Genome polyprotein
Details
- Name
- Genome polyprotein
- Synonyms
- 3.4.21.91
- NS1
- Gene Name
- Not Available
- Organism
- DENV-3
- Amino acid sequence
>lcl|BSEQ0011983|Genome polyprotein MNNQRKKTGKPSINMLKRVRNRVSTGSQLAKRFSRGLLNGQGPMKLVMAFIAFLRFLAIP PTAGVLARWGTFKKSGAIKVLKGFKKEISNMLSIINKRKKTSLCLMMMLPATLAFHLTSR DGEPRMIVGKNERGKSLLFKTASGINMCTLIAMDLGEMCDDTVTYKCPHITEVEPEDIDC WCNLTSTWVTYGTCNQAGEHRRDKRSVALAPHVGMGLDTRTQTWMSAEGAWRQVEKVETW ALRHPGFTILALFLAHYIGTSLTQKVVIFILLMLVTPSMTMRCVGVGNRDFVEGLSGATW VDVVLEHGGCVTTMAKNKPTLDIELQKTEATQLATLRKLCIEGKITNITTDSRCPTQGEA ILPEEQDQNYVCKHTYVDRGWGNGCGLFGKGSLVTCAKFQCLESIEGKVVQHENLKYTVI ITVHTGDQHQVGNETQGVTAEITSQASTAEAILPEYGTLGLECSPRTGLDFNEMILLTMK NKAWMVHRQWFFDLPLPWTSGATTKTPTWNRKELLVTFKNAHAKKQEVVVLGSQEGAMHT ALTGATEIQTSGGTSIFAGHLKCRLKMDKLKLKGMSYAMCLNTFVLKKEVSETQHGTILI KVEYKGEDAPCKIPFSTEDGQGKAHNGRLITANPVVTKKEEPVNIEAEPPFGESNIVIGI GDKALKINWYRKGSSIGKMFEATARGARRMAILGDTAWDFGSVGGVLNSLGKMVHQIFGS AYTALFSGVSWIMKIGIGVLLTWIGLNSKNTSMSFSCIAIGIITLYLGVVVQADMGCVIN WKGKELKCGSGIFVTNEVHTWTEQYKFQADSPKRVATAIAGAWENGVCGIRSTTRMENLL WKQIANELNYILWENDIKLTVVVGDITGVLEQGKRTLTPQPMELKYSWKTWGLAKIVTAE TQNSSFIIDGPSTPECPSASRAWNVWEVEDYGFGVFTTNIWLKLREVYTQLCDHRLMSAA VKDERAVHADMGYWIESQKNGSWKLEKASLIEVKTCTWPKSHTLWSNGVLESDMIIPKSL AGPISQHNHRPGYHTQTAGPWHLGKLELDFNYCEGTTVVISENCGTRGPSLRTTTVSGKL IHEWCCRSCTLPPLRYMGEDGCWYGMEIRPINEKEENMVKSLASAGSGKVDNFTMGVLCL AILFEEVMRGKFGKKHMIAGVLFTFVLLLSGQITWRGMAHTLIMIGSNASDRMGMGVTYL ALIATFKIQPFLALGFFLRKLTSRENLLLGVGLAMAATLRLPEDIEQMANGIALGLMALK LITQFETYQLWTALVSLTCSNTIFTLTVAWRTATLILAGISLLPVCQSSSMRKTDWLPMT VAAMGVPPLPLFIFSLKDTLKRRSWPLNEGVMAVGLVSILASSLLRNDVPMAGPLVAGGL LIACYVITGTSADLTVEKAADVTWEEEAEQTGVSHNLMITVDDDGTMRIKDDETENILTV LLKTALLIVSGIFPYSIPATMLVWHTWQKQTQRSGVLWDVPSPPETQKAELEEGVYRIKQ QGIFGKTQVGVGVQKEGVFHTMWHVTRGAVLTHNGKRLEPNWASVKKDLISYGGGWRLSA QWQKGEEVQVIAVEPGKNPKNFQTMPGIFQTTTGEIGAIALDFKPGTSGSPIINREGKVV GLYGNGVVTKNGGYVSGIAQTNAEPDGPTPELEEEMFKKRNLTIMDLHPGSGKTRKYLPA IVREAIKRRLRTLILAPTRVVAAEMEEAMKGLPIRYQTTATKSEHTGREIVDLMCHATFT MRLLSPVRVPNYNLIIMDEAHFTDPASIAARGYISTRVGMGEAAAIFMTATPPGTADAFP QSNAPIQDEERDIPERSWNSGNEWITDFVGKTVWFVPSIKAGNVIANCLRKNGKKVIQLS RKTFDTEYQKTKLNDWDFVVTTDISEMGANFIADRVIDPRRCLKPVILTDGPERVILAGP MPVTVASAAQRRGRVGRNPQKENDQYIFMGQPLNKDEDHAHWTEAKMLLDNINTPEGIIP