Cellular retinoic acid-binding protein 2
Details
- Name
- Cellular retinoic acid-binding protein 2
- Synonyms
- Cellular retinoic acid-binding protein II
- CRABP-II
- Gene Name
- CRABP2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0016206|Cellular retinoic acid-binding protein 2 MPNFSGNWKIIRSENFEELLKVLGVNVMLRKIAVAAASKPAVEIKQEGDTFYIKTSTTVR TTEINFKVGEEFEEQTVDGRPCKSLVKWESENKMVCEQKLLKGEGPKTSWTRELTNDGEL ILTMTADDVVCTRVYVRE
- Number of residues
- 138
- Molecular Weight
- 15692.925
- Theoretical pI
- 5.07
- GO Classification
- Functionsretinal binding / retinoic acid binding / retinoid binding / retinol binding / transporter activityProcessesembryonic forelimb morphogenesis / epidermis development / positive regulation of collateral sprouting / regulation of retinoic acid receptor signaling pathway / regulation of transcription, DNA-templated / retinoic acid metabolic process / signal transductionComponentscytoplasm / cytosol / endoplasmic reticulum / extracellular exosome / nucleoplasm
- General Function
- Transporter activity
- Specific Function
- Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
- Pfam Domain Function
- Lipocalin (PF00061)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0016207|Cellular retinoic acid-binding protein 2 (CRABP2) ATGCCCAACTTCTCTGGCAACTGGAAAATCATCCGATCGGAAAACTTCGAGGAATTGCTC AAAGTGCTGGGGGTGAATGTGATGCTGAGGAAGATTGCTGTGGCTGCAGCGTCCAAGCCA GCAGTGGAGATCAAACAGGAGGGAGACACTTTCTACATCAAAACCTCCACCACCGTGCGC ACCACAGAGATTAACTTCAAGGTTGGGGAGGAGTTTGAGGAGCAGACTGTGGATGGGAGG CCCTGTAAGAGCCTGGTGAAATGGGAGAGTGAGAATAAAATGGTCTGTGAGCAGAAGCTC CTGAAGGGAGAGGGCCCCAAGACCTCGTGGACCAGAGAACTGACCAACGATGGGGAACTG ATCCTGACCATGACGGCGGATGACGTTGTGTGCACCAGGGTCTACGTCCGAGAGTGA
- Chromosome Location
- 1
- Locus
- 1q21.3
- External Identifiers
Resource Link UniProtKB ID P29373 UniProtKB Entry Name RABP2_HUMAN GenBank Protein ID 181026 GenBank Gene ID M68867 GenAtlas ID CRABP2 HGNC ID HGNC:2339 - General References
- Astrom A, Tavakkol A, Pettersson U, Cromie M, Elder JT, Voorhees JJ: Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro. J Biol Chem. 1991 Sep 15;266(26):17662-6. [Article]
- Eller MS, Oleksiak MF, McQuaid TJ, McAfee SG, Gilchrest BA: The molecular cloning and expression of two CRABP cDNAs from human skin. Exp Cell Res. 1992 Feb;198(2):328-36. [Article]
- Astrom A, Pettersson U, Voorhees JJ: Structure of the human cellular retinoic acid-binding protein II gene. Early transcriptional regulation by retinoic acid. J Biol Chem. 1992 Dec 15;267(35):25251-5. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00523 Alitretinoin approved, investigational unknown agonist Details DB08127 1,3,3-trimethyl-2-[(1E,3E)-3-methylpenta-1,3-dien-1-yl]cyclohexene experimental unknown Details DB08455 Ro 12-7310 experimental unknown Details DB08467 6-(2,3,4,5,6,7-HEXAHYDRO-2,4,4-TRIMETHYL-1-METYLENEINDEN-2-YL)-3-METHYLHEXA-2,4-DIENOIC ACID experimental unknown Details DB00755 Tretinoin approved, investigational, nutraceutical unknown substrate Details