V-type proton ATPase 16 kDa proteolipid subunit

Details

Name
V-type proton ATPase 16 kDa proteolipid subunit
Synonyms
  • ATP6C
  • ATP6L
  • ATPL
  • V-ATPase 16 kDa proteolipid subunit
  • Vacuolar proton pump 16 kDa proteolipid subunit
Gene Name
ATP6V0C
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052441|V-type proton ATPase 16 kDa proteolipid subunit
MSESKSGPEYASFFAVMGASAAMVFSALGAAYGTAKSGTGIAAMSVMRPEQIMKSIIPVV
MAGIIAIYGLVVAVLIANSLNDDISLYKSFLQLGAGLSVGLSGLAAGFAIGIVGDAGVRG
TAQQPRLFVGMILILIFAEVLGLYGLIVALILSTK
Number of residues
155
Molecular Weight
15735.56
Theoretical pI
Not Available
GO Classification
Functions
proton-transporting ATP synthase activity, rotational mechanism / proton-transporting ATPase activity, rotational mechanism / ubiquitin protein ligase binding
Processes
insulin receptor signaling pathway / ion transmembrane transport / neutrophil degranulation / phagosome acidification / positive regulation of Wnt signaling pathway / proton transmembrane transport / regulation of macroautophagy / transferrin transport / viral process
Components
azurophil granule membrane / cell / endosome membrane / extracellular exosome / ficolin-1-rich granule membrane / focal adhesion / integral component of membrane / lysosomal membrane / phagocytic vesicle membrane / plasma membrane / proton-transporting V-type ATPase, V0 domain / tertiary granule membrane
General Function
Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Specific Function
Proton-transporting atp synthase activity, rotational mechanism
Pfam Domain Function
Transmembrane Regions
11-33 56-76 93-114 132-152
Cellular Location
Vacuole membrane
Gene sequence
>lcl|BSEQ0052442|V-type proton ATPase 16 kDa proteolipid subunit (ATP6V0C)
ATGTCCGAGTCCAAGAGCGGCCCCGAGTATGCTTCGTTTTTCGCCGTCATGGGCGCCTCG
GCCGCCATGGTCTTCAGCGCCCTGGGCGCTGCCTATGGCACAGCCAAGAGCGGTACCGGC
ATTGCGGCCATGTCTGTCATGCGGCCGGAGCAGATCATGAAGTCCATCATCCCAGTGGTC
ATGGCTGGCATCATCGCCATCTACGGCCTGGTGGTGGCAGTCCTCATCGCCAACTCCCTG
AATGACGACATCAGCCTCTACAAGAGCTTCCTCCAGCTGGGCGCCGGCCTGAGCGTGGGC
CTGAGCGGCCTGGCAGCCGGCTTTGCCATCGGCATCGTGGGGGACGCTGGCGTGCGGGGC
ACCGCCCAGCAGCCCCGACTATTCGTGGGCATGATCCTGATTCTCATCTTCGCCGAGGTG
CTCGGCCTCTACGGTCTCATCGTCGCCCTCATCCTCTCCACAAAGTAG
Chromosome Location
16
Locus
16p13.3
External Identifiers
ResourceLink
UniProtKB IDP27449
UniProtKB Entry NameVATL_HUMAN
HGNC IDHGNC:855
General References
  1. Gillespie GA, Somlo S, Germino GG, Weinstat-Saslow D, Reeders ST: CpG island in the region of an autosomal dominant polycystic kidney disease locus defines the 5' end of a gene encoding a putative proton channel. Proc Natl Acad Sci U S A. 1991 May 15;88(10):4289-93. doi: 10.1073/pnas.88.10.4289. [Article]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  3. Hasebe M, Hanada H, Moriyama Y, Maeda M, Futai M: Vacuolar type H(+)-ATPase genes: presence of four genes including pseudogenes for the 16-kDa proteolipid subunit in the human genome. Biochem Biophys Res Commun. 1992 Mar 16;183(2):856-63. doi: 10.1016/0006-291x(92)90562-y. [Article]
  4. Koralnik IJ, Mulloy JC, Andresson T, Fullen J, Franchini G: Mapping of the intermolecular association of human T cell leukaemia/lymphotropic virus type I p12I and the vacuolar H+-ATPase 16 kDa subunit protein. J Gen Virol. 1995 Aug;76 ( Pt 8):1909-16. doi: 10.1099/0022-1317-76-8-1909. [Article]
  5. Pan H, Qin WX, Huo KK, Wan DF, Yu Y, Xu ZG, Hu QD, Gu KT, Zhou XM, Jiang HQ, Zhang PP, Huang Y, Li YY, Gu JR: Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1. Genomics. 2001 Sep;77(1-2):58-64. [Article]
  6. Liu QY, Lei JX, Sikorska M, Liu R: A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradation. Mol Neurodegener. 2008 Feb 25;3:4. doi: 10.1186/1750-1326-3-4. [Article]
  7. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
  8. Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01133Tiludronic acidapproved, investigational, vet_approvedunknowninhibitorDetails