Solute carrier family 15 member 1

Details

Name
Solute carrier family 15 member 1
Synonyms
  • Intestinal H(+)/peptide cotransporter
  • Oligopeptide transporter, small intestine isoform
  • PEPT1
  • Peptide transporter 1
Gene Name
SLC15A1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0010713|Solute carrier family 15 member 1
MGMSKSHSFFGYPLSIFFIVVNEFCERFSYYGMRAILILYFTNFISWDDNLSTAIYHTFV
ALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVTSVSSINDLTDHNHDGTPDSLPV
HVVLSLIGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGSLLSTII
TPMLRVQQCGIHSKQACYPLAFGVPAALMAVALIVFVLGSGMYKKFKPQGNIMGKVAKCI
GFAIKNRFRHRSKAFPKREHWLDWAKEKYDERLISQIKMVTRVMFLYIPLPMFWALFDQQ
GSRWTLQATTMSGKIGALEIQPDQMQTVNAILIVIMVPIFDAVLYPLIAKCGFNFTSLKK
MAVGMVLASMAFVVAAIVQVEIDKTLPVFPKGNEVQIKVLNIGNNTMNISLPGEMVTLGP
MSQTNAFMTFDVNKLTRINISSPGSPVTAVTDDFKQGQRHTLLVWAPNHYQVVKDGLNQK
PEKGENGIRFVNTFNELITITMSGKVYANISSYNASTYQFFPSGIKGFTISSTEIPPQCQ
PNFNTFYLEFGSAYTYIVQRKNDSCPEVKVFEDISANTVNMALQIPQYFLLTCGEVVFSV
TGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIVAGAGQFSKQWAEYILFAALLLVVC
VIFAIMARFYTYINPAEIEAQFDEDEKKNRLEKSNPYFMSGANSQKQM
Number of residues
708
Molecular Weight
78805.265
Theoretical pI
8.64
GO Classification
Functions
peptide / proton-dependent oligopeptide secondary active transmembrane transporter activity
Processes
digestion / ion transport / protein transport / proton transport / transmembrane transport / transport
Components
brush border / integral component of plasma membrane / membrane / plasma membrane
General Function
Proton-dependent oligopeptide secondary active transmembrane transporter activity
Specific Function
Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.
Pfam Domain Function
Transmembrane Regions
1-21 54-74 83-103 119-139 162-182 199-219 277-297 328-348 362-382 585-605 620-640 646-666
Cellular Location
Membrane
Gene sequence
>lcl|BSEQ0010714|Solute carrier family 15 member 1 (SLC15A1)
ATGGGAATGTCCAAATCACACAGTTTCTTTGGTTATCCCCTGAGCATCTTCTTCATCGTG
GTCAATGAGTTTTGCGAAAGATTTTCCTACTATGGAATGCGAGCAATCCTGATTCTGTAC
TTCACAAATTTCATCAGCTGGGATGATAACCTGTCCACCGCCATCTACCATACGTTTGTG
GCTCTGTGCTACCTGACGCCAATTCTCGGAGCTCTTATCGCCGACTCGTGGCTGGGAAAG
TTCAAGACCATTGTGTCGCTCTCCATTGTCTACACAATTGGACAAGCAGTCACCTCAGTA
AGCTCCATTAATGACCTCACAGACCACAACCATGATGGCACCCCCGACAGCCTTCCTGTG
CACGTGGTGCTGTCCTTGATCGGCCTGGCCCTGATAGCTCTCGGGACTGGAGGAATCAAA
CCCTGTGTGTCTGCGTTTGGTGGAGATCAGTTTGAAGAGGGCCAGGAGAAACAAAGAAAC
AGATTTTTTTCCATCTTTTACTTGGCTATTAATGCTGGAAGTTTGCTTTCCACAATCATC
ACACCCATGCTCAGAGTTCAACAATGTGGAATTCACAGTAAACAAGCTTGTTACCCACTG
GCCTTTGGGGTTCCTGCTGCTCTCATGGCTGTAGCCCTGATTGTGTTTGTCCTTGGCAGT
GGGATGTACAAGAAGTTCAAGCCACAGGGCAACATCATGGGTAAAGTGGCCAAGTGCATC
GGTTTTGCCATCAAAAATAGATTTAGGCATCGGAGTAAGGCATTTCCCAAGAGGGAGCAC
TGGCTGGACTGGGCTAAAGAGAAATACGATGAGCGGCTCATCTCCCAAATTAAGATGGTT
ACGAGGGTGATGTTCCTGTATATTCCACTCCCAATGTTCTGGGCCTTGTTTGACCAGCAG
GGCTCCAGGTGGACACTGCAGGCAACAACTATGTCCGGGAAAATCGGAGCTCTTGAAATT
CAGCCCGATCAGATGCAGACCGTGAACGCCATCCTGATCGTGATCATGGTCCCGATCTTC
GATGCTGTGCTGTACCCTCTCATTGCAAAATGTGGCTTCAATTTCACCTCCTTGAAGAAG
ATGGCAGTTGGCATGGTCCTGGCCTCCATGGCCTTTGTGGTGGCTGCCATCGTGCAGGTG
GAAATCGATAAAACTCTTCCAGTCTTCCCCAAAGGAAACGAAGTCCAAATTAAAGTTTTG
AATATAGGAAACAATACCATGAATATATCTCTTCCTGGAGAGATGGTGACACTTGGCCCA
ATGTCTCAAACAAATGCATTTATGACTTTTGATGTAAACAAACTGACAAGGATAAACATT
TCTTCTCCTGGATCACCAGTCACTGCTGTAACTGACGACTTCAAGCAGGGCCAACGCCAC
ACGCTTCTAGTGTGGGCCCCCAATCACTACCAGGTGGTAAAGGATGGTCTTAACCAGAAG
