Genome polyprotein

Details

Name
Genome polyprotein
Synonyms
  • 3.4.22.-
  • p23
Gene Name
Not Available
Organism
HCV
Amino acid sequence
>lcl|BSEQ0013053|Genome polyprotein
MSTNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRG
RRQPIPKDRRSTGKSWGKPGYPWPLYGNEGCGWAGWLLSPRGSRPTWGPTDPRHRSRNLG
RVIDTITCGFADLMGYIPVVGAPVGGVARALAHGVRVLEDGINYATGNLPGCSFSIFLLA
LLSCVTVPVSAVEVRNISSSYYATNDCSNNSITWQLTDAVLHLPGCVPCENDNGTLHCWI
QVTPNVAVKHRGALTRSLRTHVDMIVMAATACSALYVGDVCGAVMILSQAFMVSPQRHNF
TQECNCSIYQGHITGHRMAWDMMLSWSPTLTMILAYAARVPELVLEIIFGGHWGVVFGLA
YFSMQGAWAKVIAILLLVAGVDATTYSSGQEAGRTVAGFAGLFTTGAKQNLYLINTNGSW
HINRTALNCNDSLQTGFLASLFYTHKFNSSGCPERLSSCRGLDDFRIGWGTLEYETNVTN
DGDMRPYCWHYPPRPCGIVPARTVCGPVYCFTPSPVVVGTTDKQGVPTYTWGENETDVFL
LNSTRPPRGAWFGCTWMNGTGFTKTCGAPPCRIRKDYNSTIDLLCPTDCFRKHPDATYLK
CGAGPWLTPRCLVDYPYRLWHYPCTVNFTIFKARMYVGGVEHRFSAACNFTRGDRCRLED
RDRGQQSPLLHSTTEWAVLPCSFSDLPALSTGLLHLHQNIVDVQYLYGLSPALTRYIVKW
EWVILLFLLLADARICACLWMLIILGQAEAALEKLIILHSASAASANGPLWFFIFFTAAW
YLKGRVVPVATYSVLGLWSFLLLVLALPQQAYALDAAEQGELGLAILVIISIFTLTPAYK
ILLSRSVWWLSYMLVLAEAQIQQWVPPLEVRGGRDGIIWVAVILHPRLVFEVTKWLLAIL
GPAYLLKASLLRIPYFVRAHALLRVCTLVKHLAGARYIQMLLITIGRWTGTYIYDHLSPL
STWAAQGLRDLAIAVEPVVFSPMEKKVIVWGAETVACGDILHGLPVSARLGREVLLGPAD
GYTSKGWKLLAPITAYTQQTRGLLGAIVVSLTGRDKNEQAGQVQVLSSVTQTFLGTSISG
VLWTVYHGAGNKTLAGPKGPVTQMYTSAEGDLVGWPSPPGTKSLDPCTCGAVDLYLVTRN
ADVIPVRRKDDRRGALLSPRPLSTLKGSSGGPVLCSRGHAVGLFRAAVCARGVAKSIDFI
PVESLDVATRTPSFSDNSTPPAVPQSYQVGYLHAPTGSGKSTKVPAAYASQGYKVLVLNP
SVAATLGFGAYMSKAHGINPNIRTGVRTVTTGDSITYSTYGKFIADGGCAAGAYDIIICD
ECHSVDATTILGIGTVLDQAETAGVRLVVLATATPPGTVTTPHSNIEEVALGHEGEIPFY
GKAIPLAFIKGGRHLIFCHSKKKCDELAAALRGMGVNAVAYYRGLDVSVIPTQGDVVVVA
TDALMTGYTGDFDSVIDCNVAVSQIVDFSLDPTFTITTQTVPQDAVSRSQRRGRTGRGRL
GVYRYVSSGERPSGMFDSVVLCECYDAGAAWYELTPAETTVRLRAYFNTPGLPVCQDHLE
FWEAVFTGLTHIDAHFLSQTKQGGENFAYLTAYQATVCARAKAPPPSWDVMWKCLTRLKP
TLTGPTPLLYRLGAVTNEVTLTHPVTKYIATCMQADLEIMTSSWVLAGGVLAAVAAYCLA
TGCISIIGRLHLNDRVVVAPDKEILYEAFDEMEECASKAALIEEGQRMAEMLKSKIQGLL
QQATRQAQDIQPAIQSSWPKLEQFWAKHMWNFISGIQYLAGLSTLPGNPAVASMMAFSAA
LTSPLPTSTTILLNIMGGWLASQIAPPAGATGFVVSGLVGAAVGSIGLGKILVDVLAGYG
AGISGALVAFKIMSGEKPTVEDVVNLLPAILSPGALVVGVICAAILRRHVGQGEGAVQWM
NRLIAFASRGNHVAPTHYVVESDASQRVTQVLSSLTITSLLRRLHAWITEDCPVPCSGSW
