Mannosyl-oligosaccharide alpha-1,2-mannosidase

Details

Name
Mannosyl-oligosaccharide alpha-1,2-mannosidase
Synonyms
  • 3.2.1.113
  • Man(9)-alpha-mannosidase
Gene Name
MSDC
Organism
Penicillium citrinum
Amino acid sequence
>lcl|BSEQ0020569|Mannosyl-oligosaccharide alpha-1,2-mannosidase
MRLPVSFPLTVLSLLGSTIAHPYGETEAVLRSEPKSNQAKADAVKEAFQHAWNGYMKYAF
PHDELTPVSNGHADSRNGWGASAVDALSTAVIMGKADVVNAILEHVADIDFSKTSDTVSL
FETTIRYLAGMLSGYDLLQGPAKNLVDNQDLIDGLLDQSRNLADVLKFAFDTPSGVPYNN
INITSHGNDGATTNGLAVTGTLVLEWTRLSDLTGDEEYAKLSQKAESYLLKPQPSSSEPF
PGLVGSSININDGQFADSRVSWNGGDDSFYEYLIKMYVYDPKRFETYKDRWVLAAESTIK
HLKSHPKSRPDLTFLSSYSNRNYDLSSQHLTCFDGGSFLLGGTVLDRQDFIDFGLELVDG
CEATYNSTLTKIGPDSWGWDPKKVPSDQKEFYEKAGFYISSGSYVLRPEVIESFYYAHRV
TGKEIYRDWVWNAFVAINSTCRTDSGFAAVSDVNKANGGSKYDNQESFLFAEVMKYSYLA
HSEDAAWQVQKGGKNTFVYNTEAHPISVARN
Number of residues
511
Molecular Weight
56569.37
Theoretical pI
4.83
GO Classification
Functions
calcium ion binding / mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
Processes
protein glycosylation
Components
extracellular region / membrane
General Function
Mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
Specific Function
Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0003546|1536 bp
ATGCGTCTTCCAGTGTCATTCCCTCTGACAGTTCTGAGCTTGTTGGGCTCGACAATTGCT
CATCCCTATGGCGAGACCGAGGCTGTTTTGCGAAGTGAGCCTAAGAGTAACCAAGCCAAA
GCCGACGCTGTCAAAGAGGCCTTCCAGCACGCGTGGAATGGATACATGAAATATGCCTTC
CCTCATGACGAGTTGACTCCTGTCAGCAATGGTCATGCCGACTCTAGAAATGGATGGGGG
GCCTCAGCAGTTGACGCGCTTTCCACGGCCGTGATTATGGGCAAAGCGGATGTTGTGAAT
GCCATTCTCGAGCATGTCGCCGACATTGACTTCTCGAAGACCTCGGATACCGTCAGTCTT
TTCGAAACAACCATTCGTTACTTGGCGGGTATGCTATCGGGTTACGATCTGCTTCAGGGA
CCTGCCAAGAATTTGGTCGATAACCAAGACCTCATTGACGGATTACTGGACCAGTCAAGA
AACCTGGCCGATGTTCTGAAATTTGCTTTCGATACCCCTTCGGGTGTCCCCTATAATAAC
ATCAACATCACCTCGCACGGAAATGACGGCGCAACCACTAATGGCCTCGCTGTGACTGGC
ACACTGGTTCTGGAATGGACTCGTCTTTCTGATCTGACAGGTGATGAAGAGTATGCCAAA
TTAAGCCAGAAGGCCGAGTCTTATCTGCTCAAGCCGCAGCCATCGAGCAGCGAGCCTTTC
CCTGGTCTCGTAGGCAGCTCGATTAATATCAACGATGGTCAATTTGCCGACTCCAGAGTC
TCTTGGAATGGAGGTGACGATTCATTCTATGAGTACCTGATCAAGATGTACGTGTACGAC
CCTAAGCGGTTTGAGACATACAAGGATCGCTGGGTCCTGGCAGCCGAGTCGACTATCAAG
CATCTCAAGTCGCACCCGAAGTCCCGCCCGGACTTGACGTTCCTGTCTTCCTACAGTAAC
AGGAATTATGATCTCAGCTCGCAGCACCTGACTTGCTTCGATGGCGGTAGTTTTCTTCTG
GGCGGTACCGTTCTGGACCGCCAGGACTTCATTGATTTTGGTCTGGAGCTTGTTGACGGC
TGTGAGGCTACCTACAATTCTACTCTGACCAAGATCGGTCCAGACTCGTGGGGCTGGGAC
CCAAAGAAGGTCCCCAGTGACCAGAAAGAATTCTATGAAAAAGCTGGCTTCTATATCAGT
AGTGGTTCGTACGTCCTCCGCCCCGAGGTGATTGAAAGTTTTTACTACGCGCACCGCGTT
ACTGGAAAGGAAATTTACCGTGACTGGGTTTGGAATGCGTTCGTTGCAATTAACTCGACC
TGCCGTACCGACTCTGGTTTCGCTGCTGTATCCGACGTCAACAAGGCGAACGGTGGCTCC
AAGTACGACAACCAAGAGAGTTTCCTCTTCGCCGAGGTCATGAAGTACTCATATCTCGCT
CATTCCGAGGATGCTGCATGGCAAGTCCAGAAGGGTGGCAAGAATACCTTCGTGTACAAC
ACTGAGGCTCACCCGATTAGCGTCGCACGCAACTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP31723
UniProtKB Entry NameMAN12_PENCI
GenBank Protein ID987684
GenBank Gene IDD45839
General References
  1. Yoshida T, Ichishima E: Molecular cloning and nucleotide sequence of the genomic DNA for 1,2-alpha-D-mannosidase gene, msdC from Penicillium citrinum. Biochim Biophys Acta. 1995 Aug 22;1263(2):159-62. [Article]
  2. Yoshida T, Inoue T, Ichishima E: 1,2-alpha-D-mannosidase from Penicillium citrinum: molecular and enzymic properties of two isoenzymes. Biochem J. 1993 Mar 1;290 ( Pt 2):349-54. [Article]
  3. Lobsanov YD, Vallee F, Imberty A, Yoshida T, Yip P, Herscovics A, Howell PL: Structure of Penicillium citrinum alpha 1,2-mannosidase reveals the basis for differences in specificity of the endoplasmic reticulum and Golgi class I enzymes. J Biol Chem. 2002 Feb 15;277(7):5620-30. Epub 2001 Nov 19. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02742KifunensineexperimentalunknownDetails
DB03206DuvoglustatinvestigationalunknownDetails