Thyrotropin-releasing hormone receptor

Details

Name
Thyrotropin-releasing hormone receptor
Synonyms
  • Thyroliberin receptor
  • TRH-R
Gene Name
TRHR
Organism
Humans
Amino acid sequence
>lcl|BSEQ0050161|Thyrotropin-releasing hormone receptor
MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPT
NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT
IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCG
YKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTH
QNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW
FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKES
DHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
Number of residues
398
Molecular Weight
45084.415
Theoretical pI
Not Available
GO Classification
Functions
thyrotropin-releasing hormone receptor activity
Processes
G-protein coupled receptor signaling pathway
Components
integral component of plasma membrane / plasma membrane
General Function
Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
Specific Function
Thyrotropin-releasing hormone receptor activity
Pfam Domain Function
Transmembrane Regions
29-51 62-83 100-121 145-168 194-215 267-288 297-319
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0050162|Thyrotropin-releasing hormone receptor (TRHR)
ATGGAAAACGAGACAGTCAGTGAACTGAACCAAACACAGCTTCAGCCACGAGCAGTGGTG
GCCTTAGAATACCAGGTGGTCACCATCTTACTTGTACTCATTATTTGTGGCCTGGGCATT
GTAGGCAACATCATGGTAGTCCTGGTTGTCATGAGAACCAAGCACATGAGGACCCCCACA
AACTGCTACCTGGTGAGCCTGGCAGTAGCTGATCTCATGGTCTTGGTGGCCGCAGGCCTC
CCCAACATAACAGACAGTATCTACGGTTCCTGGGTCTATGGCTATGTTGGATGCCTCTGC
ATTACTTACCTCCAGTATTTGGGAATTAATGCATCCTCTTGTTCAATAACAGCCTTTACC
ATTGAGAGGTACATAGCAATCTGTCACCCCATCAAAGCCCAGTTTCTCTGCACATTTTCC
AGAGCCAAAAAGATTATCATCTTTGTCTGGGCTTTCACATCTCTTTACTGTATGCTCTGG
TTCTTCTTGCTGGATCTCAATATTAGCACCTACAAAGATGCTATTGTGATATCCTGTGGC
TACAAGATCTCCAGGAATTACTACTCACCTATTTACCTAATGGACTTTGGTGTCTTTTAT
GTTGTGCCAATGATCCTGGCTACCGTCCTCTATGGATTCATAGCTAGAATCCTTTTCTTA
AATCCCATTCCTTCAGATCCTAAAGAAAACTCTAAGACATGGAAAAATGATTCAACCCAT
CAGAACACAAATCTGAATGTAAATACCTCTAATAGATGTTTCAACAGCACAGTATCTTCA
AGGAAGCAGGTCACCAAGATGCTGGCAGTGGTTGTAATTCTGTTTGCCCTTTTATGGATG
CCCTACAGGACTCTAGTGGTTGTCAACTCATTTCTCTCCAGTCCTTTCCAAGAAAATTGG
TTTTTGCTCTTTTGCAGAATTTGCATTTATCTCAACAGTGCCATCAACCCGGTGATTTAC
AATCTCATGTCCCAGAAATTCCGTGCAGCCTTCAGAAAGCTCTGCAACTGCAAGCAGAAG
CCAACAGAGAAACCTGCTAACTACAGTGTGGCCCTAAATTACAGCGTCATCAAGGAGTCA
GACCATTTCAGCACAGAGCTTGATGATATCACTGTCACTGACACTTACCTGTCTGCCACA
AAAGTGTCTTTTGATGACACCTGCTTGGCTTCTGAGGTATCCTTTAGCCAAAGTTGA
Chromosome Location
8
Locus
8q23.1
External Identifiers
ResourceLink
UniProtKB IDP34981
UniProtKB Entry NameTRFR_HUMAN
HGNC IDHGNC:12299
General References
  1. Matre V, Karlsen HE, Wright MS, Lundell I, Fjeldheim AK, Gabrielsen OS, Larhammar D, Gautvik KM: Molecular cloning of a functional human thyrotropin-releasing hormone receptor. Biochem Biophys Res Commun. 1993 Aug 31;195(1):179-85. [Article]
  2. Yamada M, Monden T, Satoh T, Satoh N, Murakami M, Iriuchijima T, Kakegawa T, Mori M: Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene. Biochem Biophys Res Commun. 1993 Sep 15;195(2):737-45. [Article]
  3. Duthie SM, Taylor PL, Anderson L, Cook J, Eidne KA: Cloning and functional characterisation of the human TRH receptor. Mol Cell Endocrinol. 1993 Sep;95(1-2):R11-5. [Article]
  4. Hinuma S, Hosoya M, Ogi K, Tanaka H, Nagai Y, Onda H: Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene. Biochim Biophys Acta. 1994 Oct 18;1219(2):251-9. [Article]
  5. Iwasaki T, Yamada M, Satoh T, Konaka S, Ren Y, Hashimoto K, Kohga H, Kato Y, Mori M: Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene. J Biol Chem. 1996 Sep 6;271(36):22183-8. [Article]
  6. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  7. Matre V, Hovring PI, Orstavik S, Frengen E, Rian E, Velickovic Z, Murray-McIntosh RP, Gautvik KM: Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor. J Neurochem. 1999 Jan;72(1):40-50. [Article]
  8. Cook JV, McGregor A, Lee T, Milligan G, Eidne KA: A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor. Endocrinology. 1996 Jul;137(7):2851-8. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB09421Protirelinapproved, investigationalyesligandDetails