ALFEPEREKSAAIDGEYRLKGESRKTFVELMRRGDLPVWLAHKVASEGIKYTDRKWCFDG ERNNQILEENMDVEIWTKEGEKKKLRPRWLDARTYSDPLALKEFKDFAAGRKSIALDLVT EIGRVPSHLAHRTRNALDNLVMLHTSEHGGRAYRHAVEELPETMETLLLLGLMILLTGGA MLFLISGKGIGKTSIGLICVIASSGMLWMADVPLQWIASAIVLEFFMMVLLIPEPEKQRT PQDNQLAYVVIGILTLAAIVAANEMGLLETTKRDLGMSKEPGVVSPTSYLDVDLHPASAW TLYAVATTVITPMLRHTIENSTANVSLAAIANQAVVLMGLDKGWPISKMDLGVPLLALGC YSQVNPLTLIAAVLLLVTHYAIIGPGLQAKATREAQKRTAAGIMKNPTVDGIMTIDLDPV IYDSKFEKQLGQVMLLVLCAVQLLLMRTSWALCEVLTLATGPITTLWEGSPGKFWNTTIA VSMANIFRGSYLAGAGLALSIMKSVGTGKRGTGSQGETLGEKWKKKLNQLSRKEFDLYKK SGITEVDRTEAKEGLKRGEITHHAVSRGSAKLQWFVERNMVIPEGRVIDLGCGRGGWSYY CAGLKKVTEVRGYTKGGPGHEEPVPMSTYGWNIVKLMSGKDVFYLPPEKCDTLLCDIGES SPSPTVEESRTIRVLKMVEPWLKNNQFCIKVLNPYMPTVIEHLERLQRKHGGMLVRNPLS RNSTHEMYWISNGTGNIVSSVNMVSRLLLNRFTMTHRRPTIEKDVDLGAGTRHVNAEPET PNMDVIGERIKRIKEEHSSTWHYDDENPYKTWAYHGSYEVKATGSASSMINGVVKLLTKP WDVVPMVTQMAMTDTTPFGQQRVFKEKVDTRTPRPMPGTRKVMEITAEWLWRTLGRNKRP RLCTREEFTKKVRTNAAMGAVFTEENQWDSARAAVEDEEFWKLVDRERELHKLGKCGSCV YNMMGKREKKLGEFGKAKGSRAIWYMWLGARYLEFEALGFLNEDHWFSRENSYSGVEGEG LHKLGYILRDISKIPGGAMYADDTAGWDTRITEDDLHNEEKITQQMDPEHRQLANAIFKL TYQNKVVKVQRPTPKGTVMDIISRKDQRGSGQVGTYGLNTFTNMEAQLIRQMEGEGVLSK ADLENPHPLEKKITQWLETKGVERLKRMAISGDDCVVKPIDDRFANALLALNDMGKVRKD IPQWQPSKGWHDWQQVPFCSHHFHELIMKDGRKLVVPCRPQDELIGRARISQGAGWSLRE TACLGKAYAQMWTLMYFHRRDLRLASNAICSAVPVHWVPTSRTTWSIHAHHQWMTTEDML TVWNRVWIEDNPWMEDKTPVTTWEDVPYLGKREDQWCGSLIGLTSRATWAQNILTAIQQV RSLIGNEEFLDYMPSMKRFRKEEESEGAIW
- Number of residues
- 3390
- Molecular Weight
- 378060.625
- Theoretical pI
- 8.65
- GO Classification
- FunctionsATP binding / ATP-dependent helicase activity / double-stranded RNA binding / metal ion binding / mRNA (guanine-N7-)-methyltransferase activity / mRNA (nucleoside-2'-O-)-methyltransferase activity / RNA helicase activity / RNA-directed RNA polymerase activity / serine-type endopeptidase activity / serine-type exopeptidase activity / structural molecule activityProcessesclathrin-mediated endocytosis of virus by host cell / fusion of virus membrane with host endosome membrane / induction by virus of host autophagy / regulation of transcription, DNA-templated / suppression by virus of host STAT2 activity / suppression