LQDIWDWVCSILTDFKNWLSSKLLPKMPGIPFISCQKGYKGVWAGTGVMTTRCPCGANIS
GHVRMGTMKITGPKTCLNLWQGTFPINCYTEGPCVPKPPPNYKTAIWRVAASEYVEVTQH
GSFSYVTGLTSDNLKVPCQVPAPEFFSWVDGVQIHRFAPVPGPFFRDEVTFTVGLNSFVV
GSQLPCDPEPDTEVLASMLTDPSHITAEAAARRLARGSPPSQASSSASQLSAPSLKATCT
THKTAYDCDMVDANLFMGGDVTRIESDSKVIVLDSLDSMTEVEDDREPSVPSEYLIKRRK
FPPALPPWARPDYNPVLIETWKRPGYEPPTVLGCALPPTPQTPVPPPRRRRAKVLTQDNV
EGVLREMADKVLSPLQDNNDSGHSTGADTGGDIVQQPSDETAASEAGSLSSMPPLEGEPG
DPDLEFEPVGSAPPSEGECEVIDSDSKSWSTVSDQEDSVICCSMSYSWTGALITPCGPEE
EKLPINPLSNSLMRFHNKVYSTTSRSASLRAKKVTFDRVQVLDAHYDSVLQDVKRAASKV
SARLLTVEEACALTPPHSAKSRYGFGAKEVRSLSRRAVNHIRSVWEDLLEDQHTPIDTTI
MAKNEVFCIDPTKGGKKPARLIVYPDLGVRVCEKMALYDIAQKLPKAIMGPSYGFQYSPA
ERVDFLLKAWGSKKDPMGFSYDTRCFDSTVTERDIRTEESIYQACSLPQEARTVIHSLTE
RLYVGGPMTNSKGQSCGYRRCRASGVFTTSMGNTMTCYIKALAACKAAGIVDPVMLVCGD
DLVVISESQGNEEDERNLRAFTEAMTRYSAPPGDLPRPEYDLELITSCSSNVSVALDSRG
RRRYFLTRDPTTPITRAAWETVRHSPVNSWLGNIIQYAPTIWVRMVIMTHFFSILLAQDT
LNQNLNFEMYGAVYSVNPLDLPAIIERLHGLEAFSLHTYSPHELSRVAATLRKLGAPPLR
AWKSRARAVRASLIAQGARAAICGRYLFNWAVKTKLKLTPLPEASRLDLSGWFTVGAGGG
DIYHSVSHARPRLLLLCLLLLSVGVGIFLLPAR
Number of residues
3033
Molecular Weight
330178.68
Theoretical pI
8.14
GO Classification
Functions
ATP binding / ATP-dependent helicase activity / cysteine-type endopeptidase activity / ion channel activity / RNA binding / RNA-directed RNA polymerase activity / serine-type endopeptidase activity / structural molecule activity / zinc ion binding
Processes
apoptotic process / clathrin-mediated endocytosis of virus by host cell / fusion of virus membrane with host endosome membrane / induction by virus of host autophagy / modulation by virus of host G1/S transition checkpoint / pore formation by virus in membrane of host cell / protein oligomerization / regulation of transcription, DNA-templated / suppression by virus of host MAVS activity / suppression by virus of host STAT1 activity / suppression by virus of host TRAF activity / suppression by virus of host type I interferon-mediated signaling pathway / transcription, DNA-templated / transformation of host cell by virus / viral RNA genome replication / virion attachment to host cell
Components
