Genome polyprotein
Details
- Name
- Genome polyprotein
- Synonyms
- 3.4.22.-
- p23
- Gene Name
- Not Available
- Organism
- HCV
- Amino acid sequence
>lcl|BSEQ0013053|Genome polyprotein MSTNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRG RRQPIPKDRRSTGKSWGKPGYPWPLYGNEGCGWAGWLLSPRGSRPTWGPTDPRHRSRNLG RVIDTITCGFADLMGYIPVVGAPVGGVARALAHGVRVLEDGINYATGNLPGCSFSIFLLA LLSCVTVPVSAVEVRNISSSYYATNDCSNNSITWQLTDAVLHLPGCVPCENDNGTLHCWI QVTPNVAVKHRGALTRSLRTHVDMIVMAATACSALYVGDVCGAVMILSQAFMVSPQRHNF TQECNCSIYQGHITGHRMAWDMMLSWSPTLTMILAYAARVPELVLEIIFGGHWGVVFGLA YFSMQGAWAKVIAILLLVAGVDATTYSSGQEAGRTVAGFAGLFTTGAKQNLYLINTNGSW HINRTALNCNDSLQTGFLASLFYTHKFNSSGCPERLSSCRGLDDFRIGWGTLEYETNVTN DGDMRPYCWHYPPRPCGIVPARTVCGPVYCFTPSPVVVGTTDKQGVPTYTWGENETDVFL LNSTRPPRGAWFGCTWMNGTGFTKTCGAPPCRIRKDYNSTIDLLCPTDCFRKHPDATYLK CGAGPWLTPRCLVDYPYRLWHYPCTVNFTIFKARMYVGGVEHRFSAACNFTRGDRCRLED RDRGQQSPLLHSTTEWAVLPCSFSDLPALSTGLLHLHQNIVDVQYLYGLSPALTRYIVKW EWVILLFLLLADARICACLWMLIILGQAEAALEKLIILHSASAASANGPLWFFIFFTAAW YLKGRVVPVATYSVLGLWSFLLLVLALPQQAYALDAAEQGELGLAILVIISIFTLTPAYK ILLSRSVWWLSYMLVLAEAQIQQWVPPLEVRGGRDGIIWVAVILHPRLVFEVTKWLLAIL GPAYLLKASLLRIPYFVRAHALLRVCTLVKHLAGARYIQMLLITIGRWTGTYIYDHLSPL STWAAQGLRDLAIAVEPVVFSPMEKKVIVWGAETVACGDILHGLPVSARLGREVLLGPAD GYTSKGWKLLAPITAYTQQTRGLLGAIVVSLTGRDKNEQAGQVQVLSSVTQTFLGTSISG VLWTVYHGAGNKTLAGPKGPVTQMYTSAEGDLVGWPSPPGTKSLDPCTCGAVDLYLVTRN ADVIPVRRKDDRRGALLSPRPLSTLKGSSGGPVLCSRGHAVGLFRAAVCARGVAKSIDFI PVESLDVATRTPSFSDNSTPPAVPQSYQVGYLHAPTGSGKSTKVPAAYASQGYKVLVLNP SVAATLGFGAYMSKAHGINPNIRTGVRTVTTGDSITYSTYGKFIADGGCAAGAYDIIICD ECHSVDATTILGIGTVLDQAETAGVRLVVLATATPPGTVTTPHSNIEEVALGHEGEIPFY GKAIPLAFIKGGRHLIFCHSKKKCDELAAALRGMGVNAVAYYRGLDVSVIPTQGDVVVVA TDALMTGYTGDFDSVIDCNVAVSQIVDFSLDPTFTITTQTVPQDAVSRSQRRGRTGRGRL GVYRYVSSGERPSGMFDSVVLCECYDAGAAWYELTPAETTVRLRAYFNTPGLPVCQDHLE FWEAVFTGLTHIDAHFLSQTKQGGENFAYLTAYQATVCARAKAPPPSWDVMWKCLTRLKP TLTGPTPLLYRLGAVTNEVTLTHPVTKYIATCMQADLEIMTSSWVLAGGVLAAVAAYCLA TGCISIIGRLHLNDRVVVAPDKEILYEAFDEMEECASKAALIEEGQRMAEMLKSKIQGLL QQATRQAQDIQPAIQSSWPKLEQFWAKHMWNFISGIQYLAGLSTLPGNPAVASMMAFSAA LTSPLPTSTTILLNIMGGWLASQIAPPAGATGFVVSGLVGAAVGSIGLGKILVDVLAGYG AGISGALVAFKIMSGEKPTVEDVVNLLPAILSPGALVVGVICAAILRRHVGQGEGAVQWM NRLIAFASRGNHVAPTHYVVESDASQRVTQVLSSLTITSLLRRLHAWITEDCPVPCSGSW