by virus of host TYK2 activity / suppression by virus of host type I interferon-mediated signaling pathway / transcription, DNA-templated / viral RNA genome replication / virion attachment to host cellComponentsextracellular region / host cell endoplasmic reticulum membrane / host cell nucleus / integral component of membrane / viral capsid / viral envelope / virion membrane
- General Function
- Structural molecule activity
- Specific Function
- Capsid protein C self-assembles to form an icosahedral capsid about 30 nm in diameter. The capsid encapsulates the genomic RNA.prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated.Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes.Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome.Non-structural protein 2A may be involved viral RNA replication and capsid assembly.Non-structural protein 2B is a required cofactor for the serine protease function of NS3.Serine protease NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS2B, performs its autocleavage and cleaves the polyprotein at dibasic sites in the cytoplasm: C-prM, NS2A-NS2B, NS2B-NS3, NS3-NS4A, NS4A-2K and NS4B-NS5. NS3 RNA helicase binds RNA and unwinds dsRNA in the 3' to 5' direction (By similarity).Non-structural protein 4A induces host endoplasmic reticulum membrane rearrangements leading to the formation of virus-induced membranous vesicles hosting the dsRNA and polymerase, functioning as a replication complex. NS4A might also regulate the ATPase activity of the NS3 helicase.Peptide 2k functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.Non-structural protein 4B inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway.RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome, and performs the capping of genomes in the cytoplasm. NS5 methylates viral RNA cap at guanine N-7 and ribose 2'-O positions. Besides its role in genome replication, also prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) signaling pathway. Inhibits host TYK2 and STAT2 phosphorylation, thereby preventing activation of JAK-STAT signaling pathway (By similarity).
- Pfam Domain Function
- Transmembrane Regions