extracellular region / host cell endoplasmic reticulum membrane / host cell lipid particle / host cell mitochondrial membrane / host cell nucleus / host cell perinuclear region of cytoplasm / host cell plasma membrane / integral component of membrane / integral to membrane of host cell / viral envelope / viral nucleocapsid / virion membrane
General Function
Zinc ion binding
Specific Function
Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Thought to play a role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Could mediate apoptotic pathways through association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptor-induced apoptosis remains controversial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Seric core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage. Core protein induces up-regulation of FAS promoter activity, and thereby probably contributes to the increased triglyceride accumulation in hepatocytes (steatosis) (By similarity).E1 and E2 glycoproteins form a heterodimer that is involved in virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, but this binding is not sufficient for infection, some additional liver specific cofactors may be needed. The fusion function may possibly be carried by E1. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection (By similarity).P7 seems to be a heptameric ion channel protein (viroporin) and is inhibited by the antiviral drug amantadine. Also inhibited by long-alkyl-chain iminosugar derivatives. Essential for infectivity (By similarity).Protease NS2-3 is a cysteine protease responsible for the autocatalytic cleavage of NS2-NS3. Seems to undergo self-inactivation following maturation (By similarity).NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS3/NS4A complex also prevents phosphorylation of human IRF3, thus preventing the establishment of dsRNA induced antiviral state. NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand. Cleaves and inhibits the host antiviral protein MAVS (By similarity).NS4B induces a specific membrane alteration that serves as a scaffold for the virus replication complex. This membrane alteration gives rise to the so-called ER-derived membranous web that contains the replication complex (By similarity).NS5A is a component of the replication complex involved