CCAGAAAAAGGGGAAAATGGAATCAGATTTGTAAATACTTTTAACGAGCTCATCACCATC
ACAATGAGTGGGAAAGTTTATGCAAACATCAGCAGCTACAATGCCAGCACATACCAGTTT
TTTCCTTCTGGCATAAAAGGCTTCACAATAAGCTCAACAGAGATTCCGCCACAATGTCAA
CCTAATTTCAATACTTTCTACCTTGAATTTGGTAGTGCTTATACCTATATAGTCCAAAGG
AAGAATGACAGCTGCCCTGAAGTGAAGGTGTTTGAAGATATTTCAGCCAACACAGTTAAC
ATGGCTCTGCAAATCCCGCAGTATTTTCTTCTCACCTGTGGCGAAGTGGTCTTCTCTGTC
ACGGGATTGGAATTCTCATATTCTCAGGCTCCTTCCAACATGAAGTCGGTGCTTCAGGCA
GGATGGCTGCTGACCGTGGCTGTTGGCAACATCATTGTGCTCATCGTGGCAGGGGCAGGC
CAGTTCAGCAAACAGTGGGCCGAGTACATTCTATTTGCCGCGTTGCTTCTGGTCGTCTGT
GTAATTTTTGCCATCATGGCTCGGTTCTATACTTACATCAACCCAGCGGAGATCGAAGCT
CAATTTGATGAGGATGAAAAGAAAAACAGACTGGAAAAGAGTAACCCATATTTCATGTCA
GGGGCCAATTCACAGAAACAGATGTGA
Chromosome Location
13
Locus
13q33-q34
External Identifiers
ResourceLink
UniProtKB IDP46059
UniProtKB Entry NameS15A1_HUMAN
GenBank Protein ID773588
GenBank Gene IDU13173
GenAtlas IDSLC15A1
HGNC IDHGNC:10920
General References
  1. Liang R, Fei YJ, Prasad PD, Ramamoorthy S, Han H, Yang-Feng TL, Hediger MA, Ganapathy V, Leibach FH: Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization. J Biol Chem. 1995 Mar 24;270(12):6456-63. [PubMed:7896779]
  2. Dunham A, Matthews LH, Burton J, Ashurst JL, Howe KL, Ashcroft KJ, Beare DM, Burford DC, Hunt SE, Griffiths-Jones S, Jones MC, Keenan SJ, Oliver K, Scott CE, Ainscough R, Almeida JP, Ambrose KD, Andrews DT, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Bannerjee R, Barlow KF, Bates K, Beasley H, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burrill W, Carder C, Carter NP, Chapman JC, Clamp ME, Clark SY, Clarke G, Clee CM, Clegg SC, Cobley V, Collins JE, Corby N, Coville GJ, Deloukas P, Dhami P, Dunham I, Dunn M, Earthrowl ME, Ellington AG, Faulkner L, Frankish AG, Frankland J, French L, Garner P, Garnett J, Gilbert JG, Gilson CJ, Ghori J, Grafham DV, Gribble SM, Griffiths C, Hall RE, Hammond S, Harley JL, Hart EA, Heath PD, Howden PJ, Huckle EJ, Hunt PJ, Hunt AR, Johnson C, Johnson D, Kay M, Kimberley AM, King A, Laird GK, Langford CJ, Lawlor S, Leongamornlert DA, Lloyd DM, Lloyd C, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, McLaren SJ, McMurray A, Milne S, Moore MJ, Nickerson T, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter KM, Rice CM, Searle S, Sehra HK, Shownkeen R, Skuce CD, Smith M, Steward CA, Sycamore N, Tester J, Thomas DW, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Wilming L, Wray PW, Wright MW, Young L, Coulson A, Durbin R, Hubbard T, Sulston JE, Beck S, Bentley DR, Rogers J, Ross MT: The DNA sequence and analysis of human chromosome 13. Nature. 2004 Apr 1;428(6982):522-8. [PubMed:15057823]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334]
  4. Saito S, Iida A, Sekine A, Ogawa C, Kawauchi S, Higuchi S, Nakamura Y: Catalog of 238 variations among six human genes encoding solute carriers ( hSLCs) in the Japanese population. J Hum Genet. 2002;47(11):576-84. [PubMed:12436193]
  5. Anderle P, Nielsen CU, Pinsonneault J, Krog PL, Brodin B, Sadee W: Genetic variants of the human dipeptide transporter PEPT1. J Pharmacol Exp Ther. 2006 Feb;316(2):636-46. Epub 2005 Oct 28. [PubMed:16258023]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01197CaptoprilapprovedunknowninhibitorDetails
DB01000CyclacillinapprovedunknowninhibitorDetails
DB01140Cefadroxilapproved, vet_approved, withdrawnunknownsubstrateinhibitorDetails
