3-deoxy-manno-octulosonate cytidylyltransferase

Details

Name
3-deoxy-manno-octulosonate cytidylyltransferase
Synonyms
  • 2.7.7.38
  • CKS
  • CMP-2-keto-3-deoxyoctulosonic acid synthase
  • CMP-KDO synthase
Gene Name
kpsU
Organism
Escherichia coli
Amino acid sequence
>lcl|BSEQ0011077|3-deoxy-manno-octulosonate cytidylyltransferase
MSKAVIVIPARYGSSRLPGKPLLDIVGKPMIQHVYERALQVAGVAEVWVATDDPRVEQAV
QAFGGKAIMTRNDHESGTDRLVEVMHKVEADIYINLQGDEPMIRPRDVETLLQGMRDDPA
LPVATLCHAISAAEAAEPSTVKVVVNTRQDALYFSRSPIPYPRNAEKARYLKHVGIYAYR
RDVLQNYSQLPESMPEQAESLEQLRLMNAGINIRTFEVAATGPGVDTPACLEKVRALMAQ
ELAENA
Number of residues
246
Molecular Weight
27158.885
Theoretical pI
5.7
GO Classification
Functions
3-deoxy-manno-octulosonate cytidylyltransferase activity
Processes
CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process / keto-3-deoxy-D-manno-octulosonic acid biosynthetic process
Components
cytoplasm
General Function
3-deoxy-manno-octulosonate cytidylyltransferase activity
Specific Function
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0003021|741 bp
ATGAGCAAAGCAGTTATTGTCATTCCGGCTCGCTATGGCTCCTCGCGCCTGCCGGGTAAG
CCACTGCTCGATATTGTTGGTAAACCGATGATCCAGCATGTTTACGAGCGTGCGTTACAG
GTGGCGGGCGTTGCGGAAGTTTGGGTGGCAACAGACGATCCGCGTGTTGAACAGGCCGTA
CAGGCGTTTGGCGGGAAAGCCATCATGACGCGCAACGATCATGAATCCGGCACCGATCGG
CTGGTCGAGGTGATGCATAAAGTCGAGGCAGATATCTACATTAACCTGCAGGGCGACGAA
CCAATGATTCGCCCGCGGGATGTAGAAACGCTGCTACAAGGAATGCGTGACGATCCCGCG
TTGCCGGTGGCAACGCTATGCCACGCGATTTCTGCCGCAGAAGCGGCTGAGCCAAGCACG
GTAAAAGTGGTTGTGAATACCCGCCAGGATGCGCTTTATTTCAGCCGCTCACCGATTCCG
TATCCGCGTAATGCTGAAAAAGCGCGCTACCTGAAACACGTCGGTATTTACGCTTATCGT
CGCGATGTGCTGCAAAACTACAGCCAGTTACCGGAGTCCATGCCGGAGCAGGCGGAATCA
CTGGAGCAGCTAAGGTTGATGAACGCGGGGATCAACATCCGCACATTTGAGGTTGCCGCA
ACCGGTCCGGGCGTCGACACCCCAGCATGCCTGGAAAAAGTGCGCGCCCTGATGGCACAG
GAACTGGCTGAAAACGCATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP42216
UniProtKB Entry NameKPSU5_ECOLX
GenBank Protein ID397407
GenBank Gene IDX74567
General References
  1. Pazzani C, Rosenow C, Boulnois GJ, Bronner D, Jann K, Roberts IS: Molecular analysis of region 1 of the Escherichia coli K5 antigen gene cluster: a region encoding proteins involved in cell surface expression of capsular polysaccharide. J Bacteriol. 1993 Sep;175(18):5978-83. [Article]
  2. Rosenow C, Roberts IS, Jann K: Isolation from recombinant Escherichia coli and characterization of CMP-Kdo synthetase, involved in the expression of the capsular K5 polysaccharide (K-CKS). FEMS Microbiol Lett. 1995 Jan 15;125(2-3):159-64. [Article]
  3. Jelakovic S, Jann K, Schulz GE: The three-dimensional structure of capsule-specific CMP: 2-keto-3-deoxy-manno-octonic acid synthetase from Escherichia coli. FEBS Lett. 1996 Aug 5;391(1-2):157-61. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03721N-acetyl-alpha-neuraminic acidexperimentalunknownDetails
DB02431Cytidine-5'-TriphosphateexperimentalunknownDetails
DB03403Cytidine-5'-MonophosphateexperimentalunknownDetails
DB04482Cmp-2-Keto-3-Deoxy-Octulosonic AcidexperimentalunknownDetails
DB04555Cytidine-5'-DiphosphateexperimentalunknownDetails