Xanthine phosphoribosyltransferase
Details
- Name
- Xanthine phosphoribosyltransferase
- Synonyms
- 2.4.2.22
- XPRTase
- Gene Name
- xpt
- Organism
- Bacillus subtilis (strain 168)
- Amino acid sequence
>lcl|BSEQ0011295|Xanthine phosphoribosyltransferase MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFASRFAKDGITKIVTIESS GIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQTESQIAVSGTHLSDQDHV LIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQPGRDELVKLGYRVESLARIQS LEEGKVSFVQEVHS
- Number of residues
- 194
- Molecular Weight
- 21038.005
- Theoretical pI
- 6.24
- GO Classification
- Functionsxanthine phosphoribosyltransferase activityProcessespurine ribonucleoside salvage / xanthine metabolic process / XMP salvageComponentscytoplasm
- General Function
- Xanthine phosphoribosyltransferase activity
- Specific Function
- Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so that it can be reused for RNA or DNA synthesis.
- Pfam Domain Function
- Pribosyltran (PF00156)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0011296|Xanthine phosphoribosyltransferase (xpt) ATGGAAGCACTGAAACGGAAAATAGAGGAAGAAGGCGTCGTATTATCTGATCAGGTATTG AAAGTGGATTCTTTTTTGAATCACCAAATTGATCCGCTGCTTATGCAGAGAATTGGTGAT GAATTTGCGTCTAGGTTTGCAAAAGACGGTATTACCAAAATTGTGACAATCGAATCATCA GGTATCGCTCCCGCTGTAATGACGGGCTTGAAGCTGGGTGTGCCAGTTGTCTTCGCGAGA AAGCATAAATCGTTAACACTCACCGACAACTTGCTGACAGCGTCTGTTTATTCCTTTACG AAGCAAACAGAAAGCCAAATCGCAGTGTCTGGGACCCACCTGTCGGATCAGGATCATGTG CTGATTATCGATGATTTTTTGGCAAATGGACAGGCAGCGCACGGGCTTGTGTCGATTGTG AAGCAAGCGGGAGCTTCTATTGCGGGAATCGGCATTGTTATTGAAAAGTCATTTCAGCCG GGAAGAGATGAACTTGTAAAACTGGGCTACCGAGTGGAATCTTTGGCAAGAATTCAGTCT TTAGAAGAAGGAAAAGTGTCCTTCGTACAGGAGGTTCATTCATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P42085 UniProtKB Entry Name XPT_BACSU GenBank Protein ID 633169 GenBank Gene ID X83878 - General References
- Christiansen LC, Schou S, Nygaard P, Saxild HH: Xanthine metabolism in Bacillus subtilis: characterization of the xpt-pbuX operon and evidence for purine- and nitrogen-controlled expression of genes involved in xanthine salvage and catabolism. J Bacteriol. 1997 Apr;179(8):2540-50. [Article]
- Capuano V, Galleron N, Pujic P, Sorokin A, Ehrlich SD: Organization of the Bacillus subtilis 168 chromosome between kdg and the attachment site of the SP beta prophage: use of Long Accurate PCR and yeast artificial chromosomes for sequencing. Microbiology. 1996 Nov;142 ( Pt 11):3005-15. [Article]
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- Arent S, Kadziola A, Larsen S, Neuhard J, Jensen KF: The extraordinary specificity of xanthine phosphoribosyltransferase from Bacillus subtilis elucidated by reaction kinetics, ligand binding, and crystallography. Biochemistry. 2006 May 30;45(21):6615-27. [Article]