Solute carrier family 15 member 1
Details
- Name
- Solute carrier family 15 member 1
- Synonyms
- Intestinal H(+)/peptide cotransporter
- Oligopeptide transporter, small intestine isoform
- PEPT1
- Peptide transporter 1
- Gene Name
- SLC15A1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010713|Solute carrier family 15 member 1 MGMSKSHSFFGYPLSIFFIVVNEFCERFSYYGMRAILILYFTNFISWDDNLSTAIYHTFV ALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVTSVSSINDLTDHNHDGTPDSLPV HVVLSLIGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGSLLSTII TPMLRVQQCGIHSKQACYPLAFGVPAALMAVALIVFVLGSGMYKKFKPQGNIMGKVAKCI GFAIKNRFRHRSKAFPKREHWLDWAKEKYDERLISQIKMVTRVMFLYIPLPMFWALFDQQ GSRWTLQATTMSGKIGALEIQPDQMQTVNAILIVIMVPIFDAVLYPLIAKCGFNFTSLKK MAVGMVLASMAFVVAAIVQVEIDKTLPVFPKGNEVQIKVLNIGNNTMNISLPGEMVTLGP MSQTNAFMTFDVNKLTRINISSPGSPVTAVTDDFKQGQRHTLLVWAPNHYQVVKDGLNQK PEKGENGIRFVNTFNELITITMSGKVYANISSYNASTYQFFPSGIKGFTISSTEIPPQCQ PNFNTFYLEFGSAYTYIVQRKNDSCPEVKVFEDISANTVNMALQIPQYFLLTCGEVVFSV TGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIVAGAGQFSKQWAEYILFAALLLVVC VIFAIMARFYTYINPAEIEAQFDEDEKKNRLEKSNPYFMSGANSQKQM
- Number of residues
- 708
- Molecular Weight
- 78805.265
- Theoretical pI
- 8.64
- GO Classification
- Functionspeptide / proton-dependent oligopeptide secondary active transmembrane transporter activityProcessesdigestion / ion transport / protein transport / proton transport / transmembrane transport / transportComponentsbrush border / integral component of plasma membrane / membrane / plasma membrane
- General Function
- Proton-dependent oligopeptide secondary active transmembrane transporter activity
- Specific Function
- Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.
- Pfam Domain Function
- PTR2 (PF00854)
- Transmembrane Regions
- 1-21 54-74 83-103 119-139 162-182 199-219 277-297 328-348 362-382 585-605 620-640 646-666
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0010714|Solute carrier family 15 member 1 (SLC15A1) ATGGGAATGTCCAAATCACACAGTTTCTTTGGTTATCCCCTGAGCATCTTCTTCATCGTG GTCAATGAGTTTTGCGAAAGATTTTCCTACTATGGAATGCGAGCAATCCTGATTCTGTAC TTCACAAATTTCATCAGCTGGGATGATAACCTGTCCACCGCCATCTACCATACGTTTGTG GCTCTGTGCTACCTGACGCCAATTCTCGGAGCTCTTATCGCCGACTCGTGGCTGGGAAAG TTCAAGACCATTGTGTCGCTCTCCATTGTCTACACAATTGGACAAGCAGTCACCTCAGTA AGCTCCATTAATGACCTCACAGACCACAACCATGATGGCACCCCCGACAGCCTTCCTGTG CACGTGGTGCTGTCCTTGATCGGCCTGGCCCTGATAGCTCTCGGGACTGGAGGAATCAAA CCCTGTGTGTCTGCGTTTGGTGGAGATCAGTTTGAAGAGGGCCAGGAGAAACAAAGAAAC AGATTTTTTTCCATCTTTTACTTGGCTATTAATGCTGGAAGTTTGCTTTCCACAATCATC ACACCCATGCTCAGAGTTCAACAATGTGGAATTCACAGTAAACAAGCTTGTTACCCACTG GCCTTTGGGGTTCCTGCTGCTCTCATGGCTGTAGCCCTGATTGTGTTTGTCCTTGGCAGT GGGATGTACAAGAAGTTCAAGCCACAGGGCAACATCATGGGTAAAGTGGCCAAGTGCATC GGTTTTGCCATCAAAAATAGATTTAGGCATCGGAGTAAGGCATTTCCCAAGAGGGAGCAC TGGCTGGACTGGGCTAAAGAGAAATACGATGAGCGGCTCATCTCCCAAATTAAGATGGTT ACGAGGGTGATGTTCCTGTATATTCCACTCCCAATGTTCTGGGCCTTGTTTGACCAGCAG GGCTCCAGGTGGACACTGCAGGCAACAACTATGTCCGGGAAAATCGGAGCTCTTGAAATT CAGCCCGATCAGATGCAGACCGTGAACGCCATCCTGATCGTGATCATGGTCCCGATCTTC GATGCTGTGCTGTACCCTCTCATTGCAAAATGTGGCTTCAATTTCACCTCCTTGAAGAAG ATGGCAGTTGGCATGGTCCTGGCCTCCATGGCCTTTGTGGTGGCTGCCATCGTGCAGGTG GAAATCGATAAAACTCTTCCAGTCTTCCCCAAAGGAAACGAAGTCCAAATTAAAGTTTTG AATATAGGAAACAATACCATGAATATATCTCTTCCTGGAGAGATGGTGACACTTGGCCCA ATGTCTCAAACAAATGCATTTATGACTTTTGATGTAAACAAACTGACAAGGATAAACATT TCTTCTCCTGGATCACCAGTCACTGCTGTAACTGACGACTTCAAGCAGGGCCAACGCCAC ACGCTTCTAGTGTGGGCCCCCAATCACTACCAGGTGGTAAAGGATGGTCTTAACCAGAAG CCAGAAAAAGGGGAAAATGGAATCAGATTTGTAAATACTTTTAACGAGCTCATCACCATC