Glutamate--cysteine ligase regulatory subunit

Details

Name
Glutamate--cysteine ligase regulatory subunit
Synonyms
  • Gamma-ECS regulatory subunit
  • Gamma-glutamylcysteine synthetase regulatory subunit
  • GCS light chain
  • GLCLR
  • Glutamate--cysteine ligase modifier subunit
Gene Name
GCLM
Organism
Humans
Amino acid sequence
>lcl|BSEQ0001209|Glutamate--cysteine ligase regulatory subunit
MGTDSRAAKALLARARTLHLQTGNLLNWGRLRKKCPSTHSEELHDCIQKTLNEWSSQINP
DLVREFPDVLECTVSHAVEKINPDEREEMKVSAKLFIVESNSSSSTRSAVDMACSVLGVA
QLDSVIIASPPIEDGVNLSLEHLQPYWEELENLVQSKKIVAIGTSDLDKTQLEQLYQWAQ
VKPNSNQVNLASCCVMPPDLTAFAKQFDIQLLTHNDPKELLSEASFQEALQESIPDIQAH
EWVPLWLLRYSVIVKSRGIIKSKGYILQAKRRGS
Number of residues
274
Molecular Weight
30726.745
Theoretical pI
5.91
GO Classification
Functions
enzyme regulator activity / glutamate-cysteine ligase activity / glutamate-cysteine ligase catalytic subunit binding
Processes
apoptotic mitochondrial changes / cellular nitrogen compound metabolic process / cysteine metabolic process / glutamate metabolic process / glutathione biosynthetic process / glutathione derivative biosynthetic process / negative regulation of extrinsic apoptotic signaling pathway / negative regulation of neuron apoptotic process / positive regulation of glutamate-cysteine ligase activity / regulation of blood vessel size / regulation of mitochondrial depolarization / response to drug / response to nitrosative stress / response to oxidative stress / small molecule metabolic process / sulfur amino acid metabolic process / xenobiotic metabolic process
Components
cytosol / glutamate-cysteine ligase complex
General Function
Glutamate-cysteine ligase catalytic subunit binding
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0021272|Glutamate--cysteine ligase regulatory subunit (GCLM)
ATGGGCACCGACAGCCGCGCGGCCAAGGCGCTCCTGGCGCGGGCCCGCACCCTGCACCTG
CAGACGGGGAACCTGCTGAACTGGGGCCGCCTGCGGAAGAAGTGCCCGTCCACGCACAGC
GAGGAGGAGTTTCCAGATGTCTTGGAATGCACTGTATCTCATGCAGTAGAAAAGATAAAT
CCTGATGAAAGAGAAGAAATGAAAGTTTCTGCAAAACTGTTCATTGTAGAATCAAACTCT
TCATCATCAACTAGAAGTGCAGTTGACATGGCCTGTTCAGTCCTTGGAGTTGCACAGCTG
GATTCTGTGATCATTGCTTCACCTCCTATTGAAGATGGAGTTAATCTTTCCTTGGAGCAT
TTACAGCCTTACTGGGAGGAATTAGAAAACTTAGTTCAGAGCAAAAAGATTGTTGCCATA
GGTACCTCTGATCTAGACAAAACACAGTTGGAACAGCTGTATCAGTGGGCACAGGTAAAA
CCAAATAGTAACCAAGTTAATCTTGCCTCCTGCTGTGTGATGCCACCAGATTTGACTGCA
TTTGCTAAACAATTTGACATACAGCTGTTGACTCACAATGATCCAAAAGAACTGCTTTCT
GAAGCAAGTTTCCAAGAAGCTCTTCAGGAAAGCATTCCTGACATTCAAGCGCACGAGTGG
GTGCCGCTGTGGCTACTGCGGTATTCGGTCATTGTGAAAAGTAGAGGAATTATCAAATCA
AAAGGCTACATTTTACAAGCTAAAAGAAGGGGTTCTTAA
Chromosome Location
1
Locus
1p22.1
External Identifiers
ResourceLink
UniProtKB IDP48507
UniProtKB Entry NameGSH0_HUMAN
GenBank Protein ID530137
GenBank Gene IDL35546
GenAtlas IDGCLM
HGNC IDHGNC:4312
General References
  1. Gipp JJ, Bailey HH, Mulcahy RT: Cloning and sequencing of the cDNA for the light subunit of human liver gamma-glutamylcysteine synthetase and relative mRNA levels for heavy and light subunits in human normal tissues. Biochem Biophys Res Commun. 1995 Jan 17;206(2):584-9. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00151Cysteineapproved, nutraceuticalunknownDetails
DB00142Glutamic acidapproved, nutraceuticalunknownDetails