Heat shock 70 kDa protein 4

Details

Name

Heat shock 70 kDa protein 4

Synonyms

• APG2
• Heat shock 70-related protein APG-2
• HSP70RY

Gene Name

HSPA4

Organism

Humans

Amino acid sequence

>lcl|BSEQ0049767|Heat shock 70 kDa protein 4
MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACISFGPKNRSIGAAAKSQVISNA
KNTVQGFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAM
LLSKLKETAESVLKKPVVDCVVSVPCFYTDAERRSVMDATQIAGLNCLRLMNETTAVALA
YGIYKQDLPALEEKPRNVVFVDMGHSAYQVSVCAFNRGKLKVLATAFDTTLGGRKFDEVL
VNHFCEEFGKKYKLDIKSKIRALLRLSQECEKLKKLMSANASDLPLSIECFMNDVDVSGT
MNRGKFLEMCNDLLARVEPPLRSVLEQTKLKKEDIYAVEIVGGATRIPAVKEKISKFFGK
ELSTTLNADEAVTRGCALQCAILSPAFKVREFSITDVVPYPISLRWNSPAEEGSSDCEVF
SKNHAAPFSKVLTFYRKEPFTLEAYYSSPQDLPYPDPAIAQFSVQKVTPQSDGSSSKVKV
KVRVNVHGIFSVSSASLVEVHKSEENEEPMETDQNAKEEEKMQVDQEEPHVEEQQQQTPA
ENKAESEEMETSQAGSKDKKMDQPPQAKKAKVKTSTVDLPIENQLLWQIDREMLNLYIEN
EGKMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGEYEKFVSEDDRNSFTLKLEDTENWLY
EDGEDQPKQVYVDKLAELKNLGQPIKIRFQESEERPKLFEELGKQIQQYMKIISSFKNKE
DQYDHLDAADMTKVEKSTNEAMEWMNNKLNLQNKQSLTMDPVVKSKEIEAKIKELTSTCS
PIISKPKPKVEPPKEEQKNAEQNGPVDGQGDNPGPQAAEQGTDTAVPSDSDKKLPEMDID

Number of residues

840

Molecular Weight

94330.225

Theoretical pI

Not Available

GO Classification

Functions

ATP binding

Processes

chaperone-mediated protein complex assembly / protein import into mitochondrial outer membrane / response to unfolded protein

Components

cytosol / extracellular exosome

General Function

Not Available

Specific Function

Atp binding

Pfam Domain Function

• HSP70 (PF00012)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Gene sequence