in RNA-binding. Its interaction with Human VAPB may target the viral replication complex to vesicles. Down-regulates viral IRES translation initiation. Mediates interferon resistance, presumably by interacting with and inhibiting human EIF2AK2/PKR. Seems to inhibit apoptosis by interacting with BIN1 and FKBP8. The hyperphosphorylated form of NS5A is an inhibitor of viral replication (By similarity).NS5B is an RNA-dependent RNA polymerase that plays an essential role in the virus replication.
Pfam Domain Function
Transmembrane Regions
169-189 359-379 730-750 762-782 787-807 818-838 886-906 933-953 1662-1682 1810-1830 1833-1853 1855-1875 1886-1906 3013-3033
Cellular Location
Host endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0008325|9102 bp
ATGAGCACAAATCCTAAACCTCAAAGAAAAACCAAAAGAAACACAAACCGCCGCCCACAG
GACGTTAAGTTCCCGGGTGGCGGTCAGATCGTTGGCGGAGTTTACTTGCTGCCGCGCAGG
GGCCCCAGGTTGGGTGTGCGCGCGACAAGGAAGACTTCTGAGCGATCCCAGCCGCGTGGA
CGACGCCAGCCCATCCCGAAAGATCGGCGCTCCACCGGCAAGTCCTGGGGAAAGCCAGGA
TATCCTTGGCCCCTGTACGGAAACGAGGGTTGCGGCTGGGCGGGTTGGCTCCTGTCCCCC
CGCGGGTCTCGTCCTACTTGGGGCCCCACCGACCCCCGGCATAGATCACGCAATTTGGGC
AGAGTCATCGATACCATTACGTGTGGTTTTGCCGACCTCATGGGGTACATCCCTGTCGTT
GGCGCCCCGGTTGGAGGCGTCGCCAGAGCTCTGGCACACGGTGTTAGGGTCCTGGAGGAC
GGGATAAATTACGCAACAGGGAATTTACCCGGTTGCTCTTTTTCTATCTTTTTGCTTGCT
CTTCTGTCATGCGTCACAGTGCCAGTGTCTGCAGTGGAAGTCAGGAACATTAGTTCTAGC
TACTACGCCACTAATGATTGCTCAAACAACAGCATCACCTGGCAGCTCACTGACGCAGTT
CTCCATCTTCCTGGATGCGTCCCATGTGAGAATGATAATGGCACCTTGCATTGCTGGATA
CAAGTAACACCCAACGTGGCTGTGAAACACCGCGGTGCGCTCACTCGTAGCCTGCGAACA
CACGTCGACATGATCGTAATGGCAGCTACGGCCTGCTCGGCCTTGTATGTGGGAGATGTG
TGCGGGGCCGTGATGATTCTATCGCAGGCTTTCATGGTATCACCACAACGCCACAACTTC
ACCCAAGAGTGCAACTGTTCCATCTACCAAGGTCACATCACCGGCCATCGCATGGCATGG
GACATGATGCTAAGCTGGTCTCCAACTCTTACCATGATCCTCGCCTACGCCGCTCGTGTT
CCCGAACTGGTCCTCGAAATTATTTTCGGCGGCCATTGGGGTGTGGTGTTTGGCTTGGCC
TATTTCTCCATGCAAGGAGCGTGGGCCAAAGTCATCGCCATCCTCCTTCTTGTTGCGGGA
GTGGATGCAACCACCTATTCCAGCGGCCAGGAAGCGGGTCGTACCGTCGCGGGGTTCGCT
GGCCTCTTTACTACTGGTGCCAAGCAGAACCTCTATTTAATCAACACCAATGGCAGCTGG
CACATAAACCGGACTGCCCTCAATTGCAATGACAGCTTACAGACGGGTTTCCTCGCTTCC
TTGTTTTACACCCACAAGTTCAACAGCTCTGGCTGCCCCGAGCGCTTGTCTTCCTGCCGC
GGGCTGGACGATTTTCGCATCGGCTGGGGAACCTTGGAATACGAAACCAACGTCACCAAC