ACAATGAGTGGGAAAGTTTATGCAAACATCAGCAGCTACAATGCCAGCACATACCAGTTT TTTCCTTCTGGCATAAAAGGCTTCACAATAAGCTCAACAGAGATTCCGCCACAATGTCAA CCTAATTTCAATACTTTCTACCTTGAATTTGGTAGTGCTTATACCTATATAGTCCAAAGG AAGAATGACAGCTGCCCTGAAGTGAAGGTGTTTGAAGATATTTCAGCCAACACAGTTAAC ATGGCTCTGCAAATCCCGCAGTATTTTCTTCTCACCTGTGGCGAAGTGGTCTTCTCTGTC ACGGGATTGGAATTCTCATATTCTCAGGCTCCTTCCAACATGAAGTCGGTGCTTCAGGCA GGATGGCTGCTGACCGTGGCTGTTGGCAACATCATTGTGCTCATCGTGGCAGGGGCAGGC CAGTTCAGCAAACAGTGGGCCGAGTACATTCTATTTGCCGCGTTGCTTCTGGTCGTCTGT GTAATTTTTGCCATCATGGCTCGGTTCTATACTTACATCAACCCAGCGGAGATCGAAGCT CAATTTGATGAGGATGAAAAGAAAAACAGACTGGAAAAGAGTAACCCATATTTCATGTCA GGGGCCAATTCACAGAAACAGATGTGA
- Chromosome Location
- 13
- Locus
- 13q33-q34
- External Identifiers
Resource Link UniProtKB ID P46059 UniProtKB Entry Name S15A1_HUMAN GenBank Protein ID 773588 GenBank Gene ID U13173 GenAtlas ID SLC15A1 HGNC ID HGNC:10920 - General References
- Liang R, Fei YJ, Prasad PD, Ramamoorthy S, Han H, Yang-Feng TL, Hediger MA, Ganapathy V, Leibach FH: Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization. J Biol Chem. 1995 Mar 24;270(12):6456-63. [Article]
- Dunham A, Matthews LH, Burton J, Ashurst JL, Howe KL, Ashcroft KJ, Beare DM, Burford DC, Hunt SE, Griffiths-Jones S, Jones MC, Keenan SJ, Oliver K, Scott CE, Ainscough R, Almeida JP, Ambrose KD, Andrews DT, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Bannerjee R, Barlow KF, Bates K, Beasley H, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burrill W, Carder C, Carter NP, Chapman JC, Clamp ME, Clark SY, Clarke G, Clee CM, Clegg SC, Cobley V, Collins JE, Corby N, Coville GJ, Deloukas P, Dhami P, Dunham I, Dunn M, Earthrowl ME, Ellington AG, Faulkner L, Frankish AG, Frankland J, French L, Garner P, Garnett J, Gilbert JG, Gilson CJ, Ghori J, Grafham DV, Gribble SM, Griffiths C, Hall RE, Hammond S, Harley JL, Hart EA, Heath PD, Howden PJ, Huckle EJ, Hunt PJ, Hunt AR, Johnson C, Johnson D, Kay M, Kimberley AM, King A, Laird GK, Langford CJ, Lawlor S, Leongamornlert DA, Lloyd DM, Lloyd C, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, McLaren SJ, McMurray A, Milne S, Moore MJ, Nickerson T, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter KM, Rice CM, Searle S, Sehra HK, Shownkeen R, Skuce CD, Smith M, Steward CA, Sycamore N, Tester J, Thomas DW, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Wilming L, Wray PW, Wright MW, Young L, Coulson A, Durbin R, Hubbard T, Sulston JE, Beck S, Bentley DR, Rogers J, Ross MT: The DNA sequence and analysis of human chromosome 13. Nature. 2004 Apr 1;428(6982):522-8. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Saito S, Iida A, Sekine A, Ogawa C, Kawauchi S, Higuchi S, Nakamura Y: Catalog of 238 variations among six human genes encoding solute carriers ( hSLCs) in the Japanese population. J Hum Genet. 2002;47(11):576-84. [Article]
- Anderle P, Nielsen CU, Pinsonneault J, Krog PL, Brodin B, Sadee W: Genetic variants of the human dipeptide transporter PEPT1. J Pharmacol Exp Ther. 2006 Feb;316(2):636-46. Epub 2005 Oct 28. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01197 Captopril approved unknown inhibitor Details DB01000 Cyclacillin approved unknown inhibitor Details DB01140 Cefadroxil approved, vet_approved, withdrawn unknown substrateinhibitor Details DB00567 Cephalexin approved, investigational, vet_approved unknown substrateinhibitor Details DB00447 Loracarbef approved, investigational, withdrawn unknown inhibitor Details DB00671 Cefixime approved, investigational unknown substrateinhibitor Details DB01060 Amoxicillin approved, vet_approved unknown inhibitor Details DB00415 Ampicillin approved, vet_approved unknown inhibitor Details DB01415 Ceftibuten approved, investigational unknown substrateinhibitor Details DB00535 Cefdinir approved unknown substrateinhibitor Details DB00577 Valaciclovir approved, investigational unknown substrateinhibitor Details DB00584 Enalapril approved, vet_approved unknown substrateinhibitor Details DB01333 Cefradine approved unknown substrateinhibitor Details DB00968 Methyldopa approved unknown inhibitor Details DB01235 Levodopa approved unknown inhibitor Details DB00833 Cefaclor approved unknown inhibitor Details DB01413 Cefepime approved, investigational unknown inhibitor Details DB01212 Ceftriaxone approved unknown inhibitor Details DB00493 Cefotaxime approved unknown inhibitor Details DB01112 Cefuroxime approved unknown inhibitor Details DB01053 Benzylpenicillin approved, vet_approved unknown substrateinhibitor Details DB00456 Cefalotin approved, investigational, vet_approved unknown inhibitor Details DB00274 Cefmetazole approved, investigational unknown inhibitor Details DB00713 Oxacillin approved, investigational unknown inhibitor Details DB01147 Cloxacillin approved, investigational, vet_approved no inhibitor Details DB00485 Dicloxacillin approved, investigational, vet_approved unknown inhibitor Details DB03424 Ubenimex investigational unknown inhibitor Details DB00855 Aminolevulinic acid approved unknown inhibitor Details DB01016 Glyburide approved unknown inhibitor Details DB01124 Tolbutamide approved, investigational unknown inhibitor Details DB00731 Nateglinide approved, investigational unknown inhibitor Details DB00672 Chlorpropamide approved, investigational unknown inhibitor Details DB01332 Ceftizoxime approved, withdrawn unknown substrate Details DB00198 Oseltamivir approved unknown substrate Details DB00881 Quinapril approved, investigational unknown substrate Details DB00542 Benazepril approved, investigational unknown substrate Details DB01340 Cilazapril approved unknown substrate Details DB00492 Fosinopril approved unknown substrate Details DB00691 Moexipril approved unknown substrate Details DB00790 Perindopril approved unknown substrate Details DB00178 Ramipril approved unknown substrate Details DB01348 Spirapril approved unknown substrate Details DB00519 Trandolapril approved unknown substrate Details DB08795 Azidocillin experimental unknown inhibitor Details DB01610 Valganciclovir approved, investigational unknown Details DB00211 Midodrine approved unknown Details DB08836 Temocapril experimental, investigational unknown Details DB01095 Fluvastatin approved unknown substrateinhibitor Details DB00415 Ampicillin approved, vet_approved unknown Details DB00493 Cefotaxime approved unknown Details DB00713 Oxacillin approved, investigational unknown Details DB01053 Benzylpenicillin approved, vet_approved unknown substrateinhibitor Details DB01212 Ceftriaxone approved unknown Details DB00417 Phenoxymethylpenicillin approved, vet_approved unknown Details DB03793 Benzoic acid approved, investigational unknown Details DB01956 Taurine approved, nutraceutical no substrate Details DB09213 Dexibuprofen approved, investigational unknown Details DB01255 Lisdexamfetamine approved, investigational unknown substrate Details DB00563 Methotrexate approved unknown substrate Details DB00722 Lisinopril approved, investigational unknown substrateinhibitor Details