LQDIWDWVCSILTDFKNWLSSKLLPKMPGIPFISCQKGYKGVWAGTGVMTTRCPCGANIS GHVRMGTMKITGPKTCLNLWQGTFPINCYTEGPCVPKPPPNYKTAIWRVAASEYVEVTQH GSFSYVTGLTSDNLKVPCQVPAPEFFSWVDGVQIHRFAPVPGPFFRDEVTFTVGLNSFVV GSQLPCDPEPDTEVLASMLTDPSHITAEAAARRLARGSPPSQASSSASQLSAPSLKATCT THKTAYDCDMVDANLFMGGDVTRIESDSKVIVLDSLDSMTEVEDDREPSVPSEYLIKRRK FPPALPPWARPDYNPVLIETWKRPGYEPPTVLGCALPPTPQTPVPPPRRRRAKVLTQDNV EGVLREMADKVLSPLQDNNDSGHSTGADTGGDIVQQPSDETAASEAGSLSSMPPLEGEPG DPDLEFEPVGSAPPSEGECEVIDSDSKSWSTVSDQEDSVICCSMSYSWTGALITPCGPEE EKLPINPLSNSLMRFHNKVYSTTSRSASLRAKKVTFDRVQVLDAHYDSVLQDVKRAASKV SARLLTVEEACALTPPHSAKSRYGFGAKEVRSLSRRAVNHIRSVWEDLLEDQHTPIDTTI MAKNEVFCIDPTKGGKKPARLIVYPDLGVRVCEKMALYDIAQKLPKAIMGPSYGFQYSPA ERVDFLLKAWGSKKDPMGFSYDTRCFDSTVTERDIRTEESIYQACSLPQEARTVIHSLTE RLYVGGPMTNSKGQSCGYRRCRASGVFTTSMGNTMTCYIKALAACKAAGIVDPVMLVCGD DLVVISESQGNEEDERNLRAFTEAMTRYSAPPGDLPRPEYDLELITSCSSNVSVALDSRG RRRYFLTRDPTTPITRAAWETVRHSPVNSWLGNIIQYAPTIWVRMVIMTHFFSILLAQDT LNQNLNFEMYGAVYSVNPLDLPAIIERLHGLEAFSLHTYSPHELSRVAATLRKLGAPPLR AWKSRARAVRASLIAQGARAAICGRYLFNWAVKTKLKLTPLPEASRLDLSGWFTVGAGGG DIYHSVSHARPRLLLLCLLLLSVGVGIFLLPAR
- Number of residues
- 3033
- Molecular Weight
- 330178.68
- Theoretical pI
- 8.14
- GO Classification
- FunctionsATP binding / ATP-dependent helicase activity / cysteine-type endopeptidase activity / ion channel activity / RNA binding / RNA-directed RNA polymerase activity / serine-type endopeptidase activity / structural molecule activity / zinc ion bindingProcessesapoptotic process / clathrin-mediated endocytosis of virus by host cell / fusion of virus membrane with host endosome membrane / induction by virus of host autophagy / modulation by virus of host G1/S transition checkpoint / pore formation by virus in membrane of host cell / protein oligomerization / regulation of transcription, DNA-templated / suppression by virus of host MAVS activity / suppression by virus of host STAT1 activity / suppression by virus of host TRAF activity / suppression by virus of host type I interferon-mediated signaling pathway / transcription, DNA-templated / transformation of host cell by virus / viral RNA genome replication / virion attachment to host cellComponentsextracellular region / host cell endoplasmic reticulum membrane / host cell lipid particle / host cell mitochondrial membrane / host cell nucleus / host cell perinuclear region of cytoplasm / host cell plasma membrane / integral component of membrane / integral to membrane of host cell / viral envelope / viral nucleocapsid / virion membrane