- 101-118 244-264 266-280 1124-1144 1155-1175 1197-1217 1283-1303 1316-1336 1345-1365 1369-1389 2147-2167 2192-2212 2228-2248 2347-2367 2413-2433 2459-2479
- Cellular Location
- Virion
- Gene sequence
>lcl|BSEQ0005510|10173 bp ATGAACAACCAACGGAAAAAGACGGGAAAACCGTCTATCAATATGCTGAAACGCGTGAGA AACCGTGTGTCAACTGGATCACAGTTGGCGAAGAGATTCTCAAGAGGATTGCTGAACGGC CAAGGACCAATGAAATTGGTTATGGCGTTTATAGCTTTCCTCAGATTTCTAGCCATTCCA CCGACAGCAGGAGTCTTGGCTAGATGGGGTACCTTTAAGAAGTCGGGGGCTATTAAGGTC TTAAAAGGCTTCAAGAAGGAGATCTCAAACATGCTGAGCATTATCAACAAACGGAAAAAG ACATCGCTCTGTCTCATGATGATGTTACCAGCAACACTTGCTTTCCACTTAACTTCACGA GATGGAGAGCCGCGCATGATTGTGGGGAAGAATGAAAGAGGAAAATCCCTACTTTTTAAG ACAGCCTCTGGAATCAACATGTGCACACTCATAGCCATGGATTTGGGAGAGATGTGTGAT GACACGGTCACTTACAAATGCCCCCACATTACCGAAGTGGAGCCTGAAGACATTGACTGT TGGTGCAACCTTACATCGACATGGGTGACTTATGGAACATGCAATCAAGCTGGAGAGCAT AGACGCGATAAGAGATCAGTGGCGTTAGCTCCCCATGTCGGCATGGGACTGGACACACGC ACTCAAACCTGGATGTCGGCTGAAGGAGCTTGGAGACAAGTCGAGAAGGTAGAGACATGG GCCCTTAGGCACCCAGGGTTTACCATACTAGCCCTATTTCTTGCCCATTACATAGGCACT TCCTTGACCCAGAAAGTGGTTATTTTTATACTATTAATGCTGGTTACCCCATCCATGACA ATGAGATGTGTGGGAGTAGGAAACAGAGATTTTGTGGAAGGCCTATCGGGAGCTACGTGG GTTGACGTGGTGCTCGAGCACGGTGGGTGTGTGACTACCATGGCTAAGAACAAGCCCACG CTGGACATAGAGCTTCAGAAGACTGAGGCCACTCAGCTGGCGACCCTAAGGAAGCTATGC ATTGAGGGAAAAATTACCAACATAACAACCGACTCAAGATGTCCCACCCAAGGGGAAGCG ATTTTACCTGAGGAGCAGGACCAGAACTACGTGTGTAAGCATACATACGTGGACAGAGGC TGGGGAAACGGTTGTGGTTTGTTTGGCAAGGGAAGCTTGGTGACATGCGCGAAATTTCAA TGTTTAGAATCAATAGAGGGAAAAGTGGTGCAACATGAGAACCTCAAATACACCGTCATC ATCACAGTGCACACAGGAGACCAACACCAGGTGGGAAATGAAACGCAGGGAGTTACGGCT GAGATAACATCCCAGGCATCAACCGCTGAAGCCATTTTACCTGAATATGGAACCCTCGGG CTAGAATGCTCACCACGGACAGGTTTGGATTTCAATGAAATGATTTTATTGACAATGAAG AACAAAGCATGGATGGTACATAGACAATGGTTCTTTGACTTACCCCTACCATGGACATCA GGAGCTACAACAAAAACACCAACTTGGAACAGGAAAGAGCTTCTTGTGACATTTAAAAAT GCACATGCAAAAAAGCAAGAAGTAGTTGTCCTTGGATCACAAGAGGGAGCAATGCATACA GCACTGACAGGAGCTACAGAGATCCAAACCTCAGGAGGCACAAGTATTTTTGCGGGGCAC TTAAAATGTAGACTCAAGATGGACAAATTGAAACTCAAGGGGATGAGCTATGCAATGTGC TTGAATACCTTTGTGTTGAAGAAAGAAGTCTCCGAAACGCAGCATGGGACAATACTCATT AAGGTTGAGTACAAAGGGGAAGATGCACCCTGCAAGATTCCTTTCTCCACGGAGGATGGA CAAGGGAAAGCTCACAATGGCAGACTGATCACAGCCAATCCAGTGGTGACCAAGAAGGAG GAGCCTGTCAACATTGAGGCTGAACCTCCTTTTGGGGAAAGTAATATAGTAATTGGAATT