Neuropeptide Y receptor type 2
Details
- Name
- Neuropeptide Y receptor type 2
- Synonyms
- NPY-Y2 receptor
- NPY2-R
- Y2 receptor
- Gene Name
- NPY2R
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0019283|Neuropeptide Y receptor type 2 MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSI ILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGP VLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLA SPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYT RIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDL KEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAK KNLEVRKNSGPNDSFTEATNV
- Number of residues
- 381
- Molecular Weight
- 42730.69
- Theoretical pI
- 7.26
- GO Classification
- Functionscalcium channel regulator activity / neuropeptide Y receptor activity / peptide YY receptor activity / receptor activityProcessesadenylate cyclase-inhibiting G-protein coupled receptor signaling pathway / behavioral fear response / cardiac left ventricle morphogenesis / cell surface receptor signaling pathway / feeding behavior / locomotory behavior / negative regulation of cAMP biosynthetic process / negative regulation of excitatory postsynaptic potential / negative regulation of feeding behavior / negative regulation of neurological system process / negative regulation of secretion / negative regulation of synaptic transmission, glutamatergic / neuropeptide signaling pathway / nitric oxide mediated signal transduction / outflow tract morphogenesis / positive regulation of cell-substrate adhesion / positive regulation of circadian sleep/wake cycle, non-REM sleep / positive regulation of cytosolic calcium ion concentration / positive regulation of dopamine secretion / positive regulation of peptide secretion / positive regulation of smooth muscle contraction / regulation of sensory perception of pain / secretion / synaptic transmissionComponentscytosol / integral component of plasma membrane / nonmotile primary cilium / plasma membrane
- General Function
- Receptor activity
- Specific Function
- Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 52-72 87-107 125-145 166-186 217-237 269-289 305-325
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0019284|Neuropeptide Y receptor type 2 (NPY2R) ATGGGTCCAATAGGTGCAGAGGCTGATGAGAACCAGACAGTGGAAGAAATGAAGGTGGAA CAATACGGGCCACAAACAACTCCTAGAGGTGAACTGGTCCCTGACCCTGAGCCAGAGCTT ATAGATAGTACCAAGCTGATTGAGGTACAAGTTGTTCTCATATTGGCCTACTGCTCCATC ATCTTGCTTGGGGTAATTGGCAACTCCTTGGTGATCCATGTGGTGATCAAATTCAAGAGC ATGCGCACAGTAACCAACTTTTTCATTGCCAATCTGGCTGTGGCAGATCTTTTGGTGAAC ACTCTGTGTCTACCGTTCACTCTTACCTATACCTTAATGGGGGAGTGGAAAATGGGTCCT GTCCTGTGCCACCTGGTGCCCTATGCCCAGGGCCTGGCAGTACAAGTATCCACAATCACC TTGACAGTAATTGCCCTGGACCGGCACAGGTGCATCGTCTACCACCTAGAGAGCAAGATC TCCAAGCGAATCAGCTTCCTGATTATTGGCTTGGCCTGGGGCATCAGTGCCCTGCTGGCA AGTCCCCTGGCCATCTTCCGGGAGTATTCGCTGATTGAGATCATCCCGGACTTTGAGATT GTGGCCTGTACTGAAAAGTGGCCTGGCGAGGAGAAGAGCATCTATGGCACTGTCTATAGT CTTTCTTCCTTGTTGATCTTGTATGTTTTGCCTCTGGGCATTATATCATTTTCCTACACT CGCATTTGGAGTAAATTGAAGAACCATGTCAGTCCTGGAGCTGCAAATGACCACTACCAT CAGCGAAGGCAAAAAACCACCAAAATGCTGGTGTGTGTGGTGGTGGTGTTTGCGGTCAGC TGGCTGCCTCTCCATGCCTTCCAGCTTGCCGTTGACATTGACAGCCAGGTCCTGGACCTG AAGGAGTACAAACTCATCTTCACAGTGTTCCACATCATCGCCATGTGCTCCACTTTTGCC AATCCCCTTCTCTATGGCTGGATGAACAGCAACTACAGAAAGGCTTTCCTCTCGGCCTTC CGCTGTGAGCAGCGGTTGGATGCCATTCACTCTGAGGTGTCCGTGACATTCAAGGCTAAA AAGAACCTGGAGGTCAGAAAGAACAGTGGCCCCAATGACTCTTTCACAGAGGCTACCAAT GTCTAA
- Chromosome Location
- 4
- Locus
- 4q31
- External Identifiers
Resource Link UniProtKB ID P49146 UniProtKB Entry Name NPY2R_HUMAN GenBank Gene ID U36269 GenAtlas ID NPY2R HGNC ID HGNC:7957 - General References
- Gerald C, Walker MW, Vaysse PJ, He C, Branchek TA, Weinshank RL: Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype. J Biol Chem. 1995 Nov 10;270(45):26758-61. [Article]
- Gehlert DR, Beavers LS, Johnson D, Gackenheimer SL, Schober DA, Gadski RA: Expression cloning of a human brain neuropeptide Y Y2 receptor. Mol Pharmacol. 1996 Feb;49(2):224-8. [Article]
- Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R: Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. J Biol Chem. 1995 Sep 29;270(39):22661-4. [Article]
- Yan H, Yang J, Marasco J, Yamaguchi K, Brenner S, Collins F, Karbon W: Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4661-5. [Article]
- Ammar DA, Eadie DM, Wong DJ, Ma YY, Kolakowski LF Jr, Yang-Feng TL, Thompson DA: Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene. Genomics. 1996 Dec 15;38(3):392-8. [Article]
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