- General Function
- Zinc ion binding
- Specific Function
- Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Thought to play a role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Could mediate apoptotic pathways through association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptor-induced apoptosis remains controversial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Seric core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage. Core protein induces up-regulation of FAS promoter activity, and thereby probably contributes to the increased triglyceride accumulation in hepatocytes (steatosis) (By similarity).E1 and E2 glycoproteins form a heterodimer that is involved in virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, but this binding is not sufficient for infection, some additional liver specific cofactors may be needed. The fusion function may possibly be carried by E1. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection (By similarity).P7 seems to be a heptameric ion channel protein (viroporin) and is inhibited by the antiviral drug amantadine. Also inhibited by long-alkyl-chain iminosugar derivatives. Essential for infectivity (By similarity).Protease NS2-3 is a cysteine protease responsible for the autocatalytic cleavage of NS2-NS3. Seems to undergo self-inactivation following maturation (By similarity).NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS3/NS4A complex also prevents phosphorylation of human IRF3, thus preventing the establishment of dsRNA induced antiviral state. NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand. Cleaves and inhibits the host antiviral protein MAVS (By similarity).NS4B induces a specific membrane alteration that serves as a scaffold for the virus replication complex. This membrane alteration gives rise to the so-called ER-derived membranous web that contains the replication complex (By similarity).NS5A is a component of the replication complex involved in RNA-binding. Its interaction with Human VAPB may target the viral replication complex to vesicles. Down-regulates viral IRES translation initiation. Mediates interferon resistance, presumably by interacting with and inhibiting human EIF2AK2/PKR. Seems to inhibit apoptosis by interacting with BIN1 and FKBP8. The hyperphosphorylated form of NS5A is an inhibitor of viral replication (By similarity).NS5B is an RNA-dependent RNA polymerase that plays an essential role in the virus replication.
- Pfam Domain Function
- Transmembrane Regions
- 169-189 359-379 730-750 762-782 787-807 818-838 886-906 933-953 1662-1682 1810-1830 1833-1853 1855-1875 1886-1906 3013-3033
- Cellular Location
- Host endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0008325|9102 bp ATGAGCACAAATCCTAAACCTCAAAGAAAAACCAAAAGAAACACAAACCGCCGCCCACAG GACGTTAAGTTCCCGGGTGGCGGTCAGATCGTTGGCGGAGTTTACTTGCTGCCGCGCAGG GGCCCCAGGTTGGGTGTGCGCGCGACAAGGAAGACTTCTGAGCGATCCCAGCCGCGTGGA CGACGCCAGCCCATCCCGAAAGATCGGCGCTCCACCGGCAAGTCCTGGGGAAAGCCAGGA TATCCTTGGCCCCTGTACGGAAACGAGGGTTGCGGCTGGGCGGGTTGGCTCCTGTCCCCC CGCGGGTCTCGTCCTACTTGGGGCCCCACCGACCCCCGGCATAGATCACGCAATTTGGGC AGAGTCATCGATACCATTACGTGTGGTTTTGCCGACCTCATGGGGTACATCCCTGTCGTT GGCGCCCCGGTTGGAGGCGTCGCCAGAGCTCTGGCACACGGTGTTAGGGTCCTGGAGGAC GGGATAAATTACGCAACAGGGAATTTACCCGGTTGCTCTTTTTCTATCTTTTTGCTTGCT CTTCTGTCATGCGTCACAGTGCCAGTGTCTGCAGTGGAAGTCAGGAACATTAGTTCTAGC TACTACGCCACTAATGATTGCTCAAACAACAGCATCACCTGGCAGCTCACTGACGCAGTT CTCCATCTTCCTGGATGCGTCCCATGTGAGAATGATAATGGCACCTTGCATTGCTGGATA CAAGTAACACCCAACGTGGCTGTGAAACACCGCGGTGCGCTCACTCGTAGCCTGCGAACA CACGTCGACATGATCGTAATGGCAGCTACGGCCTGCTCGGCCTTGTATGTGGGAGATGTG TGCGGGGCCGTGATGATTCTATCGCAGGCTTTCATGGTATCACCACAACGCCACAACTTC ACCCAAGAGTGCAACTGTTCCATCTACCAAGGTCACATCACCGGCCATCGCATGGCATGG GACATGATGCTAAGCTGGTCTCCAACTCTTACCATGATCCTCGCCTACGCCGCTCGTGTT CCCGAACTGGTCCTCGAAATTATTTTCGGCGGCCATTGGGGTGTGGTGTTTGGCTTGGCC TATTTCTCCATGCAAGGAGCGTGGGCCAAAGTCATCGCCATCCTCCTTCTTGTTGCGGGA GTGGATGCAACCACCTATTCCAGCGGCCAGGAAGCGGGTCGTACCGTCGCGGGGTTCGCT GGCCTCTTTACTACTGGTGCCAAGCAGAACCTCTATTTAATCAACACCAATGGCAGCTGG CACATAAACCGGACTGCCCTCAATTGCAATGACAGCTTACAGACGGGTTTCCTCGCTTCC