GGAGACAAAGCCCTGAAAATCAACTGGTACAGGAAGGGAAGCTCGATTGGGAAGATGTTC GAGGCCACTGCCAGAGGTGCAAGGCGCATGGCCATCTTGGGAGACACAGCCTGGGACTTT GGATCAGTGGGTGGTGTTTTGAATTCATTAGGGAAAATGGTCCACCAAATATTTGGGAGT GCTTACACAGCCCTATTTAGTGGAGTCTCCTGGATAATGAAAATTGGAATAGGTGTCCTC TTAACCTGGATAGGGTTGAATTCAAAAAACACTTCTATGTCATTTTCATGCATTGCGATA GGAATCATTACACTCTATCTGGGGGTCGTGGTGCAAGCTGACATGGGGTGTGTCATAAAC TGGAAAGGCAAAGAACTCAAATGTGGAAGTGGAATTTTCGTCACTAATGAGGTCCACACC TGGACAGAGCAATACAAATTTCAAGCAGACTCCCCCAAAAGAGTGGCAACAGCCATTGCA GGCGCTTGGGAGAATGGAGTGTGCGGAATTAGGTCAACAACCAGAATGGAGAACCTCTTG TGGAAGCAAATAGCCAATGAACTGAACTACATATTATGGGAAAACGACATTAAATTAACG GTAGTTGTAGGCGACATAACTGGGGTCTTAGAGCAAGGGAAAAGAACACTAACACCACAA CCCATGGAGCTAAAATATTCTTGGAAAACATGGGGTTTGGCAAAAATAGTGACAGCTGAA ACACAAAATTCCTCTTTCATAATAGATGGGCCAAGCACACCGGAGTGTCCAAGTGCCTCA AGAGCATGGAATGTGTGGGAGGTGGAAGATTACGGGTTCGGAGTTTTCACAACCAACATA TGGCTGAAACTCCGAGAGGTGTACACCCAACTATGTGACCATAGGCTAATGTCGGCAGCC GTCAAGGATGAGAGGGCCGTACACGCCGACATGGGCTATTGGATAGAAAGCCAAAAGAAT GGAAGTTGGAAGCTAGAAAAAGCATCCCTCATAGAGGTGAAAACCTGCACATGGCCAAAA TCACACACTCTTTGGAGCAATGGTGTGCTAGAGAGTGACATGATTATCCCAAAGAGTCTA GCTGGTCCCATTTCGCAACACAACCACAGGCCCGGGTACCACACCCAAACGGCAGGACCC TGGCACTTAGGAAAATTGGAGCTGGACTTCAACTATTGTGAAGGAACAACAGTTGTCATC TCAGAAAACTGTGGGACAAGAGGCCCATCATTGAGAACAACAACAGTGTCAGGGAAGTTG ATACACGAATGGTGTTGCCGCTCGTGCACACTTCCTCCCCTGCGATACATGGGAGAAGAC GGCTGCTGGTATGGCATGGAAATCAGACCCATTAATGAGAAAGAAGAGAACATGGTAAAG TCTCTAGCCTCAGCAGGGAGTGGAAAGGTGGACAACTTCACAATGGGTGTCTTGTGTTTG GCAATCCTCTTTGAAGAGGTGATGAGAGGAAAATTTGGGAAAAAACACATGATTGCAGGG GTTCTCTTCACGTTTGTGCTCCTCCTCTCAGGGCAAATAACATGGAGAGGCATGGCGCAC ACACTCATAATGATTGGGTCCAACGCCTCTGACAGAATGGGGATGGGCGTCACTTACCTA GCTCTAATTGCAACATTTAAAATTCAGCCATTCTTGGCTTTGGGATTCTTCCTGAGGAAA CTGACATCTAGAGAAAATTTATTGCTGGGAGTTGGGTTGGCCATGGCAGCAACGTTACGA CTGCCAGAGGACATTGAACAAATGGCGAATGGAATTGCTTTGGGGCTCATGGCTCTTAAA CTGATAACACAATTTGAAACATACCAACTATGGACGGCATTAGTTTCCCTAACGTGTTCA AATACAATTTTCACGTTGACTGTTGCCTGGAGAACAGCCACTCTGATTTTAGCCGGAATT TCGCTTTTGCCAGTGTGCCAGTCTTCGAGCATGAGGAAAACAGATTGGCTCCCAATGACT GTGGCAGCTATGGGAGTTCCACCCCTACCACTTTTTATTTTCAGTCTGAAAGATACACTC AAAAGGAGAAGCTGGCCACTGAATGAGGGGGTGATGGCAGTTGGACTTGTGAGCATTCTA GCTAGTTCTCTCCTTAGGAATGATGTGCCCATGGCTGGACCATTAGTGGCTGGGGGCTTG