Cytochrome c oxidase subunit 1

Details

Name
Cytochrome c oxidase subunit 1
Synonyms
  • 1.9.3.1
  • Cytochrome aa3 subunit 1
  • Cytochrome c oxidase polypeptide I
Gene Name
ctaD
Organism
Rhodobacter sphaeroides
Amino acid sequence
>lcl|BSEQ0017313|Cytochrome c oxidase subunit 1
MADAAIHGHEHDRRGFFTRWFMSTNHKDIGVLYLFTGGLVGLISVAFTVYMRMELMAPGV
QFMCAEHLESGLVKGFFQSLWPSAVENCTPNGHLWNVMITGHGILMMFFVVIPALFGGFG
NYFMPLHIGAPDMAFPRMNNLSYWLYVAGTSLAVASLFAPGGNGQLGSGIGWVLYPPLST
SESGYSTDLAIFAVHLSGASSILGAINMITTFLNMRAPGMTMHKVPLFAWSIFVTAWLIL
LALPVLAGAITMLLTDRNFGTTFFQPSGGGDPVLYQHILWFFGHPEVYIIVLPAFGIVSH
VIATFAKKPIFGYLPMVYAMVAIGVLGFVVWAHHMYTAGLSLTQQSYFMMATMVIAVPTG
IKIFSWIATMWGGSIELKTPMLWALGFLFLFTVGGVTGIVLSQASVDRYYHDTYYVVAHF
HYVMSLGAVFGIFAGIYFWIGKMSGRQYPEWAGKLHFWMMFVGANLTFFPQHFLGRQGMP
RRYIDYPEAFATWNFVSSLGAFLSFASFLFFLGVIFYTLTRGARVTANNYWNEHADTLEW
TLTSPPPEHTFEQLPKREDWERAPAH
Number of residues
566
Molecular Weight
63146.395
Theoretical pI
7.46
GO Classification
Functions
copper ion binding / cytochrome-c oxidase activity / heme binding / iron ion binding
Processes
aerobic respiration / electron transport chain / oxidative phosphorylation
Components
integral component of membrane / plasma membrane / respiratory chain
General Function
Iron ion binding
Specific Function
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme a of subunit 1 to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.
Pfam Domain Function
Transmembrane Regions
29-49 97-117 141-161 189-209 227-247 278-298 310-330 348-368 381-401 420-440 455-475 499-519
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0007747|1701 bp
ATGGCCGACGCAGCCATCCATGGCCACGAGCACGACCGGAGGGGGTTCTTCACCCGCTGG
TTCATGTCGACGAACCACAAGGACATCGGCGTTCTCTATCTCTTCACCGGGGGCCTCGTC
GGGCTGATCTCGGTGGCCTTCACCGTCTACATGCGGATGGAGCTCATGGCGCCGGGCGTG
CAGTTCATGTGCGCCGAACATCTAGAATCGGGCCTCGTGAAGGGCTTCTTCCAGTCGCTC
TGGCCCTCGGCGGTGGAAAACTGCACCCCGAACGGCCATCTGTGGAACGTCATGATCACC
GGCCACGGGATCCTGATGATGTTCTTCGTGGTCATTCCCGCGCTCTTCGGCGGCTTCGGC
AACTATTTCATGCCGCTGCACATCGGCGCGCCGGACATGGCCTTCCCGCGGATGAACAAC
CTCTCCTACTGGCTCTATGTCGCGGGCACCTCGCTCGCCGTCGCCTCGCTCTTCGCGCCG
GGCGGCAACGGCCAGCTGGGCTCTGGCATCGGCTGGGTGCTCTATCCGCCGCTCTCCACC
TCCGAATCGGGCTATTCCACCGACCTCGCGATCTTCGCGGTGCACCTGTCGGGCGCCTCC
TCGATCCTCGGCGCGATCAACATGATCACGACCTTCCTGAACATGCGCGCACCCGGCATG
ACCATGCACAAGGTGCCGCTCTTCGCCTGGTCGATCTTCGTCACCGCCTGGCTGATCCTG
CTGGCGCTGCCCGTGCTCGCCGGCGCCATTACCATGCTGCTGACCGACCGGAACTTCGGC
ACCACCTTCTTCCAGCCCTCGGGCGGCGGCGACCCGGTGCTCTACCAGCACATCCTGTGG
TTCTTCGGCCACCCGGAGGTCTACATCATCGTGCTGCCGGCCTTCGGCATCGTCAGCCAC
GTCATCGCGACCTTCGCCAAAAAGCCGATCTTCGGCTATTTGCCGATGGTCTATGCGATG
GTGGCGATCGGCGTGCTGGGCTTCGTGGTCTGGGCCCACCACATGTATACAGCCGGCCTG
AGCCTCACCCAGCAGAGCTACTTTATGATGGCGACCATGGTGATCGCAGTGCCCACCGGC
ATCAAGATCTTCTCCTGGATCGCGACCATGTGGGGCGGCTCGATCGAGCTCAAGACGCCG
ATGCTCTGGGCGCTCGGGTTCCTCTTCCTCTTCACCGTGGGCGGCGTCACCGGCATCGTG
CTGAGCCAGGCGAGCGTCGACCGCTATTATCACGACACCTACTATGTCGTGGCGCACTTC
CATTATGTGATGAGCCTCGGCGCGGTCTTCGGCATCTTCGCAGGGATCTACTTCTGGATC
GGCAAGATGTCGGGCCGGCAATATCCGGAATGGGCCGGGAAGCTGCATTTCTGGATGATG
TTCGTGGGCGCGAACCTCACCTTCTTCCCGCAGCACTTCCTCGGCCGCCAGGGCATGCCG
CGGCGCTACATCGACTATCCCGAGGCCTTCGCCACCTGGAACTTCGTCTCGTCGCTGGGC
GCCTTCCTGTCCTTCGCCTCGTTCCTCTTCTTCCTCGGCGTGATCTTCTACACGCTGACG
CGCGGGGCGCGGGTGACGGCGAACAACTACTGGAACGAACATGCCGACACGCTGGAGTGG
ACGCTGACCTCTCCGCCGCCGGAGCATACGTTCGAGCAGCTTCCCAAGCGGGAAGACTGG
GAACGCGCGCCCGCCCACTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP33517
UniProtKB Entry NameCOX1_RHOSH
GenBank Protein ID21955871
GenBank Gene IDX62645
General References
  1. Shapleigh JP, Gennis RB: Cloning, sequencing and deletion from the chromosome of the gene encoding subunit I of the aa3-type cytochrome c oxidase of Rhodobacter sphaeroides. Mol Microbiol. 1992 Mar;6(5):635-42. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03619Deoxycholic acidapprovedunknownDetails