Thyrotropin-releasing hormone receptor
Details
- Name
- Thyrotropin-releasing hormone receptor
- Synonyms
- Thyroliberin receptor
- TRH-R
- Gene Name
- TRHR
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0050161|Thyrotropin-releasing hormone receptor MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPT NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCG YKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTH QNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKES DHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
- Number of residues
- 398
- Molecular Weight
- 45084.415
- Theoretical pI
- Not Available
- GO Classification
- Functionsthyrotropin-releasing hormone receptor activityProcessesG-protein coupled receptor signaling pathwayComponentsintegral component of plasma membrane / plasma membrane
- General Function
- Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
- Specific Function
- Thyrotropin-releasing hormone receptor activity
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 29-51 62-83 100-121 145-168 194-215 267-288 297-319
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0050162|Thyrotropin-releasing hormone receptor (TRHR) ATGGAAAACGAGACAGTCAGTGAACTGAACCAAACACAGCTTCAGCCACGAGCAGTGGTG GCCTTAGAATACCAGGTGGTCACCATCTTACTTGTACTCATTATTTGTGGCCTGGGCATT GTAGGCAACATCATGGTAGTCCTGGTTGTCATGAGAACCAAGCACATGAGGACCCCCACA AACTGCTACCTGGTGAGCCTGGCAGTAGCTGATCTCATGGTCTTGGTGGCCGCAGGCCTC CCCAACATAACAGACAGTATCTACGGTTCCTGGGTCTATGGCTATGTTGGATGCCTCTGC ATTACTTACCTCCAGTATTTGGGAATTAATGCATCCTCTTGTTCAATAACAGCCTTTACC ATTGAGAGGTACATAGCAATCTGTCACCCCATCAAAGCCCAGTTTCTCTGCACATTTTCC AGAGCCAAAAAGATTATCATCTTTGTCTGGGCTTTCACATCTCTTTACTGTATGCTCTGG TTCTTCTTGCTGGATCTCAATATTAGCACCTACAAAGATGCTATTGTGATATCCTGTGGC TACAAGATCTCCAGGAATTACTACTCACCTATTTACCTAATGGACTTTGGTGTCTTTTAT GTTGTGCCAATGATCCTGGCTACCGTCCTCTATGGATTCATAGCTAGAATCCTTTTCTTA AATCCCATTCCTTCAGATCCTAAAGAAAACTCTAAGACATGGAAAAATGATTCAACCCAT CAGAACACAAATCTGAATGTAAATACCTCTAATAGATGTTTCAACAGCACAGTATCTTCA AGGAAGCAGGTCACCAAGATGCTGGCAGTGGTTGTAATTCTGTTTGCCCTTTTATGGATG CCCTACAGGACTCTAGTGGTTGTCAACTCATTTCTCTCCAGTCCTTTCCAAGAAAATTGG TTTTTGCTCTTTTGCAGAATTTGCATTTATCTCAACAGTGCCATCAACCCGGTGATTTAC AATCTCATGTCCCAGAAATTCCGTGCAGCCTTCAGAAAGCTCTGCAACTGCAAGCAGAAG CCAACAGAGAAACCTGCTAACTACAGTGTGGCCCTAAATTACAGCGTCATCAAGGAGTCA GACCATTTCAGCACAGAGCTTGATGATATCACTGTCACTGACACTTACCTGTCTGCCACA AAAGTGTCTTTTGATGACACCTGCTTGGCTTCTGAGGTATCCTTTAGCCAAAGTTGA
- Chromosome Location
- 8
- Locus
- 8q23.1
- External Identifiers
Resource Link UniProtKB ID P34981 UniProtKB Entry Name TRFR_HUMAN HGNC ID HGNC:12299 - General References
- Matre V, Karlsen HE, Wright MS, Lundell I, Fjeldheim AK, Gabrielsen OS, Larhammar D, Gautvik KM: Molecular cloning of a functional human thyrotropin-releasing hormone receptor. Biochem Biophys Res Commun. 1993 Aug 31;195(1):179-85. [Article]
- Yamada M, Monden T, Satoh T, Satoh N, Murakami M, Iriuchijima T, Kakegawa T, Mori M: Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene. Biochem Biophys Res Commun. 1993 Sep 15;195(2):737-45. [Article]
- Duthie SM, Taylor PL, Anderson L, Cook J, Eidne KA: Cloning and functional characterisation of the human TRH receptor. Mol Cell Endocrinol. 1993 Sep;95(1-2):R11-5. [Article]
- Hinuma S, Hosoya M, Ogi K, Tanaka H, Nagai Y, Onda H: Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene. Biochim Biophys Acta. 1994 Oct 18;1219(2):251-9. [Article]
- Iwasaki T, Yamada M, Satoh T, Konaka S, Ren Y, Hashimoto K, Kohga H, Kato Y, Mori M: Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene. J Biol Chem. 1996 Sep 6;271(36):22183-8. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Matre V, Hovring PI, Orstavik S, Frengen E, Rian E, Velickovic Z, Murray-McIntosh RP, Gautvik KM: Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor. J Neurochem. 1999 Jan;72(1):40-50. [Article]
- Cook JV, McGregor A, Lee T, Milligan G, Eidne KA: A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor. Endocrinology. 1996 Jul;137(7):2851-8. [Article]