GATGGGGACATGAGGCCGTACTGCTGGCATTACCCCCCGAGGCCTTGCGGCATCGTCCCG
GCTAGGACGGTTTGCGGACCGGTCTATTGTTTCACCCCTAGCCCTGTTGTCGTGGGCACC
ACTGACAAGCAGGGCGTACCCACCTACACCTGGGGAGAAAACGAGACCGATGTCTTCCTG
CTAAATAGCACAAGACCCCCGCGAGGAGCTTGGTTCGGCTGCACCTGGATGAACGGGACT
GGGTTCACTAAGACATGCGGTGCACCACCTTGCCGCATTAGGAAAGACTACAACAGCACT
ATCGATTTATTGTGCCCCACAGACTGTTTTAGGAAGCACCCAGATGCTACCTATCTTAAG
TGTGGAGCAGGGCCTTGGTTAACTCCCAGGTGCCTGGTAGACTACCCTTATAGGTTGTGG
CATTATCCGTGCACTGTAAACTTCACCATCTTCAAGGCGCGGATGTATGTAGGAGGGGTG
GAGCATCGATTCTCCGCAGCATGCAACTTCACGCGCGGAGATCGCTGCAGACTGGAAGAT
AGGGATAGGGGCCAGCAGAGTCCACTGCTGCATTCCACTACTGAGTGGGCGGTGCTCCCA
TGCTCCTTCTCTGACCTACCAGCACTATCCACTGGCCTATTGCACCTCCACCAAAACATC
GTGGACGTGCAGTACCTCTACGGACTTTCTCCGGCTCTGACAAGATACATCGTGAAGTGG
GAGTGGGTGATCCTCCTTTTCTTGTTGTTGGCAGACGCCAGGATCTGTGCATGCCTTTGG
ATGCTCATCATACTGGGCCAAGCCGAAGCGGCGCTTGAGAAGCTCATCATCTTGCACTCC
GCTAGTGCTGCTAGTGCCAATGGTCCGCTGTGGTTTTTCATCTTCTTTACAGCGGCCTGG
TACTTAAAGGGCAGGGTGGTCCCCGTGGCCACGTACTCTGTCCTCGGCTTATGGTCCTTC
CTCCTCCTAGTCCTGGCCTTACCACAGCAGGCTTATGCCTTGGACGCTGCTGAACAAGGG
GAACTGGGGCTGGCCATATTAGTAATTATATCCATCTTTACTCTTACCCCAGCATACAAG
ATCCTCCTGAGCCGTTCAGTGTGGTGGCTGTCCTACATGCTGGTCTTGGCCGAGGCCCAG
ATTCAGCAATGGGTTCCCCCCCTGGAGGTCCGAGGGGGGCGTGACGGGATCATCTGGGTG
GCTGTCATTCTACACCCACGCCTTGTGTTTGAGGTCACGAAATGGTTGTTAGCAATCCTG
GGGCCTGCCTACCTCCTTAAAGCGTCTCTGCTACGGATACCGTACTTTGTGAGGGCCCAC
GCTTTGCTACGAGTGTGTACCCTGGTGAAACACCTCGCGGGGGCTAGGTACATCCAGATG
CTGTTGATCACCATAGGCAGATGGACCGGCACTTACATCTACGACCACCTCTCCCCTTTA
TCAACTTGGGCGGCCCAGGGTTTGCGGGACCTGGCAATCGCCGTGGAGCCTGTGGTGTTC
AGCCCAATGGAGAAGAAGGTCATTGTGTGGGGGGCTGAGACAGTGGCGTGTGGAGACATC
CTGCATGGCCTCCCGGTCTCCGCGAGGCTAGGTAGGGAGGTTCTGCTCGGCCCTGCCGAC
GGCTACACCTCCAAGGGGTGGAAGCTCCTAGCTCCCATTACTGCTTACACTCAGCAAACT
CGTGGTCTCCTGGGTGCTATCGTGGTCAGCCTAACGGGCCGCGACAAAAATGAGCAGGCT
GGGCAGGTCCAGGTTCTGTCCTCCGTCACACAAACTTTCTTGGGGACATCCATTTCGGGC
GTCCTCTGGACAGTATATCACGGGGCTGGTAATAAGACCTTGGCCGGCCCCAAGGGACCA
GTCACTCAGATGTACACCAGCGCAGAAGGGGACCTCGTGGGATGGCCTAGTCCCCCCGGG
ACTAAGTCATTGGACCCCTGTACCTGCGGGGCCGTAGACCTCTACCTGGTCACCCGAAAC
GCTGATGTCATTCCGGTCCGGAGGAAAGATGACCGACGGGGTGCATTACTCTCGCCAAGG
CCCCTCTCAACCCTCAAAGGATCATCCGGAGGGCCCGTGCTCTGCTCAAGGGGACACGCC
GTGGGCTTGTTCAGAGCGGCCGTGTGTGCCAGGGGTGTAGCCAAATCTATTGACTTCATC
