Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Details
- Name
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
- Synonyms
- Medium tumor antigen-associated 61 kDa protein
- PP2A subunit A isoform PR65-alpha
- PP2A subunit A isoform R1-alpha
- Gene Name
- PPP2R1A
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0012619|Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIY DEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHS PSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPM VRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDL EALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRA AASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDN TIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVR LAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHA TIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNV AKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA
- Number of residues
- 589
- Molecular Weight
- 65307.81
- Theoretical pI
- 4.75
- GO Classification
- Functionsantigen binding / protein heterodimerization activity / protein phosphatase type 2A regulator activity / protein serine/threonine phosphatase activityProcessesapoptotic process / ceramide metabolic process / chromosome segregation / female meiotic division / fibroblast growth factor receptor signaling pathway / G2/M transition of mitotic cell cycle / gene expression / inactivation of MAPK activity / meiotic sister chromatid cohesion, centromeric / meiotic spindle elongation / mitotic cell cycle / mitotic nuclear envelope reassembly / mitotic sister chromatid separation / negative regulation of cell growth / negative regulation of tyrosine phosphorylation of Stat3 protein / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / organelle organization / peptidyl-serine dephosphorylation / positive regulation of extrinsic apoptotic signaling pathway in absence of ligand / protein complex assembly / protein dephosphorylation / regulation of cell adhesion / regulation of cell differentiation / regulation of DNA replication / regulation of growth / regulation of meiotic cell cycle process involved in oocyte maturation / regulation of protein phosphatase type 2A activity / regulation of transcription, DNA-templated / regulation of Wnt signaling pathway / response to organic substance / RNA splicing / second-messenger-mediated signalingComponentschromosome, centromeric region / cytosol / extracellular exosome / membrane / microtubule cytoskeleton / mitochondrion / nucleus / protein phosphatase type 2A complex
- General Function
- Protein serine/threonine phosphatase activity
- Specific Function
- The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis.
- Pfam Domain Function
- HEAT (PF02985)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0012620|Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) ATGGCGGCGGCCGACGGCGACGACTCGCTGTACCCCATCGCGGTGCTCATAGACGAACTC CGCAATGAGGACGTTCAGCTTCGCCTCAACAGCATCAAGAAGCTGTCCACCATCGCCTTG GCCCTTGGGGTTGAAAGGACCCGAAGTGAGCTTCTGCCTTTCCTTACAGATACCATCTAT GATGAAGATGAGGTCCTCCTGGCCCTGGCAGAACAGCTGGGAACCTTCACTACCCTGGTG GGAGGCCCAGAGTACGTGCACTGCCTGCTGCCACCGCTGGAGTCGCTGGCCACAGTGGAG GAGACAGTGGTGCGGGACAAGGCAGTGGAGTCCTTACGGGCCATCTCACACGAGCACTCG CCCTCTGACCTGGAGGCGCACTTTGTGCCGCTAGTGAAGCGGCTGGCGGGCGGCGACTGG TTCACCTCCCGCACCTCGGCCTGCGGCCTCTTCTCCGTCTGCTACCCCCGAGTGTCCAGT GCTGTGAAGGCGGAACTTCGACAGTACTTCCGGAACCTGTGCTCAGATGACACCCCCATG GTGCGGCGGGCCGCAGCCTCCAAGCTGGGGGAGTTTGCCAAGGTGCTGGAGCTGGACAAC GTCAAGAGTGAGATCATCCCCATGTTCTCCAACCTGGCCTCTGACGAGCAGGACTCGGTG CGGCTGCTGGCGGTGGAGGCGTGCGTGAACATCGCCCAGCTTCTGCCCCAGGAGGATCTG GAGGCCCTGGTGATGCCCACTCTGCGCCAGGCCGCTGAAGACAAGTCCTGGCGCGTCCGC TACATGGTGGCTGACAAGTTCACAGAGCTCCAGAAAGCAGTGGGGCCTGAGATCACCAAG ACAGACCTGGTCCCTGCCTTCCAGAACCTGATGAAAGACTGTGAGGCCGAGGTGAGGGCC GCAGCCTCCCACAAGGTCAAAGAGTTCTGTGAAAACCTCTCAGCTGACTGTCGGGAGAAT GTGATCATGTCCCAGATCTTGCCCTGCATCAAGGAGCTGGTGTCCGATGCCAACCAACAT GTCAAGTCTGCCCTGGCCTCAGTCATCATGGGTCTCTCTCCCATCTTGGGCAAAGACAAC ACCATCGAGCACCTCTTGCCCCTCTTCCTGGCTCAGCTGAAGGATGAGTGCCCTGAGGTA CGGCTGAACATCATCTCTAACCTGGACTGTGTGAACGAGGTGATTGGCATCCGGCAGCTG TCCCAGTCCCTGCTCCCTGCCATTGTGGAGCTGGCTGAGGACGCCAAGTGGCGGGTGCGG CTGGCCATCATTGAGTACATGCCCCTCCTGGCTGGACAGCTGGGAGTGGAGTTCTTTGAT GAGAAACTTAACTCCTTGTGCATGGCCTGGCTTGTGGATCATGTATATGCCATCCGCGAG GCAGCCACCAGCAACCTGAAGAAGCTAGTGGAAAAGTTTGGGAAGGAGTGGGCCCATGCC ACAATCATCCCCAAGGTCTTGGCCATGTCCGGAGACCCCAACTACCTGCACCGCATGACT ACGCTCTTCTGCATCAATGTGCTGTCTGAGGTCTGTGGGCAGGACATCACCACCAAGCAC ATGCTACCCACGGTTCTGCGCATGGCTGGGGACCCGGTTGCCAATGTCCGCTTCAATGTG GCCAAGTCTCTGCAGAAGATAGGGCCCATCCTGGACAACAGCACCTTGCAGAGTGAAGTC AAGCCCATCCTAGAGAAGCTGACCCAGGACCAGGATGTGGACGTCAAATACTTTGCCCAG GAGGCTCTGACTGTTCTGTCTCTCGCCTGA
- Chromosome Location
- 19
- Locus
- 19q13.41
- External Identifiers
Resource Link UniProtKB ID P30153 UniProtKB Entry Name 2AAA_HUMAN GenBank Protein ID 178663 GenBank Gene ID M31786 HGNC ID HGNC:9302 - General References
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