Phosphatidylinositol 3-kinase regulatory subunit alpha

Details

Name
Phosphatidylinositol 3-kinase regulatory subunit alpha
Synonyms
  • GRB1
  • Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha
  • PI3-kinase regulatory subunit alpha
  • PI3-kinase subunit p85-alpha
  • PtdIns-3-kinase regulatory subunit p85-alpha
Gene Name
PIK3R1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0001901|Phosphatidylinositol 3-kinase regulatory subunit alpha
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE
QFAPPDIAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDTPSVDLEMIDVH
VLADAFKRYLLDLPNPVIPAAVYSEMISLAPEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFSSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
Number of residues
724
Molecular Weight
83597.675
Theoretical pI
6.06
GO Classification
Functions
1-phosphatidylinositol-3-kinase regulator activity / ErbB-3 class receptor binding / insulin binding / insulin receptor binding / insulin receptor substrate binding / insulin-like growth factor receptor binding / neurotrophin TRKA receptor binding / phosphatidylinositol 3-kinase binding / phosphatidylinositol 3-kinase regulator activity / protein phosphatase binding / transcription factor binding / transmembrane receptor protein tyrosine kinase adaptor activity
Processes
B cell differentiation / blood coagulation / cellular glucose homeostasis / cellular response to insulin stimulus / cellular response to UV / epidermal growth factor receptor signaling pathway / extrinsic apoptotic signaling pathway via death domain receptors / Fc-epsilon receptor signaling pathway / Fc-gamma receptor signaling pathway involved in phagocytosis / fibroblast growth factor receptor signaling pathway / growth hormone receptor signaling pathway / innate immune response / insulin receptor signaling pathway / insulin-like growth factor receptor signaling pathway / intrinsic apoptotic signaling pathway in response to DNA damage / leukocyte migration / negative regulation of apoptotic process / negative regulation of cell-matrix adhesion / negative regulation of osteoclast differentiation / neurotrophin TRK receptor signaling pathway / NFAT protein import into nucleus / phosphatidylinositol 3-kinase signaling / phosphatidylinositol biosynthetic process / phosphatidylinositol phosphorylation / phosphatidylinositol-mediated signaling / phospholipid metabolic process / platelet activation / positive regulation of cell migration / positive regulation of endoplasmic reticulum unfolded protein response / positive regulation of establishment of protein localization to plasma membrane / positive regulation of glucose import / positive regulation of glucose import in response to insulin stimulus / positive regulation of RNA splicing / positive regulation of transcription factor import into nucleus / positive regulation of transcription from RNA polymerase II promoter / positive regulation of tumor necrosis factor production / protein phosphorylation / protein stabilization / regulation of phosphatidylinositol 3-kinase activity / regulation of stress fiber assembly / response to endoplasmic reticulum stress / small molecule metabolic process / T cell costimulation / T cell receptor signaling pathway / vascular endothelial growth factor receptor signaling pathway / viral process
Components
cell-cell junction / cis-Golgi network / cytoplasm / cytosol / membrane / nucleus / perinuclear endoplasmic reticulum membrane / phosphatidylinositol 3-kinase complex / phosphatidylinositol 3-kinase complex, class IA / plasma membrane
General Function
Transmembrane receptor protein tyrosine kinase adaptor activity
Specific Function
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress-and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0021657|Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
ATGCATGGTGATTATACTCTTACACTAAGGAAAGGGGGAAATAACAAATTAATCAAAATA
TTTCATCGAGATGGGAAATATGGCTTCTCTGACCCATTAACCTTCAGTTCTGTGGTTGAA
TTAATAAACCACTACCGGAATGAATCTCTAGCTCAGTATAATCCCAAATTGGATGTGAAA
TTACTTTATCCAGTATCCAAATACCAACAGGATCAAGTTGTCAAAGAAGATAATATTGAA
GCTGTAGGGAAAAAATTACATGAATATAACACTCAGTTTCAAGAAAAAAGTCGAGAATAT
GATAGATTATATGAAGAATATACCCGCACATCCCAGGAAATCCAAATGAAAAGGACAGCT
ATTGAAGCATTTAATGAAACCATAAAAATATTTGAAGAACAGTGCCAGACCCAAGAGCGG
TACAGCAAAGAATACATAGAAAAGTTTAAACGTGAAGGCAATGAGAAAGAAATACAAAGG
ATTATGCATAATTATGATAAGTTGAAGTCTCGAATCAGTGAAATTATTGACAGTAGAAGA
AGATTGGAAGAAGACTTGAAGAAGCAGGCAGCTGAGTATCGAGAAATTGACAAACGTATG
AACAGCATTAAACCAGACCTTATCCAGCTGAGAAAGACGAGAGACCAATACTTGATGTGG
TTGACTCAAAAAGGTGTTCGGCAAAAGAAGTTGAACGAGTGGTTGGGCAATGAAAACACT
GAAGACCAATATTCACTGGTGGAAGATGATGAAGATTTGCCCCATCATGATGAGAAGACA
TGGAATGTTGGAAGCAGCAACCGAAACAAAGCTGAAAACCTGTTGCGAGGGAAGCGAGAT
GGCACTTTTCTTGTCCGGGAGAGCAGTAAACAGGGCTGCTATGCCTGCTCTGTAGTGGTG
GACGGCGAAGTAAAGCATTGTGTCATAAACAAAACAGCAACTGGCTATGGCTTTGCCGAG
CCCTATAACTTGTACAGCTCTCTGAAAGAACTGGTGCTACATTACCAACACACCTCCCTT
GTGCAGCACAACGACTCCCTCAATGTCACACTAGCCTACCCAGTATATGCACAGCAGAGG
CGATGA
Chromosome Location
5
Locus
5q13.1
External Identifiers
ResourceLink
UniProtKB IDP27986
UniProtKB Entry NameP85A_HUMAN
GenBank Gene IDM61906
GenAtlas IDPIK3R1
HGNC IDHGNC:8979
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01064Isoprenalineapproved, investigationalunknownagonistDetails
DB05210SF1126investigationalunknownDetails
DB06486EnzastaurininvestigationalunknownDetails
DB08059WortmanninexperimentalunknownDetails