Malate dehydrogenase, mitochondrial

Details

Name
Malate dehydrogenase, mitochondrial
Synonyms
  • 1.1.1.37
Gene Name
MDH2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0037074|Malate dehydrogenase, mitochondrial
MLSALARPASAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAH
TPGVAADLSHIETKAAVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATI
VATLTAACAQHCPEAMICVIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTF
VAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLTALTGRIQEAGTEVVKA
KAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETECTYFSTPLLLGKKGIE
KNLGIGKVSSFEEKMISDAIPELKASIKKGEDFVKTLK
Number of residues
338
Molecular Weight
35502.935
Theoretical pI
8.9
GO Classification
Functions
L-malate dehydrogenase activity / malate dehydrogenase (NADP+) activity / poly(A) RNA binding
Processes
carbohydrate metabolic process / cellular metabolic process / gluconeogenesis / glucose metabolic process / internal protein amino acid acetylation / malate metabolic process / NADH metabolic process / oxaloacetate metabolic process / small molecule metabolic process / tricarboxylic acid cycle
Components
extracellular exosome / mitochondrial inner membrane / mitochondrial matrix / mitochondrion / myelin sheath / nucleoplasm / nucleus / plasma membrane
General Function
Poly(a) rna binding
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Mitochondrion matrix
Gene sequence
>lcl|BSEQ0010551|Malate dehydrogenase, mitochondrial (MDH2)
ATGCTCTCCGCCCTCGCCCGGCCTGCCAGCGCTGCTCTCCGCCGCAGCTTCAGCACCTCG
GCCCAGAACAATGCTAAAGTAGCTGTGCTAGGGGCCTCTGGAGGCATCGGGCAGCCACTT
TCACTTCTCCTGAAGAACAGCCCCTTGGTGAGCCGCCTGACCCTCTATGATATCGCGCAC
ACACCCGGAGTGGCCGCAGATCTGAGCCACATCGAGACCAAAGCCGCTGTGAAAGGCTAC
CTCGGACCTGAACAGCTGCCTGACTGCCTGAAAGGTTGTGATGTGGTAGTTATTCCGGCT
GGAGTCCCCAGAAAGCCAGGCATGACCCGGGACGACCTGTTCAACACCAATGCCACGATT
GTGGCCACCCTGACCGCTGCCTGTGCCCAGCACTGCCCGGAAGCCATGATCTGCGTCATT
GCCAATCCGGGTTTGGATCCAGCTCGAGTCAACGTCCCTGTCATTGGTGGCCATGCTGGG
AAGACCATCATCCCCCTGATCTCTCAGTGCACCCCCAAGGTGGACTTTCCCCAGGACCAG
CTGACAGCACTCACTGGGCGGATCCAGGAGGCCGGCACGGAGGTGGTCAAGGCTAAAGCC
GGAGCAGGCTCTGCCACCCTCTCCATGGCGTATGCCGGCGCCCGCTTTGTCTTCTCCCTT
GTGGATGCAATGAATGGAAAGGAAGGTGTTGTGGAATGTTCCTTCGTTAAGTCACAGGAA
ACGGAATGTACCTACTTCTCCACACCGCTGCTGCTTGGGAAAAAGGGCATCGAGAAGAAC
CTGGGCATCGGCAAAGTCTCCTCTTTTGAGGAGAAGATGATCTCGGATGCCATCCCCGAG
CTGAAGGCCTCCATCAAGAAGGGGGAAGATTTCGTGAAGACCCTGAAGTGA
Chromosome Location
7
Locus
7p12.3-q11.2
External Identifiers
ResourceLink
UniProtKB IDP40926
UniProtKB Entry NameMDHM_HUMAN
GenBank Protein ID2906146
GenBank Gene IDAF047470
GenAtlas IDMDH2
HGNC IDHGNC:6971
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00157NADHapproved, nutraceuticalunknownDetails
DB04272Citric acidapproved, nutraceutical, vet_approvedunknownDetails
DB09092Xanthinolapproved, withdrawnyescofactorDetails