Acetolactate synthase, catabolic
Details
- Name
- Acetolactate synthase, catabolic
- Synonyms
- 2.2.1.6
- ALS
- ilvK
- Gene Name
- budB
- Organism
- Klebsiella pneumoniae
- Amino acid sequence
>lcl|BSEQ0019135|Acetolactate synthase, catabolic MDKQYPVRQWAHGADLVVSQLEAQGVRQVFGIPGAKIDKVFDSLLDSSIRIIPVRHEANA AFMAAAVGRITGKAGVALVTSGPGCSNLITGMATANSEGDPVVALGGAVKRADKAKQVHQ SMDTVAMFSPVTKYAIEVTAPDALAEVVSNAFRAAEQGRPGSAFVSLPQDVVDGPVSGKV LPASGAPQMGAAPDDAIDQVAKLIAQAKNPIFLLGLMASQPENSKALRRLLETSHIPVTS TYQAAGAVNQDNFSRFAGRVGLFNNQAGDRLLQLADLVICIGYSPVEYEPAMWNSGNATL VHIDVLPAYEERNYTPDVELVGDIAGTLNKLAQNIDHRLVLSPQAAEILRDRQHQRELLD RRGAQLNQFALHPLRIVRAMQDIVNSDVTLTVDMGSFHIWIARYLYTFRARQVMISNGQQ TMGVALPWAIGAWLVNPERKVVSVSGDGGFLQSSMELETAVRLKANVLHLIWVDNGYNMV AIQEEKKYQRLSGVEFGPMDFKAYAESFGAKGFAVESAEALEPTLRAAMDVDGPAVVAIP VDYRDNPLLMGQLHLSQIL
- Number of residues
- 559
- Molecular Weight
- 60337.52
- Theoretical pI
- 5.99
- GO Classification
- Functionsacetolactate synthase activity / magnesium ion binding / thiamine pyrophosphate bindingProcessesbutanediol metabolic process
- General Function
- Thiamine pyrophosphate binding
- Specific Function
- Not Available
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0003039|1680 bp ATGGACAAACAGTATCCGGTACGCCAGTGGGCGCACGGCGCCGATCTCGTCGTCAGTCAG CTGGAAGCTCAGGGAGTACGCCAGGTGTTCGGCATCCCCGGCGCCAAAATCGACAAGGTC TTTGATTCACTGCTGGATTCCTCCATTCGCATTATTCCGGTACGCCACGAAGCCAACGCC GCATTTATGGCCGCCGCCGTCGGACGCATTACCGGCAAAGCGGGCGTGGCGCTGGTCACC TCCGGTCCGGGCTGTTCCAACCTGATCACCGGCATGGCCACCGCGAACAGCGAAGGCGAC CCGGTGGTGGCCCTGGGCGGCGCGGTAAAACGCGCCGATAAAGCGAAGCAGGTCCACCAG AGTATGGATACGGTGGCGATGTTCAGCCCGGTCACCAAATACGCCATCGAGGTGACGGCG CCGGATGCGCTGGCGGAAGTGGTCTCCAACGCCTTCCGCGCCGCCGAGCAGGGCCGGCCG GGCAGCGCGTTCGTTAGCCTGCCGCAGGATGTGGTCGATGGCCCGGTCAGCGGCAAAGTG CTGCCGGCCAGCGGGGCCCCGCAGATGGGCGCCGCGCCGGATGATGCCATCGACCAGGTG GCGAAGCTTATCGCCCAGGCGAAGAACCCGATCTTCCTGCTCGGCCTGATGGCCAGCCAG CCGGAAAACAGCAAGGCGCTGCGCCGTTTGCTGGAGACCAGCCATATTCCAGTCACCAGC ACCTATCAGGCCGCCGGAGCGGTGAATCAGGATAACTTCTCTCGCTTCGCCGGCCGGGTT GGGCTGTTTAACAACCAGGCCGGGGACCGTCTGCTGCAGCTCGCCGACCTGGTGATCTGC ATCGGCTACAGCCCGGTGGAATACGAACCGGCGATGTGGAACAGCGGCAACGCGACGCTG GTGCACATCGACGTGCTGCCCGCCTATGAAGAGCGCAACTACACCCCGGATGTCGAGCTG GTGGGCGATATCGCCGGCACTCTCAACAAGCTGGCGCAAAATATCGATCATCGGCTGGTG CTCTCCCCGCAGGCGGCGGAGATCCTCCGCGACCGCCAGCACCAGCGCGAGCTGCTGGAC CGCCGCGGCGCGCAGCTCAACCAGTTTGCCCTGCATCCCCTGCGCATCGTTCGCGCCATG CAGGATATCGTCAACAGCGACGTCACGTTGACCGTGGACATGGGCAGCTTCCATATCTGG ATTGCCCGCTACCTGTACACGTTCCGCGCCCGTCAGGTGATGATCTCCAACGGCCAGCAG ACCATGGGCGTCGCCCTGCCCTGGGCTATCGGCGCCTGGCTGGTCAATCCTGAGCGCAAA GTGGTCTCCGTCTCCGGCGACGGCGGCTTCCTGCAGTCGAGCATGGAGCTGGAGACCGCC GTCCGCCTGAAAGCCAACGTGCTGCATCTTATCTGGGTCGATAACGGCTACAACATGGTC GCTATCCAGGAAGAGAAAAAATATCAGCGCCTGTCCGGCGTCGAGTTTGGGCCGATGGAT TTTAAAGCCTATGCCGAATCCTTCGGCGCGAAAGGGTTTGCCGTGGAAAGCGCCGAGGCG CTGGAGCCGACCCTGCGCGCGGCGATGGACGTCGACGGCCCGGCGGTAGTGGCCATCCCG GTGGATTATCGCGATAACCCGCTGCTGATGGGCCAGCTGCATCTGAGTCAGATTCTGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P27696 UniProtKB Entry Name ILVB_KLEPN GenBank Protein ID 149211 GenBank Gene ID M73842 - General References
- Peng HL, Wang PY, Wu CM, Hwang DC, Chang HY: Cloning, sequencing and heterologous expression of a Klebsiella pneumoniae gene encoding an FAD-independent acetolactate synthase. Gene. 1992 Aug 1;117(1):125-30. [Article]
- Pang SS, Duggleby RG, Schowen RL, Guddat LW: The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate. J Biol Chem. 2004 Jan 16;279(3):2242-53. Epub 2003 Oct 13. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB02327 Triethylene glycol experimental unknown Details DB03361 2-{(9as)-9a-[(1s)-1-Hydroxyethyl]-2,7-Dimethyl-9a,10-Dihydro-5h-Pyrimido[4,5-D][1,3]Thiazolo[3,2-a]Pyrimidin-8-Yl}Ethyl Trihydrogen Diphosphate experimental unknown Details DB01987 Cocarboxylase approved, experimental unknown cofactorproduct of Details