Acetolactate synthase, catabolic

Details

Name
Acetolactate synthase, catabolic
Synonyms
  • 2.2.1.6
  • ALS
  • ilvK
Gene Name
budB
Organism
Klebsiella pneumoniae
Amino acid sequence
>lcl|BSEQ0019135|Acetolactate synthase, catabolic
MDKQYPVRQWAHGADLVVSQLEAQGVRQVFGIPGAKIDKVFDSLLDSSIRIIPVRHEANA
AFMAAAVGRITGKAGVALVTSGPGCSNLITGMATANSEGDPVVALGGAVKRADKAKQVHQ
SMDTVAMFSPVTKYAIEVTAPDALAEVVSNAFRAAEQGRPGSAFVSLPQDVVDGPVSGKV
LPASGAPQMGAAPDDAIDQVAKLIAQAKNPIFLLGLMASQPENSKALRRLLETSHIPVTS
TYQAAGAVNQDNFSRFAGRVGLFNNQAGDRLLQLADLVICIGYSPVEYEPAMWNSGNATL
VHIDVLPAYEERNYTPDVELVGDIAGTLNKLAQNIDHRLVLSPQAAEILRDRQHQRELLD
RRGAQLNQFALHPLRIVRAMQDIVNSDVTLTVDMGSFHIWIARYLYTFRARQVMISNGQQ
TMGVALPWAIGAWLVNPERKVVSVSGDGGFLQSSMELETAVRLKANVLHLIWVDNGYNMV
AIQEEKKYQRLSGVEFGPMDFKAYAESFGAKGFAVESAEALEPTLRAAMDVDGPAVVAIP
VDYRDNPLLMGQLHLSQIL
Number of residues
559
Molecular Weight
60337.52
Theoretical pI
5.99
GO Classification
Functions
acetolactate synthase activity / magnesium ion binding / thiamine pyrophosphate binding
Processes
butanediol metabolic process
General Function
Thiamine pyrophosphate binding
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0003039|1680 bp
ATGGACAAACAGTATCCGGTACGCCAGTGGGCGCACGGCGCCGATCTCGTCGTCAGTCAG
CTGGAAGCTCAGGGAGTACGCCAGGTGTTCGGCATCCCCGGCGCCAAAATCGACAAGGTC
TTTGATTCACTGCTGGATTCCTCCATTCGCATTATTCCGGTACGCCACGAAGCCAACGCC
GCATTTATGGCCGCCGCCGTCGGACGCATTACCGGCAAAGCGGGCGTGGCGCTGGTCACC
TCCGGTCCGGGCTGTTCCAACCTGATCACCGGCATGGCCACCGCGAACAGCGAAGGCGAC
CCGGTGGTGGCCCTGGGCGGCGCGGTAAAACGCGCCGATAAAGCGAAGCAGGTCCACCAG
AGTATGGATACGGTGGCGATGTTCAGCCCGGTCACCAAATACGCCATCGAGGTGACGGCG
CCGGATGCGCTGGCGGAAGTGGTCTCCAACGCCTTCCGCGCCGCCGAGCAGGGCCGGCCG
GGCAGCGCGTTCGTTAGCCTGCCGCAGGATGTGGTCGATGGCCCGGTCAGCGGCAAAGTG
CTGCCGGCCAGCGGGGCCCCGCAGATGGGCGCCGCGCCGGATGATGCCATCGACCAGGTG
GCGAAGCTTATCGCCCAGGCGAAGAACCCGATCTTCCTGCTCGGCCTGATGGCCAGCCAG
CCGGAAAACAGCAAGGCGCTGCGCCGTTTGCTGGAGACCAGCCATATTCCAGTCACCAGC
ACCTATCAGGCCGCCGGAGCGGTGAATCAGGATAACTTCTCTCGCTTCGCCGGCCGGGTT
GGGCTGTTTAACAACCAGGCCGGGGACCGTCTGCTGCAGCTCGCCGACCTGGTGATCTGC
ATCGGCTACAGCCCGGTGGAATACGAACCGGCGATGTGGAACAGCGGCAACGCGACGCTG
GTGCACATCGACGTGCTGCCCGCCTATGAAGAGCGCAACTACACCCCGGATGTCGAGCTG
GTGGGCGATATCGCCGGCACTCTCAACAAGCTGGCGCAAAATATCGATCATCGGCTGGTG
CTCTCCCCGCAGGCGGCGGAGATCCTCCGCGACCGCCAGCACCAGCGCGAGCTGCTGGAC
CGCCGCGGCGCGCAGCTCAACCAGTTTGCCCTGCATCCCCTGCGCATCGTTCGCGCCATG
CAGGATATCGTCAACAGCGACGTCACGTTGACCGTGGACATGGGCAGCTTCCATATCTGG
ATTGCCCGCTACCTGTACACGTTCCGCGCCCGTCAGGTGATGATCTCCAACGGCCAGCAG
ACCATGGGCGTCGCCCTGCCCTGGGCTATCGGCGCCTGGCTGGTCAATCCTGAGCGCAAA
GTGGTCTCCGTCTCCGGCGACGGCGGCTTCCTGCAGTCGAGCATGGAGCTGGAGACCGCC
GTCCGCCTGAAAGCCAACGTGCTGCATCTTATCTGGGTCGATAACGGCTACAACATGGTC
GCTATCCAGGAAGAGAAAAAATATCAGCGCCTGTCCGGCGTCGAGTTTGGGCCGATGGAT
TTTAAAGCCTATGCCGAATCCTTCGGCGCGAAAGGGTTTGCCGTGGAAAGCGCCGAGGCG
CTGGAGCCGACCCTGCGCGCGGCGATGGACGTCGACGGCCCGGCGGTAGTGGCCATCCCG
GTGGATTATCGCGATAACCCGCTGCTGATGGGCCAGCTGCATCTGAGTCAGATTCTGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP27696
UniProtKB Entry NameILVB_KLEPN
GenBank Protein ID149211
GenBank Gene IDM73842
General References
  1. Peng HL, Wang PY, Wu CM, Hwang DC, Chang HY: Cloning, sequencing and heterologous expression of a Klebsiella pneumoniae gene encoding an FAD-independent acetolactate synthase. Gene. 1992 Aug 1;117(1):125-30. [Article]
  2. Pang SS, Duggleby RG, Schowen RL, Guddat LW: The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate. J Biol Chem. 2004 Jan 16;279(3):2242-53. Epub 2003 Oct 13. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02327Triethylene glycolexperimentalunknownDetails
DB033612-{(9as)-9a-[(1s)-1-Hydroxyethyl]-2,7-Dimethyl-9a,10-Dihydro-5h-Pyrimido[4,5-D][1,3]Thiazolo[3,2-a]Pyrimidin-8-Yl}Ethyl Trihydrogen DiphosphateexperimentalunknownDetails
DB01987Cocarboxylaseapproved, experimentalunknowncofactorproduct ofDetails