Cholecystokinin receptor type A
Details
- Name
- Cholecystokinin receptor type A
- Synonyms
- CCK-A receptor
- CCK1-R
- CCKRA
- Cholecystokinin-1 receptor
- Gene Name
- CCKAR
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010278|Cholecystokinin receptor type A MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNT LVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYF MGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYS NLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGI KFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNS SAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSY TSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSH MSASVPPQ
- Number of residues
- 428
- Molecular Weight
- 47840.645
- Theoretical pI
- 9.48
- GO Classification
- Functionscholecystokinin receptor activity / peptide bindingProcessesactin cytoskeleton reorganization / axonogenesis / cellular response to hormone stimulus / cholecystokinin signaling pathway / digestion / feeding behavior / forebrain development / gastric acid secretion / insulin secretion / neuron migration / organ regeneration / pancreas development / pancreatic juice secretion / phospholipase C-activating G-protein coupled receptor signaling pathway / positive regulation of cytosolic calcium ion concentration / positive regulation of somatostatin secretion / reduction of food intake in response to dietary excess / regulation of calcium ion transport / regulation of hormone secretion / regulation of potassium ion transport / response to glucocorticoid / response to heat / response to lipopolysaccharide / response to nutrient / response to peptide / response to radiation / response to starvation / temperature homeostasisComponentscytosol / endoplasmic reticulum / endosome / integral component of plasma membrane / lysosome / plasma membrane / terminal bouton
- General Function
- Peptide binding
- Specific Function
- Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
- Pfam Domain Function
- Transmembrane Regions
- 42-67 78-104 116-137 158-178 211-234 314-334 350-373
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010279|Cholecystokinin receptor type A (CCKAR) ATGGATGTGGTTGACAGCCTTCTTGTGAATGGAAGCAACATCACTCCTCCCTGTGAACTC GGGCTCGAAAATGAGACGCTTTTCTGCTTGGATCAGCCCCGTCCTTCCAAAGAGTGGCAG CCAGCGGTGCAGATTCTCTTGTACTCCTTGATATTCCTGCTCAGCGTGCTGGGAAACACG CTGGTCATCACCGTGCTGATTCGGAACAAGCGGATGCGGACGGTCACCAACATCTTCCTC CTCTCCCTGGCTGTCAGCGACCTCATGCTCTGTCTCTTCTGCATGCCGTTCAACCTCATC CCCAATCTGCTCAAGGATTTCATCTTCGGGAGCGCCGTTTGCAAGACCACCACCTACTTC ATGGGCACCTCTGTGAGTGTATCTACCTTTAATCTGGTAGCCATATCTCTAGAGAGATAT GGTGCGATTTGCAAACCCTTACAGTCCCGGGTCTGGCAGACAAAATCCCATGCTTTGAAG GTGATTGCTGCTACCTGGTGCCTTTCCTTTACCATCATGACTCCGTACCCCATTTATAGC AACTTGGTGCCTTTTACCAAAAATAACAACCAGACCGCGAATATGTGCCGCTTTCTACTG CCAAATGATGTTATGCAGCAGTCCTGGCACACATTCCTGTTACTCATCCTCTTTCTTATT CCTGGAATTGTGATGATGGTGGCATATGGATTAATCTCTTTGGAACTCTACCAGGGAATA AAATTTGAGGCTAGCCAGAAGAAGTCTGCTAAAGAAAGGAAACCTAGCACCACCAGCAGC GGCAAATATGAGGACAGCGATGGGTGTTACCTGCAAAAGACCAGGCCCCCGAGGAAGCTG GAGCTCCGGCAGCTGTCCACCGGCAGCAGCAGCAGGGCCAACCGCATCCGGAGTAACAGC TCCGCAGCCAACCTGATGGCCAAGAAAAGGGTGATCCGCATGCTCATCGTCATCGTGGTC CTCTTCTTCCTGTGCTGGATGCCCATCTTCAGCGCCAACGCCTGGCGGGCCTACGACACC GCCTCCGCAGAGCGCCGCCTCTCAGGAACCCCCATTTCCTTCATCCTCCTCCTGTCCTAC ACCTCCTCCTGCGTCAACCCCATCATCTACTGCTTCATGAACAAACGCTTCCGCCTCGGC TTCATGGCCACCTTCCCCTGCTGCCCCAATCCTGGTCCCCCAGGGGCGAGGGGAGAGGTG GGGGAGGAGGAGGAAGGCGGGACCACAGGAGCCTCTCTGTCCAGGTTCTCGTACAGCCAT ATGAGTGCCTCGGTGCCACCCCAGTGA
- Chromosome Location
- 4
- Locus
- 4p15.1-p15.2
- External Identifiers
Resource Link UniProtKB ID P32238 UniProtKB Entry Name CCKAR_HUMAN GenBank Protein ID 306491 GenBank Gene ID L13605 GenAtlas ID CCKAR HGNC ID HGNC:1570 - General References
- Ulrich CD, Ferber I, Holicky E, Hadac E, Buell G, Miller LJ: Molecular cloning and functional expression of the human gallbladder cholecystokinin A receptor. Biochem Biophys Res Commun. 1993 May 28;193(1):204-11. [Article]
- de Weerth A, Pisegna JR, Huppi K, Wank SA: Molecular cloning, functional expression and chromosomal localization of the human cholecystokinin type A receptor. Biochem Biophys Res Commun. 1993 Jul 30;194(2):811-8. [Article]
- Miller LJ, Holicky EL, Ulrich CD, Wieben ED: Abnormal processing of the human cholecystokinin receptor gene in association with gallstones and obesity. Gastroenterology. 1995 Oct;109(4):1375-80. [Article]
- Funakoshi A, Miyasaka K, Matsumoto H, Yamamori S, Takiguchi S, Kataoka K, Takata Y, Matsusue K, Kono A, Shimokata H: Gene structure of human cholecystokinin (CCK) type-A receptor: body fat content is related to CCK type-A receptor gene promoter polymorphism. FEBS Lett. 2000 Jan 28;466(2-3):264-6. [Article]
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- Pellegrini M, Mierke DF: Molecular complex of cholecystokinin-8 and N-terminus of the cholecystokinin A receptor by NMR spectroscopy. Biochemistry. 1999 Nov 9;38(45):14775-83. [Article]
- Giragossian C, Mierke DF: Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin A receptor. Biochemistry. 2001 Apr 3;40(13):3804-9. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00403 Ceruletide approved yes inducer Details DB04856 Dexloxiglumide investigational unknown Details DB04867 Lintitript investigational unknown Details DB08862 Cholecystokinin approved, investigational unknown agonist Details DB09142 Sincalide approved yes agonist Details