, McMiken HJ, Leonard G, Whitfield C, Messner P, Graninger M, Naismith JH: Variation on a theme of SDR. dTDP-6-deoxy-L- lyxo-4-hexulose reductase (RmlD) shows a new Mg2+-dependent dimerization mode. Structure. 2002 Jun;10(6):773-86. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB037232'-Deoxy-thymidine-beta-L-rhamnoseexperimentalunknownDetails