Stromal cell-derived factor 1

Details

Name
Stromal cell-derived factor 1
Synonyms
  • C-X-C motif chemokine 12
  • hIRH
  • Intercrine reduced in hepatomas
  • IRH
  • PBSF
  • Pre-B cell growth-stimulating factor
  • SDF-1
  • SDF1
  • SDF1A
  • SDF1B
Gene Name
CXCL12
Organism
Humans
Amino acid sequence
>lcl|BSEQ0002287|Stromal cell-derived factor 1
MNAKVVVVLVLVLTALCLSDGKPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIV
ARLKNNNRQVCIDPKLKWIQEYLEKALNKRFKM
Number of residues
93
Molecular Weight
10665.75
Theoretical pI
10.54
GO Classification
Functions
chemoattractant activity / chemokine activity / chemokine receptor binding / CXCR chemokine receptor binding / receptor binding
Processes
adult locomotory behavior / ameboidal-type cell migration / axon guidance / blood circulation / cell adhesion / cell chemotaxis / cellular calcium ion homeostasis / chemokine-mediated signaling pathway / chemotaxis / G-protein coupled receptor signaling pathway / germ cell development / germ cell migration / immune response / induction of positive chemotaxis / motor neuron axon guidance / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage / negative regulation of leukocyte apoptotic process / negative regulation of leukocyte tethering or rolling / neuron migration / organ regeneration / patterning of blood vessels / positive chemotaxis / positive regulation of axon extension involved in axon guidance / positive regulation of calcium ion import / positive regulation of cell adhesion / positive regulation of dopamine secretion / positive regulation of endothelial cell proliferation / positive regulation of monocyte chemotaxis / positive regulation of myoblast fusion / positive regulation of T cell migration / regulation of actin polymerization or depolymerization / response to heat / response to hypoxia / response to mechanical stimulus / response to peptide hormone / response to radiation / response to virus / signal transduction / T cell proliferation / telencephalon cell migration
Components
external side of plasma membrane / extracellular exosome / extracellular region / extracellular space
General Function
Not Available
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0020510|Stromal cell-derived factor 1 (CXCL12)
ATGAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTGCCTCAGCGAC
GGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTCGAAAGCCATGTTGCC
AGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCAAACTGTGCCCTTCAGATTGTA
GCCCGGCTGAAGAACAACAACAGACAAGTGTGCATTGACCCGAAGCTAAAGTGGATTCAG
GAGTACCTGGAGAAAGCTTTAAACAAGAGGTTCAAGATGTGA
Chromosome Location
Not Available
Locus
10q11.1
External Identifiers
ResourceLink
UniProtKB IDP48061
UniProtKB Entry NameSDF1_HUMAN
GenBank Protein ID571508
GenBank Gene IDU16752
GenAtlas IDCXCL12
HGNC IDHGNC:10672
General References
  1. Shirozu M, Nakano T, Inazawa J, Tashiro K, Tada H, Shinohara T, Honjo T: Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene. Genomics. 1995 Aug 10;28(3):495-500. [PubMed:7490086]
  2. Yu L, Cecil J, Peng SB, Schrementi J, Kovacevic S, Paul D, Su EW, Wang J: Identification and expression of novel isoforms of human stromal cell-derived factor 1. Gene. 2006 Jun 7;374:174-9. Epub 2006 Apr 19. [PubMed:16626895]
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  7. Oberlin E, Amara A, Bachelerie F, Bessia C, Virelizier JL, Arenzana-Seisdedos F, Schwartz O, Heard JM, Clark-Lewis I, Legler DF, Loetscher M, Baggiolini M, Moser B: The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature. 1996 Aug 29;382(6594):833-5. [PubMed:8752281]
  8. Donzella GA, Schols D, Lin SW, Este JA, Nagashima KA, Maddon PJ, Allaway GP, Sakmar TP, Henson G, De Clercq E, Moore JP: AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor. Nat Med. 1998 Jan;4(1):72-7. [PubMed:9427609]
