Tumor necrosis factor receptor superfamily member 8
Details
- Name
- Tumor necrosis factor receptor superfamily member 8
- Synonyms
- CD30
- CD30L receptor
- D1S166E
- Ki-1 antigen
- Lymphocyte activation antigen CD30
- Gene Name
- TNFRSF8
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006751|Tumor necrosis factor receptor superfamily member 8 MRVLLAALGLLFLGALRAFPQDRPFEDTCHGNPSHYYDKAVRRCCYRCPMGLFPTQQCPQ RPTDCRKQCEPDYYLDEADRCTACVTCSRDDLVEKTPCAWNSSRVCECRPGMFCSTSAVN SCARCFFHSVCPAGMIVKFPGTAQKNTVCEPASPGVSPACASPENCKEPSSGTIPQAKPT PVSPATSSASTMPVRGGTRLAQEAASKLTRAPDSPSSVGRPSSDPGLSPTQPCPEGSGDC RKQCEPDYYLDEAGRCTACVSCSRDDLVEKTPCAWNSSRTCECRPGMICATSATNSCARC VPYPICAAETVTKPQDMAEKDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQA SKTLPIPTSAPVALSSTGKPVLDAGPVLFWVILVLVVVVGSSAFLLCHRRACRKRIRQKL HLCYPVQTSQPKLELVDSRPRRSSTQLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYL ESLPLQDASPAGGPSSPRDLPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGL AGPAEPELEEELEADHTPHYPEQETEPPLGSCSDVMLSVEEEGKEDPLPTAASGK
- Number of residues
- 595
- Molecular Weight
- 63746.47
- Theoretical pI
- 5.31
- GO Classification
- Functionstransmembrane signaling receptor activity / tumor necrosis factor-activated receptor activityProcessesapoptotic signaling pathway / cellular response to mechanical stimulus / immune response / inflammatory response / multicellular organismal development / negative regulation of cell proliferation / positive regulation of apoptotic process / positive regulation of TRAIL biosynthetic process / positive regulation of tumor necrosis factor biosynthetic process / response to lipopolysaccharide / signal transduction / tumor necrosis factor-mediated signaling pathwayComponentscytoplasm / extracellular exosome / integral component of plasma membrane
- General Function
- Tumor necrosis factor-activated receptor activity
- Specific Function
- Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.
- Pfam Domain Function
- TNFR_c6 (PF00020)
- Transmembrane Regions
- 380-407
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0012428|Tumor necrosis factor receptor superfamily member 8 (TNFRSF8) ATGCGCGTCCTCCTCGCCGCGCTGGGACTGCTGTTCCTGGGGGCGCTACGAGCCTTCCCA CAGGATCGACCCTTCGAGGACACCTGTCATGGAAACCCCAGCCACTACTATGACAAGGCT GTCAGGAGGTGCTGTTACCGCTGCCCCATGGGGCTGTTCCCGACACAGCAGTGCCCACAG AGGCCTACTGACTGCAGGAAGCAGTGTGAGCCTGACTACTACCTGGATGAGGCCGACCGC TGTACAGCCTGCGTGACTTGTTCTCGAGACGACCTCGTGGAGAAGACGCCGTGTGCATGG AACTCCTCCCGTGTCTGCGAATGTCGACCCGGCATGTTCTGTTCCACGTCTGCCGTCAAC TCCTGTGCCCGCTGCTTCTTCCATTCTGTCTGTCCGGCAGGGATGATTGTCAAGTTCCCA GGCACGGCGCAGAAGAACACGGTCTGTGAGCCGGCTTCCCCAGGGGTCAGCCCTGCCTGT GCCAGCCCAGAGAACTGCAAGGAACCCTCCAGTGGCACCATCCCCCAGGCCAAGCCCACC CCGGTGTCCCCAGCAACCTCCAGTGCCAGCACCATGCCTGTAAGAGGGGGCACCCGCCTC GCCCAGGAAGCTGCTTCTAAACTGACGAGGGCTCCCGACTCTCCCTCCTCTGTGGGAAGG CCTAGTTCAGATCCAGGTCTGTCCCCAACACAGCCATGCCCAGAGGGGTCTGGTGATTGC AGAAAGCAGTGTGAGCCCGACTACTACCTGGACGAGGCCGGCCGCTGCACGGCCTGCGTG AGCTGTTCTCGAGATGACCTTGTGGAGAAGACGCCATGTGCATGGAACTCCTCCCGCACC TGCGAATGTCGACCTGGCATGATCTGTGCCACATCAGCCACCAACTCCTGTGCCCGCTGT GTCCCCTACCCAATCTGTGCAGCAGAGACGGTCACCAAGCCCCAGGATATGGCTGAGAAG GACACCACCTTTGAGGCGCCACCCCTGGGGACCCAGCCGGACTGCAACCCCACCCCAGAG AATGGCGAGGCGCCTGCCAGCACCAGCCCCACTCAGAGCTTGCTGGTGGACTCCCAGGCC AGTAAGACGCTGCCCATCCCAACCAGCGCTCCCGTCGCTCTCTCCTCCACGGGGAAGCCC GTTCTGGATGCAGGGCCAGTGCTCTTCTGGGTGATCCTGGTGTTGGTTGTGGTGGTCGGC TCCAGCGCCTTCCTCCTGTGCCACCGGAGGGCCTGCAGGAAGCGAATTCGGCAGAAGCTC CACCTGTGCTACCCGGTCCAGACCTCCCAGCCCAAGCTAGAGCTTGTGGATTCCAGACCC AGGAGGAGCTCAACGCAGCTGAGGAGTGGTGCGTCGGTGACAGAACCCGTCGCGGAAGAG CGAGGGTTAATGAGCCAGCCACTGATGGAGACCTGCCACAGCGTGGGGGCAGCCTACCTG GAGAGCCTGCCGCTGCAGGATGCCAGCCCGGCCGGGGGCCCCTCGTCCCCCAGGGACCTT CCTGAGCCCCGGGTGTCCACGGAGCACACCAATAACAAGATTGAGAAAATCTACATCATG AAGGCTGACACCGTGATCGTGGGGACCGTGAAGGCTGAGCTGCCGGAGGGCCGGGGCCTG GCGGGGCCAGCAGAGCCCGAGTTGGAGGAGGAGCTGGAGGCGGACCATACCCCCCACTAC CCCGAGCAGGAGACAGAACCGCCTCTGGGCAGCTGCAGCGATGTCATGCTCTCAGTGGAA GAGGAAGGGAAAGAAGACCCCTTGCCCACAGCTGCCTCTGGAAAGTGA
- Chromosome Location
- 1
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P28908 UniProtKB Entry Name TNR8_HUMAN GenBank Gene ID AY498860 GenAtlas ID TNFRSF8 HGNC ID HGNC:11923 - General References
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