UMP-CMP kinase

Details

Name
UMP-CMP kinase
Synonyms
  • 2.7.4.14
  • CK
  • CMK
  • CMPK
  • dCMP kinase
  • Deoxycytidylate kinase
  • Nucleoside-diphosphate kinase
  • UCK
  • UMK
  • UMP/CMP kinase
  • UMP/CMPK
  • UMPK
  • Uridine monophosphate/cytidine monophosphate kinase
Gene Name
CMPK1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0001270|UMP-CMP kinase
MKPLVVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNPDSQYGELIEKYIKEG
KIVPVEITISLLKREMDQTMAANAQKNKFLIDGFPRNQDNLQGWNKTMDGKADVSFVLFF
DCNNEICIERCLERGKSSGRSDDNRESLEKRIQTYLQSTKPIIDLYEEMGKVKKIDASKS
VDEVFDEVVQIFDKEG
Number of residues
196
Molecular Weight
22222.175
Theoretical pI
5.2
GO Classification
Functions
ATP binding / cytidylate kinase activity / nucleoside diphosphate kinase activity / uridine kinase activity / uridylate kinase activity
Processes
'de novo' pyrimidine nucleobase biosynthetic process / nucleobase-containing small molecule interconversion / nucleobase-containing small molecule metabolic process / nucleoside diphosphate phosphorylation / nucleoside triphosphate biosynthetic process / pyrimidine ribonucleotide biosynthetic process / small molecule metabolic process / UMP biosynthetic process
Components
cytoplasm / cytosol / extracellular exosome / nucleus
General Function
Uridylate kinase activity
Specific Function
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0010444|UMP-CMP kinase (CMPK1)
ATGCTGAGCCGCTGCCGCAGCGGGCTGCTCCACGTCCTGGGCCTTAGCTTCCTGCTGCAG
ACCCGCCGGCCGATTCTCCTCTGCTCTCCACGTCTCATGAAGCCGCTGGTCGTGTTCGTC
CTCGGCGGCCCCGGCGCCGGCAAGGGGACCCAGTGCGCCCGCATCGTCGAGGAAATGGAT
CAGACAATGGCTGCCAATGCTCAGAAGAATAAATTCTTGATTGATGGGTTTCCAAGAAAT
CAAGACAACCTTCAAGGATGGAACAAGACCATGGATGGGAAGGCAGATGTATCTTTCGTT
CTCTTTTTTGACTGTAATAATGAGATTTGTATTGAACGATGTCTTGAGAGGGGAAAGAGT
AGTGGTAGGAGTGATGACAACAGAGAGAGCTTGGAAAAGAGAATTCAGACCTACCTTCAG
TCAACAAAGCCAATTATTGACTTATATGAAGAAATGGGGAAAGTCAAGAAAATAGATGCT
TCTAAATCTGTTGATGAAGTTTTTGATGAAGTTGTGCAGATTTTTGACAAGGAAGGCTAA
Chromosome Location
1
Locus
1p32
External Identifiers
ResourceLink
UniProtKB IDP30085
UniProtKB Entry NameKCY_HUMAN
GenBank Protein ID6578133
GenBank Gene IDAF070416
GenAtlas IDCMPK
HGNC IDHGNC:18170
General References
  1. Van Rompay AR, Johansson M, Karlsson A: Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme. Mol Pharmacol. 1999 Sep;56(3):562-9. [PubMed:10462544]
  2. Pearman AT, Castro-Faria-Neto HC, McIntyre TM, Prescott SM, Stafforini DM: Characterization of human UMP-CMP kinase enzymatic activity and 5' untranslated region. Life Sci. 2001 Oct 5;69(20):2361-70. [PubMed:11681623]
  3. Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC: Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. Cancer Res. 2002 Mar 15;62(6):1624-31. [PubMed:11912132]
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  12. Amiri M, Conserva F, Panayiotou C, Karlsson A, Solaroli N: The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. Int J Biochem Cell Biol. 2013 May;45(5):925-31. doi: 10.1016/j.biocel.2013.02.004. Epub 2013 Feb 14. [PubMed:23416111]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00441GemcitabineapprovedunknowninhibitorDetails
DB03403Cytidine-5'-MonophosphateexperimentalunknownDetails
DB03435Uridine-5'-DiphosphateexperimentalunknownDetails
DB03664UP5experimentalunknownDetails
DB04444Tetrafluoroaluminate IonexperimentalunknownDetails
DB00709Lamivudineapproved, investigationalunknownsubstrateDetails
DB08934SofosbuvirapprovedunknownsubstrateDetails