TTGTTTTACACCCACAAGTTCAACAGCTCTGGCTGCCCCGAGCGCTTGTCTTCCTGCCGC GGGCTGGACGATTTTCGCATCGGCTGGGGAACCTTGGAATACGAAACCAACGTCACCAAC GATGGGGACATGAGGCCGTACTGCTGGCATTACCCCCCGAGGCCTTGCGGCATCGTCCCG GCTAGGACGGTTTGCGGACCGGTCTATTGTTTCACCCCTAGCCCTGTTGTCGTGGGCACC ACTGACAAGCAGGGCGTACCCACCTACACCTGGGGAGAAAACGAGACCGATGTCTTCCTG CTAAATAGCACAAGACCCCCGCGAGGAGCTTGGTTCGGCTGCACCTGGATGAACGGGACT GGGTTCACTAAGACATGCGGTGCACCACCTTGCCGCATTAGGAAAGACTACAACAGCACT ATCGATTTATTGTGCCCCACAGACTGTTTTAGGAAGCACCCAGATGCTACCTATCTTAAG TGTGGAGCAGGGCCTTGGTTAACTCCCAGGTGCCTGGTAGACTACCCTTATAGGTTGTGG CATTATCCGTGCACTGTAAACTTCACCATCTTCAAGGCGCGGATGTATGTAGGAGGGGTG GAGCATCGATTCTCCGCAGCATGCAACTTCACGCGCGGAGATCGCTGCAGACTGGAAGAT AGGGATAGGGGCCAGCAGAGTCCACTGCTGCATTCCACTACTGAGTGGGCGGTGCTCCCA TGCTCCTTCTCTGACCTACCAGCACTATCCACTGGCCTATTGCACCTCCACCAAAACATC GTGGACGTGCAGTACCTCTACGGACTTTCTCCGGCTCTGACAAGATACATCGTGAAGTGG GAGTGGGTGATCCTCCTTTTCTTGTTGTTGGCAGACGCCAGGATCTGTGCATGCCTTTGG ATGCTCATCATACTGGGCCAAGCCGAAGCGGCGCTTGAGAAGCTCATCATCTTGCACTCC GCTAGTGCTGCTAGTGCCAATGGTCCGCTGTGGTTTTTCATCTTCTTTACAGCGGCCTGG TACTTAAAGGGCAGGGTGGTCCCCGTGGCCACGTACTCTGTCCTCGGCTTATGGTCCTTC CTCCTCCTAGTCCTGGCCTTACCACAGCAGGCTTATGCCTTGGACGCTGCTGAACAAGGG GAACTGGGGCTGGCCATATTAGTAATTATATCCATCTTTACTCTTACCCCAGCATACAAG ATCCTCCTGAGCCGTTCAGTGTGGTGGCTGTCCTACATGCTGGTCTTGGCCGAGGCCCAG ATTCAGCAATGGGTTCCCCCCCTGGAGGTCCGAGGGGGGCGTGACGGGATCATCTGGGTG GCTGTCATTCTACACCCACGCCTTGTGTTTGAGGTCACGAAATGGTTGTTAGCAATCCTG GGGCCTGCCTACCTCCTTAAAGCGTCTCTGCTACGGATACCGTACTTTGTGAGGGCCCAC GCTTTGCTACGAGTGTGTACCCTGGTGAAACACCTCGCGGGGGCTAGGTACATCCAGATG CTGTTGATCACCATAGGCAGATGGACCGGCACTTACATCTACGACCACCTCTCCCCTTTA TCAACTTGGGCGGCCCAGGGTTTGCGGGACCTGGCAATCGCCGTGGAGCCTGTGGTGTTC AGCCCAATGGAGAAGAAGGTCATTGTGTGGGGGGCTGAGACAGTGGCGTGTGGAGACATC CTGCATGGCCTCCCGGTCTCCGCGAGGCTAGGTAGGGAGGTTCTGCTCGGCCCTGCCGAC GGCTACACCTCCAAGGGGTGGAAGCTCCTAGCTCCCATTACTGCTTACACTCAGCAAACT CGTGGTCTCCTGGGTGCTATCGTGGTCAGCCTAACGGGCCGCGACAAAAATGAGCAGGCT GGGCAGGTCCAGGTTCTGTCCTCCGTCACACAAACTTTCTTGGGGACATCCATTTCGGGC GTCCTCTGGACAGTATATCACGGGGCTGGTAATAAGACCTTGGCCGGCCCCAAGGGACCA GTCACTCAGATGTACACCAGCGCAGAAGGGGACCTCGTGGGATGGCCTAGTCCCCCCGGG ACTAAGTCATTGGACCCCTGTACCTGCGGGGCCGTAGACCTCTACCTGGTCACCCGAAAC GCTGATGTCATTCCGGTCCGGAGGAAAGATGACCGACGGGGTGCATTACTCTCGCCAAGG