DB00567Cephalexinapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB00447Loracarbefapproved, investigational, withdrawnunknowninhibitorDetails
DB00671Cefiximeapproved, investigationalunknownsubstrateinhibitorDetails
DB01060Amoxicillinapproved, vet_approvedunknowninhibitorDetails
DB00415Ampicillinapproved, vet_approvedunknowninhibitorDetails
DB01415Ceftibutenapproved, investigationalunknownsubstrateinhibitorDetails
DB00535CefdinirapprovedunknownsubstrateinhibitorDetails
DB00577Valaciclovirapproved, investigationalunknownsubstrateinhibitorDetails
DB00584Enalaprilapproved, vet_approvedunknownsubstrateinhibitorDetails
DB01333CefradineapprovedunknownsubstrateinhibitorDetails
DB00968MethyldopaapprovedunknowninhibitorDetails
DB01235LevodopaapprovedunknowninhibitorDetails
DB00833CefaclorapprovedunknowninhibitorDetails
DB00438CeftazidimeapprovedunknowninhibitorDetails
DB01413Cefepimeapproved, investigationalunknowninhibitorDetails
DB01212CeftriaxoneapprovedunknowninhibitorDetails
DB00493CefotaximeapprovedunknowninhibitorDetails
DB01112CefuroximeapprovedunknowninhibitorDetails
DB01053Benzylpenicillinapproved, vet_approvedunknownsubstrateinhibitorDetails
DB00456Cefalotinapproved, investigational, vet_approvedunknowninhibitorDetails
DB00274Cefmetazoleapproved, investigationalunknowninhibitorDetails
DB00713Oxacillinapproved, investigationalunknowninhibitorDetails
DB01147Cloxacillinapproved, investigational, vet_approvedunknowninhibitorDetails
DB00485Dicloxacillinapproved, investigational, vet_approvedunknowninhibitorDetails
DB03424Ubenimexexperimental, investigationalunknowninhibitorDetails
DB00855Aminolevulinic acidapprovedunknowninhibitorDetails
DB01016GlyburideapprovedunknowninhibitorDetails
DB01124Tolbutamideapproved, investigationalunknowninhibitorDetails
DB00731Nateglinideapproved, investigationalunknowninhibitorDetails
DB00672Chlorpropamideapproved, investigationalunknowninhibitorDetails
DB01332Ceftizoximeapproved, investigationalunknownsubstrateDetails
DB00198OseltamivirapprovedunknownsubstrateDetails
DB00881Quinaprilapproved, investigationalunknownsubstrateDetails
DB00542Benazeprilapproved, investigationalunknownsubstrateDetails
DB01340CilazaprilapprovedunknownsubstrateDetails
DB00492FosinoprilapprovedunknownsubstrateDetails
DB00691MoexiprilapprovedunknownsubstrateDetails
DB00790PerindoprilapprovedunknownsubstrateDetails
DB00178RamiprilapprovedunknownsubstrateDetails
DB01348SpiraprilapprovedunknownsubstrateDetails
DB00519TrandolaprilapprovedunknownsubstrateDetails
DB08795AzidocillinexperimentalunknowninhibitorDetails
DB01610Valganciclovirapproved, investigationalunknownDetails
DB00211MidodrineapprovedunknownDetails
DB08836Temocaprilexperimental, investigationalunknownDetails
DB01095FluvastatinapprovedunknownsubstrateinhibitorDetails
DB00415Ampicillinapproved, vet_approvedunknownDetails
DB00493CefotaximeapprovedunknownDetails
DB00713Oxacillinapproved, investigationalunknownDetails
DB01053Benzylpenicillinapproved, vet_approvedunknownDetails
DB01212CeftriaxoneapprovedunknownDetails
DB00417Phenoxymethylpenicillinapproved, vet_approvedunknownDetails
DB03793Benzoic Acidapproved, investigationalunknownDetails
DB01956Taurineapproved, nutraceuticalnosubstrateDetails
DB09213Dexibuprofenapproved, investigationalunknownDetails
DB01255Lisdexamfetamineapproved, investigationalunknownsubstrateDetails
DB00563MethotrexateapprovedunknownsubstrateDetails