Malate dehydrogenase, cytoplasmic

Details

Name
Malate dehydrogenase, cytoplasmic
Synonyms
  • 1.1.1.37
  • Cytosolic malate dehydrogenase
  • Diiodophenylpyruvate reductase
  • MDHA
Gene Name
MDH1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0037050|Malate dehydrogenase, cytoplasmic
MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDC
ALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYA
KKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKN
VIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKL
SSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFV
EGLPINDFSREKMDLTAKELTEEKESAFEFLSSA
Number of residues
334
Molecular Weight
36425.795
Theoretical pI
7.45
GO Classification
Functions
diiodophenylpyruvate reductase activity / L-malate dehydrogenase activity / malic enzyme activity / NAD binding
Processes
carbohydrate metabolic process / gluconeogenesis / glucose metabolic process / malate metabolic process / mitophagy in response to mitochondrial depolarization / NADH metabolic process / oxaloacetate metabolic process / positive regulation of defense response to virus by host / small molecule metabolic process / tricarboxylic acid cycle / xenophagy
Components
centrosome / cytoplasm / cytosol / extracellular exosome / extracellular space / mitochondrion / myelin sheath
General Function
Nad binding
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0021650|Malate dehydrogenase, cytoplasmic (MDH1)
ATGCGACGCTGCAGCTATTTTCCAAAGGACGTTACGGTGTTTGATAAGGACGATAAGTCT
GAACCAATCAGAGTCCTTGTGACTGGAGCAGCTGGTCAAATTGCATATTCACTGCTGTAC
AGTATTGGAAATGGATCTGTCTTTGGTAAAGATCAGCCTATAATTCTTGTGCTGTTGGAT
ATCACCCCCATGATGGGTGTCCTGGACGGTGTCCTAATGGAACTGCAAGACTGTGCCCTT
CCCCTCCTGAAAGATGTCATCGCAACAGATAAAGAAGACGTTGCCTTCAAAGACCTGGAT
GTGGCCATTCTTGTGGGCTCCATGCCAAGAAGGGAAGGCATGGAGAGAAAAGATTTACTG
AAAGCAAATGTGAAAATCTTCAAATCCCAGGGTGCAGCCTTAGATAAATACGCCAAGAAG
TCAGTTAAGGTTATTGTTGTGGGTAATCCAGCCAATACCAACTGCCTGACTGCTTCCAAG
TCAGCTCCATCCATCCCCAAGGAGAACTTCAGTTGCTTGACTCGTTTGGATCACAACCGA
GCTAAAGCTCAAATTGCTCTTAAACTTGGTGTGACTGCTAATGATGTAAAGAATGTCATT
ATCTGGGGAAACCATTCCTCGACTCAGTATCCAGATGTCAACCATGCCAAGGTGAAATTG
CAAGGAAAGGAAGTTGGTGTTTATGAAGCTCTGAAAGATGACAGCTGGCTCAAGGGAGAA
TTTGTCACGACTGTGCAGCAGCGTGGCGCTGCTGTCATCAAGGCTCGAAAACTATCCAGT
GCCATGTCTGCTGCAAAAGCCATCTGTGACCACGTCAGGGACATCTGGTTTGGAACCCCA
GAGGGAGAGTTTGTGTCCATGGGTGTTATCTCTGATGGCAACTCCTATGGTGTTCCTGAT
GATCTGCTCTACTCATTCCCTGTTGTAATCAAGAATAAGACCTGGAAGTTTGTTGAAGGT
CTCCCTATTAATGATTTCTCACGTGAGAAGATGGATCTTACTGCAAAGGAACTGACAGAA
GAAAAAGAAAGTGCTTTTGAATTTCTTTCCTCTGCCTGA
Chromosome Location
2
Locus
2p13.3
External Identifiers
ResourceLink
UniProtKB IDP40925
UniProtKB Entry NameMDHC_HUMAN
GenBank Protein ID1255604
GenBank Gene IDD55654
GenAtlas IDMDH1
HGNC IDHGNC:6970
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00157NADHapproved, nutraceuticalunknownDetails
DB03461Nicotinamide adenine dinucleotide phosphateexperimentalunknownDetails
DB11638Artenimolapproved, experimental, investigationalunknownligandDetails