Folate transporter 1
Details
- Name
- Folate transporter 1
- Synonyms
- FLOT1
- FOLT
- IFC-1
- Intestinal folate carrier 1
- Placental folate transporter
- Reduced folate carrier protein
- RFC
- RFC1
- Solute carrier family 19 member 1
- Gene Name
- SLC19A1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0008562|Folate transporter 1 MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFT REQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQ LMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRV SFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDRGRCETSASELERMNPGPGGKLGH ALRVACGDSVLARMLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTN SARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPS SIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSD VRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKA AQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPV TTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ
- Number of residues
- 591
- Molecular Weight
- 64867.62
- Theoretical pI
- Not Available
- GO Classification
- Functionsfolic acid binding / folic acid transporter activity / methotrexate transporter activity / reduced folate carrier activityProcessesfolic acid metabolic process / folic acid transport / methotrexate transport / reduced folate transmembrane transport / small molecule metabolic process / transmembrane transport / vitamin metabolic process / water-soluble vitamin metabolic processComponentsapical plasma membrane / basolateral plasma membrane / integral component of plasma membrane / plasma membrane
- General Function
- Reduced folate carrier activity
- Specific Function
- Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump.
- Pfam Domain Function
- Folate_carrier (PF01770)
- Transmembrane Regions
- 24-44 71-89 96-116 124-144 160-177 187-203 260-287 310-327 334-354 361-378 395-419 434-454
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0017517|Folate transporter 1 (SLC19A1) ATGGTGCCCTCCAGCCCAGCGGTGGAGAAGCAGGTGCCCGTGGAACCTGGGCCTGACCCC GAGCTCCGGTCCTGGCGGCACCTCGTGTGCTACCTTTGCTTCTACGGCTTCATGGCGCAG ATACGGCCAGGGGAGAGCTTCATCACCCCCTACCTCCTGGGGCCCGACAAGAACTTCACG CGGGAGCAGGTCACGAACGAGATCACGCCGGTGCTGTCGTACTCCTACCTGGCCGTGCTG GTGCCCGTGTTCCTGCTCACCGACTACCTGCGCTACACGCCGGTGCTGCTGCTGCAGGGG CTCAGCTTCGTGTCGGTGTGGCTGCTGCTGCTGCTGGGCCACTCGGTGGCGCACATGCAG CTCATGGAGCTCTTCTACAGCGTCACCATGGCCGCGCGCATCGCCTATTCCTCCTACATC TTCTCTCTCGTGCGGCCCGCGCGCTACCAGCGTGTGGCCGGCTACTCGCGCGCTGCGGTG CTGCTGGGCGTGTTCACCAGCTCCGTGCTGGGCCAGCTGCTGGTCACTGTGGGCCGAGTC TCCTTCTCCACGCTCAACTACATCTCGCTGGCCTTCCTCACCTTCAGCGTGGTCCTCGCC CTCTTCCTGAAGCGCCCCAAGCGCAGCCTCTTCTTCAACCGCGACGACCGGGGGCGGTGC GAAACCTCGGCTTCGGAGCTGGAGCGCATGAATCCTGGCCCAGGCGGGAAGCTGGGACAC GCCCTGCGGGTGGCCTGTGGGGACTCAGTGCTGGCGCGGATGCTGCGGGAGCTGGGGGAC AGCCTGCGGCGGCCGCAGCTGCGCCTGTGGTCCCTCTGGTGGGTCTTCAACTCGGCCGGC TACTACCTGGTGGTCTACTACGTGCACATCCTGTGGAACGAGGTGGACCCCACCACCAAC AGTGCGCGGGTCTACAACGGCGCGGCAGATGCTGCCTCCACGCTGCTGGGCGCCATCACG TCCTTCGCCGCGGGCTTCGTGAAGATCCGCTGGGCGCGCTGGTCCAAGCTGCTCATCGCG GGCGTCACGGCCACGCAGGCGGGGCTGGTCTTCCTTCTGGCGCACACGCGCCACCCGAGC AGCATCTGGCTGTGCTATGCGGCCTTCGTGCTGTTCCGCGGCTCCTACCAGTTCCTCGTG CCCATCGCCACCTTTCAGATTGCATCTTCTCTGTCTAAAGAGCTCTGTGCCCTGGTCTTC GGGGTCAACACGTTCTTTGCCACCATCGTCAAGACCATCATCACTTTCATTGTCTCGGAC GTGCGGGGCCTGGGCCTCCCGGTCCGCAAGCAGAATGAAGAACTGCATGTGGCTTCTCTG TCTCTGTGGAAAAGCCATCTCAGGTTGGCGGCAGACACATTGTCATCAGAGGGGAGCAGC GGCTCTGGTCCTCGGAGCTGGTTCCTCTCTCCCACCCTAAGGGCAGCCCTCCATGGTCCT GTCTGTCCTTCTGAAGTGTGTCCATCCTGA
- Chromosome Location
- 21
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P41440 UniProtKB Entry Name S19A1_HUMAN HGNC ID HGNC:10937 - General References
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- Wong SC, Proefke SA, Bhushan A, Matherly LH: Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells. J Biol Chem. 1995 Jul 21;270(29):17468-75. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB06813 Pralatrexate approved, investigational no substrate Details DB00563 Methotrexate approved unknown substrate Details DB11256 Levomefolic acid approved, investigational unknown substrate Details DB01157 Trimetrexate approved, investigational unknown substrate Details DB00642 Pemetrexed approved, investigational no substrate Details