Cytidine deaminase
Details
- Name
- Cytidine deaminase
- Synonyms
- 3.5.4.5
- CDD
- Cytidine aminohydrolase
- Gene Name
- CDA
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0011748|Cytidine deaminase MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACY PLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKP DGTYIVMTVQELLPSSFGPEDLQKTQ
- Number of residues
- 146
- Molecular Weight
- 16184.545
- Theoretical pI
- 6.95
- GO Classification
- Functionscytidine deaminase activity / nucleoside binding / protein homodimerization activity / zinc ion bindingProcessescell surface receptor signaling pathway / cytidine deamination / cytosine metabolic process / negative regulation of cell growth / negative regulation of nucleotide metabolic process / nucleobase-containing small molecule metabolic process / protein homotetramerization / pyrimidine nucleobase metabolic process / pyrimidine nucleoside salvage / pyrimidine-containing compound salvage / small molecule metabolic processComponentscytosol / extracellular region
- General Function
- Zinc ion binding
- Specific Function
- This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
- Pfam Domain Function
- dCMP_cyt_deam_1 (PF00383)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0011749|Cytidine deaminase (CDA) ATGGCCCAGAAGCGTCCTGCCTGCACCCTGAAGCCTGAGTGTGTCCAGCAGCTGCTGGTT TGCTCCCAGGAGGCCAAGAAGTCAGCCTACTGCCCCTACAGTCACTTTCCTGTGGGGGCT GCCCTGCTCACCCAGGAGGGGAGAATCTTCAAAGGGTGCAACATAGAAAATGCCTGCTAC CCGCTGGGCATCTGTGCTGAACGGACCGCTATCCAGAAGGCCGTCTCAGAAGGGTACAAG GATTTCAGGGCAATTGCTATCGCCAGTGACATGCAAGATGATTTTATCTCTCCATGTGGG GCCTGCAGGCAAGTCATGAGAGAGTTTGGCACCAACTGGCCCGTGTACATGACCAAGCCG GATGGTACGTATATTGTCATGACGGTCCAGGAGCTGCTGCCCTCCTCCTTTGGGCCTGAG GACCTGCAGAAGACCCAGTGA
- Chromosome Location
- 1
- Locus
- 1p36.2-p35
- External Identifiers
Resource Link UniProtKB ID P32320 UniProtKB Entry Name CDD_HUMAN GenBank Gene ID L27943 GenAtlas ID CDA HGNC ID HGNC:1712 - General References
- Laliberte J, Momparler RL: Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA. Cancer Res. 1994 Oct 15;54(20):5401-7. [Article]
- Demontis S, Terao M, Brivio M, Zanotta S, Bruschi M, Garattini E: Isolation and characterization of the gene coding for human cytidine deaminase. Biochim Biophys Acta. 1998 Dec 22;1443(3):323-33. [Article]
- Gran C, Boyum A, Johansen RF, Lovhaug D, Seeberg EC: Growth inhibition of granulocyte-macrophage colony-forming cells by human cytidine deaminase requires the catalytic function of the protein. Blood. 1998 Jun 1;91(11):4127-35. [Article]
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- Kuhn K, Bertling WM, Emmrich F: Cloning of a functional cDNA for human cytidine deaminase (CDD) and its use as a marker of monocyte/macrophage differentiation. Biochem Biophys Res Commun. 1993 Jan 15;190(1):1-7. [Article]
- Chung SJ, Fromme JC, Verdine GL: Structure of human cytidine deaminase bound to a potent inhibitor. J Med Chem. 2005 Feb 10;48(3):658-60. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB03185 1-Beta-Ribofuranosyl-1,3-Diazepinone experimental unknown Details DB00441 Gemcitabine approved unknown substrate Details DB00987 Cytarabine approved, investigational unknown substrate Details DB00928 Azacitidine approved, investigational unknown substrate Details DB01101 Capecitabine approved, investigational no substrate Details DB03185 1-Beta-Ribofuranosyl-1,3-Diazepinone experimental unknown ligand Details DB15694 Cedazuridine approved, investigational yes inhibitor Details DB01262 Decitabine approved, investigational no substrate Details