Peroxisome proliferator-activated receptor gamma

Details

Name
Peroxisome proliferator-activated receptor gamma
Synonyms
  • NR1C3
  • Nuclear receptor subfamily 1 group C member 3
  • PPAR-gamma
Gene Name
PPARG
Organism
Humans
Amino acid sequence
>lcl|BSEQ0000429|Peroxisome proliferator-activated receptor gamma
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL
LQVIKKTETDMSLHPLLQEIYKDLY
Number of residues
505
Molecular Weight
57619.58
Theoretical pI
5.77
GO Classification
Functions
activating transcription factor binding / alpha-actinin binding / arachidonic acid binding / chromatin binding / core promoter sequence-specific DNA binding / DNA binding / drug binding / enzyme binding / ligand-dependent nuclear receptor transcription coactivator activity / prostaglandin receptor activity / retinoid X receptor binding / RNA polymerase II regulatory region DNA binding / RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding / steroid hormone receptor activity / transcription factor activity, sequence-specific DNA binding / transcription regulatory region DNA binding / transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding / zinc ion binding
Processes
activation of cysteine-type endopeptidase activity involved in apoptotic process / brown fat cell differentiation / cell fate commitment / cell maturation / cellular response to hyperoxia / cellular response to insulin stimulus / cellular response to lithium ion / cellular response to prostaglandin E stimulus / cellular response to retinoic acid / cellular response to vitamin E / diet induced thermogenesis / epithelial cell differentiation / fatty acid oxidation / G-protein coupled receptor signaling pathway / gene expression / glucose homeostasis / heart development / innate immune response / lipid homeostasis / lipid metabolic process / lipoprotein transport / long-chain fatty acid transport / low-density lipoprotein particle receptor biosynthetic process / monocyte differentiation / negative regulation of acute inflammatory response / negative regulation of cell growth / negative regulation of cholesterol storage / negative regulation of collagen biosynthetic process / negative regulation of interferon-gamma-mediated signaling pathway / negative regulation of macrophage derived foam cell differentiation / negative regulation of pancreatic stellate cell proliferation / negative regulation of receptor biosynthetic process / negative regulation of sequestering of triglyceride / negative regulation of smooth muscle cell proliferation / negative regulation of telomerase activity / negative regulation of transcription from RNA polymerase II promoter / negative regulation of transcription, DNA-templated / organ regeneration / peroxisome proliferator activated receptor signaling pathway / placenta development / positive regulation of fat cell differentiation / positive regulation of fatty acid oxidation / positive regulation of oligodendrocyte differentiation / positive regulation of phagocytosis, engulfment / positive regulation of sequence-specific DNA binding transcription factor activity / positive regulation of transcription from RNA polymerase II promoter / positive regulation of transcription, DNA-templated / regulation of blood pressure / regulation of cholesterol transporter activity / regulation of circadian rhythm / regulation of transcription involved in cell fate commitment / response to caffeine / response to cold / response to diuretic / response to estrogen / response to immobilization stress / response to lipid / response to low-density lipoprotein particle / response to mechanical stimulus / response to metformin / response to nutrient / response to retinoic acid / response to starvation / response to vitamin A / rhythmic process / signal transduction / transcription initiation from RNA polymerase II promoter / white fat cell differentiation