CTGATAGCGTGCTACGTCATAACTGGCACGTCAGCAGACCTCACTGTAGAAAAAGCAGCA GATGTAACATGGGAGGAAGAGGCCGAGCAAACAGGAGTGTCCCACAATTTAATGATCACA GTTGATGATGATGGAACAATGAGAATAAAAGATGACGAGACTGAGAACATCTTAACAGTG CTTTTAAAAACAGCACTACTAATAGTATCAGGCATCTTTCCATACTCCATACCCGCAACA ATGTTGGTCTGGCATACTTGGCAAAAGCAAACCCAAAGATCCGGCGTCCTATGGGACGTA CCCAGCCCCCCAGAGACACAGAAAGCGGAACTGGAAGAAGGGGTCTATAGGATCAAACAG CAAGGAATTTTTGGGAAAACCCAAGTGGGGGTTGGAGTACAGAAAGAAGGAGTTTTCCAC ACCATGTGGCACGTCACAAGAGGGGCAGTGTTGACACACAATGGGAAAAGACTGGAACCA AACTGGGCTAGCGTGAAAAAAGATCTGATTTCATACGGAGGAGGATGGAGATTGAGTGCA CAATGGCAAAAGGGGGAGGAGGTGCAGGTTATTGCCGTAGAGCCTGGGAAGAACCCAAAG AACTTTCAAACCATGCCAGGCATTTTTCAGACAACAACAGGGGAAATAGGAGCAATTGCA CTGGATTTCAAGCCTGGAACTTCAGGATCTCCCATCATAAACAGAGAGGGAAAGGTAGTG GGACTGTATGGCAATGGAGTGGTTACAAAGAATGGAGGCTATGTTAGTGGAATAGCGCAA ACAAATGCAGAACCAGATGGACCGACACCAGAGTTGGAAGAAGAGATGTTCAAAAAGCGA AATCTAACCATAATGGATCTTCATCCTGGGTCAGGAAAGACGCGGAAATATCTTCCAGCT ATTGTTAGAGAGGCAATCAAGAGACGCTTAAGGACTCTAATTTTGGCACCAACAAGGGTA GTTGCAGCTGAGATGGAAGAAGCAATGAAAGGGCTCCCAATAAGGTATCAAACAACTGCA ACAAAATCTGAACACACAGGAAGAGAGATTGTTGATCTAATGTGTCACGCAACGTTCACA ATGCGCTTGCTGTCACCAGTCAGGGTTCCAAACTACAACTTGATAATAATGGATGAGGCT CATTTCACAGACCCAGCCAGTATAGCGGCTAGAGGGTACATATCAACTCGTGTAGGAATG GGAGAGGCAGCCGCAATTTTCATGACAGCAACACCCCCTGGAACAGCTGATGCCTTTCCT CAGAGCAACGCTCCAATTCAAGATGAAGAGAGAGACATACCGGAACGCTCATGGAATTCA GGCAATGAATGGATTACTGACTTTGTTGGGAAGACAGTGTGGTTTGTCCCTAGCATCAAA GCCGGAAATGTCATAGCAAACTGTTTGCGGAAAAATGGAAAAAAGGTCATTCAACTCAGC AGGAAGACCTTTGACACAGAATATCAAAAGACCAAACTGAATGATTGGGACTTTGTGGTG ACAACAGACATTTCAGAAATGGGAGCCAATTTCATAGCAGATAGAGTGATCGACCCAAGA AGATGTCTCAAGCCGGTGATTTTGACAGATGGACCCGAGCGGGTGATCCTGGCTGGACCA ATGCCAGTCACCGTAGCGAGCGCTGCGCAAAGGAGAGGGAGAGTTGGCAGGAACCCACAA AAAGAAAATGACCAGTACATATTCATGGGCCAGCCTCTCAACAAAGATGAAGACCATGCT CACTGGACAGAAGCAAAAATGCTGCTGGACAACATCAACACACCAGAAGGGATTATACCA GCTCTCTTTGAACCAGAAAGGGAGAAGTCAGCCGCCATAGACGGCGAATACCGCCTGAAG GGTGAGTCCAGGAAGACTTTCGTGGAACTCATGAGGAGGGGTGACCTCCCAGTTTGGCTA GCCCATAAAGTAGCATCAGAAGGGATCAAATATACAGATAGAAAATGGTGCTTTGATGGA GAACGTAATAATCAAATTTTAGAGGAGAATATGGATGTGGAAATCTGGACAAAGGAAGGA GAAAAGAAAAAACTGAGACCTAGGTGGCTCGATGCCCGCACTTATTCAGATCCTTTAGCA CTCAAGGAATTCAAGGATTTTGCAGCTGGCAGAAAGTCAATCGCCCTTGATCTTGTGACA