  9. Amara A, Lorthioir O, Valenzuela A, Magerus A, Thelen M, Montes M, Virelizier JL, Delepierre M, Baleux F, Lortat-Jacob H, Arenzana-Seisdedos F: Stromal cell-derived factor-1alpha associates with heparan sulfates through the first beta-strand of the chemokine. J Biol Chem. 1999 Aug 20;274(34):23916-25. [PubMed:10446158]
  10. Moepps B, Braun M, Knopfle K, Dillinger K, Knochel W, Gierschik P: Characterization of a Xenopus laevis CXC chemokine receptor 4: implications for hematopoietic cell development in the vertebrate embryo. Eur J Immunol. 2000 Oct;30(10):2924-34. [PubMed:11069075]
  11. Braun M, Wunderlin M, Spieth K, Knochel W, Gierschik P, Moepps B: Xenopus laevis Stromal cell-derived factor 1: conservation of structure and function during vertebrate development. J Immunol. 2002 Mar 1;168(5):2340-7. [PubMed:11859124]
  12. De La Luz Sierra M, Yang F, Narazaki M, Salvucci O, Davis D, Yarchoan R, Zhang HH, Fales H, Tosato G: Differential processing of stromal-derived factor-1alpha and stromal-derived factor-1beta explains functional diversity. Blood. 2004 Apr 1;103(7):2452-9. Epub 2003 Oct 2. [PubMed:14525775]
  13. Balabanian K, Lagane B, Infantino S, Chow KY, Harriague J, Moepps B, Arenzana-Seisdedos F, Thelen M, Bachelerie F: The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. J Biol Chem. 2005 Oct 21;280(42):35760-6. Epub 2005 Aug 17. [PubMed:16107333]
  14. Veldkamp CT, Peterson FC, Pelzek AJ, Volkman BF: The monomer-dimer equilibrium of stromal cell-derived factor-1 (CXCL 12) is altered by pH, phosphate, sulfate, and heparin. Protein Sci. 2005 Apr;14(4):1071-81. Epub 2005 Mar 1. [PubMed:15741341]
  15. Veldkamp CT, Seibert C, Peterson FC, Sakmar TP, Volkman BF: Recognition of a CXCR4 sulfotyrosine by the chemokine stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12). J Mol Biol. 2006 Jun 23;359(5):1400-9. Epub 2006 May 11. [PubMed:16725153]
  16. Malik M, Chen YY, Kienzle MF, Tomkowicz BE, Collman RG, Ptasznik A: Monocyte migration and LFA-1-mediated attachment to brain microvascular endothelia is regulated by SDF-1 alpha through Lyn kinase. J Immunol. 2008 Oct 1;181(7):4632-7. [PubMed:18802065]
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  20. Dealwis C, Fernandez EJ, Thompson DA, Simon RJ, Siani MA, Lolis E: Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1alpha, a potent ligand for the HIV-1 "fusin" coreceptor. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6941-6. [PubMed:9618518]
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  22. Gozansky EK, Louis JM, Caffrey M, Clore GM: Mapping the binding of the N-terminal extracellular tail of the CXCR4 receptor to stromal cell-derived factor-1alpha. J Mol Biol. 2005 Jan 28;345(4):651-8. [PubMed:15588815]
  23. Murphy JW, Cho Y, Sachpatzidis A, Fan C, Hodsdon ME, Lolis E: Structural and functional basis of CXCL12 (stromal cell-derived factor-1 alpha) binding to heparin. J Biol Chem. 2007 Mar 30;282(13):10018-27. Epub 2007 Jan 29. [PubMed:17264079]
  24. Ryu EK, Kim TG, Kwon TH, Jung ID, Ryu D, Park YM, Kim J, Ahn KH, Ban C: Crystal structure of recombinant human stromal cell-derived factor-1alpha. Proteins. 2007 Jun 1;67(4):1193-7. [PubMed:17357154]
  25. Veldkamp CT, Seibert C, Peterson FC, De la Cruz NB, Haugner JC 3rd, Basnet H, Sakmar TP, Volkman BF: Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1/CXCL12. Sci Signal. 2008 Sep 16;1(37):ra4. doi: 10.1126/scisignal.1160755. [PubMed:18799424]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB05934CTCE-0214investigationalunknownDetails
DB06822TinzaparinapprovedunknownbinderDetails