CCCGTCGAATCACTCGATGTCGCCACACGGACGCCCAGTTTCTCTGACAACAGTACGCCG
CCAGCTGTGCCCCAGTCTTACCAGGTGGGTTACTTGCACGCACCAACAGGCAGCGGAAAG
AGCACCAAGGTCCCTGCCGCGTATGCCAGTCAGGGGTATAAAGTACTCGTACTAAATCCC
TCTGTCGCGGCCACACTTGGTTTTGGGGCCTACATGTCCAAAGCCCACGGGATCAACCCT
AATATCAGAACTGGAGTGCGGACCGTTACCACCGGGGACTCTATCACTTACTCCACTTAT
GGCAAGTTTATCGCAGATGGAGGCTGTGCAGCCGGTGCCTATGACATCATCATATGCGAC
GAATGCCATTCAGTGGACGCTACTACCATCCTTGGCATTGGAACAGTCCTTGACCAAGCT
GAGACCGCAGGCGTCAGGCTAGTGGTTTTGGCCACAGCCACGCCTCCCGGTACGGTGACA
ACTCCCCACAGTAACATAGAGGAGGTGGCCCTTGGTCACGAGGGCGAGATCCCTTTTTAT
GGCAAAGCTATTCCCCTAGCTTTCATCAAGGGGGGCAGACACTTGATCTTTTGCCATTCA
AAGAAGAAGTGCGACGAGCTCGCAGCGGCCCTCCGGGGCATGGGTGTCAATGCCGTTGCA
TACTATAGGGGTCTCGACGTCTCCGTTATACCAACTCAAGGAGACGTGGTGGTTGTCGCC
ACTGATGCCCTAATGACTGGGTACACCGGCGACTTTGACTCCGTCATCGACTGTAATGTT
GCAGTCTCTCAGATTGTTGACTTCAGCCTAGACCCAACCTTCACCATCACCACTCAAACC
GTCCCTCAGGACGCTGTCTCCCGTAGTCAACGTAGAGGGAGAACTGGGAGGGGGCGATTG
GGCGTTTACAGGTATGTTTCGTCAGGCGAGAGGCCGTCTGGGATGTTCGACAGCGTAGTG
CTCTGCGAGTGCTATGATGCCGGGGCAGCCTGGTACGAGCTTACACCTGCTGAGACTACG
GTGAGACTCCGGGCTTATTTCAACACGCCCGGTTTGCCCGTATGTCAAGACCACCTGGAG
TTCTGGGAAGCGGTCTTTACAGGTCTCACACACATTGACGCCCACTTCCTCTCCCAGACG
AAGCAAGGAGGAGAAAACTTTGCGTATCTAACGGCCTACCAGGCCACAGTATGCGCCAGG
GCAAAGGCCCCTCCTCCTTCGTGGGACGTGATGTGGAAGTGTCTAACTAGGCTCAAACCT
ACACTGACTGGTCCCACCCCCCTCCTGTACCGCTTGGGTGCCGTGACCAATGAGGTCACC
TTGACGCACCCCGTGACGAAATACATCGCCACGTGCATGCAAGCTGACCTCGAGATCATG
ACAAGCTCATGGGTCCTGGCGGGGGGGGTGCTAGCCGCCGTGGCAGCTTACTGCCTGGCG
ACTGGCTGCATTTCCATCATTGGCCGCCTACACCTGAATGATCGGGTGGTTGTGGCCCCC
GACAAGGAAATCTTATATGAGGCCTTTGATGAGATGGAAGAATGCGCCTCCAAAGCCGCC
CTCATTGAGGAAGGGCAGCGGATGGCGGAGATGCTCAAATCTAAGATACAAGGCCTCCTA
CAACAGGCCACAAGGCAAGCTCAAGACATACAGCCAGCTATACAGTCATCATGGCCCAAG
CTTGAACAATTTTGGGCCAAACACATGTGGAACTTCATCAGTGGTATACAGTACCTAGCA
GGACTCTCCACCCTACCGGGAAATCCTGCAGTGGCATCAATGATGGCTTTTAGCGCCGCG
CTGACTAGCCCACTACCCACCAGCACCACCATCCTCTTGAACATCATGGGAGGATGGTTG
GCCTCTCAGATTGCCCCCCCTGCCGGAGCCACTGGCTTCGTTGTCAGTGGTCTAGTGGGG
GCGGCCGTCGGAAGCATAGGCCTGGGTAAGATACTGGTGGACGTTTTGGCCGGGTACGGC
GCAGGCATTTCAGGGGCCCTCGTAGCTTTTAAGATCATGAGCGGCGAGAAGCCCACGGTA
GAAGACGTTGTGAATCTCCTGCCTGCTATTCTGTCTCCTGGTGCGTTGGTAGTGGGAGTC
ATCTGTGCAGCAATCCTGCGCCGCCACGTCGGTCAGGGAGAGGGAGCGGTCCAGTGGATG