>lcl|BSEQ0049768|Heat shock 70 kDa protein 4 (HSPA4)
ATGTCGGTGGTGGGCATAGACCTGGGCTTCCAGAGCTGCTACGTCGCTGTGGCCCGCGCC
GGCGGCATCGAGACTATCGCTAATGAGTATAGCGACCGCTGCACGCCGGCTTGCATTTCT
TTTGGTCCTAAGAATCGTTCAATTGGAGCAGCAGCTAAAAGCCAGGTAATTTCTAATGCA
AAGAACACAGTCCAAGGATTTAAAAGATTCCATGGCCGAGCATTCTCTGATCCATTTGTG
GAGGCAGAAAAATCTAACCTTGCATATGATATTGTGCAGTTGCCTACAGGATTAACAGGT
ATAAAGGTGACATATATGGAGGAAGAGCGAAATTTTACCACTGAGCAAGTGACTGCCATG
CTTTTGTCCAAACTGAAGGAGACAGCCGAAAGTGTTCTTAAGAAGCCTGTAGTTGACTGT
GTTGTTTCGGTTCCTTGTTTCTATACTGATGCAGAAAGACGATCAGTGATGGATGCAACA
CAGATTGCTGGTCTTAATTGCTTGCGATTAATGAATGAAACCACTGCAGTTGCTCTTGCA
TATGGAATCTATAAGCAGGATCTTCCTGCCTTAGAAGAGAAACCAAGAAATGTAGTTTTT
GTAGACATGGGCCACTCTGCTTATCAAGTTTCTGTATGTGCATTTAATAGAGGAAAACTG
AAAGTTCTGGCCACTGCATTTGACACGACATTGGGAGGTAGAAAATTTGATGAAGTGTTA
GTAAATCACTTCTGTGAAGAATTTGGGAAGAAATACAAGCTAGACATTAAGTCCAAAATC
CGTGCATTATTACGACTCTCTCAGGAGTGTGAGAAACTCAAGAAATTGATGAGTGCAAAT
GCTTCAGATCTCCCTTTGAGCATTGAATGTTTTATGAATGATGTTGATGTATCTGGAACT
ATGAATAGAGGCAAATTTCTGGAGATGTGCAATGATCTCTTAGCTAGAGTGGAGCCACCA
CTTCGTAGTGTTTTGGAACAAACCAAGTTAAAGAAAGAAGATATTTATGCAGTGGAGATA
GTTGGTGGTGCTACACGAATCCCTGCGGTAAAAGAGAAGATCAGCAAATTTTTCGGTAAA
GAACTTAGTACAACATTAAATGCTGATGAAGCTGTCACTCGAGGCTGTGCATTGCAGTGT
GCCATCTTATCGCCTGCTTTCAAAGTCAGAGAATTTTCTATCACTGATGTAGTACCATAT
CCAATATCTCTGAGATGGAATTCTCCAGCTGAAGAAGGGTCAAGTGACTGTGAAGTCTTT
TCCAAAAATCATGCTGCTCCTTTCTCTAAAGTTCTTACATTTTATAGAAAGGAACCTTTC
ACTCTTGAGGCCTACTACAGCTCTCCTCAGGATTTGCCCTATCCAGATCCTGCTATAGCT
CAGTTTTCAGTTCAGAAAGTCACTCCTCAGTCTGATGGCTCCAGTTCAAAAGTGAAAGTC
AAAGTTCGAGTAAATGTCCATGGCATTTTCAGTGTGTCCAGTGCATCTTTAGTGGAGGTT
CACAAGTCTGAGGAAAATGAGGAGCCAATGGAAACAGATCAGAATGCAAAGGAGGAAGAG
AAGATGCAAGTGGACCAGGAGGAACCACATGTTGAAGAGCAACAGCAGCAGACACCAGCA
GAAAATAAGGCAGAGTCTGAAGAAATGGAGACCTCTCAAGCTGGATCCAAGGATAAAAAG
ATGGACCAACCACCCCAAGCCAAGAAGGCAAAAGTGAAGACCAGTACTGTGGACCTGCCA
ATCGAGAATCAGCTATTATGGCAGATAGACAGAGAGATGCTCAACTTGTACATTGAAAAT
GAGGGTAAGATGATCATGCAGGATAAACTGGAGAAGGAGCGGAATGATGCTAAGAACGCA
GTGGAGGAATATGTGTATGAAATGAGAGACAAGCTTAGTGGTGAATATGAGAAGTTTGTG
AGTGAAGATGATCGTAACAGTTTTACTTTGAAACTGGAAGATACTGAAAATTGGTTGTAT
GAGGATGGAGAAGACCAGCCAAAGCAAGTTTATGTTGATAAGTTGGCTGAATTAAAAAAT
CTAGGTCAACCTATTAAGATACGTTTCCAGGAATCTGAAGAACGACCAAAATTATTTGAA
GAACTAGGGAAACAGATCCAACAGTATATGAAAATAATCAGCTCTTTCAAAAACAAGGAG
GACCAGTATGATCATTTGGATGCTGCTGACATGACAAAGGTAGAAAAAAGCACAAATGAA
GCAATGGAGTGGATGAATAACAAGCTAAATCTGCAGAACAAGCAGAGTTTGACCATGGAT
CCAGTTGTCAAGTCAAAAGAGATTGAAGCTAAAATTAAGGAGCTGACAAGTACTTGTAGC
CCTATAATTTCAAAGCCCAAACCCAAAGTGGAACCTCCAAAAGAGGAACAAAAAAATGCA
GAGCAGAATGGACCAGTGGATGGACAAGGAGACAACCCAGGCCCCCAGGCTGCTGAGCAG
GGTACAGACACAGCTGTGCCTTCGGATTCAGACAAGAAGCTTCCTGAAATGGACATTGAT
TGA

Chromosome Location

5

Locus

5q31.1

External Identifiers

Resource	Link
UniProtKB ID	P34932
UniProtKB Entry Name	HSP74_HUMAN
HGNC ID	HGNC:5237

General References

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7. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [Article]
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9. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
10. Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal. 2011 Mar 15;4(164):rs3. doi: 10.1126/scisignal.2001570. [Article]
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Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB12695	Phenethyl Isothiocyanate	investigational	unknown		Details