GAAATAGGAAGAGTGCCTTCACACTTAGCCCACAGAACGAGAAACGCCCTGGACAATTTG GTGATGCTGCACACGTCAGAACATGGCGGTAGGGCCTACAGGCATGCAGTGGAGGAACTA CCAGAAACGATGGAAACACTCTTACTCCTGGGACTGATGATCTTGTTAACAGGTGGAGCA ATGCTCTTCTTGATATCAGGTAAAGGGATTGGAAAGACTTCAATAGGACTCATTTGTGTA ATTGCTTCCAGCGGCATGTTATGGATGGCTGATGTCCCACTCCAATGGATCGCGTCGGCT ATAGTCCTGGAGTTTTTTATGATGGTGTTGCTCATACCAGAACCAGAAAAGCAGAGAACT CCCCAAGACAACCAACTCGCATATGTCGTGATAGGCATACTTACATTGGCTGCAATAGTA GCGGCCAATGAAATGGGACTGTTGGAAACTACAAAGAGAGATTTAGGAATGTCTAAAGAA CCAGGTGTTGTTTCTCCAACCAGCTATTTGGATGTGGACTTGCACCCAGCATCAGCCTGG ACATTGTACGCCGTGGCCACAACAGTAATAACACCAATGTTGAGACACACCATAGAGAAT TCCACAGCAAATGTGTCCCTGGCAGCCATAGCTAACCAGGCAGTGGTCCTGATGGGTTTA GACAAAGGATGGCCGATATCGAAAATGGACTTGGGCGTACCACTATTGGCACTGGGTTGC TATTCACAAGTGAACCCACTAACTCTTATAGCGGCAGTACTTTTGCTAGTCACACATTAT GCAATTATAGGTCCAGGATTGCAGGCAAAAGCCACTCGTGAAGCTCAGAAAAGGACAGCT GCTGGAATAATGAAGAATCCAACGGTGGATGGAATAATGACAATAGACCTAGATCCTGTA ATATATGATTCAAAATTTGAAAAGCAACTAGGACAGGTTATGCTCCTGGTTCTGTGTGCA GTTCAACTTTTGTTAATGAGAACATCATGGGCCTTGTGTGAAGTTCTAACCCTAGCCACA GGACCAATAACAACACTCTGGGAAGGATCACCTGGGAAGTTCTGGAACACCACGATAGCT GTTTCCATGGCGAACATCTTTAGAGGGAGCTATTTAGCAGGAGCTGGGCTTGCTCTTTCT ATCATGAAATCAGTTGGAACAGGAAAGAGAGGAACAGGGTCACAAGGTGAAACCTTAGGA GAAAAGTGGAAAAAGAAATTAAATCAGTTATCCCGGAAAGAGTTTGACCTTTACAAGAAA TCCGGAATCACCGAAGTGGATAGAACAGAAGCCAAAGAAGGGTTAAAAAGAGGAGAAATA ACACACCATGCCGTGTCCAGAGGCAGCGCAAAACTTCAATGGTTCGTGGAGAGAAACATG GTCATTCCCGAAGGAAGAGTCATAGACTTAGGCTGTGGAAGAGGAGGCTGGTCATATTAC TGTGCAGGACTGAAAAAAGTTACAGAAGTGCGAGGATACACAAAAGGCGGCCCAGGACAC GAAGAACCAGTACCTATGTCTACATACGGATGGAACATAGTCAAGTTAATGAGTGGAAAG GATGTTTTTTATCTGCCACCTGAAAAGTGTGATACCCTATTGTGTGACATTGGAGAATCT TCACCAAGCCCAACAGTGGAAGAAAGCAGAACCATAAGAGTCTTGAAGATGGTTGAACCA TGGCTAAAAAACAACCAGTTTTGCATTAAAGTATTGAACCCATACATGCCAACTGTGATT GAGCACTTAGAAAGACTACAAAGGAAACATGGAGGAATGCTTGTGAGAAATCCACTCTCA CGAAACTCCACGCACGAAATGTATTGGATATCCAATGGTACAGGCAACATCGTCTCTTCA GTCAACATGGTATCCAGATTGCTACTGAACAGATTCACAATGACACACAGGAGACCCACC ATAGAGAAAGATGTGGATTTAGGAGCAGGAACCCGACATGTCAATGCGGAACCAGAAACA CCCAACATGGATGTCATTGGGGAAAGAATAAAAAGGATCAAAGAGGAGCATAGTTCAACA TGGCACTATGATGATGAAAATCCTTACAAAACGTGGGCTTACCATGGATCCTATGAAGTA