AACAGACTGATCGCCTTCGCCTCCAGGGGAAACCACGTTGCCCCTACCCACTACGTGGTG
GAGTCTGACGCTTCACAGCGTGTAACGCAGGTGCTGAGTTCACTTACAATTACCAGCTTA
CTTAGGAGACTACATGCCTGGATCACTGAAGATTGCCCAGTCCCATGCTCGGGGTCTTGG
CTCCAGGACATTTGGGATTGGGTTTGTTCCATCCTCACAGACTTCAAAAACTGGCTGTCT
TCAAAATTACTCCCCAAGATGCCCGGCATTCCCTTTATCTCTTGCCAGAAGGGATACAAG
GGTGTATGGGCTGGTACGGGTGTCATGACTACTCGGTGCCCATGTGGAGCAAACATCTCG
GGCCATGTCCGCATGGGCACCATGAAAATAACAGGCCCGAAGACTTGCTTGAACCTGTGG
CAGGGGACTTTCCCCATTAATTGTTACACAGAAGGGCCTTGCGTGCCAAAACCCCCTCCT
AATTACAAGACCGCAATTTGGAGGGTGGCAGCGTCGGAGTACGTTGAGGTCACACAGCAT
GGCTCTTTCTCGTATGTAACGGGGTTAACCAGTGACAACCTTAAGGTCCCTTGCCAGGTA
CCAGCTCCAGAATTTTTCTCTTGGGTGGACGGGGTGCAAATCCACCGATTCGCCCCCGTT
CCAGGTCCCTTCTTTCGGGATGAGGTAACGTTCACCGTAGGCCTTAACTCCTTCGTGGTC
GGCTCTCAGCTCCCTTGCGATCCTGAGCCGGACACCGAGGTACTGGCCTCCATGTTGACA
GACCCGTCCCACATCACCGCGGAGGCGGCAGCCAGGCGATTGGCAAGGGGATCTCCCCCT
TCACAGGCTAGCTCCTCAGCGAGCCAGCTCTCTGCCCCGTCCTTGAAGGCTACCTGTACC
ACCCATAAGACAGCATATGATTGTGACATGGTGGATGCCAACCTTTTCATGGGAGGCGAT
GTGACCCGGATTGAGTCTGACTCTAAGGTGATCGTTCTAGACTCCCTCGATTCCATGACT
GAGGTAGAGGATGATCGTGAGCCTTCTGTACCATCAGAGTACCTGATCAAGAGGAGAAAG
TTCCCACCGGCGCTGCCTCCTTGGGCCCGTCCAGACTACAATCCTGTTTTGATCGAGACA
TGGAAGAGGCCGGGCTATGAACCACCCACTGTCCTAGGCTGTGCCCTCCCCCCCACACCT
CAAACGCCAGTGCCTCCACCTCGGAGGCGCCGCGCCAAAGTCCTGACCCAGGACAATGTG
GAGGGGGTCCTCAGGGAGATGGCTGACAAAGTACTCAGCCCTCTCCAAGACAACAATGAC
TCCGGTCACTCCACTGGAGCGGATACCGGAGGAGACATCGTCCAGCAACCCTCTGACGAG
ACTGCCGCTTCAGAAGCGGGGTCACTGTCCTCCATGCCTCCCCTTGAGGGAGAGCCGGGA
GACCCTGACCTGGAGTTTGAACCAGTGGGATCCGCTCCCCCTTCTGAGGGGGAGTGTGAG
GTCATTGATTCGGACTCTAAGTCGTGGTCCACAGTCTCTGATCAAGAGGATTCTGTTATC
TGCTGCTCTATGTCATACTCCTGGACGGGGGCCCTCATAACACCATGTGGGCCCGAAGAG
GAGAAGTTACCGATCAACCCTCTGAGTAATTCGCTCATGCGGTTCCATAATAAGGTGTAC
TCCACAACCTCGAGGAGTGCCTCTCTGAGGGCAAAGAAGGTGACTTTTGACAGGGTGCAG
GTGCTGGACGCACACTATGACTCAGTCTTGCAGGACGTTAAGCGGGCCGCCTCTAAGGTT
AGTGCGAGGCTCCTCACAGTAGAGGAAGCCTGCGCGCTGACCCCGCCCCACTCCGCCAAA
TCGCGATACGGATTTGGGGCAAAAGAGGTGCGCAGCTTATCCAGGAGGGCCGTTAACCAC
ATCCGGTCCGTGTGGGAGGACCTCCTGGAAGACCAACATACCCCAATTGACACAACTATC
ATGGCTAAAAATGAGGTGTTCTGCATTGATCCAACTAAAGGTGGGAAAAAGCCAGCTCGC
CTCATCGTATACCCCGACCTTGGGGTCAGGGTGTGCGAAAAGATGGCCCTCTATGACATC
GCACAAAAGCTTCCCAAAGCGATAATGGGGCCATCCTATGGGTTCCAATACTCTCCCGCA
