60S ribosomal protein L3

Details

Name
60S ribosomal protein L3
Synonyms
  • HIV-1 TAR RNA-binding protein B
  • TARBP-B
Gene Name
RPL3
Organism
Humans
Amino acid sequence
>lcl|BSEQ0017240|60S ribosomal protein L3
MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREV
DRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYK
NWHKSKKKAFTKYCKKWQDEDGKKQLEKDFSSMKKYCQVIRVIAHTQMRLLPLRQKKAHL
MEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKL
PRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIK
NNASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRAL
EKIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRIAKEEGA
Number of residues
403
Molecular Weight
46108.72
Theoretical pI
10.89
GO Classification
Functions
poly(A) RNA binding / RNA binding / structural constituent of ribosome
Processes
cellular protein metabolic process / cellular response to interleukin-4 / gene expression / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / ribosomal large subunit assembly / SRP-dependent cotranslational protein targeting to membrane / translation / translational elongation / translational initiation / translational termination / viral life cycle / viral process / viral transcription
Components
cytoplasm / cytosol / cytosolic large ribosomal subunit / extracellular exosome / focal adhesion / nucleolus / nucleoplasm / nucleus
General Function
Structural constituent of ribosome
Specific Function
The L3 protein is a component of the large subunit of cytoplasmic ribosomes.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0017241|60S ribosomal protein L3 (RPL3)
ATGTCTCACAGAAAGTTCTCCGCTCCCAGACATGGGTCCCTCGGCTTCCTGCCTCGGAAG
CGCAGCAGCAGGCATCGTGGGAAGGTGAAGAGCTTCCCTAAGGATGACCCGTCCAAGCCG
GTCCACCTCACAGCCTTCCTGGGATACAAGGCTGGCATGACTCACATCGTGCGGGAAGTC
GACAGGCCGGGATCCAAGGTGAACAAGAAGGAGGTGGTGGAGGCTGTGACCATTGTAGAG
ACACCACCCATGGTGGTTGTGGGCATTGTGGGCTACGTGGAAACCCCTCGAGGCCTCCGG
ACCTTCAAGACTGTCTTTGCTGAGCACATCAGTGATGAATGCAAGAGGCGTTTCTATAAG
AATTGGCATAAATCTAAGAAGAAGGCCTTTACCAAGTACTGCAAGAAATGGCAGGATGAG
GATGGCAAGAAGCAGCTGGAGAAGGACTTCAGCAGCATGAAGAAGTACTGCCAAGTCATC
CGTGTCATTGCCCACACCCAGATGCGCCTGCTTCCTCTGCGCCAGAAGAAGGCCCACCTG
ATGGAGATCCAGGTGAACGGAGGCACTGTGGCCGAGAAGCTGGACTGGGCCCGCGAGAGG
CTTGAGCAGCAGGTACCTGTGAACCAAGTGTTTGGGCAGGATGAGATGATCGACGTCATC
GGGGTGACCAAGGGCAAAGGCTACAAAGGGGTCACCAGTCGTTGGCACACCAAGAAGCTG
CCCCGCAAGACCCACCGAGGCCTGCGCAAGGTGGCCTGTATTGGGGCATGGCATCCTGCT
CGTGTAGCCTTCTCTGTGGCACGCGCTGGGCAGAAAGGCTACCATCACCGCACTGAGATC
AACAAGAAGATTTATAAGATTGGCCAGGGCTACCTTATCAAGGACGGCAAGCTGATCAAG
AACAATGCCTCCACTGACTATGACCTATCTGACAAGAGCATCAACCCTCTGGGTGGCTTT
GTCCACTATGGTGAAGTGACCAATGACTTTGTCATGCTGAAAGGCTGTGTGGTGGGAACC
AAGAAGCGGGTGCTCACCCTCCGCAAGTCCTTGCTGGTGCAGACGAAGCGGCGGGCTCTG
GAGAAGATTGACCTTAAGTTCATTGACACCACCTCCAAGTTTGGCCATGGCCGCTTCCAG
ACCATGGAGGAGAAGAAAGCATTCATGGGACCACTGAAGAAAGACCGAATTGCAAAGGAA
GAAGGAGCTTAA
Chromosome Location
22
Locus
22q13
External Identifiers
ResourceLink
UniProtKB IDP39023
UniProtKB Entry NameRL3_HUMAN
GenBank Protein ID313659
GenBank Gene IDX73460
HGNC IDHGNC:10332
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB07374AnisomycinexperimentalunknownDetails
DB02494(S)-3-phenyllactic acidexperimentalunknownDetails
DB08437PuromycinexperimentalunknownDetails
DB04865Omacetaxine mepesuccinateapproved, investigationalyesantagonistDetails
DB09092Xanthinolapproved, withdrawnnobinderDetails