CCCCTCTCAACCCTCAAAGGATCATCCGGAGGGCCCGTGCTCTGCTCAAGGGGACACGCC GTGGGCTTGTTCAGAGCGGCCGTGTGTGCCAGGGGTGTAGCCAAATCTATTGACTTCATC CCCGTCGAATCACTCGATGTCGCCACACGGACGCCCAGTTTCTCTGACAACAGTACGCCG CCAGCTGTGCCCCAGTCTTACCAGGTGGGTTACTTGCACGCACCAACAGGCAGCGGAAAG AGCACCAAGGTCCCTGCCGCGTATGCCAGTCAGGGGTATAAAGTACTCGTACTAAATCCC TCTGTCGCGGCCACACTTGGTTTTGGGGCCTACATGTCCAAAGCCCACGGGATCAACCCT AATATCAGAACTGGAGTGCGGACCGTTACCACCGGGGACTCTATCACTTACTCCACTTAT GGCAAGTTTATCGCAGATGGAGGCTGTGCAGCCGGTGCCTATGACATCATCATATGCGAC GAATGCCATTCAGTGGACGCTACTACCATCCTTGGCATTGGAACAGTCCTTGACCAAGCT GAGACCGCAGGCGTCAGGCTAGTGGTTTTGGCCACAGCCACGCCTCCCGGTACGGTGACA ACTCCCCACAGTAACATAGAGGAGGTGGCCCTTGGTCACGAGGGCGAGATCCCTTTTTAT GGCAAAGCTATTCCCCTAGCTTTCATCAAGGGGGGCAGACACTTGATCTTTTGCCATTCA AAGAAGAAGTGCGACGAGCTCGCAGCGGCCCTCCGGGGCATGGGTGTCAATGCCGTTGCA TACTATAGGGGTCTCGACGTCTCCGTTATACCAACTCAAGGAGACGTGGTGGTTGTCGCC ACTGATGCCCTAATGACTGGGTACACCGGCGACTTTGACTCCGTCATCGACTGTAATGTT GCAGTCTCTCAGATTGTTGACTTCAGCCTAGACCCAACCTTCACCATCACCACTCAAACC GTCCCTCAGGACGCTGTCTCCCGTAGTCAACGTAGAGGGAGAACTGGGAGGGGGCGATTG GGCGTTTACAGGTATGTTTCGTCAGGCGAGAGGCCGTCTGGGATGTTCGACAGCGTAGTG CTCTGCGAGTGCTATGATGCCGGGGCAGCCTGGTACGAGCTTACACCTGCTGAGACTACG GTGAGACTCCGGGCTTATTTCAACACGCCCGGTTTGCCCGTATGTCAAGACCACCTGGAG TTCTGGGAAGCGGTCTTTACAGGTCTCACACACATTGACGCCCACTTCCTCTCCCAGACG AAGCAAGGAGGAGAAAACTTTGCGTATCTAACGGCCTACCAGGCCACAGTATGCGCCAGG GCAAAGGCCCCTCCTCCTTCGTGGGACGTGATGTGGAAGTGTCTAACTAGGCTCAAACCT ACACTGACTGGTCCCACCCCCCTCCTGTACCGCTTGGGTGCCGTGACCAATGAGGTCACC TTGACGCACCCCGTGACGAAATACATCGCCACGTGCATGCAAGCTGACCTCGAGATCATG ACAAGCTCATGGGTCCTGGCGGGGGGGGTGCTAGCCGCCGTGGCAGCTTACTGCCTGGCG ACTGGCTGCATTTCCATCATTGGCCGCCTACACCTGAATGATCGGGTGGTTGTGGCCCCC GACAAGGAAATCTTATATGAGGCCTTTGATGAGATGGAAGAATGCGCCTCCAAAGCCGCC CTCATTGAGGAAGGGCAGCGGATGGCGGAGATGCTCAAATCTAAGATACAAGGCCTCCTA CAACAGGCCACAAGGCAAGCTCAAGACATACAGCCAGCTATACAGTCATCATGGCCCAAG CTTGAACAATTTTGGGCCAAACACATGTGGAACTTCATCAGTGGTATACAGTACCTAGCA GGACTCTCCACCCTACCGGGAAATCCTGCAGTGGCATCAATGATGGCTTTTAGCGCCGCG CTGACTAGCCCACTACCCACCAGCACCACCATCCTCTTGAACATCATGGGAGGATGGTTG GCCTCTCAGATTGCCCCCCCTGCCGGAGCCACTGGCTTCGTTGTCAGTGGTCTAGTGGGG GCGGCCGTCGGAAGCATAGGCCTGGGTAAGATACTGGTGGACGTTTTGGCCGGGTACGGC GCAGGCATTTCAGGGGCCCTCGTAGCTTTTAAGATCATGAGCGGCGAGAAGCCCACGGTA