GAACGGGTCGATTTCCTCCTCAAAGCTTGGGGAAGTAAGAAGGACCCAATGGGGTTCTCG
TATGACACCCGCTGCTTTGACTCAACCGTCACGGAGAGGGACATAAGAACAGAAGAATCC
ATATATCAGGCTTGTTCTCTGCCTCAAGAAGCCAGAACTGTCATACACTCGCTCACTGAG
AGACTTTACGTAGGAGGGCCCATGACAAACAGCAAAGGGCAATCCTGCGGCTACAGGCGT
TGCCGCGCAAGCGGTGTTTTCACCACCAGCATGGGGAATACCATGACATGTTACATCAAA
GCCCTTGCAGCGTGTAAGGCTGCAGGGATCGTGGACCCTGTTATGTTGGTGTGTGGAGAC
GACCTGGTCGTCATCTCAGAGAGCCAAGGTAACGAGGAGGACGAGCGAAACCTGAGAGCT
TTCACGGAGGCTATGACCAGGTATTCCGCCCCTCCCGGTGACCTTCCCAGACCGGAATAT
GACTTGGAGCTTATAACATCCTGCTCCTCAAACGTATCGGTAGCGCTGGACTCTCGGGGT
CGCCGCCGGTACTTCCTAACCAGAGACCCTACCACTCCAATCACCCGAGCTGCTTGGGAA
ACAGTAAGACACTCCCCTGTCAATTCTTGGCTGGGCAACATCATCCAGTACGCCCCCACA
ATCTGGGTCCGGATGGTCATAATGACTCACTTCTTCTCCATACTATTGGCCCAGGACACT
CTGAACCAAAATCTCAATTTTGAGATGTACGGGGCAGTATACTCGGTCAATCCATTAGAC
CTACCGGCCATAATTGAAAGGCTACATGGGCTTGAAGCCTTTTCACTGCACACATACTCT
CCCCACGAACTCTCACGGGTGGCAGCAACTCTCAGAAAACTTGGAGCGCCTCCCCTTAGA
GCGTGGAAGAGTCGGGCGCGTGCCGTGAGAGCTTCACTCATCGCCCAAGGAGCGAGGGCG
GCCATTTGTGGCCGCTACCTCTTCAACTGGGCGGTGAAAACAAAGCTCAAACTCACTCCA
TTGCCCGAGGCGAGCCGCCTGGATTTATCCGGGTGGTTCACCGTGGGCGCCGGCGGGGGC
GACATTTATCACAGCGTGTCGCATGCCCGACCCCGCCTATTACTCCTTTGCCTACTCCTA
CTTAGCGTAGGAGTAGGCATCTTTTTACTCCCCGCTCGGTAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP26661
UniProtKB Entry NamePOLG_HCVJ8
GenBank Protein ID221609
GenBank Gene IDD10988
General References
  1. Okamoto H, Kurai K, Okada S, Yamamoto K, Lizuka H, Tanaka T, Fukuda S, Tsuda F, Mishiro S: Full-length sequence of a hepatitis C virus genome having poor homology to reported isolates: comparative study of four distinct genotypes. Virology. 1992 May;188(1):331-41. [Article]
  2. McLauchlan J: Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes. J Viral Hepat. 2000 Jan;7(1):2-14. [Article]
  3. Penin F, Dubuisson J, Rey FA, Moradpour D, Pawlotsky JM: Structural biology of hepatitis C virus. Hepatology. 2004 Jan;39(1):5-19. [Article]
  4. Kim CS, Seol SK, Song OK, Park JH, Jang SK: An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication. J Virol. 2007 Apr;81(8):3852-65. Epub 2007 Jan 17. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB087012-(3-BROMOPHENYL)-6-[(2-HYDROXYETHYL)AMINO]-1H-BENZO[DE]ISOQUINOLINE-1,3(2H)-DIONEexperimentalunknownDetails