GTP-binding nuclear protein Ran

Details

Name

GTP-binding nuclear protein Ran

Synonyms

• GTPase Ran
• Ras-like protein TC4

Gene Name

Not Available

Organism

Plasmodium falciparum

Amino acid sequence

>lcl|BSEQ0051517|GTP-binding nuclear protein Ran
MDSQEYIPQYKLILVGDGGVGKTTFVKRHLTGEFEKKYIPTLGVEVHPLKFQTNFGKTQF
NVWDTAGQEKFGGLRDGYYIKSDCAIIMFDVSSRITYKNVPNWYRDITRVCETIPMVLVG
NKVDVKDRQVKSRQIQFHRKRNLQYYDLSARSNYNFEKPFLWLARRLSNQPNLVFVGEHA
KAPEFQIDLNIVREAEKELEQAAAVAIDEEDIEN

Number of residues

214

Molecular Weight

24875.185

Theoretical pI

Not Available

GO Classification

Functions

GTP binding / GTPase activity

Processes

nucleocytoplasmic transport / protein transport

Components

nucleus

General Function

GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity).

Specific Function

Gtp binding

Pfam Domain Function

• Ras (PF00071)

Transmembrane Regions

Not Available

Cellular Location

Nucleus

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	P38545
UniProtKB Entry Name	RAN_PLAFA

General References

1. Dontfraid FF, Chakrabarti D: Cloning and expression of a cDNA encoding the homologue of Ran/TC4 GTP-binding protein from Plasmodium falciparum. Biochem Biophys Res Commun. 1994 May 30;201(1):423-9. doi: 10.1006/bbrc.1994.1718. [Article]
2. Sultan AA, Richardson WA, Alano P, Arnot DE, Doerig C: Cloning and characterisation of a Plasmodium falciparum homologue of the Ran/TC4 signal transducing GTPase involved in cell cycle control. Mol Biochem Parasitol. 1994 Jun;65(2):331-8. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB11638	Artenimol	approved, experimental, investigational	unknown	ligand	Details