Components
cytosol / Golgi apparatus / intracellular membrane-bounded organelle / nucleoplasm / nucleus / perinuclear region of cytoplasm / RNA polymerase II transcription factor complex
General Function
Zinc ion binding
Specific Function
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0021642|Peroxisome proliferator-activated receptor gamma (PPARG)
ATGACCATGGTTGACACAGAGATGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCGTG
GATCTCTCCGTAATGGAAGACCACTCCCACTCCTTTGATATCAAGCCCTTCACTACTGTT
GACTTCTCCAGCATTTCTACTCCACATTACGAAGACATTCCATTCACAAGAACAGATCCA
GTGGTTGCAGATTACAAGTATGACCTGAAACTTCAAGAGTACCAAAGTGCAATCAAAGTG
GAGCCTGCATCTCCACCTTATTATTCTGAGAAGACTCAGCTCTACAATAAGCCTCATGAA
GAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGTGTCTGTGGAGATAAAGCTTCTGGA
TTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAGGGTTTCTTCCGGAGAACAATCAGA
TTGAAGCTTATCTATGACAGATGTGATCTTAACTGTCGGATCCACAAAAAAAGTAGAAAT
AAATGTCAGTACTGTCGGTTTCAGAAATGCCTTGCAGTGGGGATGTCTCATAATGCCATC
AGGTTTGGGCGGATGCCACAGGCCGAGAAGGAGAAGCTGTTGGCGGAGATCTCCAGTGAT
ATCGACCAGCTGAATCCAGAGTCCGCTGACCTCCGGGCCCTGGCAAAACATTTGTATGAC
TCATACATAAAGTCCTTCCCGCTGACCAAAGCAAAGGCGAGGGCGATCTTGACAGGAAAG
ACAACAGACAAATCACCATTCGTTATCTATGACATGAATTCCTTAATGATGGGAGAAGAT
AAAATCAAGTTCAAACACATCACCCCCCTGCAGGAGCAGAGCAAAGAGGTGGCCATCCGC
ATCTTTCAGGGCTGCCAGTTTCGCTCCGTGGAGGCTGTGCAGGAGATCACAGAGTATGCC
AAAAGCATTCCTGGTTTTGTAAATCTTGACTTGAACGACCAAGTAACTCTCCTCAAATAT
GGAGTCCACGAGATCATTTACACAATGCTGGCCTCCTTGATGAATAAAGATGGGGTTCTC
ATATCCGAGGGCCAAGGCTTCATGACAAGGGAGTTTCTAAAGAGCCTGCGAAAGCCTTTT
GGTGACTTTATGGAGCCCAAGTTTGAGTTTGCTGTGAAGTTCAATGCACTGGAATTAGAT
GACAGCGACTTGGCAATATTTATTGCTGTCATTATTCTCAGTGGAGACCGCCCAGGTTTG
CTGAATGTGAAGCCCATTGAAGACATTCAAGACAACCTGCTACAAGCCCTGGAGCTCCAG
CTGAAGCTGAACCACCCTGAGTCCTCACAGCTGTTTGCCAAGCTGCTCCAGAAAATGACA
GACCTCAGACAGATTGTCACGGAACACGTGCAGCTACTGCAGGTGATCAAGAAGACGGAG
ACAGACATGAGTCTTCACCCGCTCCTGCAGGAGATCTACAAGGACTTGTACTAG
Chromosome Location
3
Locus
3p25
External Identifiers
ResourceLink
UniProtKB IDP37231
UniProtKB Entry NamePPARG_HUMAN
GenBank Protein ID1711117
GenBank Gene IDU79012
GenAtlas IDPPARG
HGNC IDHGNC:9236
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00197Troglitazoneinvestigational, withdrawnyesagonistDetails
DB00412Rosiglitazoneapproved, investigationalyesagonistDetails
DB01132Pioglitazoneapproved, investigationalyesagonistDetails
DB00159Icosapentapproved, nutraceuticalyesagonistDetails
DB04971ReglitazarinvestigationalunknownDetails
DB046892-{5-[3-(6-BENZOYL-1-PROPYLNAPHTHALEN-2-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACIDexperimentalunknownDetails
DB05187ElafibranorinvestigationalunknownDetails
DB05490AMG-131investigationalyespartial agonistDetails
DB05854CLX-0921investigationalunknownDetails
DB11811ArhalofenateinvestigationalunknownDetails
DB12662NaveglitazarinvestigationalunknownDetails
DB06510MuraglitazarinvestigationalunknownDetails
DB06521ErtiprotafibinvestigationalunknownDetails
DB06533RagaglitazarinvestigationalunknownDetails
DB06536TesaglitazarinvestigationalunknownDetails
DB00328Indometacinapproved, investigationalunknownactivatorDetails
DB00731Nateglinideapproved, investigationalunknownagonistDetails
DB00912Repaglinideapproved, investigationalunknownagonistDetails
DB01252MitiglinideinvestigationalunknownagonistDetails
DB01067Glipizideapproved, investigationalunknownagonistDetails
DB00966Telmisartanapproved, investigationalyespartial agonistDetails
DB01014Balsalazideapproved, investigationalyesagonistDetails