AAAGCCACAGGCTCAGCCTCCTCCATGATAAATGGAGTCGTGAAACTCCTCACAAAACCA TGGGATGTGGTGCCCATGGTGACACAGATGGCAATGACAGATACAACTCCATTTGGCCAG CAAAGAGTTTTTAAAGAGAAAGTGGACACCAGGACACCTAGGCCCATGCCAGGAACAAGA AAGGTTATGGAGATCACAGCGGAGTGGCTTTGGAGGACCCTGGGAAGGAACAAAAGACCC AGATTATGCACAAGGGAGGAGTTCACAAAGAAGGTCAGAACCAACGCAGCTATGGGCGCT GTCTTCACAGAAGAGAACCAATGGGACAGTGCGAGAGCTGCTGTTGAGGACGAAGAATTT TGGAAACTTGTGGACAGAGAACGTGAACTCCACAAACTGGGCAAGTGTGGAAGCTGCGTT TACAACATGATGGGCAAGAGAGAGAAAAAACTTGGAGAGTTTGGTAAAGCAAAAGGCAGT AGGGCTATATGGTACATGTGGTTGGGAGCCAGGTACCTTGAGTTCGAGGCGCTCGGATTC CTCAATGAAGACCACTGGTTCTCGCGTGAAAACTCTTACAGTGGAGTAGAAGGAGAAGGA CTGCACAAGCTGGGATACATCTTGAGAGATATTTCCAAGATACCCGGAGGAGCCATGTAT GCTGATGACACAGCCGGTTGGGACACAAGAATAACAGAAGATGACCTGCACAATGAGGAA AAAATCACACAGCAGATGGACCCTGAACACAGGCAGCTAGCGAACGCTATATTCAAGCTC ACATACCAAAACAAAGTGGTCAAAGTCCAACGACCAACTCCAAAGGGCACGGTAATGGAC ATCATATCTAGGAAAGACCAAAGAGGCAGTGGACAGGTGGGAACTTATGGTCTGAACACA TTCACCAACATGGAAGCCCAGCTAATCAGACAAATGGAAGGAGAAGGCGTGTTGTCAAAG GCAGACCTCGAGAACCCCCATCCGCTAGAGAAGAAAATTACACAATGGTTGGAAACTAAA GGAGTGGAGAGGTTAAAAAGAATGGCCATCAGCGGGGATGATTGCGTAGTGAAACCAATC GACGACAGATTCGCCAATGCCCTGCTTGCCCTGAACGATATGGGAAAGGTTAGGAAGGAC ATACCTCAATGGCAGCCATCAAAGGGATGGCATGATTGGCAACAGGTCCCTTTCTGCTCC CACCACTTTCATGAATTGATCATGAAAGATGGAAGAAAGTTGGTAGTTCCCTGCAGACCC CAGGACGAACTAATAGGAAGAGCGAGAATCTCTCAAGGAGCAGGATGGAGCCTTAGAGAA ACTGCATGTCTAGGGAAAGCCTACGCTCAAATGTGGACTCTCATGTATTTTCACAGAAGA GATCTTAGACTAGCATCCAACGCCATATGTTCAGCAGTACCAGTCCATTGGGTCCCCACG AGCAGAACGACATGGTCTATTCATGCTCACCATCAGTGGATGACTACAGAAGACATGCTT ACTGTCTGGAACAGGGTGTGGATAGAGGACAATCCATGGATGGAAGACAAAACTCCAGTC ACAACGTGGGAAGATGTTCCATATCTAGGAAAGAGAGAAGACCAATGGTGCGGATCACTC ATAGGTCTCACTTCCAGAGCAACCTGGGCCCAGAACATACTCACAGCAATCCAACAGGTG AGAAGCCTCATAGGCAATGAAGAGTTTCTGGACTACATGCCTTCGATGAAGAGATTCAGG AAGGAGGAGGAGTCAGAGGGAGCCATTTGGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P27915 UniProtKB Entry Name POLG_DEN3P GenBank Gene ID M93130 - General References
- Osatomi K, Sumiyoshi H: Complete nucleotide sequence of dengue type 3 virus genome RNA. Virology. 1990 Jun;176(2):643-7. [Article]
- Modis Y, Ogata S, Clements D, Harrison SC: Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein. J Virol. 2005 Jan;79(2):1223-31. [Article]