Cytidine deaminase

Details

Name
Cytidine deaminase
Synonyms
  • 3.5.4.5
  • CDD
  • Cytidine aminohydrolase
Gene Name
CDA
Organism
Humans
Amino acid sequence
>lcl|BSEQ0011748|Cytidine deaminase
MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACY
PLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKP
DGTYIVMTVQELLPSSFGPEDLQKTQ
Number of residues
146
Molecular Weight
16184.545
Theoretical pI
6.95
GO Classification
Functions
cytidine deaminase activity / nucleoside binding / protein homodimerization activity / zinc ion binding
Processes
cell surface receptor signaling pathway / cytidine deamination / cytosine metabolic process / negative regulation of cell growth / negative regulation of nucleotide metabolic process / nucleobase-containing small molecule metabolic process / protein homotetramerization / pyrimidine nucleobase metabolic process / pyrimidine nucleoside salvage / pyrimidine-containing compound salvage / small molecule metabolic process
Components
cytosol / extracellular region
General Function
Zinc ion binding
Specific Function
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0011749|Cytidine deaminase (CDA)
ATGGCCCAGAAGCGTCCTGCCTGCACCCTGAAGCCTGAGTGTGTCCAGCAGCTGCTGGTT
TGCTCCCAGGAGGCCAAGAAGTCAGCCTACTGCCCCTACAGTCACTTTCCTGTGGGGGCT
GCCCTGCTCACCCAGGAGGGGAGAATCTTCAAAGGGTGCAACATAGAAAATGCCTGCTAC
CCGCTGGGCATCTGTGCTGAACGGACCGCTATCCAGAAGGCCGTCTCAGAAGGGTACAAG
GATTTCAGGGCAATTGCTATCGCCAGTGACATGCAAGATGATTTTATCTCTCCATGTGGG
GCCTGCAGGCAAGTCATGAGAGAGTTTGGCACCAACTGGCCCGTGTACATGACCAAGCCG
GATGGTACGTATATTGTCATGACGGTCCAGGAGCTGCTGCCCTCCTCCTTTGGGCCTGAG
GACCTGCAGAAGACCCAGTGA
Chromosome Location
1
Locus
1p36.2-p35
External Identifiers
ResourceLink
UniProtKB IDP32320
UniProtKB Entry NameCDD_HUMAN
GenBank Gene IDL27943
GenAtlas IDCDA
HGNC IDHGNC:1712
General References
  1. Laliberte J, Momparler RL: Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA. Cancer Res. 1994 Oct 15;54(20):5401-7. [PubMed:7923172]
  2. Demontis S, Terao M, Brivio M, Zanotta S, Bruschi M, Garattini E: Isolation and characterization of the gene coding for human cytidine deaminase. Biochim Biophys Acta. 1998 Dec 22;1443(3):323-33. [PubMed:9878810]
  3. Gran C, Boyum A, Johansen RF, Lovhaug D, Seeberg EC: Growth inhibition of granulocyte-macrophage colony-forming cells by human cytidine deaminase requires the catalytic function of the protein. Blood. 1998 Jun 1;91(11):4127-35. [PubMed:9596658]
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  6. Kuhn K, Bertling WM, Emmrich F: Cloning of a functional cDNA for human cytidine deaminase (CDD) and its use as a marker of monocyte/macrophage differentiation. Biochem Biophys Res Commun. 1993 Jan 15;190(1):1-7. [PubMed:8422236]
  7. Chung SJ, Fromme JC, Verdine GL: Structure of human cytidine deaminase bound to a potent inhibitor. J Med Chem. 2005 Feb 10;48(3):658-60. [PubMed:15689149]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB031851-Beta-Ribofuranosyl-1,3-DiazepinoneexperimentalunknownDetails
DB00441GemcitabineapprovedunknownsubstrateDetails
DB00987Cytarabineapproved, investigationalunknownsubstrateDetails
DB00928Azacitidineapproved, investigationalunknownsubstrateDetails
DB01101Capecitabineapproved, investigationalunknownsubstrateDetails
DB031851-Beta-Ribofuranosyl-1,3-DiazepinoneexperimentalunknownligandDetails