Adenosine receptor A1

Details

Name
Adenosine receptor A1
Synonyms
Not Available
Gene Name
ADORA1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0000026|Adenosine receptor A1
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT
PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPIDEDLPEERPDD
Number of residues
326
Molecular Weight
36511.325
Theoretical pI
8.75
GO Classification
Functions
G-protein coupled adenosine receptor activity / phospholipase C activity / purine nucleoside binding
Processes
activation of MAPKK activity / adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway / apoptotic signaling pathway / cell-cell signaling / cognition / detection of temperature stimulus involved in sensory perception of pain / excitatory postsynaptic potential / inflammatory response / lipid catabolic process / negative regulation of acute inflammatory response / negative regulation of apoptotic process / negative regulation of blood pressure / negative regulation of cardiac muscle contraction / negative regulation of cell proliferation / negative regulation of circadian sleep/wake cycle, non-REM sleep / negative regulation of glutamate secretion / negative regulation of hormone secretion / negative regulation of leukocyte migration / negative regulation of lipid catabolic process / negative regulation of long term synaptic depression / negative regulation of mucus secretion / negative regulation of neurotrophin production / negative regulation of renal sodium excretion / negative regulation of synaptic transmission, GABAergic / negative regulation of synaptic transmission, glutamatergic / negative regulation of vasodilation / nervous system development / phagocytosis / positive regulation of blood pressure / positive regulation of epidermal growth factor-activated receptor activity / positive regulation of nucleoside transport / positive regulation of peptide secretion / positive regulation of potassium ion transport / positive regulation of protein dephosphorylation / protein targeting to membrane / regulation of glomerular filtration / regulation of respiratory gaseous exchange by neurological system process / regulation of sensory perception of pain / regulation of synaptic plasticity / relaxation of vascular smooth muscle / response to hypoxia / signal transduction / temperature homeostasis
Components
asymmetric synapse / axolemma / basolateral plasma membrane / dendritic spine / endoplasmic reticulum / integral component of plasma membrane / neuronal cell body / plasma membrane / postsynaptic density / postsynaptic membrane / presynaptic active zone / presynaptic membrane / terminal bouton
General Function
Purine nucleoside binding
Specific Function
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
Pfam Domain Function
Transmembrane Regions
11-33 47-69 81-102 124-146 177-201 236-259 268-292
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0010133|Adenosine receptor A1 (ADORA1)
ATGCCGCCCTCCATCTCAGCTTTCCAGGCCGCCTACATCGGCATCGAGGTGCTCATCGCC
CTGGTCTCTGTGCCCGGGAACGTGCTGGTGATCTGGGCGGTGAAGGTGAACCAGGCGCTG
CGGGATGCCACCTTCTGCTTCATCGTGTCGCTGGCGGTGGCTGATGTGGCCGTGGGTGCC
CTGGTCATCCCCCTCGCCATCCTCATCAACATTGGGCCACAGACCTACTTCCACACCTGC
CTCATGGTTGCCTGTCCGGTCCTCATCCTCACCCAGAGCTCCATCCTGGCCCTGCTGGCA
ATTGCTGTGGACCGCTACCTCCGGGTCAAGATCCCTCTCCGGTACAAGATGGTGGTGACC
CCCCGGAGGGCGGCGGTGGCCATAGCCGGCTGCTGGATCCTCTCCTTCGTGGTGGGACTG
ACCCCTATGTTTGGCTGGAACAATCTGAGTGCGGTGGAGCGGGCCTGGGCAGCCAACGGC
AGCATGGGGGAGCCCGTGATCAAGTGCGAGTTCGAGAAGGTCATCAGCATGGAGTACATG
GTCTACTTCAACTTCTTTGTGTGGGTGCTGCCCCCGCTTCTCCTCATGGTCCTCATCTAC
CTGGAGGTCTTCTACCTAATCCGCAAGCAGCTCAACAAGAAGGTGTCGGCCTCCTCCGGC
GACCCGCAGAAGTACTATGGGAAGGAGCTGAAGATCGCCAAGTCGCTGGCCCTCATCCTC
TTCCTCTTTGCCCTCAGCTGGCTGCCTTTGCACATCCTCAACTGCATCACCCTCTTCTGC
CCGTCCTGCCACAAGCCCAGCATCCTTACCTACATTGCCATCTTCCTCACGCACGGCAAC
TCGGCCATGAACCCCATTGTCTATGCCTTCCGCATCCAGAAGTTCCGCGTCACCTTCCTT
AAGATTTGGAATGACCATTTCCGCTGCCAGCCTGCACCTCCCATTGACGAGGATCTCCCA
GAAGAGAGGCCTGATGACTAG
Chromosome Location
1
Locus
1q32.1
External Identifiers
ResourceLink
UniProtKB IDP30542
UniProtKB Entry NameAA1R_HUMAN
GenBank Protein ID256155
GenBank Gene IDS45235
GenAtlas IDADORA1
HGNC IDHGNC:262
General References
  1. Libert F, Van Sande J, Lefort A, Czernilofsky A, Dumont JE, Vassart G, Ensinger HA, Mendla KD: Cloning and functional characterization of a human A1 adenosine receptor. Biochem Biophys Res Commun. 1992 Sep 16;187(2):919-26. [PubMed:1530647]
  2. Townsend-Nicholson A, Shine J: Molecular cloning and characterisation of a human brain A1 adenosine receptor cDNA. Brain Res Mol Brain Res. 1992 Dec;16(3-4):365-70. [PubMed:1339301]
  3. Ren H, Stiles GL: Characterization of the human A1 adenosine receptor gene. Evidence for alternative splicing. J Biol Chem. 1994 Jan 28;269(4):3104-10. [PubMed:8300646]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00201CaffeineapprovedyesantagonistmultitargetDetails
DB00996Gabapentinapproved, investigationalunknownagonistDetails
DB04954TecadenosoninvestigationalunknownDetails
DB04932Defibrotideapproved, investigationalunknownDetails
DB12670RolofyllineinvestigationalunknownDetails
DB01223AminophyllineapprovedyesantagonistDetails
DB00277TheophyllineapprovedyesantagonistDetails
DB12569TonapofyllineinvestigationalunknownDetails
DB00640Adenosineapproved, investigationalyesagonistDetails
DB00806Pentoxifyllineapproved, investigationalyesantagonistDetails
DB00651DyphyllineapprovedyesantagonistDetails
DB01303OxtriphyllineapprovedyesantagonistDetails
DB01412TheobromineinvestigationalyesantagonistDetails
DB00824Enprofyllineapproved, experimentalunknowninhibitorDetails
DB06471NaxifyllineinvestigationalunknownantagonistDetails
DB00555Lamotrigineapproved, investigationalunknowninhibitorDetails
DB09061Cannabidiolapproved, investigationalunknownactivatorDetails
DB00193Tramadolapproved, investigationalyesstimulatorDetails
DB11757Istradefyllineapproved, investigationalnoantagonistDetails