DB01393Bezafibrateapproved, investigationalyesagonistDetails
DB06908(2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACIDexperimentalunknownDetails
DB06926(9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acidexperimentalunknownDetails
DB070532-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACIDexperimentalunknownDetails
DB07111(4S,5E,7Z,10Z,13Z,16Z,19Z)-4-hydroxydocosa-5,7,10,13,16,19-hexaenoic acidexperimentalunknownDetails
DB07172(5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acidexperimentalunknownDetails
DB07208(8E,10S,12Z)-10-hydroxy-6-oxooctadeca-8,12-dienoic acidexperimentalunknownDetails
DB07209(8R,9Z,12Z)-8-hydroxy-6-oxooctadeca-9,12-dienoic acidexperimentalunknownDetails
DB07302(9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acidexperimentalunknownDetails
DB07509difluoro(5-{2-[(5-octyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}pentanoato)boronexperimentalunknownDetails
DB07675(2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACIDexperimentalunknownDetails
DB077233-(5-methoxy-1H-indol-3-yl)propanoic acidexperimentalunknownDetails
DB07724IndeglitazarexperimentalunknownDetails
DB07842(2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acidexperimentalunknownDetails
DB078632-chloro-5-nitro-N-phenylbenzamideexperimentalunknownDetails
DB08121(2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acidexperimentalunknownDetails
DB083023-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acidexperimentalunknownDetails
DB084022-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACIDexperimentalunknownDetails
DB08435(5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acidexperimentalunknownDetails
DB085603-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDEexperimentalunknownDetails
DB04270(S)-3-(4-(2-Carbazol-9-Yl-Ethoxy)-Phenyl)-2-Ethoxy-Propionic AcidexperimentalunknownDetails
DB08760(2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acidexperimentalunknownDetails
DB00244MesalazineapprovedyesagonistDetails
DB00795SulfasalazineapprovedyesagonistDetails
DB01050IbuprofenapprovedunknownactivatorDetails
DB08915AleglitazarinvestigationalyesagonistDetails
DB09213Dexibuprofenapproved, investigationalunknownactivatorDetails
DB11133Omega-3 fatty acidsapproved, nutraceuticalyesligandDetails
DB03756Doconexentapproved, investigationalyesligandDetails
DB09198LobeglitazoneexperimentalyesactivatorDetails
DB09006ClinofibrateexperimentalunknownDetails
DB01039FenofibrateapprovedunknownDetails
DB09201CiglitazoneexperimentalunknownDetails
DB11672Curcuminapproved, experimental, investigationalunknownDetails
DB00132Alpha-Linolenic Acidapproved, investigational, nutraceuticalunknownDetails
DB02746Phthalic AcidexperimentalunknownDetails
DB02709Resveratrolapproved, experimental, investigationalunknownDetails
DB01118Amiodaroneapproved, investigationalunknownDetails
DB00313Valproic Acidapproved, investigationalunknownDetails
DB03600Capric acidexperimentalunknownligandDetails
DB04224Oleic Acidapproved, investigational, vet_approvedunknownligandDetails
DB08604Triclosanapproved, investigationalunknownDetails
DB00573FenoprofenapprovedunknownDetails
DB02266Flufenamic AcidapprovedunknownagonistDetails
DB09061Cannabidiolapproved, investigationalunknownactivatorDetails
DB13873Fenofibric acidapprovedunknownDetails
DB14011NabiximolsinvestigationalunknownDetails
DB14009Medical Cannabisexperimental, investigationalunknownDetails
DB13961Fish oilapproved, nutraceuticalunknownDetails
DB14034DarglitazoneexperimentalunknownagonistDetails
DB12007IsoflavoneexperimentalunknownagonistDetails
DB14635Curcumin sulfateexperimentalunknownDetails