GAAGACGTTGTGAATCTCCTGCCTGCTATTCTGTCTCCTGGTGCGTTGGTAGTGGGAGTC ATCTGTGCAGCAATCCTGCGCCGCCACGTCGGTCAGGGAGAGGGAGCGGTCCAGTGGATG AACAGACTGATCGCCTTCGCCTCCAGGGGAAACCACGTTGCCCCTACCCACTACGTGGTG GAGTCTGACGCTTCACAGCGTGTAACGCAGGTGCTGAGTTCACTTACAATTACCAGCTTA CTTAGGAGACTACATGCCTGGATCACTGAAGATTGCCCAGTCCCATGCTCGGGGTCTTGG CTCCAGGACATTTGGGATTGGGTTTGTTCCATCCTCACAGACTTCAAAAACTGGCTGTCT TCAAAATTACTCCCCAAGATGCCCGGCATTCCCTTTATCTCTTGCCAGAAGGGATACAAG GGTGTATGGGCTGGTACGGGTGTCATGACTACTCGGTGCCCATGTGGAGCAAACATCTCG GGCCATGTCCGCATGGGCACCATGAAAATAACAGGCCCGAAGACTTGCTTGAACCTGTGG CAGGGGACTTTCCCCATTAATTGTTACACAGAAGGGCCTTGCGTGCCAAAACCCCCTCCT AATTACAAGACCGCAATTTGGAGGGTGGCAGCGTCGGAGTACGTTGAGGTCACACAGCAT GGCTCTTTCTCGTATGTAACGGGGTTAACCAGTGACAACCTTAAGGTCCCTTGCCAGGTA CCAGCTCCAGAATTTTTCTCTTGGGTGGACGGGGTGCAAATCCACCGATTCGCCCCCGTT CCAGGTCCCTTCTTTCGGGATGAGGTAACGTTCACCGTAGGCCTTAACTCCTTCGTGGTC GGCTCTCAGCTCCCTTGCGATCCTGAGCCGGACACCGAGGTACTGGCCTCCATGTTGACA GACCCGTCCCACATCACCGCGGAGGCGGCAGCCAGGCGATTGGCAAGGGGATCTCCCCCT TCACAGGCTAGCTCCTCAGCGAGCCAGCTCTCTGCCCCGTCCTTGAAGGCTACCTGTACC ACCCATAAGACAGCATATGATTGTGACATGGTGGATGCCAACCTTTTCATGGGAGGCGAT GTGACCCGGATTGAGTCTGACTCTAAGGTGATCGTTCTAGACTCCCTCGATTCCATGACT GAGGTAGAGGATGATCGTGAGCCTTCTGTACCATCAGAGTACCTGATCAAGAGGAGAAAG TTCCCACCGGCGCTGCCTCCTTGGGCCCGTCCAGACTACAATCCTGTTTTGATCGAGACA TGGAAGAGGCCGGGCTATGAACCACCCACTGTCCTAGGCTGTGCCCTCCCCCCCACACCT CAAACGCCAGTGCCTCCACCTCGGAGGCGCCGCGCCAAAGTCCTGACCCAGGACAATGTG GAGGGGGTCCTCAGGGAGATGGCTGACAAAGTACTCAGCCCTCTCCAAGACAACAATGAC TCCGGTCACTCCACTGGAGCGGATACCGGAGGAGACATCGTCCAGCAACCCTCTGACGAG ACTGCCGCTTCAGAAGCGGGGTCACTGTCCTCCATGCCTCCCCTTGAGGGAGAGCCGGGA GACCCTGACCTGGAGTTTGAACCAGTGGGATCCGCTCCCCCTTCTGAGGGGGAGTGTGAG GTCATTGATTCGGACTCTAAGTCGTGGTCCACAGTCTCTGATCAAGAGGATTCTGTTATC TGCTGCTCTATGTCATACTCCTGGACGGGGGCCCTCATAACACCATGTGGGCCCGAAGAG GAGAAGTTACCGATCAACCCTCTGAGTAATTCGCTCATGCGGTTCCATAATAAGGTGTAC TCCACAACCTCGAGGAGTGCCTCTCTGAGGGCAAAGAAGGTGACTTTTGACAGGGTGCAG GTGCTGGACGCACACTATGACTCAGTCTTGCAGGACGTTAAGCGGGCCGCCTCTAAGGTT AGTGCGAGGCTCCTCACAGTAGAGGAAGCCTGCGCGCTGACCCCGCCCCACTCCGCCAAA TCGCGATACGGATTTGGGGCAAAAGAGGTGCGCAGCTTATCCAGGAGGGCCGTTAACCAC ATCCGGTCCGTGTGGGAGGACCTCCTGGAAGACCAACATACCCCAATTGACACAACTATC ATGGCTAAAAATGAGGTGTTCTGCATTGATCCAACTAAAGGTGGGAAAAAGCCAGCTCGC CTCATCGTATACCCCGACCTTGGGGTCAGGGTGTGCGAAAAGATGGCCCTCTATGACATC GCACAAAAGCTTCCCAAAGCGATAATGGGGCCATCCTATGGGTTCCAATACTCTCCCGCA GAACGGGTCGATTTCCTCCTCAAAGCTTGGGGAAGTAAGAAGGACCCAATGGGGTTCTCG TATGACACCCGCTGCTTTGACTCAACCGTCACGGAGAGGGACATAAGAACAGAAGAATCC ATATATCAGGCTTGTTCTCTGCCTCAAGAAGCCAGAACTGTCATACACTCGCTCACTGAG AGACTTTACGTAGGAGGGCCCATGACAAACAGCAAAGGGCAATCCTGCGGCTACAGGCGT TGCCGCGCAAGCGGTGTTTTCACCACCAGCATGGGGAATACCATGACATGTTACATCAAA GCCCTTGCAGCGTGTAAGGCTGCAGGGATCGTGGACCCTGTTATGTTGGTGTGTGGAGAC GACCTGGTCGTCATCTCAGAGAGCCAAGGTAACGAGGAGGACGAGCGAAACCTGAGAGCT TTCACGGAGGCTATGACCAGGTATTCCGCCCCTCCCGGTGACCTTCCCAGACCGGAATAT GACTTGGAGCTTATAACATCCTGCTCCTCAAACGTATCGGTAGCGCTGGACTCTCGGGGT CGCCGCCGGTACTTCCTAACCAGAGACCCTACCACTCCAATCACCCGAGCTGCTTGGGAA ACAGTAAGACACTCCCCTGTCAATTCTTGGCTGGGCAACATCATCCAGTACGCCCCCACA ATCTGGGTCCGGATGGTCATAATGACTCACTTCTTCTCCATACTATTGGCCCAGGACACT CTGAACCAAAATCTCAATTTTGAGATGTACGGGGCAGTATACTCGGTCAATCCATTAGAC CTACCGGCCATAATTGAAAGGCTACATGGGCTTGAAGCCTTTTCACTGCACACATACTCT CCCCACGAACTCTCACGGGTGGCAGCAACTCTCAGAAAACTTGGAGCGCCTCCCCTTAGA GCGTGGAAGAGTCGGGCGCGTGCCGTGAGAGCTTCACTCATCGCCCAAGGAGCGAGGGCG GCCATTTGTGGCCGCTACCTCTTCAACTGGGCGGTGAAAACAAAGCTCAAACTCACTCCA TTGCCCGAGGCGAGCCGCCTGGATTTATCCGGGTGGTTCACCGTGGGCGCCGGCGGGGGC GACATTTATCACAGCGTGTCGCATGCCCGACCCCGCCTATTACTCCTTTGCCTACTCCTA CTTAGCGTAGGAGTAGGCATCTTTTTACTCCCCGCTCGGTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P26661 UniProtKB Entry Name POLG_HCVJ8 GenBank Protein ID 221609 GenBank Gene ID D10988 - General References
- Okamoto H, Kurai K, Okada S, Yamamoto K, Lizuka H, Tanaka T, Fukuda S, Tsuda F, Mishiro S: Full-length sequence of a hepatitis C virus genome having poor homology to reported isolates: comparative study of four distinct genotypes. Virology. 1992 May;188(1):331-41. [Article]
- McLauchlan J: Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes. J Viral Hepat. 2000 Jan;7(1):2-14. [Article]
- Penin F, Dubuisson J, Rey FA, Moradpour D, Pawlotsky JM: Structural biology of hepatitis C virus. Hepatology. 2004 Jan;39(1):5-19. [Article]
- Kim CS, Seol SK, Song OK, Park JH, Jang SK: An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication. J Virol. 2007 Apr;81(8):3852-65. Epub 2007 Jan 17. [Article]